MX2019000708A - Factores de coagulacion de accion prolongada y metodos de produccion de los mismos. - Google Patents
Factores de coagulacion de accion prolongada y metodos de produccion de los mismos.Info
- Publication number
- MX2019000708A MX2019000708A MX2019000708A MX2019000708A MX2019000708A MX 2019000708 A MX2019000708 A MX 2019000708A MX 2019000708 A MX2019000708 A MX 2019000708A MX 2019000708 A MX2019000708 A MX 2019000708A MX 2019000708 A MX2019000708 A MX 2019000708A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- producing same
- long
- coagulation factors
- acting coagulation
- Prior art date
Links
- 102000015081 Blood Coagulation Factors Human genes 0.000 title abstract 2
- 108010039209 Blood Coagulation Factors Proteins 0.000 title abstract 2
- 239000003114 blood coagulation factor Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 101800005309 Carboxy-terminal peptide Proteins 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 229960004407 chorionic gonadotrophin Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Surgery (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Glass Compositions (AREA)
Abstract
Se describen polipéptidos que comprenden al menos un péptido de extremo carboxi (CTP) de gonadotropina coriónica unida al extremo carboxi pero no al extremo amino de un factor de coagulación y polinucleótidos que codifican los mismos. También se describen composiciones farmacéuticas que comprenden los polipéptidos y polinucleótidos de la invención y métodos de utilización y producción de los mismos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/372,540 US8759292B2 (en) | 2006-02-03 | 2012-02-14 | Long-acting coagulation factors and methods of producing same |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019000708A true MX2019000708A (es) | 2020-09-02 |
Family
ID=48983616
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014009910A MX362446B (es) | 2012-02-14 | 2013-02-05 | Factores de coagulacion de accion prolongada y metodos de produccion de los mismos. |
MX2019000708A MX2019000708A (es) | 2012-02-14 | 2014-08-14 | Factores de coagulacion de accion prolongada y metodos de produccion de los mismos. |
MX2022008807A MX2022008807A (es) | 2012-02-14 | 2014-08-14 | Factores de coagulacion de accion prolongada y metodos de produccion de los mismos. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014009910A MX362446B (es) | 2012-02-14 | 2013-02-05 | Factores de coagulacion de accion prolongada y metodos de produccion de los mismos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022008807A MX2022008807A (es) | 2012-02-14 | 2014-08-14 | Factores de coagulacion de accion prolongada y metodos de produccion de los mismos. |
Country Status (22)
Country | Link |
---|---|
EP (3) | EP3791890A1 (es) |
JP (2) | JP6242819B2 (es) |
KR (3) | KR102118729B1 (es) |
CN (2) | CN104427994A (es) |
AU (3) | AU2013219935B2 (es) |
BR (1) | BR122021004014B1 (es) |
CA (1) | CA2870621C (es) |
CL (2) | CL2014002183A1 (es) |
CO (1) | CO7131365A2 (es) |
DK (2) | DK2822576T3 (es) |
EA (2) | EA028578B1 (es) |
ES (2) | ES2665319T3 (es) |
HK (1) | HK1205460A1 (es) |
HU (1) | HUE053068T2 (es) |
IL (2) | IL264959B (es) |
MX (3) | MX362446B (es) |
MY (1) | MY172539A (es) |
NO (1) | NO2920022T3 (es) |
PE (1) | PE20142290A1 (es) |
PL (1) | PL3326642T3 (es) |
SG (1) | SG11201404836QA (es) |
WO (1) | WO2013121416A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9249407B2 (en) | 2006-02-03 | 2016-02-02 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
US9663778B2 (en) | 2009-07-09 | 2017-05-30 | OPKO Biologies Ltd. | Long-acting coagulation factors and methods of producing same |
MY172539A (en) | 2012-02-14 | 2019-11-30 | Opko Biologics Ltd | Long-acting coagulation factors and methods of producing same |
US20150158926A1 (en) | 2013-10-21 | 2015-06-11 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
EP4212546A1 (en) * | 2014-12-10 | 2023-07-19 | OPKO Biologics Ltd. | Methods of producing long acting ctp-modified polypeptides |
IL301728A (en) * | 2015-06-19 | 2023-05-01 | Opko Biologics Ltd | Long-term coagulation factors and methods for their preparation |
EA201890423A1 (ru) | 2015-08-03 | 2018-07-31 | Биовератив Терапьютикс Инк. | Слитые белки фактора ix, способы их получения и применения |
BR112019000610A2 (pt) * | 2016-07-11 | 2019-07-02 | Opko Biologics Ltd | fator vii de coagulação de longa ação e métodos de produção do mesmo |
