WO1999001567A3 - Methods and compositions for a deubiquitinating enzyme and variants thereof - Google Patents
Methods and compositions for a deubiquitinating enzyme and variants thereof Download PDFInfo
- Publication number
- WO1999001567A3 WO1999001567A3 PCT/US1998/013776 US9813776W WO9901567A3 WO 1999001567 A3 WO1999001567 A3 WO 1999001567A3 US 9813776 W US9813776 W US 9813776W WO 9901567 A3 WO9901567 A3 WO 9901567A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- variants
- methods
- enzyme
- compositions
- deubiquitinating
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
- C12N9/60—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Mycology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US5143797P | 1997-07-01 | 1997-07-01 | |
US60/051,437 | 1997-07-01 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO1999001567A2 WO1999001567A2 (en) | 1999-01-14 |
WO1999001567A3 true WO1999001567A3 (en) | 1999-04-01 |
WO1999001567A9 WO1999001567A9 (en) | 1999-05-14 |
Family
ID=21971318
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1998/013776 WO1999001567A2 (en) | 1997-07-01 | 1998-07-01 | Methods and compositions for a deubiquitinating enzyme and variants thereof |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO1999001567A2 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1297053A (en) * | 1999-11-22 | 2001-05-30 | 上海博容基因开发有限公司 | Polypeptide-human ubiquitin C-end hydrolase 28 and polynucleotide for coding said polypeptide |
CN1315559A (en) * | 2000-03-27 | 2001-10-03 | 上海博德基因开发有限公司 | Polypeptide-human obiqitin carboxylic acid terminal hydrolase 10 and polynucleotide for coding it |
US20020133842A1 (en) * | 2000-12-08 | 2002-09-19 | Leviten Michael W. | Transgenic mice containing deubiquitinated enzyme gene disruptions |
WO2002052269A2 (en) * | 2000-12-22 | 2002-07-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Method for identifying substances which positively influence inflammatory conditions of chronic inflammatory airway diseases |
CA2609271C (en) | 2005-05-27 | 2014-02-25 | Proteolix, Inc. | Novel substrate for rpn 11 enzymatic activity |
AU2012202284B2 (en) * | 2005-05-27 | 2014-11-20 | Onyx Therapeutics, Inc. | Novel substrate for Rpn11 enzymatic activity |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5585466A (en) * | 1994-12-06 | 1996-12-17 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Crystals of serum albumin for use in genetic engineering and rational drug design |
US5834228A (en) * | 1997-02-13 | 1998-11-10 | Merck & Co., Inc. | Method for identifying inhibitors for apopain based upon the crystal structure of the apopain: Ac-DEVD-CHO complex |
-
1998
- 1998-07-01 WO PCT/US1998/013776 patent/WO1999001567A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5585466A (en) * | 1994-12-06 | 1996-12-17 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Crystals of serum albumin for use in genetic engineering and rational drug design |
US5834228A (en) * | 1997-02-13 | 1998-11-10 | Merck & Co., Inc. | Method for identifying inhibitors for apopain based upon the crystal structure of the apopain: Ac-DEVD-CHO complex |
Non-Patent Citations (1)
Title |
---|
LARSEN C. N., PRICE J. S., WILKINSON K. D.: "SUBSTRATE BINDING AND CATALYSIS BY UBIQUITIN C-TERMINAL HYDROLASES: IDENTIFICATION OF TWO ACTIVE SITE RESIDUES.", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 35., 1 May 1996 (1996-05-01), US, pages 6735 - 6744., XP002916369, ISSN: 0006-2960, DOI: 10.1021/bi960099f * |
Also Published As
Publication number | Publication date |
---|---|
WO1999001567A2 (en) | 1999-01-14 |
WO1999001567A9 (en) | 1999-05-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BG103977A (en) | Low molecular rotamase enzymic activity inhibitors | |
WO1999043651A3 (en) | Inhibitors of phospholipase enzymes | |
NZ520659A (en) | Xylanase variants having altered sensitivity to xylanase inhibitors caused by mutations in the lid region | |
CA2270289A1 (en) | Proteins with enhanced levels of essential amino acids | |
WO1996016172A3 (en) | Modulators of anchoring protein function | |
EE200000488A (en) | Phospholipase enzyme inhibitors and pharmaceutical compositions | |
IS5905A (en) | Alzheimer's secretion | |
WO2001049097A3 (en) | Alzheimer's disease secretase, app substrates therefor, and uses therefor | |
EE200000522A (en) | Phospholipase A2 Enzyme Inhibitor, a Pharmaceutical Composition Containing It and a Method for Inhibiting the Phospholipase Enzyme Activity | |
WO1995021601A3 (en) | Kallikrein-inhibiting 'kunitz domain' proteins and analogues thereof | |
ZA974542B (en) | New amino acid derivatives and their use as thrombin inhibitors. | |
DE69822307D1 (en) | HUMAN ADAMTS-1 PROTEIN, GENE WHICH CODES THIS, PHARMACEUTICAL COMPOSITION AND METHOD FOR THE IMMUNOLOGICAL DETERMINATION OF HUMAN ADAMTS-1 PROTEINS | |
AR244544A1 (en) | Amino acid beta-lyase enzyme inhibitors as deodorants | |
WO1999045098A3 (en) | Delivery or proteins into eukaryotic cells with recombinant yersinia | |
ATE108205T1 (en) | RECOMBINANT METHODS FOR THE PRODUCTION OF SERIN PROTEAS INHIBITORS, AND DNA SEQUENCES THEREFOR. | |
DK1025236T3 (en) | Human checkpoint kinase, HCDS1, preparations and methods | |
CA2128711A1 (en) | Trypsin inhibitors | |
WO2003010291A3 (en) | Treatment of immune disorders and b cell disorders | |
WO2000034511A3 (en) | Aβ-PEPTIDE SCREENING ASSAY | |
FI955130A0 (en) | L-amino acid oxidase | |
IE820637L (en) | Dipeptides | |
WO1999001567A3 (en) | Methods and compositions for a deubiquitinating enzyme and variants thereof | |
EP0614970A3 (en) | Hydroxyphenylpyruvate-dioxygenase inhibitors and assay for the identification of the enzyme. | |
EP1080724A4 (en) | Mtp activity-lowering compositions | |
AU6877998A (en) | Dipeptide inhibitors of protein farnesyltransferase |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): CA JP KR US |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE |
|
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
AK | Designated states |
Kind code of ref document: A3 Designated state(s): CA JP KR US |
|
AL | Designated countries for regional patents |
Kind code of ref document: A3 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
AK | Designated states |
Kind code of ref document: C2 Designated state(s): CA JP KR US |
|
AL | Designated countries for regional patents |
Kind code of ref document: C2 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE |
|
COP | Corrected version of pamphlet |
Free format text: PAGES 6-163, DESCRIPTION, REPLACED BY NEW PAGES 6-170; PAGES 164-166, CLAIMS, REPLACED BY NEW PAGES171-173; PAGES 1/19-19/19, DRAWINGS, REPLACED BY NEW PAGES 1/19-19/19; DUE TO LATE TRANSMITTAL BY THE RECEIVING OFFICE |
|
NENP | Non-entry into the national phase |
Ref country code: KR |
|
NENP | Non-entry into the national phase |
Ref country code: CA |
|
NENP | Non-entry into the national phase |
Ref country code: JP Ref document number: 1999508763 Format of ref document f/p: F |
|
122 | Ep: pct application non-entry in european phase |