HUP0104090A2 - A kolera toxin B vagy enterotoxin B peptidfragmentumai, mint vakcina adjuvánsok - Google Patents
A kolera toxin B vagy enterotoxin B peptidfragmentumai, mint vakcina adjuvánsokInfo
- Publication number
- HUP0104090A2 HUP0104090A2 HU0104090A HUP0104090A HUP0104090A2 HU P0104090 A2 HUP0104090 A2 HU P0104090A2 HU 0104090 A HU0104090 A HU 0104090A HU P0104090 A HUP0104090 A HU P0104090A HU P0104090 A2 HUP0104090 A2 HU P0104090A2
- Authority
- HU
- Hungary
- Prior art keywords
- substance
- enterotoxin
- peptide fragments
- cholera toxin
- vaccine adjuvants
- Prior art date
Links
- 102000009016 Cholera Toxin Human genes 0.000 title 1
- 108010049048 Cholera Toxin Proteins 0.000 title 1
- 101000867232 Escherichia coli Heat-stable enterotoxin II Proteins 0.000 title 1
- 108010033276 Peptide Fragments Proteins 0.000 title 1
- 102000007079 Peptide Fragments Human genes 0.000 title 1
- 239000012646 vaccine adjuvant Substances 0.000 title 1
- 229940124931 vaccine adjuvant Drugs 0.000 title 1
- 239000000126 substance Substances 0.000 abstract 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 abstract 1
- 206010012735 Diarrhoea Diseases 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 230000027455 binding Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 239000002955 immunomodulating agent Substances 0.000 abstract 1
- 229940121354 immunomodulator Drugs 0.000 abstract 1
- 230000002584 immunomodulator Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
- 108700012359 toxins Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
A találmány tárgya egy olyan anyag, mely a következők közül egyet vagytöbbet tartalmaz: egy 2. azonosítószámú szekvenciában bemutatottszekvenciát tartalmazó aminosav-szekvencia vagy ennek egy változatavagy ennek egy homológja vagy ennek egy fragmentuma vagy ennek egyszármazéka vagy ennek egy mimetikuma, mely anyag képes ugyanolyan vagyhasonló módon működni, mint az EtxB és/vagy CtxB; viszont ahol azanyag nem mutat GM-1 kötő aktivitást. A találmány szerinti anyagimmunmodulátorként, adjuvánsként, toxin által kiváltott hasmenésinhibitoraként alkalmazható. A találmány a fenti anyagot tartalmazógyógyszerkészítményre is vonatkozik. A találmány további tárgya egymérőeljárás a találmány szerinti anyaggal kölcsönhatásba lépő szerekszűrésére. Ó
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9819484.8A GB9819484D0 (en) | 1998-09-07 | 1998-09-07 | Therapeutic agents |
| PCT/GB1999/002970 WO2000014114A1 (en) | 1998-09-07 | 1999-09-07 | Peptide fragments of cholera toxin b or enterotoxin b as vaccine adjuvants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0104090A2 true HUP0104090A2 (hu) | 2002-01-28 |
Family
ID=10838466
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0104090A HUP0104090A2 (hu) | 1998-09-07 | 1999-09-07 | A kolera toxin B vagy enterotoxin B peptidfragmentumai, mint vakcina adjuvánsok |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1109828A1 (hu) |
| JP (1) | JP2002524469A (hu) |
| KR (1) | KR20010044842A (hu) |
| CN (1) | CN1317013A (hu) |
| AU (1) | AU772015B2 (hu) |
| BR (1) | BR9913501A (hu) |
| CA (1) | CA2338384A1 (hu) |
| CZ (1) | CZ2001839A3 (hu) |
| EA (1) | EA200100314A1 (hu) |
| GB (2) | GB9819484D0 (hu) |
| HU (1) | HUP0104090A2 (hu) |
| IL (1) | IL141695A0 (hu) |
| IS (1) | IS5829A (hu) |
| MX (1) | MXPA01002387A (hu) |
| NO (1) | NO20011075L (hu) |
| NZ (1) | NZ509631A (hu) |
| PL (1) | PL346549A1 (hu) |
| WO (1) | WO2000014114A1 (hu) |
| ZA (1) | ZA200100758B (hu) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010036917A1 (en) | 1995-07-05 | 2001-11-01 | Williams Neil Andrew | Therapeutic agents |
| GB9800487D0 (en) * | 1998-01-09 | 1998-03-04 | Oratol Limited | Therapies |
