BRPI9909018B8 - processo para a síntese de um peptídeo - Google Patents
processo para a síntese de um peptídeoInfo
- Publication number
- BRPI9909018B8 BRPI9909018B8 BRPI9909018A BRPI9909018A BRPI9909018B8 BR PI9909018 B8 BRPI9909018 B8 BR PI9909018B8 BR PI9909018 A BRPI9909018 A BR PI9909018A BR PI9909018 A BRPI9909018 A BR PI9909018A BR PI9909018 B8 BRPI9909018 B8 BR PI9909018B8
- Authority
- BR
- Brazil
- Prior art keywords
- peptide
- peptides
- synthesis
- present
- fragments
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Abstract
"processo para a síntese de um peptídeo, conjunto de fragmentos de peptídeo,e,peptídeo". a presente invenção refere-se, primeiro, aos processos de síntese de peptídeos, em particular de t-20 (também referido como "dp178"; seq id no: 1) e de peptídeos semelhantes a t-20. tais processos utilizam procedimentos de síntese em fases liquida e sólida e combinam grupos de fragmentos de peptídeo específicos para dar o peptídeo de interesse. a presente invenção refere-se em adição aos fragmentos de peptídeo individuais que atuam como intermediários na síntese de peptídeos de interesse (por exemplo, t-20). a presente invenção ainda refere-se adicionalmente aos grupos de tais fragmentos de intermediário de peptídeo que podem ser empregados juntos para produzir t-20 de comprimento total e peptídeos semelhantes a t-20.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/045,920 US6281331B1 (en) | 1998-03-23 | 1998-03-23 | Methods and compositions for peptide synthesis |
US09/045920 | 1998-03-23 | ||
US09/071877 | 1998-05-01 | ||
US09/071,877 US6015881A (en) | 1998-03-23 | 1998-05-01 | Methods and compositions for peptide synthesis |
PCT/US1999/006230 WO1999048513A1 (en) | 1998-03-23 | 1999-03-22 | Methods and compositions for peptide synthesis |
Publications (2)
Publication Number | Publication Date |
---|---|
BRPI9909018B1 BRPI9909018B1 (pt) | 2019-04-09 |
BRPI9909018B8 true BRPI9909018B8 (pt) | 2021-05-25 |
Family
ID=21940553
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9909018A BRPI9909018B8 (pt) | 1998-03-23 | 1999-03-22 | processo para a síntese de um peptídeo |
Country Status (4)
Country | Link |
---|---|
US (2) | US6281331B1 (pt) |
JP (1) | JP4755713B2 (pt) |
KR (1) | KR100633214B1 (pt) |
BR (1) | BRPI9909018B8 (pt) |
Families Citing this family (61)
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SK782002A3 (en) * | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
AU3334001A (en) | 2000-02-10 | 2001-08-20 | Panacos Pharmaceuticals Inc | Assay for detection of viral fusion inhibitors |
US20050065319A1 (en) * | 2000-12-19 | 2005-03-24 | Baroudy Bahige M. | Combination method for treating viral infections |
US7906102B2 (en) | 2001-10-03 | 2011-03-15 | Vanderbilt University | Ligands to radiation-induced molecules |
KR20040058229A (ko) | 2001-10-22 | 2004-07-03 | 더 스크립스 리서치 인스티튜트 | 항체 표적화 화합물 |
KR100451432B1 (ko) * | 2002-07-12 | 2004-10-06 | 강충경 | T-20 펩타이드의 생물학적 제조방법 |
RU2296769C2 (ru) * | 2002-07-24 | 2007-04-10 | Ф.Хоффманн-Ля Рош Аг | Пэгилированный полипептид т20 |
