JPS57149257A - 4-benzyloxyphenylacetamide - Google Patents
4-benzyloxyphenylacetamideInfo
- Publication number
- JPS57149257A JPS57149257A JP3632681A JP3632681A JPS57149257A JP S57149257 A JPS57149257 A JP S57149257A JP 3632681 A JP3632681 A JP 3632681A JP 3632681 A JP3632681 A JP 3632681A JP S57149257 A JPS57149257 A JP S57149257A
- Authority
- JP
- Japan
- Prior art keywords
- formulai
- useful
- benzyloxyphenylacetamide
- benzyloxyphenylacetonitrile
- hydroxyphenylacetamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:4-Benzyloxyphenylacetamide expressed by formulaI.
USE: Useful as an intermediate for preparing 4-(2-hydroxy-3-isopropylaminopropoxy)phenylacetamide ("Atenolol ") useful as a β-sympathetic inhibitor, easily convertible into a 4-hydroxyphenylacetamide, and industrially, easily, economically and advantageously obtainable.
PROCESS: 4-Benzyloxyphenylacetonitrile of formula II is reacted with hydrogen peroxide in the absence or presence of a solvent, e.g. ethanol or tetrahydrofuran, in the presence of an acidic catalyst, e.g. hydrogen chloride or sulfuric acid, or in an aqueous solution of an alkali to give the aimed compound of formulaI.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3632681A JPS57149257A (en) | 1981-03-13 | 1981-03-13 | 4-benzyloxyphenylacetamide |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3632681A JPS57149257A (en) | 1981-03-13 | 1981-03-13 | 4-benzyloxyphenylacetamide |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57149257A true JPS57149257A (en) | 1982-09-14 |
Family
ID=12466709
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3632681A Pending JPS57149257A (en) | 1981-03-13 | 1981-03-13 | 4-benzyloxyphenylacetamide |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57149257A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008545807A (en) * | 2006-07-26 | 2008-12-18 | テバ ファーマシューティカル インダストリーズ リミティド | Method for synthesizing O-desmethylvenlafaxine |
-
1981
- 1981-03-13 JP JP3632681A patent/JPS57149257A/en active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008545807A (en) * | 2006-07-26 | 2008-12-18 | テバ ファーマシューティカル インダストリーズ リミティド | Method for synthesizing O-desmethylvenlafaxine |
JP4763788B2 (en) * | 2006-07-26 | 2011-08-31 | テバ ファーマシューティカル インダストリーズ リミティド | Method for synthesizing O-desmethylvenlafaxine |
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