EP1080724A4 - Mtp activity-lowering compositions - Google Patents
Mtp activity-lowering compositionsInfo
- Publication number
- EP1080724A4 EP1080724A4 EP99913682A EP99913682A EP1080724A4 EP 1080724 A4 EP1080724 A4 EP 1080724A4 EP 99913682 A EP99913682 A EP 99913682A EP 99913682 A EP99913682 A EP 99913682A EP 1080724 A4 EP1080724 A4 EP 1080724A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- compositions
- mtp activity
- lowering compositions
- lowering
- mtp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
Abstract
Compositions which are useful in inhibiting the secretion of biological substances such as VLDL into the blood. These compositions are MTP activity-lowering compositions characterized by containing sulfur-containing amino acids such as cycloalliin and S-ethyl-L-cysteine or physiologically acceptable salts thereof.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP14117698 | 1998-05-22 | ||
JP14117698 | 1998-05-22 | ||
PCT/JP1999/002023 WO1999061015A1 (en) | 1998-05-22 | 1999-04-16 | Mtp activity-lowering compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
EP1080724A1 EP1080724A1 (en) | 2001-03-07 |
EP1080724A4 true EP1080724A4 (en) | 2004-06-23 |
Family
ID=15285921
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP99913682A Withdrawn EP1080724A4 (en) | 1998-05-22 | 1999-04-16 | Mtp activity-lowering compositions |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1080724A4 (en) |
KR (1) | KR20010025074A (en) |
AU (1) | AU3170699A (en) |
CA (1) | CA2332511A1 (en) |
WO (1) | WO1999061015A1 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TNSN03146A1 (en) | 2001-06-28 | 2005-12-23 | Pfizer Prod Inc | TRIAMIDE SUBSTITUTED INDOLES, BENZOFURANS AND BENZOTHIOPHENES, USEFUL AS SECRETION INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND / OR APOLIPO-PROTEIN B (APO B). |
JP4954523B2 (en) * | 2005-09-26 | 2012-06-20 | 長谷川香料株式会社 | Method for producing an extract containing a high concentration of S-alkenyl (or alkyl) cysteine sulfoxides |
JP2008271983A (en) * | 2008-06-06 | 2008-11-13 | Sunstar Inc | Food having hypocholesterolemic action on human serum, and agent for prevention or treatment of human hypercholesterolemia |
JP5834307B2 (en) * | 2010-03-11 | 2015-12-16 | 地方独立行政法人青森県産業技術センター | Allium plant material and method for producing the same |
JP2011244833A (en) * | 2011-09-02 | 2011-12-08 | Sunstar Inc | Food having action to lower human serum cholesterol level and preventive or treating agent for human hypercholesterolemia |
JP5808243B2 (en) * | 2011-12-27 | 2015-11-10 | ハウス食品グループ本社株式会社 | Method for producing onion extract with suppressed browning reaction |
US9340808B2 (en) * | 2012-03-14 | 2016-05-17 | Nisshin Pharma Inc. | Sulfur amino acid-containing composition |
JP6046451B2 (en) * | 2012-11-08 | 2016-12-14 | 日清ファルマ株式会社 | Stress improving composition |
JP6298388B2 (en) * | 2013-09-04 | 2018-03-20 | 日清ファルマ株式会社 | Sulfur-containing amino acid-containing composition |
JP2014183849A (en) * | 2014-06-25 | 2014-10-02 | Sunstar Inc | Food having human serum cholesterol value reduction action, and preventive or therapeutic agent for human being hypercholesterolemia |
KR101672007B1 (en) * | 2014-09-15 | 2016-11-03 | 한국식품연구원 | Composition comprising Fermented Garlic using Monascus pilosus |
JP2016189785A (en) * | 2016-06-16 | 2016-11-10 | サンスター株式会社 | Food having human serum cholesterol value reduction action, and agent for preventing human hypercholesterolemia |
JP6976515B2 (en) * | 2017-07-21 | 2021-12-08 | 国立大学法人 筑波大学 | Sleep improver |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2329821A1 (en) * | 1972-06-15 | 1974-01-03 | Rech Pharm Scientifiques | MEDICINAL PRODUCTS CONTAINING CYSTEIN DERIVATIVES |
JPS5522648A (en) * | 1978-08-07 | 1980-02-18 | Tanabe Seiyaku Co Ltd | Preparatin of 5-methyl-1,4-thiazan-3-carboxylic acid |
JPS62423A (en) * | 1985-06-25 | 1987-01-06 | Wakunaga Pharmaceut Co Ltd | Remedy for hepatopathy |
US5084482A (en) * | 1990-04-10 | 1992-01-28 | The Lithox Corporation | Methods for inhibiting inflammatory ischemic, thrombotic and cholesterolemic disease response with methionine compounds |
