DK2076535T3 - Receptor(SSTR2)-selektive somatostatinantagonister - Google Patents

Receptor(SSTR2)-selektive somatostatinantagonister

Info

Publication number
DK2076535T3
DK2076535T3 DK07854075.4T DK07854075T DK2076535T3 DK 2076535 T3 DK2076535 T3 DK 2076535T3 DK 07854075 T DK07854075 T DK 07854075T DK 2076535 T3 DK2076535 T3 DK 2076535T3
Authority
DK
Denmark
Prior art keywords
sstr2
receptor
somatostatin antagonists
selective somatostatin
selective
Prior art date
Application number
DK07854075.4T
Other languages
English (en)
Inventor
Jean E F Rivier
Judit Erchegyi
Jean Claude Reubi
Helmut R Maecke
Original Assignee
Salk Inst For Biological Studi
Univ Bern
Univ Hospital Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Inst For Biological Studi, Univ Bern, Univ Hospital Basel filed Critical Salk Inst For Biological Studi
Application granted granted Critical
Publication of DK2076535T3 publication Critical patent/DK2076535T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK07854075.4T 2006-10-16 2007-10-15 Receptor(SSTR2)-selektive somatostatinantagonister DK2076535T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82963706P 2006-10-16 2006-10-16
PCT/US2007/081430 WO2008048942A2 (en) 2006-10-16 2007-10-15 Receptor(sstr2)-selective somatostatin antagonists

Publications (1)

Publication Number Publication Date
DK2076535T3 true DK2076535T3 (da) 2013-06-10

Family

ID=39144622

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07854075.4T DK2076535T3 (da) 2006-10-16 2007-10-15 Receptor(SSTR2)-selektive somatostatinantagonister

Country Status (14)

Country Link
US (2) US7960342B2 (da)
EP (3) EP2433963B1 (da)
JP (1) JP5295967B2 (da)
CN (2) CN101631801B (da)
AU (1) AU2007311137B2 (da)
BR (1) BRPI0717135B8 (da)
CA (1) CA2666642C (da)
DK (1) DK2076535T3 (da)
ES (2) ES2410207T3 (da)
HK (1) HK1132515A1 (da)
PL (3) PL2076535T3 (da)
PT (1) PT2076535E (da)
SI (1) SI2076535T1 (da)
WO (1) WO2008048942A2 (da)

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PL2076535T3 (pl) 2006-10-16 2013-08-30 Salk Inst Biological Studies Antagoniści somatostatyny selektywni względem receptora (SSTR2)
US8691761B2 (en) * 2006-10-16 2014-04-08 Jean E. F. Rivier Somatostatin receptor 2 antagonists
CA2677045C (en) 2007-01-31 2016-10-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
CA2682174C (en) 2007-03-28 2021-04-06 President And Fellows Of Harvard College Stitched polypeptides
WO2012021876A2 (en) 2010-08-13 2012-02-16 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CN108929375A (zh) 2011-10-18 2018-12-04 爱勒让治疗公司 拟肽大环化合物
WO2013123267A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
ES2817877T3 (es) 2012-02-15 2021-04-08 Aileron Therapeutics Inc Macrociclos peptidomiméticos
JP6526563B2 (ja) 2012-11-01 2019-06-05 エイルロン セラピューティクス，インコーポレイテッド 二置換アミノ酸ならびにその調製および使用の方法
EP2943511B1 (en) 2013-01-14 2019-08-07 Xencor, Inc. Novel heterodimeric proteins
US11053316B2 (en) 2013-01-14 2021-07-06 Xencor, Inc. Optimized antibody variable regions
US10858417B2 (en) 2013-03-15 2020-12-08 Xencor, Inc. Heterodimeric proteins
SG10202008629XA (en) 2014-03-28 2020-10-29 Xencor Inc Bispecific antibodies that bind to cd38 and cd3
CN104086630B (zh) * 2014-06-25 2016-06-29 天津欧德莱生物医药科技有限公司 一种生长抑素受体激动剂多肽及其应用
CN104045690B (zh) * 2014-06-25 2016-06-08 舟山医院 生长抑素受体激动剂多肽及其应用
CN104045689B (zh) * 2014-06-25 2016-08-24 新乡医学院 一种关于生长抑素受体激动剂多肽及其应用
SG10201902594QA (en) 2014-09-24 2019-04-29 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
CN104491890A (zh) * 2014-11-21 2015-04-08 北京肿瘤医院 放射性核素标记的新型生长抑素类似物分子探针及其应用
US10259887B2 (en) 2014-11-26 2019-04-16 Xencor, Inc. Heterodimeric antibodies that bind CD3 and tumor antigens
IL252480B2 (en) 2014-11-26 2023-12-01 Xencor Inc Heterodimeric antibodies that bind CD3 and tumor antigens
CA2979847A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US11623957B2 (en) 2015-12-07 2023-04-11 Xencor, Inc. Heterodimeric antibodies that bind CD3 and PSMA
CA3013882A1 (en) * 2016-02-09 2017-08-17 Cdrd Ventures Inc. Somatostatin receptor antagonist compounds and methods of using the same
IL263542B1 (en) 2016-06-14 2024-06-01 Xencor Inc Bispecific antibodies inhibit immunological checkpoint
US10849955B2 (en) 2016-09-28 2020-12-01 City Of Hope Methods of treating pancreatic cancer using GPCR antagonists
TW202017600A (zh) * 2018-06-21 2020-05-16 法商艾普森藥品公司 用於放射性醫藥之含有體抑素類似物之組成物
TW202015744A (zh) * 2018-06-21 2020-05-01 法商艾普森藥品公司 用於放射性醫藥之含有體抑素類似物之組成物
WO2021231976A1 (en) 2020-05-14 2021-11-18 Xencor, Inc. Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3
IL300666A (en) 2020-08-19 2023-04-01 Xencor Inc ANTI–CD28 COMPOSITIONS
CN117157319A (zh) 2021-03-09 2023-12-01 Xencor股份有限公司 结合cd3和cldn6的异二聚抗体
JP2024509274A (ja) 2021-03-10 2024-02-29 ゼンコア インコーポレイテッド Ｃｄ３及びｇｐｃ３に結合するヘテロ二量体抗体
CN115583989B (zh) * 2022-12-09 2023-02-28 烟台蓝纳成生物技术有限公司 一种靶向sstr2的化合物及其制备方法和应用

