BR9909018A - Process for the synthesis of a peptide, a set of peptide fragments, and, peptide - Google Patents

Process for the synthesis of a peptide, a set of peptide fragments, and, peptide

Info

Publication number
BR9909018A
BR9909018A BR9909018-0A BR9909018A BR9909018A BR 9909018 A BR9909018 A BR 9909018A BR 9909018 A BR9909018 A BR 9909018A BR 9909018 A BR9909018 A BR 9909018A
Authority
BR
Brazil
Prior art keywords
peptide
peptides
synthesis
fragments
present
Prior art date
Application number
BR9909018-0A
Other languages
Portuguese (pt)
Inventor
Myung-Chol Kang
Brian Bray
Maynard Lichty
Catherine Mader
Gene Merutka
Original Assignee
Trimeris Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/045,920 external-priority patent/US6281331B1/en
Application filed by Trimeris Inc filed Critical Trimeris Inc
Publication of BR9909018A publication Critical patent/BR9909018A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present invention relates, first, to methods for the synthesis of peptides, in particular T-20 (also referred to as "DP-178"; SEQ ID NO:1) and T-20-like peptides. Such methods utilize solid and liquid phase synthesis procedures to synthesize and combine groups of specific peptide fragments to yield the peptide of interest. The present invention further relates to individual peptide fragments which act as intermediates in the synthesis of the peptides of interest (e.g., T-20). The present invention still further relates to groups of such peptide intermediate fragments which can be utilized together to produce full length T-20 and T-20-like peptides.
BR9909018-0A 1998-03-23 1999-03-22 Process for the synthesis of a peptide, a set of peptide fragments, and, peptide BR9909018A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/045,920 US6281331B1 (en) 1998-03-23 1998-03-23 Methods and compositions for peptide synthesis
US09/071,877 US6015881A (en) 1998-03-23 1998-05-01 Methods and compositions for peptide synthesis
PCT/US1999/006230 WO1999048513A1 (en) 1998-03-23 1999-03-22 Methods and compositions for peptide synthesis

Publications (1)

Publication Number Publication Date
BR9909018A true BR9909018A (en) 2001-10-16

Family

ID=26723345

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9909018-0A BR9909018A (en) 1998-03-23 1999-03-22 Process for the synthesis of a peptide, a set of peptide fragments, and, peptide

Country Status (13)

Country Link
EP (1) EP1071442B9 (en)
JP (1) JP4602547B2 (en)
CN (1) CN100383158C (en)
AT (1) ATE299029T1 (en)
AU (1) AU751358B2 (en)
BR (1) BR9909018A (en)
CA (1) CA2324348C (en)
DE (1) DE69926061T2 (en)
DK (1) DK1071442T3 (en)
ES (1) ES2245505T3 (en)
NZ (1) NZ507083A (en)
TW (1) TWI233931B (en)
WO (1) WO1999048513A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6281331B1 (en) * 1998-03-23 2001-08-28 Trimeris, Inc. Methods and compositions for peptide synthesis
US6469136B1 (en) * 1999-07-07 2002-10-22 Trimeris, Inc. Methods and composition for peptide synthesis
CN1255548C (en) 2001-06-15 2006-05-10 霍夫曼-拉罗奇有限公司 Acetylation of GP41 framgnets
PL375254A1 (en) * 2002-07-24 2005-11-28 F.Hoffmann-La Roche Ag Pegylated t20 polypeptide
WO2005063791A2 (en) 2003-12-31 2005-07-14 F. Hoffmann-La Roche Ag Process for peptide synthesis using a reduced amount of deprotection agent
EP1701976A2 (en) * 2003-12-31 2006-09-20 F.Hoffmann-La Roche Ag Peptide synthesis and deprotection with co-solvent
WO2005063793A1 (en) 2003-12-31 2005-07-14 F. Hoffmann-La Roche Ag Process and systems for recovery of peptides
MX2007007917A (en) * 2004-12-30 2007-08-14 Hoffmann La Roche Synthesis of peptide t-20 using peptide intermediate fragments.
US8022181B2 (en) 2006-05-03 2011-09-20 Mallinckrodt Llc Composition and method for the release of protected peptides from a resin
EP2181983A4 (en) * 2007-07-25 2013-01-02 Ajinomoto Kk Method for selective removal of dibenzofulvene derivative
EP2205624B1 (en) * 2007-10-27 2016-09-07 Corden Pharma Colorado, Inc. Insulinotropic peptide synthesis using solid and solution phase combination techniques
EP2222695A2 (en) * 2007-12-11 2010-09-01 F. Hoffmann-La Roche AG Insulinotropic peptide synthesis using solid and solution phase combination techniques
JP5445456B2 (en) * 2008-08-06 2014-03-19 味の素株式会社 Method for removing dibenzofulvene
US20110288235A1 (en) * 2008-09-03 2011-11-24 Scinopharm Taiwan Ltd. Process for the Preparation of Pramlintide
EP2349307B1 (en) * 2008-09-03 2015-03-04 ScinoPharm Taiwan, Ltd. Process for making bivalirudin
WO2011095989A2 (en) * 2010-02-04 2011-08-11 Matrix Laboratories Ltd An improved process for the preparation of enfuvirtide
PL219569B1 (en) * 2010-02-19 2015-05-29 Peptaderm Spółka Z Ograniczoną Odpowiedzialnością Cyclic tetrapeptides and their application
CN103374054B (en) * 2012-04-28 2014-12-24 上海第一生化药业有限公司 One-step method based solid-phase polypeptide synthesis method
GB201315335D0 (en) 2013-08-29 2013-10-09 Of Singapore Amino diacids containing peptide modifiers
EP4100417A2 (en) * 2020-02-05 2022-12-14 Eli Lilly and Company Resin reactors in series peptide synthesizer
CN114315957B (en) * 2021-12-30 2023-07-07 深圳瑞德林生物技术有限公司 Preparation method of polypeptide