EP3502143A4 (en) | 2016-08-19 | 2020-07-15 | Ampsource Biopharma Shanghai Inc. | BINDING PEPTIDE FOR THE CONSTRUCTION OF A FUSION PROTEIN |
CN106279437B (zh) * | 2016-08-19 | 2017-10-31 | 安源医药科技(上海)有限公司 | 高糖基化人凝血因子viii融合蛋白及其制备方法与用途 |
CN107759694B (zh) | 2016-08-19 | 2023-01-13 | 安源医药科技(上海)有限公司 | 双特异性抗体及其制备方法与用途 |
WO2018163586A1 (ja) | 2017-03-08 | 2018-09-13 | テイ・エス テック株式会社 | 乗物用シート |
US11981718B2 (en) | 2020-05-27 | 2024-05-14 | Ampsource Biopharma Shanghai Inc. | Dual-function protein for lipid and blood glucose regulation |
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NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
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US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
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US7795210B2 (en) * | 2001-10-10 | 2010-09-14 | Novo Nordisk A/S | Protein remodeling methods and proteins/peptides produced by the methods |
CN1245510C (zh) * | 2003-09-25 | 2006-03-15 | 复旦大学 | 长效重组组织因子途径抑制物及其制备方法 |
US8048849B2 (en) * | 2006-02-03 | 2011-11-01 | Modigene, Inc. | Long-acting polypeptides and methods of producing same |
US7553941B2 (en) | 2006-02-03 | 2009-06-30 | Modigene Inc | Long-acting polypeptides and methods of producing same |
US8476234B2 (en) * | 2006-02-03 | 2013-07-02 | Prolor Biotech Inc. | Long-acting coagulation factors and methods of producing same |
US8759292B2 (en) * | 2006-02-03 | 2014-06-24 | Prolor Biotech, Llc | Long-acting coagulation factors and methods of producing same |
TWI538916B (zh) * | 2008-04-11 | 2016-06-21 | 介控生化科技公司 | 經修飾的因子vii多肽和其用途 |
CN102112157B (zh) * | 2008-08-06 | 2013-05-29 | 诺沃-诺迪斯克保健股份有限公司 | 具有延长的体内效能的缀合蛋白 |
MY172539A (en) | 2012-02-14 | 2019-11-30 | Opko Biologics Ltd | Long-acting coagulation factors and methods of producing same |
MY172997A (en) * | 2012-11-20 | 2019-12-18 | Opko Biologics Ltd | Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides |
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2013
- 2013-02-05 MY MYPI2014002356A patent/MY172539A/en unknown
- 2013-02-05 EP EP20204439.2A patent/EP3791890A1/en active Pending
- 2013-02-05 CN CN201380019660.8A patent/CN104427994A/zh active Pending
- 2013-02-05 EP EP13749077.7A patent/EP2822576B1/en active Active
- 2013-02-05 EA EA201491519A patent/EA028578B1/ru unknown
- 2013-02-05 DK DK13749077.7T patent/DK2822576T3/en active
- 2013-02-05 MX MX2014009910A patent/MX362446B/es active IP Right Grant
- 2013-02-05 PE PE2014001261A patent/PE20142290A1/es active IP Right Grant
- 2013-02-05 PL PL18150731T patent/PL3326642T3/pl unknown
- 2013-02-05 EP EP18150731.0A patent/EP3326642B1/en active Active
- 2013-02-05 CA CA2870621A patent/CA2870621C/en active Active
- 2013-02-05 ES ES13749077.7T patent/ES2665319T3/es active Active
- 2013-02-05 AU AU2013219935A patent/AU2013219935B2/en active Active
- 2013-02-05 ES ES18150731T patent/ES2855133T3/es active Active
- 2013-02-05 WO PCT/IL2013/050107 patent/WO2013121416A1/en active Application Filing
- 2013-02-05 KR KR1020147025500A patent/KR102118729B1/ko active IP Right Grant
- 2013-02-05 CN CN201811365443.5A patent/CN109535245A/zh active Pending
- 2013-02-05 BR BR122021004014-1A patent/BR122021004014B1/pt active IP Right Grant
- 2013-02-05 SG SG11201404836QA patent/SG11201404836QA/en unknown
- 2013-02-05 EA EA201790960A patent/EA201790960A3/ru unknown
- 2013-02-05 DK DK18150731.0T patent/DK3326642T3/da active
- 2013-02-05 HU HUE18150731A patent/HUE053068T2/hu unknown
- 2013-02-05 KR KR1020207015367A patent/KR102310704B1/ko active IP Right Grant
- 2013-02-05 JP JP2014557168A patent/JP6242819B2/ja active Active
- 2013-02-05 KR KR1020217031683A patent/KR102630953B1/ko active IP Right Grant
- 2013-11-13 NO NO13855153A patent/NO2920022T3/no unknown
-
2014
- 2014-08-14 MX MX2019000708A patent/MX2019000708A/es unknown
- 2014-08-14 CL CL2014002183A patent/CL2014002183A1/es unknown
- 2014-08-14 MX MX2022008807A patent/MX2022008807A/es unknown
- 2014-08-14 CO CO14178314A patent/CO7131365A2/es unknown
-
2015
- 2015-06-25 HK HK15106044.6A patent/HK1205460A1/xx unknown
-
2016
- 2016-05-03 AU AU2016202829A patent/AU2016202829B2/en active Active
-
2017
- 2017-08-24 AU AU2017219044A patent/AU2017219044B2/en active Active
- 2017-09-04 CL CL2017002233A patent/CL2017002233A1/es unknown
- 2017-11-08 JP JP2017215861A patent/JP6510002B2/ja active Active
-
2019
- 2019-02-21 IL IL264959A patent/IL264959B/en unknown
-
2021
- 2021-04-07 IL IL282121A patent/IL282121B/en unknown
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