ES2526292T3 - Antagonistas de la somatostatina selectivos para receptor (SSTR2) - Google Patents

Antagonistas de la somatostatina selectivos para receptor (SSTR2) Download PDF

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Publication number
ES2526292T3
ES2526292T3 ES11173287.1T ES11173287T ES2526292T3 ES 2526292 T3 ES2526292 T3 ES 2526292T3 ES 11173287 T ES11173287 T ES 11173287T ES 2526292 T3 ES2526292 T3 ES 2526292T3
Authority
ES
Spain
Prior art keywords
refers
sstr2
somatostatin receptor
srif
peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11173287.1T
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English (en)
Inventor
Jean E.F. Rivier
Judit Erchegyi
Jean Claude Reubi
Helmut R. Maecke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universitaet Bern
Universitaetsspital Basel USB
Salk Institute for Biological Studies
Original Assignee
Universitaet Bern
Universitaetsspital Basel USB
Salk Institute for Biological Studies
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Application filed by Universitaet Bern, Universitaetsspital Basel USB, Salk Institute for Biological Studies filed Critical Universitaet Bern
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Publication of ES2526292T3 publication Critical patent/ES2526292T3/es
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Un péptido análogo de somatostatina (SRIF) cíclico que se une selectivamente al receptor de SRIF SSTR2 sin desencadenar la internalización en una célula, péptido que tiene una de las siguientes secuencias de aminoácidos en las que el extremo C está amidado:**Fórmula** en las que Cpa se refiere a cloro-Phe, Aph (Cbm) se refiere a 4-ureido-fenilalanina y 2 Nal se refiere al isómero de alanina que está sustituido con naftilo sobre el átomo de carbono ß, siendo la unión al naftaleno en la posición 2 sobre el anillo; y sales no tóxicas del mismo.

Description

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Claims (1)

  1. imagen1
ES11173287.1T 2006-10-16 2007-10-15 Antagonistas de la somatostatina selectivos para receptor (SSTR2) Active ES2526292T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82963706P 2006-10-16 2006-10-16
US829637P 2006-10-16

Publications (1)

Publication Number Publication Date
ES2526292T3 true ES2526292T3 (es) 2015-01-09

Family

ID=39144622

Family Applications (2)

Application Number Title Priority Date Filing Date
ES07854075T Active ES2410207T3 (es) 2006-10-16 2007-10-15 Antagonistas de la somatostatina selectivos para receptor(SSTR2)
ES11173287.1T Active ES2526292T3 (es) 2006-10-16 2007-10-15 Antagonistas de la somatostatina selectivos para receptor (SSTR2)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES07854075T Active ES2410207T3 (es) 2006-10-16 2007-10-15 Antagonistas de la somatostatina selectivos para receptor(SSTR2)

Country Status (14)

Country Link
US (2) US7960342B2 (es)
EP (3) EP2433963B1 (es)
JP (1) JP5295967B2 (es)
CN (2) CN103288919B (es)
AU (1) AU2007311137B2 (es)
BR (1) BRPI0717135B8 (es)
CA (1) CA2666642C (es)
DK (1) DK2076535T3 (es)
ES (2) ES2410207T3 (es)
HK (1) HK1132515A1 (es)
PL (3) PL2383289T3 (es)
PT (1) PT2076535E (es)
SI (1) SI2076535T1 (es)
WO (1) WO2008048942A2 (es)

