MX2022008807A - Factores de coagulacion de accion prolongada y metodos de produccion de los mismos. - Google Patents
Factores de coagulacion de accion prolongada y metodos de produccion de los mismos.Info
- Publication number
- MX2022008807A MX2022008807A MX2022008807A MX2022008807A MX2022008807A MX 2022008807 A MX2022008807 A MX 2022008807A MX 2022008807 A MX2022008807 A MX 2022008807A MX 2022008807 A MX2022008807 A MX 2022008807A MX 2022008807 A MX2022008807 A MX 2022008807A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- producing same
- long
- coagulation factors
- acting coagulation
- Prior art date
Links
- 102000015081 Blood Coagulation Factors Human genes 0.000 title abstract 2
- 108010039209 Blood Coagulation Factors Proteins 0.000 title abstract 2
- 239000003114 blood coagulation factor Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 101800005309 Carboxy-terminal peptide Proteins 0.000 abstract 2
- 108091033319 polynucleotide Proteins 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 2
- 239000002157 polynucleotide Substances 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 229960004407 chorionic gonadotrophin Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/24—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Surgery (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Glass Compositions (AREA)
Abstract
Se describen polipéptidos que comprenden al menos un péptido de extremo carboxi (CTP) de gonadotropina coriónica unida al extremo carboxi pero no al extremo amino de un factor de coagulación y polinucleótidos que codifican los mismos. También se describen composiciones farmacéuticas que comprenden los polipéptidos y polinucleótidos de la invención y métodos de utilización y producción de los mismos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/372,540 US8759292B2 (en) | 2006-02-03 | 2012-02-14 | Long-acting coagulation factors and methods of producing same |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022008807A true MX2022008807A (es) | 2022-08-11 |
Family
ID=48983616
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014009910A MX362446B (es) | 2012-02-14 | 2013-02-05 | Factores de coagulacion de accion prolongada y metodos de produccion de los mismos. |
MX2022008807A MX2022008807A (es) | 2012-02-14 | 2014-08-14 | Factores de coagulacion de accion prolongada y metodos de produccion de los mismos. |
MX2019000708A MX2019000708A (es) | 2012-02-14 | 2014-08-14 | Factores de coagulacion de accion prolongada y metodos de produccion de los mismos. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2014009910A MX362446B (es) | 2012-02-14 | 2013-02-05 | Factores de coagulacion de accion prolongada y metodos de produccion de los mismos. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019000708A MX2019000708A (es) | 2012-02-14 | 2014-08-14 | Factores de coagulacion de accion prolongada y metodos de produccion de los mismos. |
Country Status (22)
Country | Link |
---|---|
EP (3) | EP3791890A1 (es) |
JP (2) | JP6242819B2 (es) |
KR (3) | KR102118729B1 (es) |
CN (2) | CN109535245A (es) |
AU (3) | AU2013219935B2 (es) |
BR (1) | BR122021004014B1 (es) |
CA (1) | CA2870621C (es) |
CL (2) | CL2014002183A1 (es) |
CO (1) | CO7131365A2 (es) |
DK (2) | DK3326642T3 (es) |
EA (2) | EA028578B1 (es) |
ES (2) | ES2665319T3 (es) |
