WO2009014177A1 - ジベンゾフルベン誘導体の淘汰方法 - Google Patents

ジベンゾフルベン誘導体の淘汰方法 Download PDF

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Publication number
WO2009014177A1
WO2009014177A1 PCT/JP2008/063281 JP2008063281W WO2009014177A1 WO 2009014177 A1 WO2009014177 A1 WO 2009014177A1 JP 2008063281 W JP2008063281 W JP 2008063281W WO 2009014177 A1 WO2009014177 A1 WO 2009014177A1
Authority
WO
WIPO (PCT)
Prior art keywords
dibenzofulvene
hydrocarbon solvent
deprotection
amino acid
acid compound
Prior art date
Application number
PCT/JP2008/063281
Other languages
English (en)
French (fr)
Inventor
Daisuke Takahashi
Original Assignee
Ajinomoto Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co., Inc. filed Critical Ajinomoto Co., Inc.
Priority to JP2009524510A priority Critical patent/JP5515738B2/ja
Priority to EP08791533A priority patent/EP2181983A4/en
Publication of WO2009014177A1 publication Critical patent/WO2009014177A1/ja
Priority to US12/692,852 priority patent/US20100184952A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C209/00—Preparation of compounds containing amino groups bound to a carbon skeleton
    • C07C209/82—Purification; Separation; Stabilisation; Use of additives
    • C07C209/86—Separation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/38—Separation; Purification; Stabilisation; Use of additives
    • C07C227/40—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/26—Separation; Purification; Stabilisation; Use of additives
    • C07C319/28—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/063—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha-amino functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

　Ｆｍｏｃ基で保護されたアミノ酸化合物をアミンと反応させることにより脱保護して得られる、ジベンゾフルベン及び／又はジベンゾフルベンアミン付加体を含む反応混合物を、炭素数５以上の炭化水素溶媒および該炭化水素溶媒に混和しない極性有機溶媒（但し、アミド系有機溶媒を除く。）中で攪拌、分層させ、炭化水素溶媒層を除去することにより、脱保護後に副成するジベンゾフルベン及び／又はジベンゾフルベンアミン付加体を効率的に淘汰することができる。
PCT/JP2008/063281 2007-07-25 2008-07-24 ジベンゾフルベン誘導体の淘汰方法 WO2009014177A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009524510A JP5515738B2 (ja) 2007-07-25 2008-07-24 ジベンゾフルベン誘導体の淘汰方法
EP08791533A EP2181983A4 (en) 2007-07-25 2008-07-24 METHOD FOR THE SELECTIVE REMOVAL OF A DIBENZOFULVENE DERIVATIVE
US12/692,852 US20100184952A1 (en) 2007-07-25 2010-01-25 Method for selective removal of dibenzofulvene derivative

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007193153 2007-07-25
JP2007-193153 2007-07-25

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/692,852 Continuation US20100184952A1 (en) 2007-07-25 2010-01-25 Method for selective removal of dibenzofulvene derivative

Publications (1)

Publication Number Publication Date
WO2009014177A1 true WO2009014177A1 (ja) 2009-01-29

Family

ID=40281425

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/063281 WO2009014177A1 (ja) 2007-07-25 2008-07-24 ジベンゾフルベン誘導体の淘汰方法

Country Status (4)

Country Link
US (1) US20100184952A1 (ja)
EP (1) EP2181983A4 (ja)
JP (1) JP5515738B2 (ja)
WO (1) WO2009014177A1 (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012029794A1 (ja) 2010-08-30 2012-03-08 味の素株式会社 分岐鎖含有芳香族化合物
WO2013089241A1 (ja) * 2011-12-15 2013-06-20 味の素株式会社 Ｆｍｏｃ基の除去方法
CN114585916A (zh) * 2019-10-15 2022-06-03 中外制药株式会社 含有用具有Fmoc骨架的保护基保护的氨基的化合物的定量法
JP7260725B1 (ja) * 2021-12-27 2023-04-18 株式会社トクヤマ ペプチド製造方法、保護基の除去方法、及び除去剤
WO2023127331A1 (ja) * 2021-12-27 2023-07-06 株式会社トクヤマ ペプチド製造方法、保護基の除去方法、除去剤、及びベンジル化合物
WO2024096023A1 (ja) * 2022-11-01 2024-05-10 中外製薬株式会社 ジベンゾフルベンまたはジベンゾフルベン誘導体の除去方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006045503A1 (en) 2004-10-19 2006-05-04 Lonza Ag Method for solid phase peptide synthesis
EP2280993A1 (en) * 2008-05-15 2011-02-09 Novo Nordisk A/S Purification of peptides prepared by solid phase synthesis
WO2012171987A1 (en) 2011-06-16 2012-12-20 Lonza Ltd A process for extraction of peptides and its application in liquid phase peptide synthesis
CN109970609B (zh) * 2019-03-20 2021-05-11 广州同隽医药科技有限公司 一种组合物及其应用