EP1546193A1 (en) * | 2002-07-24 | 2005-06-29 | F. Hoffmann-La Roche Ag | Pegylated t1249 polypeptide |
US20040209999A1 (en) * | 2002-08-16 | 2004-10-21 | Bohling James Charles | Method of manufacturing polypeptides, including T-20 and T-1249, at commercial scale, and polypeptide compositions related thereto |
EA007918B1 (ru) | 2002-09-24 | 2007-02-27 | Франтиэ Биотекнолоджиз Ко., Лтд. | Пептидные производные-ингибиторы слияния при вич-инфекции |
US20040076637A1 (en) * | 2002-09-27 | 2004-04-22 | Delmedico Mary Kay | HIV-derived HR1 peptides modified to form stable trimers, and their use in therapy to inhibit transmission of human immunodeficiency virus |
US7556813B2 (en) * | 2002-09-27 | 2009-07-07 | Trimeris, Inc. | Antiviral peptide-polymer conjugate comprising a polymer covalently attached to two or more synthetic HIV gp41 HR1 and/or HR2 peptides |
US20040063856A1 (en) * | 2002-09-30 | 2004-04-01 | Bohling James Charles | Resin for solid phase synthesis |
WO2004035808A2 (en) * | 2002-10-16 | 2004-04-29 | Panacos Pharmaceuticals, Inc. | Method for detecting viral inactivating agents |
US20040158037A1 (en) * | 2003-02-12 | 2004-08-12 | Bohling James Charles | Amino acid loaded trityl alcohol resins, method of production of amino acid loaded trityl alcohol resins and biologically active substances and therapeutics produced therewith |
AU2004200485A1 (en) * | 2003-02-25 | 2004-09-09 | Rohm And Haas Company | Method of manufacturing T-20 and T-1249 peptides at commercial scale, and T-20 and T-1249 compositions related thereto |
US20050281829A1 (en) * | 2003-05-06 | 2005-12-22 | Hehir Cristina A T | Fc chimeric proteins with anti-HIV drugs |
WO2004100882A2 (en) * | 2003-05-06 | 2004-11-25 | Syntonix Pharmaceuticals, Inc. | Inhibition of drug binding to serum albumin |
TWI353991B (en) * | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
US7348004B2 (en) | 2003-05-06 | 2008-03-25 | Syntonix Pharmaceuticals, Inc. | Immunoglobulin chimeric monomer-dimer hybrids |
PL2077121T3 (pl) * | 2003-05-06 | 2011-07-29 | Syntonix Pharmaceuticals Inc | Białka chimeryczne o strukturze czynnik krzepliwości krwi VII-FC do leczenia zaburzenia hemostatycznego |
KR20050024730A (ko) * | 2003-09-01 | 2005-03-11 | 코바이오텍 (주) | T―20 펩타이드 코딩 유전자를 포함하는 재조합대장균의 고농도 세포 배양 방법 및 이로부터 생산된t―20 펩타이드의 분리 및 정제 방법 |
EP1701972B1 (en) * | 2003-12-31 | 2008-10-08 | F. Hoffmann-La Roche Ag | Process and systems for recovery of peptides |
WO2005063799A2 (en) * | 2003-12-31 | 2005-07-14 | F.Hoffmann-La Roche Ag | Peptide synthesis and deprotection with co-solvent |
WO2005063800A2 (en) * | 2003-12-31 | 2005-07-14 | F. Hoffmann-La Roche Ag | Peptide synthesis using decanting filter |
WO2005063792A2 (en) * | 2003-12-31 | 2005-07-14 | F. Hoffmann-La Roche Ag | Methods for recovering cleaved peptide from a support |
DE602004009710T2 (de) * | 2003-12-31 | 2008-08-07 | F. Hoffmann-La Roche Ag | Verfahren zur peptidsynthese unter verwendung einer reduzierten menge an entschützungsmittel |
