PE20091214A1 - Sintesis de peptidos insulinotropicos utilizando una combinacion de tecnicas en fase solida y en solucion - Google Patents
Sintesis de peptidos insulinotropicos utilizando una combinacion de tecnicas en fase solida y en solucionInfo
- Publication number
- PE20091214A1 PE20091214A1 PE2008002033A PE2008002033A PE20091214A1 PE 20091214 A1 PE20091214 A1 PE 20091214A1 PE 2008002033 A PE2008002033 A PE 2008002033A PE 2008002033 A PE2008002033 A PE 2008002033A PE 20091214 A1 PE20091214 A1 PE 20091214A1
- Authority
- PE
- Peru
- Prior art keywords
- seq
- peptide fragment
- solution
- amino acid
- acid sequence
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
SE REFIERE A UN METODO PARA OBTENER UN PEPTIDO INSULINOTROPICO TALES COMO GLP-1 Y SUS HOMOLOGOS NATURALES Y NO NATURALES, QUE COMPRENDE: A) PROPORCIONAR UN PRIMER FRAGMENTO PEPTIDICO QUE INCLUYE LA SECUENCIA DE AMINOACIDOS (ID. DE SEC. Nº 5); B) ACOPLAR EL PRIMER FRAGMENTO PEPTIDICO EN SOLUCION CON ARGININA AMIDA PARA PROPORCIONAR UN SEGUNDO FRAGMENTO PEPTIDICO CUYA SECUENCIA DE AMINOACIDOS ES ID. SEC. Nº 6; C) ELIMINAR EL GRUPO PROTECTOR EN N-TERMINAL PARA CONSEGUIR UN TERCER FRAGMENTO PEPTIDICO QUE INCLUYE LA SECUENCIA DE AMINOACIDOS (ID. DE SEC. Nº 6); D) PROPORCIONAR UN CUARTO FRAGMENTO PEPTIDICO QUE INCLUYE LA SECUENCIA DE AMINOACIDOS (ID. DE SEC. Nº 7); E) ACOPLAR EL CUARTO FRAGMENTO PEPTIDICO AL TERCER FRAGMENTO PEPTIDICO EN SOLUCION PARA PROPORCIONAR UN QUINTO FRAGMENTO PEPTIDICO QUE INCLUYE LA SECUENCIA DE AMINOACIDOS (ID. DE SEC. Nº 8); F) ELIMINAR EL GRUPO PROTECTOR EN N-TERMINAL PARA CONSEGUIR UN SEXTO FRAGMENTO PEPTIDICO QUE INCLUYE LA SECUENCIA DE AMINOACIDOS (ID. DE SEC. Nº 14); G) PROPORCIONAR UN SEPTIMO FRAGMENTO PEPTIDICO QUE INCLUYE LA SECUENCIA DE AMINOACIDOS (ID. DE SEC. Nº 9); H) ACOPLAR EL SEPTIMO FRAGMENTO PEPTIDICO AL SEXTO FRAGMENTO PEPTIDICO EN SOLUCION PARA PROPORCIONAR UN PEPTIDO INSULINOTROPICO QUE INCLUYE LA SECUENCIA DE AMINOACIDOS (ID. DE SEC. Nº 10)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US723807P | 2007-12-11 | 2007-12-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091214A1 true PE20091214A1 (es) | 2009-08-14 |
Family
ID=40755926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008002033A PE20091214A1 (es) | 2007-12-11 | 2008-12-09 | Sintesis de peptidos insulinotropicos utilizando una combinacion de tecnicas en fase solida y en solucion |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8227571B2 (es) |
| EP (1) | EP2222695A2 (es) |
| JP (1) | JP2011506376A (es) |
| KR (1) | KR20100102652A (es) |
| CN (1) | CN101903400B (es) |
| AR (1) | AR069608A1 (es) |
| AU (1) | AU2008334783A1 (es) |
| BR (1) | BRPI0820765A2 (es) |
| CA (1) | CA2707132A1 (es) |
| CL (1) | CL2008003660A1 (es) |
| IL (1) | IL205932A0 (es) |
| MX (1) | MX2010006044A (es) |
| PE (1) | PE20091214A1 (es) |