HK (1) | HK1205460A1 (es) |
HU (1) | HUE053068T2 (es) |
IL (2) | IL264959B (es) |
MX (3) | MX362446B (es) |
MY (1) | MY172539A (es) |
NO (1) | NO2920022T3 (es) |
PE (1) | PE20142290A1 (es) |
PL (1) | PL3326642T3 (es) |
SG (1) | SG11201404836QA (es) |
WO (1) | WO2013121416A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9249407B2 (en) | 2006-02-03 | 2016-02-02 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
US9663778B2 (en) | 2009-07-09 | 2017-05-30 | OPKO Biologies Ltd. | Long-acting coagulation factors and methods of producing same |
KR102118729B1 (ko) * | 2012-02-14 | 2020-06-05 | 옵코 바이오로직스 리미티드 | 장기 작용 응고 인자들 및 이를 생산하는 방법들 |
US20150158926A1 (en) | 2013-10-21 | 2015-06-11 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
PE20171380A1 (es) | 2014-12-10 | 2017-09-15 | Opko Biologics Ltd | Metodos de produccion de polipeptidos de hormona de crecimiento modificada por ctp de accion prolongada |
WO2016203482A2 (en) * | 2015-06-19 | 2016-12-22 | Opko Biologics Ltd. | Long-acting coagulation factors and methods of producing same |
WO2017024060A1 (en) | 2015-08-03 | 2017-02-09 | Biogen Ma Inc. | Factor ix fusion proteins and methods of making and using same |
CA3030533A1 (en) | 2016-07-11 | 2018-01-18 | Oren HERSHKOVITZ | Long-acting coagulation factor vii and methods of producing same |
CN106279437B (zh) | 2016-08-19 | 2017-10-31 | 安源医药科技(上海)有限公司 | 高糖基化人凝血因子viii融合蛋白及其制备方法与用途 |
CN107759694B (zh) | 2016-08-19 | 2023-01-13 | 安源医药科技(上海)有限公司 | 双特异性抗体及其制备方法与用途 |
WO2018032638A1 (zh) | 2016-08-19 | 2018-02-22 | 安源医药科技(上海)有限公司 | 用于构建融合蛋白的连接肽 |
WO2018163586A1 (ja) | 2017-03-08 | 2018-09-13 | テイ・エス テック株式会社 | 乗物用シート |
US11981718B2 (en) | 2020-05-27 | 2024-05-14 | Ampsource Biopharma Shanghai Inc. | Dual-function protein for lipid and blood glucose regulation |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
DE3421468A1 (de) | 1984-06-08 | 1985-12-19 | Dr. Rentschler Arzneimittel Gmbh & Co, 7958 Laupheim | Lipidnanopellets als traegersystem fuer arzneimittel zur peroralen anwendung |
US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
ATE141646T1 (de) | 1986-04-09 | 1996-09-15 | Genzyme Corp | Genetisch transformierte tiere, die ein gewünschtes protein in milch absondern |
US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
US6225449B1 (en) * | 1991-10-04 | 2001-05-01 | Washington University | Hormone analogs with multiple CTP extensions |
AU648020B2 (en) | 1989-02-21 | 1994-04-14 | Washington University | Modified forms of reproductive hormones |
US5792460A (en) * | 1989-02-21 | 1998-08-11 | Washington University | Modified glycoprotein hormones having a CTP at the amino terminus |
US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
US5541110A (en) | 1994-05-17 | 1996-07-30 | Bristol-Myers Squibb | Cloning and expression of a gene encoding bryodin 1 from Bryonia dioica |
US7795210B2 (en) * | 2001-10-10 | 2010-09-14 | Novo Nordisk A/S | Protein remodeling methods and proteins/peptides produced by the methods |
CN1245510C (zh) * | 2003-09-25 | 2006-03-15 | 复旦大学 | 长效重组组织因子途径抑制物及其制备方法 |
WO2007092252A2 (en) | 2006-02-03 | 2007-08-16 | Modigene Inc | Long-acting polypeptides and methods of producing same |
US8476234B2 (en) * | 2006-02-03 | 2013-07-02 | Prolor Biotech Inc. | Long-acting coagulation factors and methods of producing same |