CA2551082A1 (en) * | 2004-01-07 | 2005-07-28 | Trimeris, Inc. | Hiv gp41 hr2-derived synthetic peptides, and their use in therapy to inhibit transmission of human immunodeficiency virus |
US20050249667A1 (en) * | 2004-03-24 | 2005-11-10 | Tuszynski Jack A | Process for treating a biological organism |
US20060051396A1 (en) | 2004-06-16 | 2006-03-09 | Affinergy, Inc. | Biofunctional coatings |
WO2006045503A1 (en) | 2004-10-19 | 2006-05-04 | Lonza Ag | Method for solid phase peptide synthesis |
CN101133077B (zh) * | 2004-12-30 | 2012-09-05 | 弗·哈夫曼-拉罗切有限公司 | 使用肽中间片段合成肽t-20 |
WO2006069779A1 (en) * | 2004-12-30 | 2006-07-06 | F. Hoffmann-La Roche Ag | Preparing of peptides with excellent solubility |
CA2593864C (en) * | 2004-12-30 | 2013-08-06 | F. Hoffmann-La Roche Ag | Synthesis using peptide intermediate fragments iii |
WO2006069697A1 (en) * | 2004-12-30 | 2006-07-06 | F. Hoffmann-La Roche Ag | Colorimetrically assessing peptide characteristics |
ES2329270T3 (es) * | 2004-12-30 | 2009-11-24 | F. Hoffmann-La Roche Ag | Sintesis del peptido t-1249 utilizando fragmentos intermediarios del ipeptido. |
MX2007012505A (es) * | 2005-04-08 | 2007-12-06 | Lonza Ab | Sintesis peptidica de helices alfa sobre una resina peg. |
US20070122408A1 (en) * | 2005-10-20 | 2007-05-31 | The Scripps Research Institute | Fc Labeling for Immunostaining and Immunotargeting |
EP1968995A1 (en) * | 2005-12-30 | 2008-09-17 | F. Hoffmann-la Roche AG | Methods for the synthesis of arginine-containing peptides |
AR059300A1 (es) * | 2006-02-02 | 2008-03-26 | Trimeris Inc | Peptidos inhibidores de la fusion de vih con propiedades biologicas mejoradas |
TW200745163A (en) * | 2006-02-17 | 2007-12-16 | Syntonix Pharmaceuticals Inc | Peptides that block the binding of IgG to FcRn |
EP2013223A2 (en) * | 2006-05-03 | 2009-01-14 | Mallinckrodt Inc. | Composition and method for the release of protected peptides from a resin |
JP4537495B2 (ja) * | 2006-06-23 | 2010-09-01 | エフ.ホフマン−ラ ロシュ アーゲー | インスリン分泌性ペプチドの合成 |
MX2009010689A (es) * | 2007-04-03 | 2009-12-14 | Trimeris Inc | Formulaciones novedosas para el suministro de agentes terapeuticos de peptidos antivirales. |
CN101790535A (zh) * | 2007-06-29 | 2010-07-28 | 隆萨股份公司 | 制备普兰林肽的方法 |
WO2009014177A1 (ja) * | 2007-07-25 | 2009-01-29 | Ajinomoto Co., Inc. | ジベンゾフルベン誘導体の淘汰方法 |
EA201070231A1 (ru) * | 2007-08-09 | 2010-10-29 | Синтоникс Фармасьютикалз, Инк. | Иммуномодулирующие пептиды |
WO2009042194A2 (en) * | 2007-09-25 | 2009-04-02 | Trimeris, Inc. | Methods of synthesis for therapeuthic anti-hiv peptides |
CA2703113A1 (en) * | 2007-10-27 | 2009-04-30 | F. Hoffmann-La Roche Ag | Insulinotropic peptide synthesis using solid and solution phase combination techniques |
WO2009094636A2 (en) * | 2008-01-25 | 2009-07-30 | The University Of North Carolina At Chapel Hill | Ixodes scapularis salivary proteins and methods of use for modulation of the alternative complement pathway |
WO2010014909A1 (en) * | 2008-08-01 | 2010-02-04 | Syntonix Pharmaceuticals, Inc. | Immunomodulatory peptides |
