BR0115036A - Processo para a preparação de um composto - Google Patents

Processo para a preparação de um composto

Info

Publication number
BR0115036A
BR0115036A BR0115036-7A BR0115036A BR0115036A BR 0115036 A BR0115036 A BR 0115036A BR 0115036 A BR0115036 A BR 0115036A BR 0115036 A BR0115036 A BR 0115036A
Authority
BR
Brazil
Prior art keywords
compound
preparation
useful
cancers
mammalian
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
BR0115036-7A
Other languages
English (en)
Inventor
Daniel E Petrillo
Steven A Weissman
Kai Rossen
Shouichi Hiraga
Nobuya Satake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
MSD KK
Merck Sharp & Dohme Corp
Original Assignee
MSD KK
Merck Sharp & Dohme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MSD KK, Merck Sharp & Dohme Corp filed Critical MSD KK
Publication of BR0115036A publication Critical patent/BR0115036A/pt
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

"PROCESSO PARA A PREPARAçãO DE UM COMPOSTO". A presente invenção diz respeito a um novo processo de glicosidação para fabricar intermediários úteis na preparação de derivados de indolopirrolocarbazol que inibem o crescimento de células tumorais e são, portanto, úteis no tratamento de câncer em mamíferos, e outros.
BR0115036-7A 2000-10-31 2001-10-26 Processo para a preparação de um composto Withdrawn BR0115036A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24467500P 2000-10-31 2000-10-31
PCT/US2001/047603 WO2002036601A2 (en) 2000-10-31 2001-10-26 Phase transfer catalyzed glycosidation of an indolocarbazole

Publications (1)

Publication Number Publication Date
BR0115036A true BR0115036A (pt) 2004-02-25

Family

ID=22923680

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0115036-7A Withdrawn BR0115036A (pt) 2000-10-31 2001-10-26 Processo para a preparação de um composto

Country Status (21)

Country Link
US (2) US6555677B2 (pt)
EP (1) EP1333826A2 (pt)
JP (1) JP3554560B2 (pt)
KR (1) KR100813086B1 (pt)
CN (1) CN1240380C (pt)
AU (2) AU2894502A (pt)
BG (1) BG107737A (pt)
BR (1) BR0115036A (pt)
CA (1) CA2426815A1 (pt)
CZ (1) CZ20031209A3 (pt)
EA (1) EA005209B1 (pt)
HK (1) HK1064053A1 (pt)
HU (1) HUP0302923A3 (pt)
IL (1) IL155543A0 (pt)
IS (1) IS6791A (pt)
MX (1) MXPA03003871A (pt)
NO (1) NO20031922L (pt)
NZ (1) NZ525398A (pt)
PL (1) PL365574A1 (pt)
WO (1) WO2002036601A2 (pt)
ZA (1) ZA200303198B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6555677B2 (en) * 2000-10-31 2003-04-29 Merck & Co., Inc. Phase transfer catalyzed glycosidation of an indolocarbazole
ES2726998T3 (es) * 2003-05-30 2019-10-11 Gilead Pharmasset Llc Análogos de nucleósidos fluorados modificados
JPWO2005026185A1 (ja) * 2003-09-16 2006-11-16 萬有製薬株式会社 抗腫瘍性新規インドロピロロカルバゾール誘導体
CN1960999A (zh) * 2004-05-28 2007-05-09 万有制药株式会社 吲哚并吡咯并咔唑衍生物的制备方法
CN101023094B (zh) * 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
PT3109244T (pt) * 2004-09-14 2019-06-04 Gilead Pharmasset Llc ¿preparação de ribofuranosil pirimidinas e purinas 2¿-fluoro-2¿-alquil substituídas ou outras opcionalmente substituídas e os seus derivados
US7537774B2 (en) * 2005-12-23 2009-05-26 Orion Therapeautics, Llc Therapeutic formulation
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
JP5793084B2 (ja) 2008-12-23 2015-10-14 ギリアド ファーマセット エルエルシー プリンヌクレオシドの合成
CA2748057C (en) 2008-12-23 2018-07-03 Pharmasset, Inc. Nucleoside phosphoramidates
BRPI0922508A8 (pt) 2008-12-23 2016-01-19 Pharmasset Inc Análogos de nucleosídeo
TWI598358B (zh) 2009-05-20 2017-09-11 基利法瑪席特有限責任公司 核苷磷醯胺
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
US8563530B2 (en) 2010-03-31 2013-10-22 Gilead Pharmassel LLC Purine nucleoside phosphoramidate
CN102858790A (zh) 2010-03-31 2013-01-02 吉利德制药有限责任公司 核苷氨基磷酸酯
PT3042910T (pt) 2010-11-30 2019-04-16 Gilead Pharmasset Llc 2'-espiro-nucleósidos para utilização na terapia da hepatite c
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
MX2016002185A (es) 2013-08-27 2016-06-06 Gilead Pharmasset Llc Formulacion combinada de dos compuestos antivirales.