JPH05194237A (en) * | 1992-01-21 | 1993-08-03 | M S C:Kk | Blood sugar and blood lipid reducing agent |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999008548A1 (en) * | 1997-08-13 | 1999-02-25 | Nippon Shinyaku Co., Ltd. | Onion extract rich in sulfurized cyclic amino acid and process for producing the same |
-
1999
- 1999-04-16 EP EP99913682A patent/EP1080724A4/en not_active Withdrawn
- 1999-04-16 CA CA002332511A patent/CA2332511A1/en not_active Abandoned
- 1999-04-16 KR KR1020007013055A patent/KR20010025074A/en not_active Application Discontinuation
- 1999-04-16 AU AU31706/99A patent/AU3170699A/en not_active Abandoned
- 1999-04-16 WO PCT/JP1999/002023 patent/WO1999061015A1/en not_active Application Discontinuation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2329821A1 (en) * | 1972-06-15 | 1974-01-03 | Rech Pharm Scientifiques | MEDICINAL PRODUCTS CONTAINING CYSTEIN DERIVATIVES |
JPS5522648A (en) * | 1978-08-07 | 1980-02-18 | Tanabe Seiyaku Co Ltd | Preparatin of 5-methyl-1,4-thiazan-3-carboxylic acid |
JPS62423A (en) * | 1985-06-25 | 1987-01-06 | Wakunaga Pharmaceut Co Ltd | Remedy for hepatopathy |
US5084482A (en) * | 1990-04-10 | 1992-01-28 | The Lithox Corporation | Methods for inhibiting inflammatory ischemic, thrombotic and cholesterolemic disease response with methionine compounds |
JPH05194237A (en) * | 1992-01-21 | 1993-08-03 | M S C:Kk | Blood sugar and blood lipid reducing agent |
Non-Patent Citations (11)
Title |
---|
AGARWAL R K ET AL: "CONTROLLED TRIAL OF THE EFFECT OF CYCLO ALLIIN ON THE FIBRINOLYTIC ACTIVITY OF VENOUS BLOOD", ATHEROSCLEROSIS, vol. 27, no. 3, 1977, pages 347 - 352, XP009029571, ISSN: 0021-9150 * |
BORDIA A ET AL: "The effective of active principle of garlic and onion on blood lipids and experimental atherosclerosis in rabbits and their comparison with clofibrate.", THE JOURNAL OF THE ASSOCIATION OF PHYSICIANS OF INDIA. INDIA AUG 1977, vol. 25, no. 8, August 1977 (1977-08-01), pages 509 - 516, XP009030212, ISSN: 0004-5772 * |
DATABASE WPI Section Ch Week 199335, Derwent World Patents Index; Class B03, AN 1993-278201, XP002278678 * |
EFENDY JOHNNY L ET AL: "The effect of the aged garlic extract, 'Kyolic', on the development of experimental atherosclerosis", ATHEROSCLEROSIS, AMSTERDAM, NL, vol. 132, no. 1, 1997, pages 37 - 42, XP002202141, ISSN: 0021-9150 * |
ITOKAWA Y ET AL: "EFFECT OF S METHYL CYSTEINE SULFOXIDE S ALLYL CYSTEINE SULFOXIDE AND RELATED SULFUR CONTAINING AMINO-ACIDS ON LIPID METABOLISM OF EXPERIMENTAL HYPER CHOLESTEREMIC RATS", JOURNAL OF NUTRITION, vol. 103, no. 1, 1973, pages 88 - 92, XP009030197, ISSN: 0022-3166 * |
KOMATSU W ET AL: "Suppression of hypercholesterolemia in hepatoma-bearing rats by cabbage extract and its component, S-methyl-L-cysteine sulfoxide.", LIPIDS. UNITED STATES MAY 1998, vol. 33, no. 5, May 1998 (1998-05-01), pages 499 - 503, XP009030228, ISSN: 0024-4201 * |
LUTOMSKI J: "Value of garlic and its components in phytotherapy", PHARMAZIE IN UNSERER ZEIT 1980 GERMANY, vol. 9, no. 2, 1980, pages 45 - 57, XP009029623 * |
OREKHOV ALEXANDER N ET AL: "Direct anti-atherosclerosis-related effects of garlic", ANNALS OF MEDICINE, vol. 27, no. 1, 1995, pages 63 - 65, XP009030222, ISSN: 0785-3890 * |
PATENT ABSTRACTS OF JAPAN vol. 004, no. 050 (C - 007) 16 April 1980 (1980-04-16) * |
PATENT ABSTRACTS OF JAPAN vol. 011, no. 167 (C - 425) 28 May 1987 (1987-05-28) * |
See also references of WO9961015A1 * |
Also Published As
Publication number | Publication date |
---|---|
WO1999061015A1 (en) | 1999-12-02 |
CA2332511A1 (en) | 1999-12-02 |
EP1080724A1 (en) | 2001-03-07 |
AU3170699A (en) | 1999-12-13 |
KR20010025074A (en) | 2001-03-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20001215 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): DE ES FR GB IT NL |
|
A4 | Supplementary search report drawn up and despatched |
Effective date: 20040512 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: 7A 61K 31/195 B Ipc: 7A 61K 31/54 A |
|
17Q | First examination report despatched |
Effective date: 20050210 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20050621 |