Citations (4)

* Cited by examiner, † Cited by third party
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JPH09506336A (ja) * 1993-09-24 1997-06-24 テラピン テクノロジーズ，インコーポレイテッド グルタチオンアナログおよびグルタチオン模擬物を含むパラログパネル
JP2002507576A (ja) * 1998-03-23 2002-03-12 トリメリス，インコーポレーテッド ペプチド合成のための方法および組成物
WO2003018188A1 (fr) * 2001-08-24 2003-03-06 Japan Science And Technology Agency Systeme de solvant multiphase compatible
JP2005534739A (ja) * 2002-07-30 2005-11-17 アマシャム バイオサイエンス ユーケイ リミテッド シアニン染料リポーターを用いたタンパク質の部位特異的標識

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US5599903A (en) * 1992-04-03 1997-02-04 Terrapin Technologies, Inc. Glutathione analogs and paralog panels comprising glutathione mimics
RU2079491C1 (ru) * 1995-02-15 1997-05-20 Акционерное общество закрытого типа "Вектор-БиоПродукт" Nα -2-(4-НИТРОФЕНИЛСУЛЬФОНИЛ)ЭТОКСИКАРБОНИЛ-АМИНОКИСЛОТЫ В КАЧЕСТВЕ Nα -ЗАЩИЩЕННЫХ АМИНОКИСЛОТ ДЛЯ ТВЕРДОФАЗНОГО СИНТЕЗА ПЕПТИДОВ
US6281331B1 (en) * 1998-03-23 2001-08-28 Trimeris, Inc. Methods and compositions for peptide synthesis
US7323538B2 (en) * 2001-04-27 2008-01-29 Japan Science And Technology Agency Polymer having unique optical property and polymerizable monomer therefor
US7256257B2 (en) * 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
GB0217556D0 (en) * 2002-07-30 2002-09-11 Amersham Biosciences Uk Ltd Site-specific labelling of proteins using cyanine dye reporters
SI2735568T1 (en) * 2006-05-10 2018-01-31 Sarepta Therapeutics, Inc. Analogues of the oligonucleotide, with cationic links between subunits

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09506336A (ja) * 1993-09-24 1997-06-24 テラピン テクノロジーズ，インコーポレイテッド グルタチオンアナログおよびグルタチオン模擬物を含むパラログパネル
JP2002507576A (ja) * 1998-03-23 2002-03-12 トリメリス，インコーポレーテッド ペプチド合成のための方法および組成物
WO2003018188A1 (fr) * 2001-08-24 2003-03-06 Japan Science And Technology Agency Systeme de solvant multiphase compatible
JP2005534739A (ja) * 2002-07-30 2005-11-17 アマシャム バイオサイエンス ユーケイ リミテッド シアニン染料リポーターを用いたタンパク質の部位特異的標識

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012029794A1 (ja) 2010-08-30 2012-03-08 味の素株式会社 分岐鎖含有芳香族化合物
US8546534B2 (en) 2010-08-30 2013-10-01 Ajinomoto Co., Inc. Branched chain-containing aromatic compound
US9499579B2 (en) 2010-08-30 2016-11-22 Ajinomoto Co., Inc. Branched chain-containing aromatic compound
US10711033B2 (en) 2010-08-30 2020-07-14 Ajinomoto Co., Inc. Branched chain-containing aromatic compound
WO2013089241A1 (ja) * 2011-12-15 2013-06-20 味の素株式会社 Ｆｍｏｃ基の除去方法
US9334302B2 (en) 2011-12-15 2016-05-10 Ajinomoto Co., Inc. Method for removing FMOC group
CN114585916A (zh) * 2019-10-15 2022-06-03 中外制药株式会社 含有用具有Fmoc骨架的保护基保护的氨基的化合物的定量法
JP7260725B1 (ja) * 2021-12-27 2023-04-18 株式会社トクヤマ ペプチド製造方法、保護基の除去方法、及び除去剤
WO2023127331A1 (ja) * 2021-12-27 2023-07-06 株式会社トクヤマ ペプチド製造方法、保護基の除去方法、除去剤、及びベンジル化合物
WO2024096023A1 (ja) * 2022-11-01 2024-05-10 中外製薬株式会社 ジベンゾフルベンまたはジベンゾフルベン誘導体の除去方法

Also Published As

Publication number Publication date
JP5515738B2 (ja) 2014-06-11
JPWO2009014177A1 (ja) 2010-10-07
EP2181983A4 (en) 2013-01-02
EP2181983A1 (en) 2010-05-05
US20100184952A1 (en) 2010-07-22

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