US8759292B2 (en) * | 2006-02-03 | 2014-06-24 | Prolor Biotech, Llc | Long-acting coagulation factors and methods of producing same |
US8048849B2 (en) * | 2006-02-03 | 2011-11-01 | Modigene, Inc. | Long-acting polypeptides and methods of producing same |
TWI465247B (zh) * | 2008-04-11 | 2014-12-21 | Catalyst Biosciences Inc | 經修飾的因子vii多肽和其用途 |
CN102112157B (zh) * | 2008-08-06 | 2013-05-29 | 诺沃-诺迪斯克保健股份有限公司 | 具有延长的体内效能的缀合蛋白 |
KR102118729B1 (ko) * | 2012-02-14 | 2020-06-05 | 옵코 바이오로직스 리미티드 | 장기 작용 응고 인자들 및 이를 생산하는 방법들 |
SG10202010383YA (en) * | 2012-11-20 | 2020-11-27 | Opko Biologics Ltd | Method of increasing the hydrodynamic volume of polypeptides by attaching to gonadotrophin carboxy terminal peptides |
-
2013
- 2013-02-05 KR KR1020147025500A patent/KR102118729B1/ko active IP Right Grant
- 2013-02-05 KR KR1020207015367A patent/KR102310704B1/ko active IP Right Grant
- 2013-02-05 CN CN201811365443.5A patent/CN109535245A/zh active Pending
- 2013-02-05 HU HUE18150731A patent/HUE053068T2/hu unknown
- 2013-02-05 MX MX2014009910A patent/MX362446B/es active IP Right Grant
- 2013-02-05 CA CA2870621A patent/CA2870621C/en active Active
- 2013-02-05 CN CN201380019660.8A patent/CN104427994A/zh active Pending
- 2013-02-05 ES ES13749077.7T patent/ES2665319T3/es active Active
- 2013-02-05 SG SG11201404836QA patent/SG11201404836QA/en unknown
- 2013-02-05 EA EA201491519A patent/EA028578B1/ru unknown
- 2013-02-05 JP JP2014557168A patent/JP6242819B2/ja active Active
- 2013-02-05 EP EP20204439.2A patent/EP3791890A1/en active Pending
- 2013-02-05 MY MYPI2014002356A patent/MY172539A/en unknown
- 2013-02-05 ES ES18150731T patent/ES2855133T3/es active Active
- 2013-02-05 PE PE2014001261A patent/PE20142290A1/es active IP Right Grant
- 2013-02-05 PL PL18150731T patent/PL3326642T3/pl unknown
- 2013-02-05 WO PCT/IL2013/050107 patent/WO2013121416A1/en active Application Filing
- 2013-02-05 AU AU2013219935A patent/AU2013219935B2/en active Active
- 2013-02-05 KR KR1020217031683A patent/KR102630953B1/ko active IP Right Grant
- 2013-02-05 EA EA201790960A patent/EA201790960A3/ru unknown
- 2013-02-05 EP EP13749077.7A patent/EP2822576B1/en active Active
- 2013-02-05 EP EP18150731.0A patent/EP3326642B1/en active Active
- 2013-02-05 DK DK18150731.0T patent/DK3326642T3/da active
- 2013-02-05 DK DK13749077.7T patent/DK2822576T3/en active
- 2013-02-05 BR BR122021004014-1A patent/BR122021004014B1/pt active IP Right Grant
- 2013-11-13 NO NO13855153A patent/NO2920022T3/no unknown
-
2014
- 2014-08-14 CL CL2014002183A patent/CL2014002183A1/es unknown
- 2014-08-14 MX MX2022008807A patent/MX2022008807A/es unknown
- 2014-08-14 CO CO14178314A patent/CO7131365A2/es unknown
- 2014-08-14 MX MX2019000708A patent/MX2019000708A/es unknown
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2015
- 2015-06-25 HK HK15106044.6A patent/HK1205460A1/xx unknown
-
2016
- 2016-05-03 AU AU2016202829A patent/AU2016202829B2/en active Active
-
2017
- 2017-08-24 AU AU2017219044A patent/AU2017219044B2/en active Active
- 2017-09-04 CL CL2017002233A patent/CL2017002233A1/es unknown
- 2017-11-08 JP JP2017215861A patent/JP6510002B2/ja active Active
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2019
- 2019-02-21 IL IL264959A patent/IL264959B/en unknown
-
2021
- 2021-04-07 IL IL282121A patent/IL282121B/en unknown
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