| RU (1) | RU2010128247A (es) |
| TW (1) | TWI374890B (es) |
| WO (1) | WO2009074483A2 (es) |
| ZA (1) | ZA201003849B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010054326A2 (en) * | 2008-11-07 | 2010-05-14 | The General Hospital Corporation | C-terminal fragments of glucagon-like peptide-1 (glp-1) |
| SG175411A1 (en) * | 2009-05-01 | 2011-12-29 | Hoffmann La Roche | Insulinotropic peptide synthesis using solid and solution phase combination techniques |
| US20110313131A1 (en) | 2010-06-21 | 2011-12-22 | Christelle Carl | Reversed phase hplc purification of a glp-1 analogue |
| US20120157382A1 (en) | 2010-12-21 | 2012-06-21 | Siegfried Krimmer | Pharmaceutical glp-1 compositions having an improved release profile |
| US20150218546A1 (en) | 2011-04-05 | 2015-08-06 | Lars Klareskog | Novel peptides that bind to types of mhc class ii and their use on diagnosis and treatment |
| WO2013006692A2 (en) | 2011-07-06 | 2013-01-10 | The General Hospital Corporation | Methods of treatment using a pentapeptide derived from the c-terminus of glucagon-like peptide 1 (glp-1) |
| WO2014077801A1 (en) | 2012-11-13 | 2014-05-22 | Ipsen Pharma S.A.S. | Purification process for preparing highly pure taspoglutide |
| WO2014077802A1 (en) | 2012-11-13 | 2014-05-22 | Ipsen Pharma S.A.S. | Purification method of a glp-1 analogue |
| KR20150110529A (ko) | 2013-01-28 | 2015-10-02 | 솔레 엘엘씨 | 포만 호르몬 방출 활성을 갖는 신규 폴리펩티드 |
| SG11201506804VA (en) | 2013-03-21 | 2015-09-29 | Sanofi Aventis Deutschland | Synthesis of hydantoin containing peptide products |
| MX365465B (es) | 2013-03-21 | 2019-06-04 | Sanofi Aventis Deutschland | Sintesis de productos peptidicos que contienen imida ciclica. |
| GR20140100479A (el) * | 2014-09-23 | 2016-05-05 | Novetide, Ltd., | Συνθεση λιραγλουτιδης |
| WO2019069274A1 (en) * | 2017-10-04 | 2019-04-11 | Chemical & Biopharmaceutical Laboratories Of Patras S.A. | PROCESS FOR THE PREPARATION OF A GLUCAGON-LIKE PEPTIDE |
| KR20200001546A (ko) * | 2018-06-27 | 2020-01-06 | 주식회사 시선바이오머티리얼스 | Pna 올리고머의 제조방법 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9909018A (pt) * | 1998-03-23 | 2001-10-16 | Trimeris Inc | Processo para a sìntese de um peptìdeo, conjunto de fragmentos de peptìdeo, e, peptìdeo |
| WO2000034331A2 (en) * | 1998-12-07 | 2000-06-15 | Societe De Conseils De Recherches Et D'applications Scientifiques Sas | Analogues of glp-1 |
| US6469136B1 (en) * | 1999-07-07 | 2002-10-22 | Trimeris, Inc. | Methods and composition for peptide synthesis |
| CN1918177A (zh) * | 2003-12-18 | 2007-02-21 | 诺和诺德公司 | 新型glp－1化合物 |
| AU2005203925A1 (en) * | 2004-01-08 | 2005-07-21 | Theratechnologies Inc. | Glucagon-Like Peptide-1 analogs with long duration of action |
| DE602005017188D1 (de) * | 2004-12-30 | 2009-11-26 | Hoffmann La Roche | Synthese des peptides t-20 aus peptidfragmenten als zwischenprodukte |
