EA200100314A1 - Пептидные фрагменты холерного экзотоксина в или энтеротоксина в в качестве адъювантов вакцины - Google Patents

Пептидные фрагменты холерного экзотоксина в или энтеротоксина в в качестве адъювантов вакцины

Info

Publication number
EA200100314A1
EA200100314A1 EA200100314A EA200100314A EA200100314A1 EA 200100314 A1 EA200100314 A1 EA 200100314A1 EA 200100314 A EA200100314 A EA 200100314A EA 200100314 A EA200100314 A EA 200100314A EA 200100314 A1 EA200100314 A1 EA 200100314A1
Authority
EA
Eurasian Patent Office
Prior art keywords
substance
fragles
enteroxine
choler
exotoxin
Prior art date
Application number
EA200100314A
Other languages
English (en)
Inventor
Нил Эндрью Уилльямс
Тимоти Реймонд Херст
Original Assignee
Юниверсити Оф Бристоль
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Юниверсити Оф Бристоль filed Critical Юниверсити Оф Бристоль
Publication of EA200100314A1 publication Critical patent/EA200100314A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

В заявке описана субстанция. Субстанция включает одну или несколько аминокислотных последовательностей, содержащих последовательность, которая представлена в SEQ ID NO:2, или ее вариант, или ее гомолог, или ее фрагмент, или ее производное, или ее миметик; причем, субстанция обладает способностью действовать также или аналогично Etx и/или Ctx; но где субстанция не проявляет GM-1-связывающей активности.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200100314A 1998-09-07 1999-09-07 Пептидные фрагменты холерного экзотоксина в или энтеротоксина в в качестве адъювантов вакцины EA200100314A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9819484.8A GB9819484D0 (en) 1998-09-07 1998-09-07 Therapeutic agents
PCT/GB1999/002970 WO2000014114A1 (en) 1998-09-07 1999-09-07 Peptide fragments of cholera toxin b or enterotoxin b as vaccine adjuvants

Publications (1)

Publication Number Publication Date
EA200100314A1 true EA200100314A1 (ru) 2001-10-22

Family

ID=10838466

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100314A EA200100314A1 (ru) 1998-09-07 1999-09-07 Пептидные фрагменты холерного экзотоксина в или энтеротоксина в в качестве адъювантов вакцины

Country Status (19)

Country Link
EP (1) EP1109828A1 (ru)
JP (1) JP2002524469A (ru)
KR (1) KR20010044842A (ru)
CN (1) CN1317013A (ru)
AU (1) AU772015B2 (ru)
BR (1) BR9913501A (ru)
CA (1) CA2338384A1 (ru)
CZ (1) CZ2001839A3 (ru)
EA (1) EA200100314A1 (ru)
GB (2) GB9819484D0 (ru)
HU (1) HUP0104090A2 (ru)
IL (1) IL141695A0 (ru)
IS (1) IS5829A (ru)
MX (1) MXPA01002387A (ru)
NO (1) NO20011075L (ru)
NZ (1) NZ509631A (ru)
PL (1) PL346549A1 (ru)
WO (1) WO2000014114A1 (ru)
ZA (1) ZA200100758B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010036917A1 (en) 1995-07-05 2001-11-01 Williams Neil Andrew Therapeutic agents
GB9800487D0 (en) * 1998-01-09 1998-03-04 Oratol Limited Therapies
GB0115382D0 (en) 2001-06-22 2001-08-15 Univ Bristol Mutant
WO2004047793A1 (en) * 2002-11-26 2004-06-10 Alk-Abelló A/S Pharmaceutical allergen product
CN104402974B (zh) * 2014-12-10 2017-11-14 重庆医科大学 一种具有粘膜免疫佐剂活性的多肽及其在制备粘膜免疫佐剂中的用途
WO2024121125A1 (en) * 2022-12-06 2024-06-13 Bactolife A/S Single-domain antibodies to reduce the risk of cholera infection

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2527445A1 (fr) * 1982-05-26 1983-12-02 Centre Nat Rech Scient Medicaments contenant au moins une sequence de la sous-unite b1 de la toxine cholerique
IL69558A (en) * 1983-08-23 1988-06-30 Yeda Res & Dev Synthetic cholera vaccine
ZA839512B (en) * 1983-12-12 1984-08-29 Scripps Clinic Res Synthetic heat-stable enterotoxin polypeptide of escherichia coli and multimers thereof
FR2636842B1 (fr) * 1988-09-27 1994-06-10 Liege Universite Etat Proteine de fusion d'une sequence derivee de la sous-unite b de la toxine cholerique et d'un antigene heterologue doue de proprietes immunogenes, compositions de vaccins les contenant et acides nucleiques recombinants contenant une sequence de nucleotides codant pour ladite proteine de fusion
EP0738325A1 (en) * 1994-01-27 1996-10-23 GX BioSystems A/S Receptor specific bacterial adhesins and their use
IL109519A (en) * 1994-05-03 1999-03-12 Yeda Res & Dev Vaccines for oral immunization against infecting agents
US6019982A (en) * 1994-08-26 2000-02-01 The Administrators Of The Tulane Educational Fund Mutant enterotoxin effective as a non-toxic oral adjuvant

Also Published As

Publication number Publication date
KR20010044842A (ko) 2001-06-05
PL346549A1 (en) 2002-02-11
CZ2001839A3 (cs) 2001-08-15
JP2002524469A (ja) 2002-08-06
AU5751699A (en) 2000-03-27
ZA200100758B (en) 2001-07-16
WO2000014114A1 (en) 2000-03-16
CA2338384A1 (en) 2000-03-16
GB9819484D0 (en) 1998-10-28
AU772015B2 (en) 2004-04-08
MXPA01002387A (es) 2002-05-08
NZ509631A (en) 2003-11-28
BR9913501A (pt) 2001-06-05
NO20011075D0 (no) 2001-03-02
IS5829A (is) 2001-03-07
NO20011075L (no) 2001-05-07
IL141695A0 (en) 2002-03-10
GB0107375D0 (en) 2001-05-16
EP1109828A1 (en) 2001-06-27
CN1317013A (zh) 2001-10-10
GB2357507A (en) 2001-06-27
HUP0104090A2 (hu) 2002-01-28

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