BR9909018A - Processo para a sìntese de um peptìdeo, conjunto de fragmentos de peptìdeo, e, peptìdeo - Google Patents

Processo para a sìntese de um peptìdeo, conjunto de fragmentos de peptìdeo, e, peptìdeo

Info

Publication number
BR9909018A
BR9909018A BR9909018-0A BR9909018A BR9909018A BR 9909018 A BR9909018 A BR 9909018A BR 9909018 A BR9909018 A BR 9909018A BR 9909018 A BR9909018 A BR 9909018A
Authority
BR
Brazil
Prior art keywords
peptide
peptides
synthesis
fragments
present
Prior art date
Application number
BR9909018-0A
Other languages
English (en)
Inventor
Myung-Chol Kang
Brian Bray
Maynard Lichty
Catherine Mader
Gene Merutka
Original Assignee
Trimeris Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/045,920 external-priority patent/US6281331B1/en
Application filed by Trimeris Inc filed Critical Trimeris Inc
Publication of BR9909018A publication Critical patent/BR9909018A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"PROCESSO PARA A SìNTESE DE UM PEPTìDEO, CONJUNTO DE FRAGMENTOS DE PEPTìDEO,E,PEPTìDEO". A presente invenção refere-se, primeiro, aos processos de síntese de peptídeos, em particular de T-20 (também referido como "DP178"; SEQ ID NO: 1) e de peptídeos semelhantes a T-20. Tais processos utilizam procedimentos de síntese em fases liquida e sólida e combinam grupos de fragmentos de peptídeo específicos para dar o peptídeo de interesse. A presente invenção refere-se em adição aos fragmentos de peptídeo individuais que atuam como intermediários na síntese de peptídeos de interesse (por exemplo, T-20). A presente invenção ainda refere-se adicionalmente aos grupos de tais fragmentos de intermediário de peptídeo que podem ser empregados juntos para produzir T-20 de comprimento total e peptídeos semelhantes a T-20.
BR9909018-0A 1998-03-23 1999-03-22 Processo para a sìntese de um peptìdeo, conjunto de fragmentos de peptìdeo, e, peptìdeo BR9909018A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/045,920 US6281331B1 (en) 1998-03-23 1998-03-23 Methods and compositions for peptide synthesis
US09/071,877 US6015881A (en) 1998-03-23 1998-05-01 Methods and compositions for peptide synthesis
PCT/US1999/006230 WO1999048513A1 (en) 1998-03-23 1999-03-22 Methods and compositions for peptide synthesis

Publications (1)

Publication Number Publication Date
BR9909018A true BR9909018A (pt) 2001-10-16

Family

ID=26723345

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9909018-0A BR9909018A (pt) 1998-03-23 1999-03-22 Processo para a sìntese de um peptìdeo, conjunto de fragmentos de peptìdeo, e, peptìdeo

Country Status (13)

