MX2010006044A - Sintesis de peptidos insulinotropicos utilizando una combinacion de tecnicas en fase solida y en solucion. - Google Patents

Sintesis de peptidos insulinotropicos utilizando una combinacion de tecnicas en fase solida y en solucion.

Info

Publication number
MX2010006044A
MX2010006044A MX2010006044A MX2010006044A MX2010006044A MX 2010006044 A MX2010006044 A MX 2010006044A MX 2010006044 A MX2010006044 A MX 2010006044A MX 2010006044 A MX2010006044 A MX 2010006044A MX 2010006044 A MX2010006044 A MX 2010006044A
Authority
MX
Mexico
Prior art keywords
fragment
solution phase
solid
different
coupled
Prior art date
Application number
MX2010006044A
Other languages
English (en)
Inventor
Yeun-Kwei Han
Li Chen
Christopher R Roberts
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2010006044A publication Critical patent/MX2010006044A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención refiere a la preparación de péptidos insulinotrópicos que se sintetizan utilizando una técnica en fase sólida y en solución ("híbrida") Generalmente la técnica incluye la síntesis de tres fragmentos intermediarios de péptido diferentes utilizando la química en fase sólida. Luego se utiliza la química en fase de solución para añadir material aminoácido adicional al tercer fragmento que entonces se acopla al segundo fragmento y luego al primer fragmento en solución. Alternativamente, un segundo fragmento diferente se acopla al primer fragmento en la fase sólida. Luego, se utiliza la química en fase de solución para añadir material aminoácido adicional a un tercer fragmento diferente. A continuación, este tercer fragmento diferente se acopla al primero acoplado y al segundo fragmento diferente en la fase de solución. La utilización de una pseudoprolina en uno de los fragmentos facilita la síntesis en fase sólida de ese fragmento y también facilita el subsiguiente acoplamiento en fase de solución de este fragmento a otros fragmentos. La presente invención es muy útil en la obtención de péptidos insulinotrópicos tal como el GLP-1 (7-36) y sus homólogos naturales y no naturales.
MX2010006044A 2007-12-11 2008-12-02 Sintesis de peptidos insulinotropicos utilizando una combinacion de tecnicas en fase solida y en solucion. MX2010006044A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US723807P 2007-12-11 2007-12-11
PCT/EP2008/066585 WO2009074483A2 (en) 2007-12-11 2008-12-02 Insulinotropic peptide synthesis using solid and solution phase combination techniques

Publications (1)

Publication Number Publication Date
MX2010006044A true MX2010006044A (es) 2010-06-23

Family

ID=40755926

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010006044A MX2010006044A (es) 2007-12-11 2008-12-02 Sintesis de peptidos insulinotropicos utilizando una combinacion de tecnicas en fase solida y en solucion.

Country Status (17)

Country Link
US (1) US8227571B2 (es)
EP (1) EP2222695A2 (es)
JP (1) JP2011506376A (es)
KR (1) KR20100102652A (es)
CN (1) CN101903400B (es)
AR (1) AR069608A1 (es)
AU (1) AU2008334783A1 (es)
BR (1) BRPI0820765A2 (es)
CA (1) CA2707132A1 (es)
CL (1) CL2008003660A1 (es)
IL (1) IL205932A0 (es)
MX (1) MX2010006044A (es)
PE (1) PE20091214A1 (es)
RU (1) RU2010128247A (es)
TW (1) TWI374890B (es)
WO (1) WO2009074483A2 (es)
ZA (1) ZA201003849B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2344519T3 (en) * 2008-11-07 2017-01-23 Massachusetts Gen Hospital C-TERMINAL FRAGMENTS OF GLUCAGON SIMILAR PEPTID-1 (GLP-1)
EP2424888A2 (en) * 2009-05-01 2012-03-07 F. Hoffmann-La Roche AG Insulinotropic peptide synthesis using solid and solution phase combination techniques
US20110313131A1 (en) 2010-06-21 2011-12-22 Christelle Carl Reversed phase hplc purification of a glp-1 analogue
US20120157382A1 (en) 2010-12-21 2012-06-21 Siegfried Krimmer Pharmaceutical glp-1 compositions having an improved release profile
EP3412680B1 (en) 2011-04-05 2020-11-04 Curara AB Novel peptides that bind to types of mhc class ii and their use in diagnosis and treatment
EP2729157B1 (en) 2011-07-06 2019-01-16 The General Hospital Corporation A pentapeptide derived from the c-terminus of glucagon-like peptide 1 (glp-1) for use in treatment
CN104936610A (zh) 2012-11-13 2015-09-23 益普生制药股份有限公司 Glp-1类似物的纯化方法
WO2014077801A1 (en) 2012-11-13 2014-05-22 Ipsen Pharma S.A.S. Purification process for preparing highly pure taspoglutide
EP2948468A1 (en) 2013-01-28 2015-12-02 Solae, LLC Novel polypeptides having satiety hormone releasing activity
ES2624961T3 (es) 2013-03-21 2017-07-18 Sanofi-Aventis Deutschland Gmbh Síntesis de productos de péptido que contienen imida cíclica
US10087221B2 (en) 2013-03-21 2018-10-02 Sanofi-Aventis Deutschland Gmbh Synthesis of hydantoin containing peptide products
GR20140100479A (el) * 2014-09-23 2016-05-05 Novetide, Ltd., Συνθεση λιραγλουτιδης
EP3692056A1 (en) * 2017-10-04 2020-08-12 Chemical & Biopharmaceutical Laboratories of Patras S.A. A process for preparing a glucagon-like peptide
KR20200001546A (ko) * 2018-06-27 2020-01-06 주식회사 시선바이오머티리얼스 Pna 올리고머의 제조방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2324348C (en) * 1998-03-23 2006-03-14 Trimeris, Inc. Methods and compositions for peptide synthesis
CZ295890B6 (cs) * 1998-12-07 2005-11-16 Societe De Conseils De Recherches Et D'application Analogy GLP-1, mající kyselinu aminoizomáselnou pozici 8 a D-arginin na pozici 36, jejich použití a farmaceutické prostředky je obsahující
US6469136B1 (en) * 1999-07-07 2002-10-22 Trimeris, Inc. Methods and composition for peptide synthesis
CN1918177A (zh) * 2003-12-18 2007-02-21 诺和诺德公司 新型glp－1化合物
WO2005066207A1 (en) * 2004-01-08 2005-07-21 Theratechnologies Inc. Glucagon-like peptide-1 analogs with long duration of action
MX2007007917A (es) * 2004-12-30 2007-08-14 Hoffmann La Roche Sintesis del peptido t-20 utilizando fragmentos peptidicos intermediarios.
CA2593866C (en) * 2004-12-30 2013-08-06 F. Hoffmann-La Roche Ag Synthesis of peptide t-1249 using peptide intermediate fragments
KR20070111463A (ko) * 2004-12-30 2007-11-21 에프. 호프만-라 로슈 아게 펩타이드 중간체 단편 ⅲ을 사용하는 합성 방법
EP1891106A2 (en) * 2005-05-05 2008-02-27 Cadila Healthcare Ltd. Novel compounds as glp-i agonists
KR101297942B1 (ko) * 2006-02-08 2013-08-19 론자 아게 글루카곤형 펩티드의 합성
PT2035451E (pt) * 2006-06-23 2010-06-09 Hoffmann La Roche Síntese de péptidos insulinotrópicos
EP2205624B1 (en) * 2007-10-27 2016-09-07 Corden Pharma Colorado, Inc. Insulinotropic peptide synthesis using solid and solution phase combination techniques