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PL2383289T3 (pl) 2006-10-16 2015-03-31 Salk Inst Biological Studies Antagoniści somatostatyny selektywni względem receptora (SSTR2)
US8691761B2 (en) * 2006-10-16 2014-04-08 Jean E. F. Rivier Somatostatin receptor 2 antagonists
CA2939778C (en) 2007-01-31 2019-01-29 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
EP2508531B1 (en) 2007-03-28 2016-10-19 President and Fellows of Harvard College Stitched polypeptides
JP2013535514A (ja) 2010-08-13 2013-09-12 エイルロン セラピューティクス，インコーポレイテッド ペプチド模倣大環状分子
MX358886B (es) 2011-10-18 2018-08-31 Aileron Therapeutics Inc Macrociclos peptidomimeticos.
BR112014020103A2 (pt) 2012-02-15 2018-10-09 Aileron Therapeutics, Inc. macrociclos peptidomiméticos
CN108912211A (zh) 2012-02-15 2018-11-30 爱勒让治疗公司 三唑交联的和硫醚交联的拟肽大环化合物
BR112015009470A2 (pt) 2012-11-01 2019-12-17 Aileron Therapeutics Inc aminoácidos dissubstituídos e seus métodos de preparação e uso
US11053316B2 (en) 2013-01-14 2021-07-06 Xencor, Inc. Optimized antibody variable regions
WO2014110601A1 (en) 2013-01-14 2014-07-17 Xencor, Inc. Novel heterodimeric proteins
US10858417B2 (en) 2013-03-15 2020-12-08 Xencor, Inc. Heterodimeric proteins
PL3122781T3 (pl) 2014-03-28 2020-06-15 Xencor, Inc. Dwuswoiste przeciwciała, które wiążą się z CD38 i CD3
CN104086630B (zh) * 2014-06-25 2016-06-29 天津欧德莱生物医药科技有限公司 一种生长抑素受体激动剂多肽及其应用
CN104045689B (zh) * 2014-06-25 2016-08-24 新乡医学院 一种关于生长抑素受体激动剂多肽及其应用
CN104045690B (zh) * 2014-06-25 2016-06-08 舟山医院 生长抑素受体激动剂多肽及其应用
WO2016049359A1 (en) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CN104491890A (zh) * 2014-11-21 2015-04-08 北京肿瘤医院 放射性核素标记的新型生长抑素类似物分子探针及其应用
US10259887B2 (en) 2014-11-26 2019-04-16 Xencor, Inc. Heterodimeric antibodies that bind CD3 and tumor antigens
BR112017011092A2 (pt) 2014-11-26 2017-12-26 Xencor Inc anticorpos heterodiméricos que ligam cd3 e antígenos de tumor
CA2979847A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US11623957B2 (en) 2015-12-07 2023-04-11 Xencor, Inc. Heterodimeric antibodies that bind CD3 and PSMA
EP3414259A4 (en) * 2016-02-09 2019-10-16 CDRD Ventures Inc. SOMATOSTATIN RECEPTOR ANTAGONIST COMPOUNDS AND METHOD FOR USE THEREOF
KR20230054508A (ko) 2016-06-14 2023-04-24 젠코어 인코포레이티드 이중특이적 체크포인트 억제제 항체
US10849955B2 (en) 2016-09-28 2020-12-01 City Of Hope Methods of treating pancreatic cancer using GPCR antagonists
TW202015744A (zh) 2018-06-21 2020-05-01 法商艾普森藥品公司 用於放射性醫藥之含有體抑素類似物之組成物
TW202017600A (zh) * 2018-06-21 2020-05-16 法商艾普森藥品公司 用於放射性醫藥之含有體抑素類似物之組成物
WO2021231976A1 (en) 2020-05-14 2021-11-18 Xencor, Inc. Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3
KR20230166150A (ko) 2020-08-19 2023-12-06 젠코어 인코포레이티드 항-cd28 조성물
KR20230156079A (ko) 2021-03-09 2023-11-13 젠코어 인코포레이티드 Cd3과 cldn6에 결합하는 이종이량체 항체
US11859012B2 (en) 2021-03-10 2024-01-02 Xencor, Inc. Heterodimeric antibodies that bind CD3 and GPC3
CN115583989B (zh) * 2022-12-09 2023-02-28 烟台蓝纳成生物技术有限公司 一种靶向sstr2的化合物及其制备方法和应用

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Also Published As

Publication number Publication date
US7960342B2 (en) 2011-06-14
CN103288919B (zh) 2014-11-12
PL2076535T3 (pl) 2013-08-30
AU2007311137A1 (en) 2008-04-24
CN101631801B (zh) 2013-06-05
US20110269683A1 (en) 2011-11-03
BRPI0717135B1 (pt) 2020-09-15
EP2076535B1 (en) 2013-03-06
WO2008048942A3 (en) 2008-09-18
CA2666642C (en) 2015-11-17
JP2010506943A (ja) 2010-03-04
EP2076535A2 (en) 2009-07-08
PL2383289T3 (pl) 2015-03-31
DK2076535T3 (da) 2013-06-10
CN103288919A (zh) 2013-09-11
SI2076535T1 (sl) 2013-07-31
EP2383289A1 (en) 2011-11-02
BRPI0717135A2 (pt) 2013-10-15
EP2433963B1 (en) 2014-06-04
JP5295967B2 (ja) 2013-09-18
PT2076535E (pt) 2013-06-12
EP2383289B1 (en) 2014-10-08
CA2666642A1 (en) 2008-04-24
US20080260638A1 (en) 2008-10-23
AU2007311137B2 (en) 2013-06-20
HK1132515A1 (en) 2010-02-26
BRPI0717135B8 (pt) 2021-05-25
PL2433963T3 (pl) 2014-11-28
US8501687B2 (en) 2013-08-06
CN101631801A (zh) 2010-01-20
WO2008048942A2 (en) 2008-04-24
ES2410207T3 (es) 2013-07-01
EP2433963A1 (en) 2012-03-28

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