DE602004016968D1 - Auf substanz p basierende radiomarkierte konjugate und deren gebrauch - Google Patents
Auf substanz p basierende radiomarkierte konjugate und deren gebrauchInfo
- Publication number
- DE602004016968D1 DE602004016968D1 DE602004016968T DE602004016968T DE602004016968D1 DE 602004016968 D1 DE602004016968 D1 DE 602004016968D1 DE 602004016968 T DE602004016968 T DE 602004016968T DE 602004016968 T DE602004016968 T DE 602004016968T DE 602004016968 D1 DE602004016968 D1 DE 602004016968D1
- Authority
- DE
- Germany
- Prior art keywords
- substance
- dodecane
- radiomarked
- conjugates
- tetraazacyclo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000126 substance Substances 0.000 title abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- 239000002738 chelating agent Substances 0.000 abstract 2
- QDZOEBFLNHCSSF-PFFBOGFISA-N (2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CCCNC(N)=N)C1=CC=CC=C1 QDZOEBFLNHCSSF-PFFBOGFISA-N 0.000 abstract 1
- QBPPRVHXOZRESW-UHFFFAOYSA-N 1,4,7,10-tetraazacyclododecane Chemical compound C1CNCCNCCNCCN1 QBPPRVHXOZRESW-UHFFFAOYSA-N 0.000 abstract 1
- 208000003174 Brain Neoplasms Diseases 0.000 abstract 1
- 206010018338 Glioma Diseases 0.000 abstract 1
- 102100024304 Protachykinin-1 Human genes 0.000 abstract 1
- 101800003906 Substance P Proteins 0.000 abstract 1
- 239000012217 radiopharmaceutical Substances 0.000 abstract 1
- 229940121896 radiopharmaceutical Drugs 0.000 abstract 1
- 230000002799 radiopharmaceutical effect Effects 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Radiology & Medical Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Steroid Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03006061 | 2003-03-19 | ||
| PCT/EP2004/050329 WO2004082722A2 (en) | 2003-03-19 | 2004-03-18 | Radiolabeled conjugates based on substance p and the uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004016968D1 true DE602004016968D1 (de) | 2008-11-20 |
Family
ID=33016829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004016968T Expired - Lifetime DE602004016968D1 (de) | 2003-03-19 | 2004-03-18 | Auf substanz p basierende radiomarkierte konjugate und deren gebrauch |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20070053837A1 (de) |
| EP (1) | EP1603598B1 (de) |
| JP (1) | JP2007527366A (de) |
| AT (1) | ATE410191T1 (de) |
| AU (1) | AU2004222531A1 (de) |
| CA (1) | CA2519315A1 (de) |
| DE (1) | DE602004016968D1 (de) |
| DK (1) | DK1603598T3 (de) |
| ES (1) | ES2312983T3 (de) |
| HK (1) | HK1081884A1 (de) |
| NZ (1) | NZ542371A (de) |
| SI (1) | SI1603598T1 (de) |
| WO (1) | WO2004082722A2 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8691761B2 (en) | 2006-10-16 | 2014-04-08 | Jean E. F. Rivier | Somatostatin receptor 2 antagonists |
| SI2076535T1 (sl) | 2006-10-16 | 2013-07-31 | The Salk Institute For Biological Studies | Antagonisti somatostatina, selektivni za receptor (SSTR2) |
| GB0624587D0 (en) * | 2006-12-08 | 2007-01-17 | Univ Muenchen Tech | Chelating agent |
| US20100247590A1 (en) * | 2009-03-30 | 2010-09-30 | Johnson & Johnson | Peptide-Based Systems For Delivery Of Cosmetic Agents |
| WO2016025322A1 (en) * | 2014-08-09 | 2016-02-18 | Purdue Research Foundation | Design and development of neurokinin-1 receptor-binding agent delivery conjugates |