Also Published As

Publication number Publication date
US20090292108A1 (en) 2009-11-26
CN101903400B (zh) 2013-12-18
ZA201003849B (en) 2011-04-28
AU2008334783A1 (en) 2009-06-18
JP2011506376A (ja) 2011-03-03
WO2009074483A2 (en) 2009-06-18
EP2222695A2 (en) 2010-09-01
BRPI0820765A2 (pt) 2015-06-16
CN101903400A (zh) 2010-12-01
US8227571B2 (en) 2012-07-24
WO2009074483A3 (en) 2010-05-14
IL205932A0 (en) 2010-11-30
TWI374890B (en) 2012-10-21
AR069608A1 (es) 2010-02-03
KR20100102652A (ko) 2010-09-24
PE20091214A1 (es) 2009-08-14
CA2707132A1 (en) 2009-06-18
RU2010128247A (ru) 2012-01-20
CL2008003660A1 (es) 2010-01-04
TW200927756A (en) 2009-07-01

Similar Documents

Publication Publication Date Title
UA96602C2 (ru) Способ получения инсулинотропных пептидов
MX2010006044A (es) Sintesis de peptidos insulinotropicos utilizando una combinacion de tecnicas en fase solida y en solucion.
WO2010125079A3 (en) Insulinotropic peptide synthesis using solid and solution phase combination techniques
GEP20146112B (en) Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154 and usage thereof
TR201816260T4 (tr) Wt1-antijen peptid konjugat aşı.
MX348154B (es) Anticuerpos de enlace a il-1-beta y fragmentos de los mismos.
WO2009018126A3 (en) Collagen-related peptides and uses thereof
WO2006009902A3 (en) Non-natural amino acids
WO2001034635A3 (en) Methods and compositions for peptide synthesis
MX2011003502A (es) Anticuerpo de cadena sencilla biespecifica de psmaxcd3 especifico a traves de especies.
NZ612327A (en) Her2 binding peptides labelled with a 18f - containing organosilicon compound
WO2009080764A3 (en) Oral or nasal administration of compounds comprising amino acid sequences
WO2010115995A3 (en) Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders
WO2005000086A3 (en) FRAGMENTS OF NKp44 AND NKp46 FOR TARGETING VIRAL-INFECTED AND TUMOR CELLS
WO2008113970A3 (en) Peptides
WO2007070672A3 (en) Non-natural amino acids and neurotensin analogues thereof
TW200833371A (en) Process for solid formulations
IL184080A (en) Synthesis of peptide t-20 using peptide intermediate fragments
MX2009012085A (es) Métodos para la expansión dirigida de epítopes para el uso como ligandos de anticuerpos.
WO2007100358A3 (en) Convergent synthesis of proteins by kinetically controlled ligation
IL184081A0 (en) Synthesis using peptide intermediate fragments iii
MX2009008754A (es) Anticuerpos novedosos contra igf-1r.
DE602005016024D1 (de) Synthese von peptid t-1249 mit peptidzwischenproduktfragmenten
GB0522295D0 (en) Peptides and uses thereof
TH107349A (th) การสังเคราะห์อินซูลิโนโทรพิค เปปไทด์

Legal Events

Date Code Title Description
FG Grant or registration