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU617088B2 (en) * 1986-06-12 1991-11-21 Biogen, Inc. Peptides involved in the pathogenesis of hiv infection
US4787222A (en) * 1986-11-24 1988-11-29 Novatek Medical Inc. Combination lock for blood identification system
US5444044A (en) * 1992-03-26 1995-08-22 New York Blood Center Synthetic polypeptides as inhibitors of HIV-1
US5464933A (en) * 1993-06-07 1995-11-07 Duke University Synthetic peptide inhibitors of HIV transmission
AU700371B2 (en) * 1993-06-07 1999-01-07 Genentech Inc. Hiv envelope polypeptides
US6479055B1 (en) * 1993-06-07 2002-11-12 Trimeris, Inc. Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission
UA43350C2 (en) * 1993-09-11 2001-12-17 Полімун Саіентіфік Іммунобіологіше Форшунг Гмбх Peptide induced production antibodies having neutralizing activity concerning hiv-1 strains and/or isolates, and/or inhibite due to vil-1 injured cell fusion, farmaceutical agent for antibody formation, method for antibody obtaining, iga, antibody demonstrating counteractive activity neutralizing hiv-1 and/or inhibits due to vil-1 injured cell fusion
AU722895B2 (en) * 1996-02-09 2000-08-10 F. Hoffmann-La Roche Ag Synthesis of VIP analog

Also Published As

Publication number Publication date
CN1303299A (en) 2001-07-11
ATE299029T1 (en) 2005-07-15
WO1999048513A1 (en) 1999-09-30
EP1071442B9 (en) 2006-01-18
JP2002507576A (en) 2002-03-12
TWI233931B (en) 2005-06-11
DE69926061D1 (en) 2005-08-11
DE69926061T2 (en) 2006-06-01
AU751358B2 (en) 2002-08-15
CA2324348A1 (en) 1999-09-30
AU3109799A (en) 1999-10-18
EP1071442A1 (en) 2001-01-31
CN100383158C (en) 2008-04-23
ES2245505T3 (en) 2006-01-01
DK1071442T3 (en) 2005-10-24
CA2324348C (en) 2006-03-14
NZ507083A (en) 2003-10-31
EP1071442A4 (en) 2002-06-05
JP4602547B2 (en) 2010-12-22
EP1071442B1 (en) 2005-07-06

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 37, 8O, 13 DA LPI 9279/06

B12B Appeal against refusal [chapter 12.2 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 09/04/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 09/04/2019, OBSERVADAS AS CONDICOES LEGAIS

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/03/1999 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 22/03/2019