| CN101133076B (zh) * | 2004-12-30 | 2011-07-13 | 弗·哈夫曼-拉罗切有限公司 | 使用肽中间片段合成肽t-1249 |
| EP1960423B1 (en) * | 2004-12-30 | 2009-10-14 | F. Hoffmann-Roche AG | Synthesis of peptide t-20 using peptide intermediate fragments |
| EP1891106A2 (en) * | 2005-05-05 | 2008-02-27 | Cadila Healthcare Ltd. | Novel compounds as glp-i agonists |
| CN101379075B (zh) * | 2006-02-08 | 2013-05-15 | 隆萨股份公司 | 类胰高血糖素肽的合成 |
| PL2035451T3 (pl) * | 2006-06-23 | 2010-08-31 | Hoffmann La Roche | Synteza peptydów insulinotropowych |
| JP5473925B2 (ja) * | 2007-10-27 | 2014-04-16 | コーデン ファーマ コロラド インコーポレイテッド | 固相および溶液相の組み合わせ技法を使用するインスリン分泌性ペプチドの合成 |
-
2008
- 2008-12-02 RU RU2010128247/10A patent/RU2010128247A/ru not_active Application Discontinuation
- 2008-12-02 KR KR1020107015264A patent/KR20100102652A/ko active IP Right Grant
- 2008-12-02 JP JP2010537379A patent/JP2011506376A/ja active Pending
- 2008-12-02 AU AU2008334783A patent/AU2008334783A1/en not_active Abandoned
- 2008-12-02 CA CA2707132A patent/CA2707132A1/en not_active Abandoned
- 2008-12-02 MX MX2010006044A patent/MX2010006044A/es active IP Right Grant
- 2008-12-02 WO PCT/EP2008/066585 patent/WO2009074483A2/en active Application Filing
- 2008-12-02 BR BRPI0820765-8A patent/BRPI0820765A2/pt not_active IP Right Cessation
- 2008-12-02 EP EP08860359A patent/EP2222695A2/en not_active Withdrawn
- 2008-12-02 CN CN2008801198008A patent/CN101903400B/zh not_active Expired - Fee Related
- 2008-12-08 TW TW097147695A patent/TWI374890B/zh not_active IP Right Cessation
- 2008-12-09 AR ARP080105329A patent/AR069608A1/es not_active Application Discontinuation
- 2008-12-09 PE PE2008002033A patent/PE20091214A1/es not_active Application Discontinuation
- 2008-12-10 CL CL2008003660A patent/CL2008003660A1/es unknown
- 2008-12-11 US US12/316,309 patent/US8227571B2/en not_active Expired - Fee Related
-
2010
- 2010-05-24 IL IL205932A patent/IL205932A0/en unknown
- 2010-05-28 ZA ZA2010/03849A patent/ZA201003849B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL205932A0 (en) | 2010-11-30 |
| BRPI0820765A2 (pt) | 2015-06-16 |
| ZA201003849B (en) | 2011-04-28 |
| EP2222695A2 (en) | 2010-09-01 |
| US8227571B2 (en) | 2012-07-24 |
| CN101903400B (zh) | 2013-12-18 |
| MX2010006044A (es) | 2010-06-23 |
| KR20100102652A (ko) | 2010-09-24 |
| JP2011506376A (ja) | 2011-03-03 |
| CL2008003660A1 (es) | 2010-01-04 |
| WO2009074483A3 (en) | 2010-05-14 |
| AR069608A1 (es) | 2010-02-03 |
| TW200927756A (en) | 2009-07-01 |
| WO2009074483A2 (en) | 2009-06-18 |
| AU2008334783A1 (en) | 2009-06-18 |
| CN101903400A (zh) | 2010-12-01 |
| RU2010128247A (ru) | 2012-01-20 |
| TWI374890B (en) | 2012-10-21 |
| CA2707132A1 (en) | 2009-06-18 |
| US20090292108A1 (en) | 2009-11-26 |
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Legal Events
| Date | Code | Title | Description |
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| FC | Refusal |