RS51281B - Sinteza insulinotropičnog peptida - Google Patents
Sinteza insulinotropičnog peptidaInfo
- Publication number
- RS51281B RS51281B RSP-2010/0267A RSP20100267A RS51281B RS 51281 B RS51281 B RS 51281B RS P20100267 A RSP20100267 A RS P20100267A RS 51281 B RS51281 B RS 51281B
- Authority
- RS
- Serbia
- Prior art keywords
- amino acid
- fragment
- sequence
- seq
- optionally
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Postupak dobijanja insulinotropičnog peptida, koji obuhvata sledeće korake a) do f):a) obezbeđivanje prvog peptidnog fragmenta sa amino kiselinskom sekvencom HX8EX10 (SEQ ID NO. 6), gde je svaki od ostataka X8 i X10, chiralna amino kiselina, svaki od H i E po izboru ima zaštitu bočnog lanca;b) obezbeđivanje drugog peptidnog fragmenta sa amino kiselinskom sekvencom TFTSDVX17-18YLEG (SEQ ID NO. 8) gde je ostatak ozbeležen simbolom X17-18, dipeptidni ostatak pseudoprolina, dati amino kiselinski ostaci sekvence po izboru uključuju zaštitu bočnog lanca;c) kuplovanje prvog fragmenta za drugi fragment pri čemu se dobija treći peptidni fragment sa amino kiselinskom sekvencom HX8EX10 TFTSDVX17-18YLEG (SEQ ID NO. 11), dati amino kiselinski ostaci sekvence po izboru imaju zaštitu bočnog lanca;d) obezbeđivanje četvrtog peptidnog fragmenta sa amino kiselinskom sekvencom QAAKEFIAWLVKX35 (SEQ ID NO. 9), gde X35 je ostatak ahiralne amino kiseline, dati amino kiselinski ostaci sekvence po izboru uključuju zaštitu bočnog lanca;e) kupolvanje četvrtog peptidnog fragmenta za arginin u cilju dobijanja petog peptidnog fragmenta sa amino kiselinskom sekvencom QAAKEFIAWLVK X35R (SEQ ID NO. 12), dati ostaci sekvence po izboru imaju zaštitu bočnog lanca; if) kuplovanje petog fragmenta za treći fragment pri čemu se dobija insulinotropic peptide including the amino acid sekvence HX8EX10TFTSDVX17-18YLEGQAAKEFIAWLVK X35R (SEQ ID NO. 13), dati ostaci sekvence po izboru imaju zaštitu bočnog lanca.Prijava sadrži još 18 zavisnih patentnih zahteva.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81591906P | 2006-06-23 | 2006-06-23 | |
| PCT/EP2007/056052 WO2007147816A1 (en) | 2006-06-23 | 2007-06-19 | Insulinotropic peptide synthesis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS51281B true RS51281B (sr) | 2010-12-31 |
Family
ID=38596729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RSP-2010/0267A RS51281B (sr) | 2006-06-23 | 2007-06-19 | Sinteza insulinotropičnog peptida |
Country Status (33)
| Country | Link |
|---|---|
| US (2) | US20080004429A1 (sr) |
| EP (1) | EP2035451B1 (sr) |
| JP (1) | JP4537495B2 (sr) |
| KR (1) | KR101087859B1 (sr) |
| CN (1) | CN101563364B (sr) |
| AR (1) | AR061604A1 (sr) |
| AT (1) | ATE466881T1 (sr) |
| AU (1) | AU2007263043B2 (sr) |
| BR (1) | BRPI0713575A2 (sr) |
| CA (1) | CA2654610C (sr) |
| CL (1) | CL2007001835A1 (sr) |
| CR (1) | CR10463A (sr) |
| CY (1) | CY1110186T1 (sr) |
| DE (1) | DE602007006310D1 (sr) |
| DK (1) | DK2035451T3 (sr) |
| EC (1) | ECSP088999A (sr) |
| ES (1) | ES2341588T3 (sr) |
| HR (1) | HRP20100302T1 (sr) |
| IL (1) | IL195421A0 (sr) |
| MA (1) | MA30530B1 (sr) |
| MX (1) | MX2008015935A (sr) |