| GB0115382D0 (en) | 2001-06-22 | 2001-08-15 | Univ Bristol | Mutant |
| MXPA05005528A (es) * | 2002-11-26 | 2006-04-05 | Alk Abello As | Producto farmaceutico de alergeno. |
| CN104402974B (zh) * | 2014-12-10 | 2017-11-14 | 重庆医科大学 | 一种具有粘膜免疫佐剂活性的多肽及其在制备粘膜免疫佐剂中的用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2527445A1 (fr) * | 1982-05-26 | 1983-12-02 | Centre Nat Rech Scient | Medicaments contenant au moins une sequence de la sous-unite b1 de la toxine cholerique |
| IL69558A (en) * | 1983-08-23 | 1988-06-30 | Yeda Res & Dev | Synthetic cholera vaccine |
| ZA839512B (en) * | 1983-12-12 | 1984-08-29 | Scripps Clinic Res | Synthetic heat-stable enterotoxin polypeptide of escherichia coli and multimers thereof |
| FR2636842B1 (fr) * | 1988-09-27 | 1994-06-10 | Liege Universite Etat | Proteine de fusion d'une sequence derivee de la sous-unite b de la toxine cholerique et d'un antigene heterologue doue de proprietes immunogenes, compositions de vaccins les contenant et acides nucleiques recombinants contenant une sequence de nucleotides codant pour ladite proteine de fusion |
| WO1995020657A1 (en) * | 1994-01-27 | 1995-08-03 | Gx Biosystems A/S | Receptor specific bacterial adhesins and their use |
| IL109519A (en) * | 1994-05-03 | 1999-03-12 | Yeda Res & Dev | Vaccines for oral immunization against infecting agents |
| US6019982A (en) * | 1994-08-26 | 2000-02-01 | The Administrators Of The Tulane Educational Fund | Mutant enterotoxin effective as a non-toxic oral adjuvant |
-
1998
- 1998-09-07 GB GBGB9819484.8A patent/GB9819484D0/en not_active Ceased
-
1999
- 1999-09-07 JP JP2000568871A patent/JP2002524469A/ja not_active Withdrawn
- 1999-09-07 IL IL14169599A patent/IL141695A0/xx unknown
- 1999-09-07 PL PL99346549A patent/PL346549A1/xx not_active Application Discontinuation
- 1999-09-07 NZ NZ509631A patent/NZ509631A/en unknown
- 1999-09-07 CN CN99810666A patent/CN1317013A/zh active Pending
- 1999-09-07 MX MXPA01002387A patent/MXPA01002387A/es unknown
- 1999-09-07 CZ CZ2001839A patent/CZ2001839A3/cs unknown
- 1999-09-07 BR BR9913501-9A patent/BR9913501A/pt not_active IP Right Cessation
- 1999-09-07 KR KR1020017002217A patent/KR20010044842A/ko not_active Application Discontinuation
- 1999-09-07 CA CA002338384A patent/CA2338384A1/en not_active Abandoned
- 1999-09-07 WO PCT/GB1999/002970 patent/WO2000014114A1/en not_active Application Discontinuation
- 1999-09-07 GB GB0107375A patent/GB2357507A/en not_active Withdrawn
- 1999-09-07 AU AU57516/99A patent/AU772015B2/en not_active Ceased
- 1999-09-07 EA EA200100314A patent/EA200100314A1/ru unknown
- 1999-09-07 HU HU0104090A patent/HUP0104090A2/hu unknown
- 1999-09-07 EP EP99944696A patent/EP1109828A1/en not_active Withdrawn
-
2001
- 2001-01-26 IS IS5829A patent/IS5829A/is unknown
- 2001-01-26 ZA ZA200100758A patent/ZA200100758B/en unknown
- 2001-03-02 NO NO20011075A patent/NO20011075L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA200100314A1 (ru) | 2001-10-22 |
| CZ2001839A3 (cs) | 2001-08-15 |
| NZ509631A (en) | 2003-11-28 |
| WO2000014114A1 (en) | 2000-03-16 |
| EP1109828A1 (en) | 2001-06-27 |
| GB9819484D0 (en) | 1998-10-28 |
| AU772015B2 (en) | 2004-04-08 |
| MXPA01002387A (es) | 2002-05-08 |
| CN1317013A (zh) | 2001-10-10 |
| GB2357507A (en) | 2001-06-27 |
| ZA200100758B (en) | 2001-07-16 |
| PL346549A1 (en) | 2002-02-11 |
| IS5829A (is) | 2001-03-07 |
| NO20011075L (no) | 2001-05-07 |
| NO20011075D0 (no) | 2001-03-02 |
| BR9913501A (pt) | 2001-06-05 |
| JP2002524469A (ja) | 2002-08-06 |
| KR20010044842A (ko) | 2001-06-05 |
| IL141695A0 (en) | 2002-03-10 |
| AU5751699A (en) | 2000-03-27 |
| GB0107375D0 (en) | 2001-05-16 |
| CA2338384A1 (en) | 2000-03-16 |
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