JPS5522648A - Preparatin of 5-methyl-1,4-thiazan-3-carboxylic acid - Google Patents
Preparatin of 5-methyl-1,4-thiazan-3-carboxylic acidInfo
- Publication number
- JPS5522648A JPS5522648A JP9641878A JP9641878A JPS5522648A JP S5522648 A JPS5522648 A JP S5522648A JP 9641878 A JP9641878 A JP 9641878A JP 9641878 A JP9641878 A JP 9641878A JP S5522648 A JPS5522648 A JP S5522648A
- Authority
- JP
- Japan
- Prior art keywords
- carboxylic acid
- methyl
- cycloalliin
- monohalo
- thiazin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To prepare the title compound useful as a synthetic intermediate of cycloalliin which is a remedy for thrombogenesis and arteriosclerosis, easily, in a short step, in high yield, by reacting cysteine with a monohalo-acetone, and reducing the product.
CONSTITUTION: Cysteine is reacted with a monohalo-acetone of formula (X is halogen) in a solvent such as water, in the presence of an lakali metal hydroxide to afford 5-methyl-2,3-dihydro-6H-1,4-thiazin-3-carboxylic acid. The product is, without separating from the reaction mixture, reduced pref. with soldium borohydride to obtain 5-methyl-1,4-thiazin-3-carboxylic acid (C=N double bond of the starting compound is reduced to C-N single bond). The carboxylic acid thus obtained is easily oxidized with sodium periodate to afford cycloalliin.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9641878A JPS5522648A (en) | 1978-08-07 | 1978-08-07 | Preparatin of 5-methyl-1,4-thiazan-3-carboxylic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9641878A JPS5522648A (en) | 1978-08-07 | 1978-08-07 | Preparatin of 5-methyl-1,4-thiazan-3-carboxylic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5522648A true JPS5522648A (en) | 1980-02-18 |
Family
ID=14164419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9641878A Pending JPS5522648A (en) | 1978-08-07 | 1978-08-07 | Preparatin of 5-methyl-1,4-thiazan-3-carboxylic acid |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5522648A (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5972361U (en) * | 1982-11-05 | 1984-05-16 | 日本精工株式会社 | Bearing unit using magnetic fluid seal |
| JPH02124319U (en) * | 1990-03-15 | 1990-10-12 | ||
| US4992535A (en) * | 1988-10-26 | 1991-02-12 | G. D. Searle & Co. | Methods of making novel R and S diastereomers of N6 -[(2-hydroxypropyl)aryl]adenosines |
| DE19733101C2 (en) * | 1996-07-31 | 1999-03-18 | Nsk Ltd | roller bearing |
| EP1080724A1 (en) * | 1998-05-22 | 2001-03-07 | Nippon Shinyaku Co., Ltd. | Mtp activity-lowering compositions |
| US6241396B1 (en) | 1998-01-08 | 2001-06-05 | Nsk Ltd. | Sealing device for a rolling bearing |
-
1978
- 1978-08-07 JP JP9641878A patent/JPS5522648A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5972361U (en) * | 1982-11-05 | 1984-05-16 | 日本精工株式会社 | Bearing unit using magnetic fluid seal |
| JPS6329944Y2 (en) * | 1982-11-05 | 1988-08-11 | ||
| US4992535A (en) * | 1988-10-26 | 1991-02-12 | G. D. Searle & Co. | Methods of making novel R and S diastereomers of N6 -[(2-hydroxypropyl)aryl]adenosines |
| JPH02124319U (en) * | 1990-03-15 | 1990-10-12 | ||
| DE19733101C2 (en) * | 1996-07-31 | 1999-03-18 | Nsk Ltd | roller bearing |
| US6241396B1 (en) | 1998-01-08 | 2001-06-05 | Nsk Ltd. | Sealing device for a rolling bearing |
| EP1080724A1 (en) * | 1998-05-22 | 2001-03-07 | Nippon Shinyaku Co., Ltd. | Mtp activity-lowering compositions |
| EP1080724A4 (en) * | 1998-05-22 | 2004-06-23 | Nippon Shinyaku Co Ltd | Mtp activity-lowering compositions |
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