MX346920B - Factores de coagulacion de accion prolongada y metodos de produccion de los mismos. - Google Patents

Factores de coagulacion de accion prolongada y metodos de produccion de los mismos.

Info

Publication number
MX346920B
MX346920B MX2014010834A MX2014010834A MX346920B MX 346920 B MX346920 B MX 346920B MX 2014010834 A MX2014010834 A MX 2014010834A MX 2014010834 A MX2014010834 A MX 2014010834A MX 346920 B MX346920 B MX 346920B
Authority
MX
Mexico
Prior art keywords
methods
long
coagulation factors
producing same
acting coagulation
Prior art date
Application number
MX2014010834A
Other languages
English (en)
Inventor
Eyal Fima Udi
Hart Gili
Original Assignee
Prolor Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prolor Biotech Inc filed Critical Prolor Biotech Inc
Publication of MX346920B publication Critical patent/MX346920B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/505—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
    • C07K2319/91—Fusion polypeptide containing a motif for post-translational modification containing a motif for glycosylation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Reproductive Health (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Glass Compositions (AREA)

Abstract

La presente invención se refiere a un polipéptido que consiste de un factor de coagulación y cinco péptidos carboxi terminales de gonadotropina coriónica de humano (CPTs) unidos al extremo carboxi terminal de dicho facto de coagulación, en el cual dicho factor de coagulación es el Factor VII o Factor VIIa, o un factor de coagulación y tres CTPs de gonadotropina coriónica de humano unidos al extremo carboxi terminal de dicho factor de coagulación, en el cual dicho factor de coagulación es el Factox IX, en donde la secuencia de dichos CTPs comprende los primeros 10 aminoácidos de SEQ ID NO: 4.
MX2014010834A 2009-07-09 2010-07-01 Factores de coagulacion de accion prolongada y metodos de produccion de los mismos. MX346920B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22436609P 2009-07-09 2009-07-09
PCT/IL2010/000532 WO2011004361A2 (en) 2009-07-09 2010-07-01 Long-acting coagulation factors and methods of producing same

Publications (1)

Publication Number Publication Date
MX346920B true MX346920B (es) 2017-04-05

Family

ID=43429620

Family Applications (4)

Application Number Title Priority Date Filing Date
MX2012000469A MX2012000469A (es) 2009-07-09 2010-07-01 Factores de coagulacion de accion prolongada y metodos de produccion de los mismos.
MX2014010834A MX346920B (es) 2009-07-09 2010-07-01 Factores de coagulacion de accion prolongada y metodos de produccion de los mismos.
MX2017002687A MX386807B (es) 2009-07-09 2010-07-01 Factores de coagulación de acción prolongada y métodos de producción de los mismos.
MX2021012106A MX2021012106A (es) 2009-07-09 2012-01-09 Factores de coagulacion de accion prolongada y metodos de produccion de los mismos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2012000469A MX2012000469A (es) 2009-07-09 2010-07-01 Factores de coagulacion de accion prolongada y metodos de produccion de los mismos.

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2017002687A MX386807B (es) 2009-07-09 2010-07-01 Factores de coagulación de acción prolongada y métodos de producción de los mismos.
MX2021012106A MX2021012106A (es) 2009-07-09 2012-01-09 Factores de coagulacion de accion prolongada y metodos de produccion de los mismos.

Country Status (19)

Country Link
US (1) US8476234B2 (es)
EP (2) EP3130346A1 (es)
JP (3) JP5823960B2 (es)
KR (3) KR102014844B1 (es)
CN (2) CN102639144B (es)
AU (1) AU2010269884B2 (es)
CA (1) CA2767503C (es)
CY (1) CY1118733T1 (es)
DK (1) DK2451473T3 (es)
ES (1) ES2618209T3 (es)
HR (1) HRP20170051T1 (es)
HU (1) HUE032973T2 (es)
IL (2) IL235377A (es)
LT (1) LT2451473T (es)
MX (4) MX2012000469A (es)
PL (1) PL2451473T3 (es)
PT (1) PT2451473T (es)
SI (1) SI2451473T1 (es)
WO (1) WO2011004361A2 (es)

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DK2451473T3 (en) 2017-01-30
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MX2021012106A (es) 2022-06-14
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