| MY (1) | MY144608A (sr) |
| NO (1) | NO20084863L (sr) |
| NZ (1) | NZ573093A (sr) |
| PL (1) | PL2035451T3 (sr) |
| PT (1) | PT2035451E (sr) |
| RS (1) | RS51281B (sr) |
| RU (1) | RU2448978C2 (sr) |
| SI (1) | SI2035451T1 (sr) |
| TW (1) | TWI331155B (sr) |
| UA (1) | UA96602C2 (sr) |
| WO (1) | WO2007147816A1 (sr) |
| ZA (1) | ZA200810072B (sr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5473925B2 (ja) | 2007-10-27 | 2014-04-16 | コーデン ファーマ コロラド インコーポレイテッド | 固相および溶液相の組み合わせ技法を使用するインスリン分泌性ペプチドの合成 |
| EP2222695A2 (en) * | 2007-12-11 | 2010-09-01 | F. Hoffmann-La Roche AG | Insulinotropic peptide synthesis using solid and solution phase combination techniques |
| US20100317057A1 (en) * | 2007-12-28 | 2010-12-16 | Novo Nordisk A/S | Semi-recombinant preparation of glp-1 analogues |
| US20100183876A1 (en) * | 2008-12-23 | 2010-07-22 | Hell Andre | Process for the Preparation of a Peptide Powder Form |
| CN102414220A (zh) * | 2009-05-01 | 2012-04-11 | 霍夫曼-拉罗奇有限公司 | 使用固相和液相组合技术的促胰岛素肽合成 |
| US20110313131A1 (en) * | 2010-06-21 | 2011-12-22 | Christelle Carl | Reversed phase hplc purification of a glp-1 analogue |
| US20120157382A1 (en) | 2010-12-21 | 2012-06-21 | Siegfried Krimmer | Pharmaceutical glp-1 compositions having an improved release profile |
| WO2013086514A1 (en) * | 2011-12-08 | 2013-06-13 | Pentair Water Pool And Spa, Inc. | Aquaculture pump system and method |
| CN104011064A (zh) | 2011-12-29 | 2014-08-27 | 诺沃—诺迪斯克有限公司 | 包含非成蛋白质性的氨基酸的二肽 |
| CN104936610A (zh) | 2012-11-13 | 2015-09-23 | 益普生制药股份有限公司 | Glp-1类似物的纯化方法 |
| WO2014077801A1 (en) | 2012-11-13 | 2014-05-22 | Ipsen Pharma S.A.S. | Purification process for preparing highly pure taspoglutide |
| GR20140100479A (el) * | 2014-09-23 | 2016-05-05 | Novetide, Ltd., | Συνθεση λιραγλουτιδης |
| PL3704143T3 (pl) | 2018-03-09 | 2024-04-15 | Fresenius Kabi Ipsum S.R.L. | Chemo-enzymatyczna synteza liraglutydu, semaglutydu i glp-1 |
| WO2019170895A1 (en) | 2018-03-09 | 2019-09-12 | Enzypep B.V. | Chemo-enzymatic synthesis of semaglutide, liraglutide and glp-1 |
| US11396533B2 (en) | 2018-10-09 | 2022-07-26 | Fresenius Kabi Ipsum S.R.L. | Process for the manufacture of GLP-1 analogues |
| TWI738260B (zh) | 2019-03-25 | 2021-09-01 | 台灣神隆股份有限公司 | 純化利拉魯肽之方法 |
| CN114401981A (zh) * | 2019-06-18 | 2022-04-26 | 北京费森尤斯卡比医药有限公司 | 胰高血糖素制造方法 |
| EP3753946A1 (en) | 2019-06-18 | 2020-12-23 | Fresenius Kabi iPSUM S.r.l. | Improved process for the preparation of high purity glucagon |
| US20230406900A1 (en) * | 2022-06-01 | 2023-12-21 | Scinopharm Taiwan, Ltd. | Process for preparing glucagon-like peptide-1 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6281335B1 (en) * | 1993-10-08 | 2001-08-28 | Coulter Corporation | Hybridoma and anti-KC-4 humanized monoclonal antibody |
| US5705483A (en) * | 1993-12-09 | 1998-01-06 | Eli Lilly And Company | Glucagon-like insulinotropic peptides, compositions and methods |
| CA2218173A1 (en) * | 1995-04-14 | 1996-10-17 | The Administrators Of The Tulane Educational Fund | Analogs of growth hormone-releasing factor |
| UA65549C2 (uk) * | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція |
| US6281331B1 (en) * | 1998-03-23 | 2001-08-28 | Trimeris, Inc. | Methods and compositions for peptide synthesis |
| CZ295889B6 (cs) * | 1998-12-07 | 2005-11-16 | Societe De Conseils De Recherches Et D'application | Analogy GLP-1, mající arginin na pozicích 26 a 34, jejich použití a farmaceutické prostředky je obsahující |
| US6514500B1 (en) * | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
| US7238671B2 (en) * | 2001-10-18 | 2007-07-03 | Bristol-Myers Squibb Company | Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions |
| EP1701970A2 (en) * | 2003-12-31 | 2006-09-20 | F.Hoffmann-La Roche Ag | Methods for recovering cleaved peptide from a support |
-
2007
- 2007-06-19 JP JP2009515856A patent/JP4537495B2/ja not_active Expired - Fee Related
- 2007-06-19 AT AT07765481T patent/ATE466881T1/de active
- 2007-06-19 UA UAA200900414A patent/UA96602C2/ru unknown
- 2007-06-19 RU RU2009101969/04A patent/RU2448978C2/ru not_active IP Right Cessation
- 2007-06-19 DE DE602007006310T patent/DE602007006310D1/de active Active
- 2007-06-19 MY MYPI20085211A patent/MY144608A/en unknown
- 2007-06-19 MX MX2008015935A patent/MX2008015935A/es active IP Right Grant
- 2007-06-19 PL PL07765481T patent/PL2035451T3/pl unknown
- 2007-06-19 CA CA2654610A patent/CA2654610C/en not_active Expired - Fee Related
- 2007-06-19 CN CN200780023265.1A patent/CN101563364B/zh not_active Expired - Fee Related
- 2007-06-19 WO PCT/EP2007/056052 patent/WO2007147816A1/en active Application Filing
- 2007-06-19 SI SI200730229T patent/SI2035451T1/sl unknown
- 2007-06-19 PT PT07765481T patent/PT2035451E/pt unknown
- 2007-06-19 KR KR1020087031096A patent/KR101087859B1/ko not_active IP Right Cessation
- 2007-06-19 DK DK07765481.2T patent/DK2035451T3/da active
- 2007-06-19 ES ES07765481T patent/ES2341588T3/es active Active
- 2007-06-19 EP EP07765481A patent/EP2035451B1/en active Active
- 2007-06-19 AU AU2007263043A patent/AU2007263043B2/en not_active Ceased
- 2007-06-19 BR BRPI0713575-0A patent/BRPI0713575A2/pt not_active IP Right Cessation
- 2007-06-19 NZ NZ573093A patent/NZ573093A/en not_active IP Right Cessation
- 2007-06-19 RS RSP-2010/0267A patent/RS51281B/sr unknown
- 2007-06-21 US US11/821,017 patent/US20080004429A1/en not_active Abandoned
- 2007-06-21 AR ARP070102735A patent/AR061604A1/es not_active Application Discontinuation
- 2007-06-22 CL CL200701835A patent/CL2007001835A1/es unknown
- 2007-06-22 TW TW096122579A patent/TWI331155B/zh not_active IP Right Cessation
-
2008
- 2008-11-19 NO NO20084863A patent/NO20084863L/no not_active Application Discontinuation
- 2008-11-20 IL IL195421A patent/IL195421A0/en unknown
- 2008-11-26 ZA ZA200810072A patent/ZA200810072B/xx unknown
- 2008-11-26 CR CR10463A patent/CR10463A/es not_active Application Discontinuation
- 2008-12-22 EC EC2008008999A patent/ECSP088999A/es unknown
- 2008-12-25 MA MA31510A patent/MA30530B1/fr unknown
-
2010
- 2010-05-27 HR HR20100302T patent/HRP20100302T1/hr unknown
- 2010-06-11 CY CY20101100519T patent/CY1110186T1/el unknown
-
2011
- 2011-05-11 US US13/105,435 patent/US20110213082A1/en not_active Abandoned
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