BG107737A - Гликозидиране на индолокарбазол чрез фазопреносен катализ - Google Patents

Гликозидиране на индолокарбазол чрез фазопреносен катализ Download PDF

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Publication number
BG107737A
BG107737A BG107737A BG10773703A BG107737A BG 107737 A BG107737 A BG 107737A BG 107737 A BG107737 A BG 107737A BG 10773703 A BG10773703 A BG 10773703A BG 107737 A BG107737 A BG 107737A
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BG
Bulgaria
Prior art keywords
alkyl
formula
compound
och
hydroxide
Prior art date
Application number
BG107737A
Other languages
Bulgarian (bg)
English (en)
Inventor
Daniel E. Petrillo
Steven A. Weissman
Kai Rossen
Shouichi Hiraga
Nobuya Satake
Original Assignee
Merck & Co.,Inc.
Banyu Pharmaceutical Co.,Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co.,Inc., Banyu Pharmaceutical Co.,Ltd. filed Critical Merck & Co.,Inc.
Publication of BG107737A publication Critical patent/BG107737A/bg

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BG107737A 2000-10-31 2003-04-17 Гликозидиране на индолокарбазол чрез фазопреносен катализ BG107737A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24467500P 2000-10-31 2000-10-31
PCT/US2001/047603 WO2002036601A2 (en) 2000-10-31 2001-10-26 Phase transfer catalyzed glycosidation of an indolocarbazole

Publications (1)

Publication Number Publication Date
BG107737A true BG107737A (bg) 2004-01-30

Family

ID=22923680

Family Applications (1)

Application Number Title Priority Date Filing Date
BG107737A BG107737A (bg) 2000-10-31 2003-04-17 Гликозидиране на индолокарбазол чрез фазопреносен катализ

Country Status (21)

Country Link
US (2) US6555677B2 (pt)
EP (1) EP1333826A2 (pt)
JP (1) JP3554560B2 (pt)
KR (1) KR100813086B1 (pt)
CN (1) CN1240380C (pt)
AU (2) AU2002228945B2 (pt)
BG (1) BG107737A (pt)
BR (1) BR0115036A (pt)
CA (1) CA2426815A1 (pt)
CZ (1) CZ20031209A3 (pt)
EA (1) EA005209B1 (pt)
HK (1) HK1064053A1 (pt)
HU (1) HUP0302923A3 (pt)
IL (1) IL155543A0 (pt)
IS (1) IS6791A (pt)
MX (1) MXPA03003871A (pt)
NO (1) NO20031922L (pt)
NZ (1) NZ525398A (pt)
PL (1) PL365574A1 (pt)
WO (1) WO2002036601A2 (pt)
ZA (1) ZA200303198B (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6555677B2 (en) * 2000-10-31 2003-04-29 Merck & Co., Inc. Phase transfer catalyzed glycosidation of an indolocarbazole
US7429572B2 (en) 2003-05-30 2008-09-30 Pharmasset, Inc. Modified fluorinated nucleoside analogues
AU2004272457A1 (en) * 2003-09-16 2005-03-24 Banyu Pharmaceutical Co., Ltd. Novel indolopyrrolocarbazole derivative with antitumor activity
CN1960999A (zh) * 2004-05-28 2007-05-09 万有制药株式会社 吲哚并吡咯并咔唑衍生物的制备方法
CN101023094B (zh) * 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
WO2006031725A2 (en) 2004-09-14 2006-03-23 Pharmasset, Inc. Preparation of 2'­fluoro-2'- alkyl- substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
US7537774B2 (en) * 2005-12-23 2009-05-26 Orion Therapeautics, Llc Therapeutic formulation
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US8173621B2 (en) * 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
EA019295B1 (ru) 2008-12-23 2014-02-28 Джилид Фармассет, Ллс. Соединения пуриновых нуклеозидов и способ их получения
US8551973B2 (en) 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
EP2376088B1 (en) 2008-12-23 2017-02-22 Gilead Pharmasset LLC 6-O-Substituted-2-amino-purine nucleoside phosphoramidates
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI576352B (zh) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 核苷磷醯胺
JP2013527145A (ja) 2010-03-31 2013-06-27 ギリード・ファーマセット・エルエルシー リン含有活性化剤の立体選択的合成
PL3290428T3 (pl) 2010-03-31 2022-02-07 Gilead Pharmasset Llc Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
AR084044A1 (es) 2010-11-30 2013-04-17 Pharmasset Inc Compuestos 2’-espiro-nucleosidos
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
PL3650014T3 (pl) 2013-08-27 2022-01-31 Gilead Pharmasset Llc Preparat złożony dwóch związków przeciwwirusowych