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4808613A (en) 1986-11-21 1989-02-28 Bristol-Myers Company Rebeccamycin derivative containing pharmaceutical composition
GB8818430D0 (en) * 1988-08-03 1988-09-07 Tate & Lyle Plc Process
US5668271A (en) 1991-11-29 1997-09-16 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
US5589365A (en) 1991-11-29 1996-12-31 Banyu Pharmaceutical Co., Ltd. Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms
US5591842A (en) 1991-11-29 1997-01-07 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
NZ245203A (en) 1991-11-29 1997-07-27 Banyu Pharma Co Ltd 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
US5437996A (en) 1992-11-24 1995-08-01 Banyu Pharmaceutical Co., Ltd. Microtetraspora strain for preparation of indolopyrrolocarbazole derivatives
US5468872A (en) 1993-09-16 1995-11-21 Cephalon, Inc. K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders
EP0675125A1 (en) 1994-03-18 1995-10-04 Kyowa Hakko Kogyo Co., Ltd. A therapeutic agent for thrombocytopenia and indolocarbazole derivatives
US5804564A (en) 1994-05-09 1998-09-08 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
US5922860A (en) * 1994-05-09 1999-07-13 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
FR2750135B1 (fr) * 1996-06-20 1998-08-14 Ceca Sa Acides fluoroalkyl glycosides uroniques et lactones-6(3) correspondantes, preparation et utilisations
BR9711306A (pt) 1996-08-22 1999-08-17 Bristol Myers Squibb Co Amino a-Úcar citotÄxico e derivados de a-Úcar correlatos de indolopirrolocarbazÄis
US6555677B2 (en) * 2000-10-31 2003-04-29 Merck & Co., Inc. Phase transfer catalyzed glycosidation of an indolocarbazole

Also Published As

Publication number Publication date
BG107737A (bg) 2004-01-30
WO2002036601A2 (en) 2002-05-10
US20040024196A1 (en) 2004-02-05
MXPA03003871A (es) 2003-07-28
CZ20031209A3 (cs) 2003-10-15
JP3554560B2 (ja) 2004-08-18
PL365574A1 (en) 2005-01-10
CN1240380C (zh) 2006-02-08
NO20031922L (no) 2003-06-27
AU2894502A (en) 2002-05-15
CA2426815A1 (en) 2002-05-10
IL155543A0 (en) 2003-11-23
KR20030082545A (ko) 2003-10-22
US20020058803A1 (en) 2002-05-16
NZ525398A (en) 2004-12-24
HUP0302923A3 (en) 2005-02-28
HK1064053A1 (en) 2005-01-21
IS6791A (is) 2003-04-16
EA005209B1 (ru) 2004-12-30
NO20031922D0 (no) 2003-04-29
CN1482908A (zh) 2004-03-17
KR100813086B1 (ko) 2008-03-17
EA200300525A1 (ru) 2003-08-28
AU2002228945B2 (en) 2006-02-02
US6555677B2 (en) 2003-04-29
EP1333826A2 (en) 2003-08-13
JP2004513131A (ja) 2004-04-30
WO2002036601A3 (en) 2002-11-28
ZA200303198B (en) 2004-04-23
HUP0302923A2 (hu) 2003-12-29

Similar Documents

Publication Publication Date Title
BR0115036A (pt) Processo para a preparação de um composto
BR9507615A (pt) Composto e processo para produzir um composto
PT96857A (pt) Processo para a preparacao de oxetanonas
BR0316375A (pt) Diazinopirimidinas
BR0114252A (pt) Derivados de nitrosodifenilamina
PT865498E (pt) Processo para a preparacao de ciclodepsipeptideos com 24 atomos no anel substituidos contendo acido aril-lactico
BR9810838A (pt) Processo para preparar derivados de 2-(3-pirazoliloximetileno)nitrobenzeno
BR9807988A (pt) Processo para a preparação de um composto, e, composto.
BR0301667A (pt) Processo para a preparação de polìmeros em emulsão com pureza elevada
BR9808854A (pt) Processo para preparação de um composto, e, composto
BR9713159A (pt) Composição substancialmente sólida, composto, composição de sal substancialmente sólida, mistura, e, processo para preparar um composto
BR0007982A (pt) Processo para a preparação de um composto, e,composto
BR0113259A (pt) Processo para a preparação de um composto, composto e processo para a preparação de compostos
BRPI0108990B8 (pt) processo para preparação de derivados de pirimidona com atividade antifungos
BR0212390A (pt) Processo para a preparação de cilastatina
BR9911250A (pt) Processo para preparação de compostos
BR0211066A (pt) produção de células progenitoras hematopoiéticas transduzidas
BR0011996A (pt) Preparação de piperidin-4-onas substituìdas
BR0009453A (pt) Processo para a preparação de um composto
BRPI0411652A (pt) processo para a preparação de derivados de espirobenzoazepina substituìdos não-peptìdicos
BR0209842A (pt) Processo para a preparação de imipenem
BR9909260A (pt) Processo para o preparo de (r)-alfa-(2,3-dimetóxifenil)-1-[2-(4-fluoro-fenil)etil]-4-pi peridinametanol
BR9909151A (pt) processos para preparação de intermediários
BR0013799A (pt) Processo para a preparação de um composto, e, composto
BR0000184A (pt) Processo para a preparação de compostos heterocìclicos

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE(S).

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2060 DE 29/06/2010.