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US7238340B1 (en) * 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5590656A (en) * 1992-09-15 1997-01-07 The Ohio State University Research Foundation Application of peptide/cell receptor kinetics utilizing radiolabeled somatostatin congeners in the in situ, in vivo detection and differentiation of neoplastic tissue
US5879657A (en) 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
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US5663292A (en) * 1994-12-12 1997-09-02 The Salk Institute For Biological Studies Cyclic CRF analogs
US5688489A (en) * 1995-09-15 1997-11-18 Resolution Pharmaceuticals, Inc. Non-receptor mediated imaging agents
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US5750499A (en) 1995-10-18 1998-05-12 The Salk Institute For Biological Studies Receptor-selective somatostatin analogs
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ES2264174T3 (es) * 1996-12-04 2006-12-16 Societe De Conseils De Recherches Et D'applications Scientifiques (Scras) S.A.S Antagonistas de somatostatina.
US6262229B1 (en) * 1996-12-04 2001-07-17 Biomeasure Incorporated Somatostatin antagonists
US5925618A (en) * 1997-03-06 1999-07-20 American Cyanamid Company Peptides useful as somatostatin antagonists
CA2246791A1 (en) 1998-09-01 2000-03-01 Alison Buchan Treatment of endothelium with somatostatin analogues
US6579967B1 (en) * 1999-12-14 2003-06-17 The Salk Institute For Biological Studies Receptor-selective somatostatin analogs
DE60130802T2 (de) * 2000-10-20 2008-07-03 Société de Conseils de Recherches et d'Applications Scientifiques S.A.S. Agonisten und antagonisten von urotensin-ii
ES2306766T3 (es) * 2001-03-08 2008-11-16 The Administrators Of The Tulane Educational Fund Antagonistas de somatostatina.
US7019109B2 (en) 2001-03-16 2006-03-28 The Salk Institute For Bilogical Studies SSTR1-selective analogs
EP1283216A1 (en) * 2001-08-10 2003-02-12 Mallinckrodt Inc. Somatostatin analogues binding to all somatostatin receptor subtypes and their use
CA2461099A1 (en) 2001-09-21 2003-04-10 The Administrators Of The Tulane Educational Fund Diagnostic or therapeutic somatostatin or bombesin analog conjugates and uses thereof
WO2004009614A2 (en) 2002-07-24 2004-01-29 The Salk Institute For Biological Studies Receptor (sstr4)- selective somatostatin analogs
DE602004016968D1 (de) 2003-03-19 2008-11-20 Universitaetsspital Basel Auf substanz p basierende radiomarkierte konjugate und deren gebrauch
PL2076535T3 (pl) 2006-10-16 2013-08-30 Salk Inst Biological Studies Antagoniści somatostatyny selektywni względem receptora (SSTR2)

Also Published As

Publication number Publication date
CN103288919B (zh) 2014-11-12
JP5295967B2 (ja) 2013-09-18
BRPI0717135B1 (pt) 2020-09-15
WO2008048942A2 (en) 2008-04-24
US7960342B2 (en) 2011-06-14
BRPI0717135A2 (pt) 2013-10-15
JP2010506943A (ja) 2010-03-04
EP2076535B1 (en) 2013-03-06
PL2433963T3 (pl) 2014-11-28
CN101631801A (zh) 2010-01-20
EP2433963A1 (en) 2012-03-28
PL2383289T3 (pl) 2015-03-31
HK1132515A1 (en) 2010-02-26
EP2076535A2 (en) 2009-07-08
WO2008048942A3 (en) 2008-09-18
EP2383289B1 (en) 2014-10-08
CA2666642C (en) 2015-11-17
ES2526292T3 (es) 2015-01-09
US8501687B2 (en) 2013-08-06
US20110269683A1 (en) 2011-11-03
CA2666642A1 (en) 2008-04-24
ES2410207T3 (es) 2013-07-01
EP2383289A1 (en) 2011-11-02
CN103288919A (zh) 2013-09-11
AU2007311137A1 (en) 2008-04-24
BRPI0717135B8 (pt) 2021-05-25
PT2076535E (pt) 2013-06-12
EP2433963B1 (en) 2014-06-04
CN101631801B (zh) 2013-06-05
US20080260638A1 (en) 2008-10-23
PL2076535T3 (pl) 2013-08-30
AU2007311137B2 (en) 2013-06-20
SI2076535T1 (sl) 2013-07-31

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