US8518927B2 (en) | 2009-02-10 | 2013-08-27 | The Scripps Research Institute | Chemically programmed vaccination |
US9296805B2 (en) | 2009-06-18 | 2016-03-29 | Dana-Farber Cancer Institute, Inc. | Stabilized insulinotropic peptides and methods of use |
WO2011031662A1 (en) | 2009-09-08 | 2011-03-17 | Kent Stephen B H | Ester insulin |
PL219569B1 (pl) | 2010-02-19 | 2015-05-29 | Peptaderm Spółka Z Ograniczoną Odpowiedzialnością | Cykliczne tetrapeptydy i ich zastosowanie |
AU2011274423B2 (en) | 2010-07-09 | 2016-02-11 | Bioverativ Therapeutics Inc. | Chimeric clotting factors |
EA037906B1 (ru) | 2013-03-15 | 2021-06-04 | Биовератив Терапьютикс Инк. | Препараты полипептида фактора ix |
WO2016014939A1 (en) | 2014-07-24 | 2016-01-28 | Washington University | Compositions targeting radiation-induced molecules and methods of use thereof |
US20180154007A1 (en) | 2015-05-20 | 2018-06-07 | Syracuse University | Glycemic Control Using Intrinsic Factor Bound to A Vitamin B12 Conjugate of a Glucagon-Like Peptide-1 Receptor Agonist |
WO2016187512A1 (en) | 2015-05-20 | 2016-11-24 | Syracuse University | Compositions and methods for enhancing peptide stability against protease digestion |
CN110546155B (zh) * | 2017-03-31 | 2023-06-23 | 浜理药品工业株式会社 | 肽的制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU617088B2 (en) * | 1986-06-12 | 1991-11-21 | Biogen, Inc. | Peptides involved in the pathogenesis of hiv infection |
US4787222A (en) * | 1986-11-24 | 1988-11-29 | Novatek Medical Inc. | Combination lock for blood identification system |
US5444044A (en) * | 1992-03-26 | 1995-08-22 | New York Blood Center | Synthetic polypeptides as inhibitors of HIV-1 |
NZ254640A (en) | 1992-07-20 | 1997-04-24 | Univ Duke | Hiv protein fragments of transmembrane glycoprotein gp41 (dp-107) with antiviral activity and their use |
US5464933A (en) | 1993-06-07 | 1995-11-07 | Duke University | Synthetic peptide inhibitors of HIV transmission |
US6479055B1 (en) | 1993-06-07 | 2002-11-12 | Trimeris, Inc. | Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission |
DE69735991D1 (de) * | 1996-02-09 | 2006-07-06 | Hoffmann La Roche | Herstellung eines vip-analogen |
NZ507083A (en) * | 1998-03-23 | 2003-10-31 | Trimeris Inc | Methods and compositions for peptide synthesis, in particular T-20 (DP-178) and T-20-like peptides |
-
1998
- 1998-03-23 US US09/045,920 patent/US6281331B1/en not_active Expired - Lifetime
- 1998-05-01 US US09/071,877 patent/US6015881A/en not_active Expired - Lifetime
-
1999
- 1999-03-22 KR KR1020007010534A patent/KR100633214B1/ko not_active IP Right Cessation
- 1999-03-22 BR BRPI9909018A patent/BRPI9909018B8/pt unknown
-
2009
- 2009-10-28 JP JP2009247579A patent/JP4755713B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6015881A (en) | 2000-01-18 |
JP2010065044A (ja) | 2010-03-25 |
KR100633214B1 (ko) | 2006-10-11 |
JP4755713B2 (ja) | 2011-08-24 |
BRPI9909018B1 (pt) | 2019-04-09 |
US6281331B1 (en) | 2001-08-28 |
KR20010042131A (ko) | 2001-05-25 |
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