JPS5695178A - Production of n-mercaptoalkanoylaminoacid - Google Patents

Production of n-mercaptoalkanoylaminoacid

Info

Publication number
JPS5695178A
JPS5695178A JP17190479A JP17190479A JPS5695178A JP S5695178 A JPS5695178 A JP S5695178A JP 17190479 A JP17190479 A JP 17190479A JP 17190479 A JP17190479 A JP 17190479A JP S5695178 A JPS5695178 A JP S5695178A
Authority
JP
Japan
Prior art keywords
alcohol
salt
remedy
water
hypertension
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP17190479A
Other languages
Japanese (ja)
Other versions
JPS6128667B2 (en
Inventor
Takehisa Ohashi
Masami Shimazaki
Kazunori Suga
Hideo Kondo
Kiyoshi Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanegafuchi Chemical Industry Co Ltd
Original Assignee
Kanegafuchi Chemical Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanegafuchi Chemical Industry Co Ltd filed Critical Kanegafuchi Chemical Industry Co Ltd
Priority to JP17190479A priority Critical patent/JPS5695178A/en
Priority to GB8038469A priority patent/GB2065643B/en
Priority to DE19803046271 priority patent/DE3046271A1/en
Priority to US06/214,780 priority patent/US4371699A/en
Priority to FR8026234A priority patent/FR2471975B1/en
Priority to IT50342/80A priority patent/IT1188971B/en
Priority to ES497665A priority patent/ES8200863A1/en
Priority to NL8006768A priority patent/NL192264C/en
Priority to IE2603/80A priority patent/IE50548B1/en
Publication of JPS5695178A publication Critical patent/JPS5695178A/en
Publication of JPS6128667B2 publication Critical patent/JPS6128667B2/ja
Granted legal-status Critical Current

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  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)

Abstract

PURPOSE: The reaction of an N-haloalkanoylaminoacid or its salt with an alkali or alkaline earth hydrosulfide is conducted in water or a 1W3C alcohol to produce the titled compound used as a raw material for a remedy for hypertension economically in high yield.
CONSTITUTION: An aminoacid of formula I [X is halogen; n is integer of 0W3; R is H, methyl; Y is O, S, So, SO2, (CH2)m; m is 1, 2] or its salt is made to react with an alkali or alkaline earth metal salt with hydrogen sulfide in water or a 1W3C alcohol, preferably at 40°W100°C, when water is used or at 40° Wthe boiling point of the alcohol, when an alcohol is empolyed, further preferably in the presence of a catalyst of an inorganic iodine salt to give the compound of formula II using inexpensive reagents and solvent economically in high yield. The product is used as a raw material for an orally administered remedy for hypertension and enables the very ecomonical synthesis of the remedy.
COPYRIGHT: (C)1981,JPO&Japio
JP17190479A 1979-12-13 1979-12-28 Production of n-mercaptoalkanoylaminoacid Granted JPS5695178A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP17190479A JPS5695178A (en) 1979-12-28 1979-12-28 Production of n-mercaptoalkanoylaminoacid
GB8038469A GB2065643B (en) 1979-12-13 1980-12-01 Optically active n-mercaptoalkanoylamino acids
DE19803046271 DE3046271A1 (en) 1979-12-13 1980-12-09 METHOD FOR PRODUCING OPTICALLY ACTIVE N-MERCAPTOALKANOYLAMINO ACIDS
US06/214,780 US4371699A (en) 1979-12-13 1980-12-09 Process for preparation of optically active N-mercaptoalkanoylamino acids
FR8026234A FR2471975B1 (en) 1979-12-13 1980-12-10 PROCESS FOR THE PREPARATION OF OPTICALLY ACTIVE N-MERCAPTOALCANOYLAMINOACIDS
IT50342/80A IT1188971B (en) 1979-12-13 1980-12-11 PROCEDURE FOR PREPARING OPTICALLY ACTIVE N-MERCAPTOALCANOYL-AMINO ACIDS
ES497665A ES8200863A1 (en) 1979-12-13 1980-12-12 Process for preparation of optically active N-mercaptoalkanoylamino acids
NL8006768A NL192264C (en) 1979-12-13 1980-12-12 Process for preparing optically active N-mercaptoalkanoylamino acids.
IE2603/80A IE50548B1 (en) 1979-12-13 1980-12-12 Process for preparation of optically active n-mercaptoalkanoylamino acids

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17190479A JPS5695178A (en) 1979-12-28 1979-12-28 Production of n-mercaptoalkanoylaminoacid

Publications (2)

Publication Number Publication Date
JPS5695178A true JPS5695178A (en) 1981-08-01
JPS6128667B2 JPS6128667B2 (en) 1986-07-01

Family

ID=15931965

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17190479A Granted JPS5695178A (en) 1979-12-13 1979-12-28 Production of n-mercaptoalkanoylaminoacid

Country Status (1)

Country Link
JP (1) JPS5695178A (en)

Also Published As

Publication number Publication date
JPS6128667B2 (en) 1986-07-01

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