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4808613A (en) 1986-11-21 1989-02-28 Bristol-Myers Company Rebeccamycin derivative containing pharmaceutical composition
GB8818430D0 (en) * 1988-08-03 1988-09-07 Tate & Lyle Plc Process
NZ245203A (en) 1991-11-29 1997-07-27 Banyu Pharma Co Ltd 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
US5591842A (en) 1991-11-29 1997-01-07 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
US5437996A (en) 1992-11-24 1995-08-01 Banyu Pharmaceutical Co., Ltd. Microtetraspora strain for preparation of indolopyrrolocarbazole derivatives
US5589365A (en) 1991-11-29 1996-12-31 Banyu Pharmaceutical Co., Ltd. Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms
US5668271A (en) 1991-11-29 1997-09-16 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
US5468872A (en) 1993-09-16 1995-11-21 Cephalon, Inc. K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders
CA2144940A1 (en) 1994-03-18 1995-09-19 Chikara Murakata Therapeutic agent for thrombocytopenia and indolocarbazole derivatives
US5922860A (en) * 1994-05-09 1999-07-13 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
US5804564A (en) 1994-05-09 1998-09-08 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
FR2750135B1 (fr) * 1996-06-20 1998-08-14 Ceca Sa Acides fluoroalkyl glycosides uroniques et lactones-6(3) correspondantes, preparation et utilisations
IL127918A0 (en) 1996-08-22 1999-11-30 Bristol Myers Squibb Co Novel amino sugar and related sugar derivatives of indolylopyrrolocarbazoles their use as antitumor agents and pharmaceutical formulations
US6555677B2 (en) * 2000-10-31 2003-04-29 Merck & Co., Inc. Phase transfer catalyzed glycosidation of an indolocarbazole

Also Published As

Publication number Publication date
PL365574A1 (en) 2005-01-10
JP3554560B2 (ja) 2004-08-18
NO20031922D0 (no) 2003-04-29
HK1064053A1 (en) 2005-01-21
IL155543A0 (en) 2003-11-23
WO2002036601A3 (en) 2002-11-28
CN1240380C (zh) 2006-02-08
KR100813086B1 (ko) 2008-03-17
KR20030082545A (ko) 2003-10-22
NO20031922L (no) 2003-06-27
ZA200303198B (en) 2004-04-23
JP2004513131A (ja) 2004-04-30
CZ20031209A3 (cs) 2003-10-15
HUP0302923A2 (hu) 2003-12-29
AU2894502A (en) 2002-05-15
US20020058803A1 (en) 2002-05-16
EA200300525A1 (ru) 2003-08-28
US20040024196A1 (en) 2004-02-05
MXPA03003871A (es) 2003-07-28
CA2426815A1 (en) 2002-05-10
AU2002228945B2 (en) 2006-02-02
EP1333826A2 (en) 2003-08-13
NZ525398A (en) 2004-12-24
EA005209B1 (ru) 2004-12-30
BR0115036A (pt) 2004-02-25
HUP0302923A3 (en) 2005-02-28
US6555677B2 (en) 2003-04-29
CN1482908A (zh) 2004-03-17
IS6791A (is) 2003-04-16
WO2002036601A2 (en) 2002-05-10

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