WO1999063094A3 - Nucleotide and protein sequences of gpr1 and methods based thereon - Google Patents

Nucleotide and protein sequences of gpr1 and methods based thereon Download PDF

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Publication number
WO1999063094A3
WO1999063094A3 PCT/US1999/011838 US9911838W WO9963094A3 WO 1999063094 A3 WO1999063094 A3 WO 1999063094A3 US 9911838 W US9911838 W US 9911838W WO 9963094 A3 WO9963094 A3 WO 9963094A3
Authority
WO
WIPO (PCT)
Prior art keywords
gpr1
analogs
derivatives
protein
nucleotide
Prior art date
Application number
PCT/US1999/011838
Other languages
French (fr)
Other versions
WO1999063094A9 (en
WO1999063094A2 (en
Inventor
Jeanne P Hirsch
Yong Xue
Original Assignee
Sinai School Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sinai School Medicine filed Critical Sinai School Medicine
Priority to AU43181/99A priority Critical patent/AU4318199A/en
Publication of WO1999063094A2 publication Critical patent/WO1999063094A2/en
Publication of WO1999063094A3 publication Critical patent/WO1999063094A3/en
Publication of WO1999063094A9 publication Critical patent/WO1999063094A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/37—Assays involving biological materials from specific organisms or of a specific nature from fungi
    • G01N2333/39—Assays involving biological materials from specific organisms or of a specific nature from fungi from yeasts
    • G01N2333/395—Assays involving biological materials from specific organisms or of a specific nature from fungi from yeasts from Saccharomyces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention relates to a (GPR1). The method provides nucleotide sequences of GPR1 genes, and amino acid sequences of their encoded proteins, as well as derivatives (e.g., fragments) and analogs thereof. In a specific embodiment, the GPR1 protein is a yeast protein. The invention further relates to fragments (and derivatives and analogs thereof) of GPR1 which comprise one or more domains of a GPR1 protein. Antibodies to GPR1, its derivatives and analogs, are additionally provided. Methods of production of the GPR1 proteins, derivatives and analogs, e.g., by recombinant means, are also provided. The invention provides for screening assays for identification of compounds that modulate GPR1 expression or activity. Therapeutic methods and pharmaceutical compositions are provided. In specific examples, isolated GPR1 genes and the sequences thereof, are provided.
PCT/US1999/011838 1998-06-01 1999-05-28 Nucleotide and protein sequences of gpr1 and methods based thereon WO1999063094A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU43181/99A AU4318199A (en) 1998-06-01 1999-05-28 Nucleotide and protein sequences of gpr1 and methods based thereon

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8831198A 1998-06-01 1998-06-01
US09/088,311 1998-06-01

Publications (3)

Publication Number Publication Date
WO1999063094A2 WO1999063094A2 (en) 1999-12-09
WO1999063094A3 true WO1999063094A3 (en) 2000-04-13
WO1999063094A9 WO1999063094A9 (en) 2000-07-20

Family

ID=22210627

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/011838 WO1999063094A2 (en) 1998-06-01 1999-05-28 Nucleotide and protein sequences of gpr1 and methods based thereon

Country Status (2)

Country Link
AU (1) AU4318199A (en)
WO (1) WO1999063094A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003025218A2 (en) * 2001-09-21 2003-03-27 K.U.Leuven Research & Development Methods and yeast strains for screening antifungal agents
CN109942680B (en) * 2017-12-19 2020-12-01 深圳先进技术研究院 GPR1 antagonistic polypeptide, and derivative and application thereof
CN109942674B (en) * 2017-12-19 2020-12-01 深圳先进技术研究院 GPR1 antagonistic polypeptide, and derivative and application thereof
CN109942681B (en) * 2017-12-19 2020-12-01 深圳先进技术研究院 GPR1 antagonistic polypeptide, and derivative and application thereof
CN109942672B (en) * 2017-12-19 2020-11-27 深圳先进技术研究院 GPR1 antagonistic polypeptide, and derivative and application thereof
CN109942673B (en) * 2017-12-19 2020-12-01 深圳先进技术研究院 GPR1 antagonistic polypeptide, and derivative and application thereof
CN109942671B (en) * 2017-12-19 2020-12-01 深圳先进技术研究院 GPR1 antagonistic polypeptide, and derivative and application thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
XUE Y ET AL: "GPR1 encodes a putative G protein-coupled receptor that associates with the Gpa2p Galpha subunit and functions in a Ras-independent pathway", EMBO JOURNAL., vol. 17, no. 7, 1 April 1998 (1998-04-01), pages 1996 - 2007, XP002127969 *
YUN C ET AL: "G-protein coupled receptor from yeast Saccharomyces cerevisiae", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS., vol. 240, no. 2, 17 November 1997 (1997-11-17), pages 287 - 292, XP002127968 *

Also Published As

Publication number Publication date
WO1999063094A9 (en) 2000-07-20
AU4318199A (en) 1999-12-20
WO1999063094A2 (en) 1999-12-09

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