PL3704143T3 - Chemo-enzymatyczna synteza liraglutydu, semaglutydu i glp-1 - Google Patents
Chemo-enzymatyczna synteza liraglutydu, semaglutydu i glp-1Info
- Publication number
- PL3704143T3 PL3704143T3 PL19709061.6T PL19709061T PL3704143T3 PL 3704143 T3 PL3704143 T3 PL 3704143T3 PL 19709061 T PL19709061 T PL 19709061T PL 3704143 T3 PL3704143 T3 PL 3704143T3
- Authority
- PL
- Poland
- Prior art keywords
- semaglutide
- liraglutide
- chemo
- glp
- enzymatic synthesis
- Prior art date
Links
- 101100337060 Caenorhabditis elegans glp-1 gene Proteins 0.000 title 1
- YSDQQAXHVYUZIW-QCIJIYAXSA-N Liraglutide Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCC)C(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 YSDQQAXHVYUZIW-QCIJIYAXSA-N 0.000 title 1
- 108010019598 Liraglutide Proteins 0.000 title 1
- DLSWIYLPEUIQAV-UHFFFAOYSA-N Semaglutide Chemical compound CCC(C)C(NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(O)=O)NC(=O)C(CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CCC(NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCC(N)=O)NC(=O)CNC(=O)C(CCC(O)=O)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(NC(=O)CNC(=O)C(CCC(O)=O)NC(=O)C(C)(C)NC(=O)C(N)Cc1cnc[nH]1)C(C)O)C(C)O)C(C)C)C(=O)NC(C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CCCNC(N)=N)C(=O)NCC(O)=O DLSWIYLPEUIQAV-UHFFFAOYSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 229960002701 liraglutide Drugs 0.000 title 1
- 229950011186 semaglutide Drugs 0.000 title 1
- 108010060325 semaglutide Proteins 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
- C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
- C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21062—Subtilisin (3.4.21.62)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Analytical Chemistry (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18161084 | 2018-03-09 | ||
| PCT/EP2019/056046 WO2019170918A1 (en) | 2018-03-09 | 2019-03-11 | Chemo-enzymatic synthesis of liraglutide, semaglutide and glp-1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3704143T3 true PL3704143T3 (pl) | 2024-04-15 |
Family
ID=61800262
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL19709061.6T PL3704143T3 (pl) | 2018-03-09 | 2019-03-11 | Chemo-enzymatyczna synteza liraglutydu, semaglutydu i glp-1 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10883132B2 (pl) |
| EP (1) | EP3704143B1 (pl) |
| JP (2) | JP2021516556A (pl) |
| KR (1) | KR20200130712A (pl) |
| CN (1) | CN111819191B (pl) |
| CA (1) | CA3093221A1 (pl) |
| ES (1) | ES2962666T3 (pl) |
| PL (1) | PL3704143T3 (pl) |
| WO (1) | WO2019170918A1 (pl) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11421213B2 (en) * | 2017-09-05 | 2022-08-23 | Henkel Ag & Co. Kgaa | Performance-enhanced protease variants II |
| KR20200141469A (ko) | 2018-04-05 | 2020-12-18 | 썬 파마슈티칼 인더스트리스 리미티드 | 신규한 glp-1 유사체 |
| CN110590934B (zh) * | 2019-09-25 | 2020-12-08 | 北京乐普医药科技有限公司 | 一种glp-1化合物 |
| EP4146249A4 (en) * | 2020-05-05 | 2024-08-21 | Neuland Laboratories Ltd | IMPROVED PROCESS FOR THE PREPARATION OF SEMAGLUTIDE |
| KR20240118914A (ko) | 2021-01-20 | 2024-08-05 | 바이킹 테라퓨틱스 인코포레이티드 | 대사 및 간 질환 치료를 위한 조성물 및 방법 |
| EP4291647A1 (en) | 2021-02-12 | 2023-12-20 | Fresenius Kabi iPSUM S.r.l. | Subtilisin variants and their use |
| WO2024133313A1 (en) | 2022-12-19 | 2024-06-27 | Enzypep B.V. | Thermostable subtilisin variants and their use |
| WO2024163584A1 (en) * | 2023-02-01 | 2024-08-08 | Danisco Us Inc. | Subtilisin variants and methods of use |
| WO2024163600A1 (en) * | 2023-02-01 | 2024-08-08 | Danisco Us Inc. | Subtilisin variants and methods of use |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0542931T3 (da) | 1990-08-09 | 2000-05-22 | Genentech Inc | Serinproteasevarianter med peptidligaseaktivitet |
| US5567601A (en) * | 1993-06-01 | 1996-10-22 | University Of Maryland | Subtilisin mutants lacking a primary calcium binding site |
| US6451974B1 (en) | 1999-03-17 | 2002-09-17 | Novo Nordisk A/S | Method of acylating peptides and novel acylating agents |
| US6541235B1 (en) | 2000-09-29 | 2003-04-01 | University Of Maryland Biotechnology Institute | Calcium free subtilisin mutants |
| CA2546843C (en) * | 2003-11-20 | 2015-01-06 | Neuronova Ab | Compounds and methods for increasing neurogenesis |
| AU2007263043B2 (en) * | 2006-06-23 | 2012-11-29 | F. Hoffmann-La Roche Ag | Insulinotropic peptide synthesis |
| WO2014199397A2 (en) | 2013-06-11 | 2014-12-18 | Mylan Laboratories Ltd | Process for the preparation of liraglutide |
| GR20140100479A (el) | 2014-09-23 | 2016-05-05 | Novetide, Ltd., | Συνθεση λιραγλουτιδης |
| CN107002110A (zh) * | 2014-10-10 | 2017-08-01 | 恩细贝普有限公司 | 用具有改善的合成水解比的枯草杆菌蛋白酶变体的肽片段缩合和环化 |
| US10752931B2 (en) * | 2015-07-09 | 2020-08-25 | Enzypep B.V. | Designing an enzymatic peptide fragment condensation strategy |
| WO2018032521A1 (zh) | 2016-08-19 | 2018-02-22 | 深圳市健元医药科技有限公司 | 一种利拉鲁肽的合成方法 |
-
2019
- 2019-03-11 KR KR1020207028592A patent/KR20200130712A/ko not_active Application Discontinuation
- 2019-03-11 PL PL19709061.6T patent/PL3704143T3/pl unknown
- 2019-03-11 JP JP2020570646A patent/JP2021516556A/ja active Pending
- 2019-03-11 EP EP19709061.6A patent/EP3704143B1/en active Active
- 2019-03-11 CN CN201980018036.3A patent/CN111819191B/zh active Active
- 2019-03-11 ES ES19709061T patent/ES2962666T3/es active Active
- 2019-03-11 US US16/463,471 patent/US10883132B2/en active Active
- 2019-03-11 CA CA3093221A patent/CA3093221A1/en active Pending
- 2019-03-11 WO PCT/EP2019/056046 patent/WO2019170918A1/en unknown
-
2020
- 2020-02-06 US US16/783,570 patent/US10920258B2/en active Active
-
2023
- 2023-11-09 JP JP2023191845A patent/JP2024010221A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2024010221A (ja) | 2024-01-23 |
| US10920258B2 (en) | 2021-02-16 |
| US10883132B2 (en) | 2021-01-05 |
| ES2962666T3 (es) | 2024-03-20 |
| CA3093221A1 (en) | 2019-09-12 |
| JP2021516556A (ja) | 2021-07-08 |
| US20190345529A1 (en) | 2019-11-14 |
| CN111819191A (zh) | 2020-10-23 |
| EP3704143B1 (en) | 2023-10-18 |
| EP3704143A1 (en) | 2020-09-09 |
| US20200347427A1 (en) | 2020-11-05 |
| CN111819191B (zh) | 2024-08-20 |
| WO2019170918A1 (en) | 2019-09-12 |
| EP3704143C0 (en) | 2023-10-18 |
| KR20200130712A (ko) | 2020-11-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL3704143T3 (pl) | Chemo-enzymatyczna synteza liraglutydu, semaglutydu i glp-1 | |
| IL272232A (en) | GLP-1 compounds and their uses | |
| ZA201806637B (en) | Glucagon and glp-1 co-agonists for the treatment of obesity | |
| GB201803568D0 (en) | Novel compounds and uses | |
| GB201804514D0 (en) | Treatment of pyroptosis | |
| HK1247936A1 (zh) | 超純化dsba和dsbc及其製備和使用方法 | |
| MX2020003217A (es) | Coagonistas de accion prolongada de los receptores de glucagon y glp-1. | |
| IL277483A (en) | New anti-GLP-1 analogs | |
| WO2017100107A3 (en) | Co-agonists of the glucagon and glp-1 receptors | |
| WO2017074798A3 (en) | Long-acting co-agonists of the glucagon and glp-1 receptors | |
| SG11202011227VA (en) | Compositions comprising bisfluoroalkyl-1,4-benzodiazepinone compounds and methods of use thereof | |
| GB2574074B (en) | Time synchronisation | |
| GB201804515D0 (en) | Treatment of necroptosis | |
| SG11202011041YA (en) | Combination compositions comprising bisfluoroalkyl-1,4- benzodiazepinone compounds and methods of use thereof | |
| GB202204020D0 (en) | Cachability of single page application | |
| IL276107A (en) | Crystalline forms of psoorstam | |
| GB2572173B (en) | Personal cleansing composition | |
| ZA202105399B (en) | Use of spiropidion | |
| SG11202105136WA (en) | Application of chidamide | |
| IL283421A (en) | Crystalline forms of Refroxlap | |
| AU201814164S (en) | High chair |