| CA3013882A1 (en) | 2016-02-09 | 2017-08-17 | Cdrd Ventures Inc. | Somatostatin receptor antagonist compounds and methods of using the same |
| US11607466B2 (en) * | 2016-12-23 | 2023-03-21 | The Johns Hopkins University | Tumor and immune cell imaging based on PD-L1 expression |
| GB201705258D0 (en) * | 2017-03-31 | 2017-05-17 | South African Nuclear Energy Corp Ltd | Imaging agent |
| US10093741B1 (en) | 2017-05-05 | 2018-10-09 | Fusion Pharmaceuticals Inc. | IGF-1R monoclonal antibodies and uses thereof |
| AU2018261890A1 (en) | 2017-05-05 | 2019-11-28 | Centre For Probe Development And Commercialization | IGF-1R monoclonal antibodies and uses thereof |
| EP3619191A4 (de) * | 2017-05-05 | 2020-12-16 | Fusion Pharmaceuticals Inc. | Pharmakokinetische verbesserungen von bifunktionellen chelaten und deren verwendungen |
| JP2022523947A (ja) * | 2019-03-11 | 2022-04-27 | バイオコンパティブルズ ユーケー リミテッド | 中枢神経系腫瘍の治療方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5750646A (en) * | 1987-09-24 | 1998-05-12 | The Administrators Of The Tulane Educational Fund | Bradykinin analogs with non-peptide bond |
| EP1196200A2 (de) * | 1999-07-05 | 2002-04-17 | Pedro Ortiz Aruma | Radiomarkierte saugentierliche tachykinin peptide analoge |
| EP1289571B1 (de) * | 2000-05-12 | 2004-07-21 | University Hospital | Prochelators von radiometall markierten molekülen |
| EP1283216A1 (de) * | 2001-08-10 | 2003-02-12 | Mallinckrodt Inc. | Alle somatostatinrezeptorsubtypen-bindende Somatostatinanaloge und deren Verwendung |
| RU2376314C2 (ru) * | 2002-10-02 | 2009-12-20 | Зилэнд Фарма А/С | Стабилизированные соединения эксендина-4 |
-
2004
- 2004-03-18 SI SI200430981T patent/SI1603598T1/sl unknown
- 2004-03-18 AU AU2004222531A patent/AU2004222531A1/en not_active Abandoned
- 2004-03-18 WO PCT/EP2004/050329 patent/WO2004082722A2/en active Application Filing
- 2004-03-18 EP EP04721547A patent/EP1603598B1/de not_active Expired - Lifetime
- 2004-03-18 JP JP2006505475A patent/JP2007527366A/ja active Pending
- 2004-03-18 US US10/549,665 patent/US20070053837A1/en not_active Abandoned
- 2004-03-18 AT AT04721547T patent/ATE410191T1/de not_active IP Right Cessation
- 2004-03-18 ES ES04721547T patent/ES2312983T3/es not_active Expired - Lifetime
- 2004-03-18 CA CA002519315A patent/CA2519315A1/en not_active Abandoned
- 2004-03-18 DK DK04721547T patent/DK1603598T3/da active
- 2004-03-18 NZ NZ542371A patent/NZ542371A/en not_active IP Right Cessation
- 2004-03-18 DE DE602004016968T patent/DE602004016968D1/de not_active Expired - Lifetime
-
2006
- 2006-04-03 HK HK06104090.5A patent/HK1081884A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007527366A (ja) | 2007-09-27 |
| EP1603598B1 (de) | 2008-10-08 |
| CA2519315A1 (en) | 2004-09-30 |
| US20070053837A1 (en) | 2007-03-08 |
| SI1603598T1 (sl) | 2009-02-28 |
| EP1603598A2 (de) | 2005-12-14 |
| WO2004082722A2 (en) | 2004-09-30 |
| ATE410191T1 (de) | 2008-10-15 |
| AU2004222531A1 (en) | 2004-09-30 |
| ES2312983T3 (es) | 2009-03-01 |
| DK1603598T3 (da) | 2009-01-26 |
| HK1081884A1 (en) | 2006-05-26 |
| NZ542371A (en) | 2008-10-31 |
| WO2004082722A3 (en) | 2005-01-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |