CY1110186T1 - Συνθεση ινσουλινοτροπου πεπτιδιου - Google Patents
Συνθεση ινσουλινοτροπου πεπτιδιουInfo
- Publication number
- CY1110186T1 CY1110186T1 CY20101100519T CY101100519T CY1110186T1 CY 1110186 T1 CY1110186 T1 CY 1110186T1 CY 20101100519 T CY20101100519 T CY 20101100519T CY 101100519 T CY101100519 T CY 101100519T CY 1110186 T1 CY1110186 T1 CY 1110186T1
- Authority
- CY
- Cyprus
- Prior art keywords
- fragments
- phase
- solid phase
- solution
- fragment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Η παρούσα εφεύρεση αφορά στην παρασκευή ινσουλινοτρόπων πεπτιδίων που συντίθενται με χρήση μιας προσέγγισης στερεάς φάσης και μιας φάσης διαλύματος («υβριδικής»). Γενικά, η προσέγγιση περιλαμβάνει τη σύνθεση τριών διαφορετικών ενδιάμεσων πεπτιδικών θραυσμάτων με χρήση χημείας στερεάς φάσης. Στη συνέχεια χρησιμοποιείται η χημεία φάσης διαλύματος προκειμένου να προστεθεί επιπλέον αμινοξικό υλικό σε ένα από τα θραύσματα. Στη συνέχεια τα θραύσματα συζευγνύονται μεταξύ τους σε στερεά φάση και σε φάση διαλύματος. Η χρήση μιας ψευδοπρολίνης σε ένα από τα θραύσματα διευκολύνει τη σύνθεση στερεάς φάσης του θραύσματος αυτού και επίσης διευκολύνει τη μετέπειτα σύζευξη σε φάση διαλύματος αυτού του θραύσματος με άλλα θραύσματα. Η παρούσα εφεύρεση είναι πολύ χρήσιμη για τη δημιουργία ινσουλινοτρόπων πεπτιδίων του τύπου του GLP-1(7-36) και των φυσικών και των μη φυσικών αναλόγων αυτού.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US81591906P | 2006-06-23 | 2006-06-23 | |
EP07765481A EP2035451B1 (en) | 2006-06-23 | 2007-06-19 | Insulinotropic peptide synthesis |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1110186T1 true CY1110186T1 (el) | 2015-01-14 |
Family
ID=38596729
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20101100519T CY1110186T1 (el) | 2006-06-23 | 2010-06-11 | Συνθεση ινσουλινοτροπου πεπτιδιου |
Country Status (33)
Country | Link |
---|---|
US (2) | US20080004429A1 (el) |
EP (1) | EP2035451B1 (el) |
JP (1) | JP4537495B2 (el) |
KR (1) | KR101087859B1 (el) |
CN (1) | CN101563364B (el) |
AR (1) | AR061604A1 (el) |
AT (1) | ATE466881T1 (el) |
AU (1) | AU2007263043B2 (el) |
BR (1) | BRPI0713575A2 (el) |
CA (1) | CA2654610C (el) |
CL (1) | CL2007001835A1 (el) |
CR (1) | CR10463A (el) |
CY (1) | CY1110186T1 (el) |
DE (1) | DE602007006310D1 (el) |
DK (1) | DK2035451T3 (el) |
EC (1) | ECSP088999A (el) |
ES (1) | ES2341588T3 (el) |
HR (1) | HRP20100302T1 (el) |
IL (1) | IL195421A0 (el) |
MA (1) | MA30530B1 (el) |
MX (1) | MX2008015935A (el) |
MY (1) | MY144608A (el) |
NO (1) | NO20084863L (el) |
NZ (1) | NZ573093A (el) |
PL (1) | PL2035451T3 (el) |
PT (1) | PT2035451E (el) |
RS (1) | RS51281B (el) |
RU (1) | RU2448978C2 (el) |
SI (1) | SI2035451T1 (el) |
TW (1) | TWI331155B (el) |
UA (1) | UA96602C2 (el) |
WO (1) | WO2007147816A1 (el) |
ZA (1) | ZA200810072B (el) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5473925B2 (ja) | 2007-10-27 | 2014-04-16 | コーデン ファーマ コロラド インコーポレイテッド | 固相および溶液相の組み合わせ技法を使用するインスリン分泌性ペプチドの合成 |
EP2222695A2 (en) * | 2007-12-11 | 2010-09-01 | F. Hoffmann-La Roche AG | Insulinotropic peptide synthesis using solid and solution phase combination techniques |
US20100317057A1 (en) * | 2007-12-28 | 2010-12-16 | Novo Nordisk A/S | Semi-recombinant preparation of glp-1 analogues |
US20100183876A1 (en) * | 2008-12-23 | 2010-07-22 | Hell Andre | Process for the Preparation of a Peptide Powder Form |
CN102414220A (zh) * | 2009-05-01 | 2012-04-11 | 霍夫曼-拉罗奇有限公司 | 使用固相和液相组合技术的促胰岛素肽合成 |
US20110313131A1 (en) | 2010-06-21 | 2011-12-22 | Christelle Carl | Reversed phase hplc purification of a glp-1 analogue |
US20120157382A1 (en) | 2010-12-21 | 2012-06-21 | Siegfried Krimmer | Pharmaceutical glp-1 compositions having an improved release profile |
DK2788110T3 (en) * | 2011-12-08 | 2019-02-11 | Pentair Water Pool & Spa Inc | AQUACULTURE SYSTEM AND PROCEDURE TO OPERATE A PUMP IN SUCH A SYSTEM |
RU2643515C2 (ru) | 2011-12-29 | 2018-02-02 | Ново Нордиск А/С | Дипептид, содержащий непротеиногенную аминокислоту |
CN104936610A (zh) | 2012-11-13 | 2015-09-23 | 益普生制药股份有限公司 | Glp-1类似物的纯化方法 |
WO2014077801A1 (en) | 2012-11-13 | 2014-05-22 | Ipsen Pharma S.A.S. | Purification process for preparing highly pure taspoglutide |
GR20140100479A (el) * | 2014-09-23 | 2016-05-05 | Novetide, Ltd., | Συνθεση λιραγλουτιδης |
CA3093221A1 (en) | 2018-03-09 | 2019-09-12 | Enzypep B.V. | Chemo-enzymatic synthesis of liraglutide, semaglutide and glp-1 |
EP3762408A1 (en) | 2018-03-09 | 2021-01-13 | Enzypep B.V. | Chemo-enzymatic synthesis of semaglutide, liraglutide and glp-1 |
ES2938734T3 (es) * | 2018-10-09 | 2023-04-14 | Fresenius Kabi Ipsum S R L | Procedimiento para la fabricación de análogos de GLP-1 |
TWI738260B (zh) | 2019-03-25 | 2021-09-01 | 台灣神隆股份有限公司 | 純化利拉魯肽之方法 |
CN114401981A (zh) * | 2019-06-18 | 2022-04-26 | 北京费森尤斯卡比医药有限公司 | 胰高血糖素制造方法 |
EP3753946A1 (en) | 2019-06-18 | 2020-12-23 | Fresenius Kabi iPSUM S.r.l. | Improved process for the preparation of high purity glucagon |
US20230406900A1 (en) * | 2022-06-01 | 2023-12-21 | Scinopharm Taiwan, Ltd. | Process for preparing glucagon-like peptide-1 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6281335B1 (en) * | 1993-10-08 | 2001-08-28 | Coulter Corporation | Hybridoma and anti-KC-4 humanized monoclonal antibody |
US5705483A (en) * | 1993-12-09 | 1998-01-06 | Eli Lilly And Company | Glucagon-like insulinotropic peptides, compositions and methods |
EP0820296A4 (en) * | 1995-04-14 | 1999-06-30 | Univ Tulane | ANALOGS OF THE GROWTH HORMONE-RELEASING FACTOR |
UA65549C2 (uk) * | 1996-11-05 | 2004-04-15 | Елі Ліллі Енд Компані | Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція |
US6281331B1 (en) * | 1998-03-23 | 2001-08-28 | Trimeris, Inc. | Methods and compositions for peptide synthesis |
US6903186B1 (en) * | 1998-12-07 | 2005-06-07 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S | Analogues of GLP-1 |
US6514500B1 (en) * | 1999-10-15 | 2003-02-04 | Conjuchem, Inc. | Long lasting synthetic glucagon like peptide {GLP-!} |
US7238671B2 (en) | 2001-10-18 | 2007-07-03 | Bristol-Myers Squibb Company | Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions |
WO2005063792A2 (en) * | 2003-12-31 | 2005-07-14 | F. Hoffmann-La Roche Ag | Methods for recovering cleaved peptide from a support |
-
2007
- 2007-06-19 BR BRPI0713575-0A patent/BRPI0713575A2/pt not_active IP Right Cessation
- 2007-06-19 RS RSP-2010/0267A patent/RS51281B/sr unknown
- 2007-06-19 NZ NZ573093A patent/NZ573093A/en not_active IP Right Cessation
- 2007-06-19 EP EP07765481A patent/EP2035451B1/en active Active
- 2007-06-19 AU AU2007263043A patent/AU2007263043B2/en not_active Ceased
- 2007-06-19 SI SI200730229T patent/SI2035451T1/sl unknown
- 2007-06-19 DK DK07765481.2T patent/DK2035451T3/da active
- 2007-06-19 CA CA2654610A patent/CA2654610C/en not_active Expired - Fee Related
- 2007-06-19 JP JP2009515856A patent/JP4537495B2/ja not_active Expired - Fee Related
- 2007-06-19 WO PCT/EP2007/056052 patent/WO2007147816A1/en active Application Filing
- 2007-06-19 UA UAA200900414A patent/UA96602C2/ru unknown
- 2007-06-19 CN CN200780023265.1A patent/CN101563364B/zh not_active Expired - Fee Related
- 2007-06-19 RU RU2009101969/04A patent/RU2448978C2/ru not_active IP Right Cessation
- 2007-06-19 AT AT07765481T patent/ATE466881T1/de active
- 2007-06-19 KR KR1020087031096A patent/KR101087859B1/ko not_active IP Right Cessation
- 2007-06-19 MY MYPI20085211A patent/MY144608A/en unknown
- 2007-06-19 MX MX2008015935A patent/MX2008015935A/es active IP Right Grant
- 2007-06-19 DE DE602007006310T patent/DE602007006310D1/de active Active
- 2007-06-19 ES ES07765481T patent/ES2341588T3/es active Active
- 2007-06-19 PL PL07765481T patent/PL2035451T3/pl unknown
- 2007-06-19 PT PT07765481T patent/PT2035451E/pt unknown
- 2007-06-21 US US11/821,017 patent/US20080004429A1/en not_active Abandoned
- 2007-06-21 AR ARP070102735A patent/AR061604A1/es not_active Application Discontinuation
- 2007-06-22 CL CL200701835A patent/CL2007001835A1/es unknown
- 2007-06-22 TW TW096122579A patent/TWI331155B/zh not_active IP Right Cessation
-
2008
- 2008-11-19 NO NO20084863A patent/NO20084863L/no not_active Application Discontinuation
- 2008-11-20 IL IL195421A patent/IL195421A0/en unknown
- 2008-11-26 CR CR10463A patent/CR10463A/es not_active Application Discontinuation
- 2008-11-26 ZA ZA200810072A patent/ZA200810072B/xx unknown
- 2008-12-22 EC EC2008008999A patent/ECSP088999A/es unknown
- 2008-12-25 MA MA31510A patent/MA30530B1/fr unknown
-
2010
- 2010-05-27 HR HR20100302T patent/HRP20100302T1/hr unknown
- 2010-06-11 CY CY20101100519T patent/CY1110186T1/el unknown
-
2011
- 2011-05-11 US US13/105,435 patent/US20110213082A1/en not_active Abandoned
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