Country Link
EP (1) EP1071442B9 (pt)
JP (1) JP4602547B2 (pt)
CN (1) CN100383158C (pt)
AT (1) ATE299029T1 (pt)
AU (1) AU751358B2 (pt)
BR (1) BR9909018A (pt)
CA (1) CA2324348C (pt)
DE (1) DE69926061T2 (pt)
DK (1) DK1071442T3 (pt)
ES (1) ES2245505T3 (pt)
NZ (1) NZ507083A (pt)
TW (1) TWI233931B (pt)
WO (1) WO1999048513A1 (pt)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6281331B1 (en) * 1998-03-23 2001-08-28 Trimeris, Inc. Methods and compositions for peptide synthesis
US6469136B1 (en) * 1999-07-07 2002-10-22 Trimeris, Inc. Methods and composition for peptide synthesis
ES2525317T3 (es) 2001-06-15 2014-12-22 F. Hoffmann-La Roche Ag Producción recombinante de inhibidores de la fusión antivirales peptídicos
ATE489401T1 (de) * 2002-07-24 2010-12-15 Hoffmann La Roche Pegyliertes t20-polypeptid
EP1701976A2 (en) * 2003-12-31 2006-09-20 F.Hoffmann-La Roche Ag Peptide synthesis and deprotection with co-solvent
ES2315729T3 (es) 2003-12-31 2009-04-01 F. Hoffmann-La Roche Ag Procedimiento y sistemas para la recuperacion de peptidos.
DE602004009710T2 (de) 2003-12-31 2008-08-07 F. Hoffmann-La Roche Ag Verfahren zur peptidsynthese unter verwendung einer reduzierten menge an entschützungsmittel
DE602005017188D1 (de) * 2004-12-30 2009-11-26 Hoffmann La Roche Synthese des peptides t-20 aus peptidfragmenten als zwischenprodukte
EP2013223A2 (en) 2006-05-03 2009-01-14 Mallinckrodt Inc. Composition and method for the release of protected peptides from a resin
EP2181983A4 (en) * 2007-07-25 2013-01-02 Ajinomoto Kk METHOD FOR THE SELECTIVE REMOVAL OF A DIBENZOFULVENE DERIVATIVE
CN101835794A (zh) * 2007-10-27 2010-09-15 霍夫曼-拉罗奇有限公司 使用固相和溶液相组合技术的促胰岛素肽合成法
EP2222695A2 (en) * 2007-12-11 2010-09-01 F. Hoffmann-La Roche AG Insulinotropic peptide synthesis using solid and solution phase combination techniques
EP2322498B1 (en) * 2008-08-06 2014-04-16 Ajinomoto Co., Inc. Processes for removing dibenzofulvene
EP2334314A4 (en) * 2008-09-03 2012-03-21 Scinopharm Taiwan Ltd PROCESS FOR THE PREPARATION OF PRAMLINTIDE
US20110288235A1 (en) * 2008-09-03 2011-11-24 Scinopharm Taiwan Ltd. Process for the Preparation of Pramlintide
WO2011095989A2 (en) * 2010-02-04 2011-08-11 Matrix Laboratories Ltd An improved process for the preparation of enfuvirtide
PL219569B1 (pl) * 2010-02-19 2015-05-29 Peptaderm Spółka Z Ograniczoną Odpowiedzialnością Cykliczne tetrapeptydy i ich zastosowanie
CN103374054B (zh) * 2012-04-28 2014-12-24 上海第一生化药业有限公司 一步法固相合成多肽的方法
GB201315335D0 (en) 2013-08-29 2013-10-09 Of Singapore Amino diacids containing peptide modifiers
EP4100417A2 (en) * 2020-02-05 2022-12-14 Eli Lilly and Company Resin reactors in series peptide synthesizer
CN114315957B (zh) * 2021-12-30 2023-07-07 深圳瑞德林生物技术有限公司 一种多肽的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU617088B2 (en) * 1986-06-12 1991-11-21 Biogen, Inc. Peptides involved in the pathogenesis of hiv infection
US4787222A (en) * 1986-11-24 1988-11-29 Novatek Medical Inc. Combination lock for blood identification system
US5444044A (en) * 1992-03-26 1995-08-22 New York Blood Center Synthetic polypeptides as inhibitors of HIV-1
US6479055B1 (en) * 1993-06-07 2002-11-12 Trimeris, Inc. Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission
US5464933A (en) * 1993-06-07 1995-11-07 Duke University Synthetic peptide inhibitors of HIV transmission
CA2164505A1 (en) * 1993-06-07 1994-12-22 Phillip W. Berman Hiv envelope polypeptides
JPH09502348A (ja) * 1993-09-11 1997-03-11 ポリムン・シエンティフィーク・イムノビオロギッシェ・フォルシュング・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 遺伝学的に分岐したｈｉｖ−１株に対する中和抗体を誘導するペプチド
DE69735991D1 (de) * 1996-02-09 2006-07-06 Hoffmann La Roche Herstellung eines vip-analogen

Also Published As

Publication number Publication date
EP1071442B9 (en) 2006-01-18
CN1303299A (zh) 2001-07-11
AU751358B2 (en) 2002-08-15
NZ507083A (en) 2003-10-31
ATE299029T1 (de) 2005-07-15
EP1071442A4 (en) 2002-06-05
CA2324348C (en) 2006-03-14
DK1071442T3 (da) 2005-10-24
TWI233931B (en) 2005-06-11
JP4602547B2 (ja) 2010-12-22
AU3109799A (en) 1999-10-18
CA2324348A1 (en) 1999-09-30
DE69926061D1 (de) 2005-08-11
EP1071442B1 (en) 2005-07-06
CN100383158C (zh) 2008-04-23
DE69926061T2 (de) 2006-06-01
EP1071442A1 (en) 2001-01-31
ES2245505T3 (es) 2006-01-01
WO1999048513A1 (en) 1999-09-30
JP2002507576A (ja) 2002-03-12

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 37, 8O, 13 DA LPI 9279/06

B12B Appeal against refusal [chapter 12.2 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 09/04/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 09/04/2019, OBSERVADAS AS CONDICOES LEGAIS

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/03/1999 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 22/03/2019