AR069608A1 - Metodo para obtener peptidos insulinotropicos utilizando una combinacion de tecnicas en fase solida y en solucion - Google Patents
Metodo para obtener peptidos insulinotropicos utilizando una combinacion de tecnicas en fase solida y en solucionInfo
- Publication number
- AR069608A1 AR069608A1 ARP080105329A ARP080105329A AR069608A1 AR 069608 A1 AR069608 A1 AR 069608A1 AR P080105329 A ARP080105329 A AR P080105329A AR P080105329 A ARP080105329 A AR P080105329A AR 069608 A1 AR069608 A1 AR 069608A1
- Authority
- AR
- Argentina
- Prior art keywords
- fragment
- solid phase
- solution
- different
- coupled
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Método para obtener péptidos insulinotropicos que se sintetizan utilizando una aproximacion en fase solida y en solucion (ôhíbridaö). Generalmente la aproximacion incluye la síntesis de tres fragmentos intermediarios de péptido diferentes utilizando la química en fase solida. Luego se utiliza la química en fase de solucion para anadir material aminoacídico adicional al tercer fragmento que entonces se acopla al segundo fragmento y luego al primer fragmento en solucion. Alternativamente, un segundo fragmento diferente se acopla al primer fragmento en la fase solida. Luego, se utiliza la química en fase de solucion para anadir material aminoacídico adicional a un tercer fragmento diferente. A continuacion, este tercer fragmento diferente se acopla al primero acoplado y al segundo fragmento diferente en la fase de solucion. La utilizacion de una pseudoprolina en uno de los fragmentos facilita la síntesis en fase solida de ese fragmento y también facilita el subsiguiente acoplamiento en fase de solucion de este fragmento a otros fragmentos. El método resulta util para la obtencion de péptidos insulinotropicos como el GLP-1(7-36) y sus homologos naturales y no naturales.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US723807P | 2007-12-11 | 2007-12-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR069608A1 true AR069608A1 (es) | 2010-02-03 |
Family
ID=40755926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080105329A AR069608A1 (es) | 2007-12-11 | 2008-12-09 | Metodo para obtener peptidos insulinotropicos utilizando una combinacion de tecnicas en fase solida y en solucion |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8227571B2 (es) |
| EP (1) | EP2222695A2 (es) |
| JP (1) | JP2011506376A (es) |
| KR (1) | KR20100102652A (es) |
| CN (1) | CN101903400B (es) |
| AR (1) | AR069608A1 (es) |
| AU (1) | AU2008334783A1 (es) |
| BR (1) | BRPI0820765A2 (es) |
| CA (1) | CA2707132A1 (es) |
| CL (1) | CL2008003660A1 (es) |
| IL (1) | IL205932A0 (es) |
| MX (1) | MX2010006044A (es) |
| PE (1) | PE20091214A1 (es) |
| RU (1) | RU2010128247A (es) |
| TW (1) | TWI374890B (es) |
| WO (1) | WO2009074483A2 (es) |
| ZA (1) | ZA201003849B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2344519T3 (en) * | 2008-11-07 | 2017-01-23 | Massachusetts Gen Hospital | C-TERMINAL FRAGMENTS OF GLUCAGON SIMILAR PEPTID-1 (GLP-1) |
| EP2424888A2 (en) * | 2009-05-01 | 2012-03-07 | F. Hoffmann-La Roche AG | Insulinotropic peptide synthesis using solid and solution phase combination techniques |
| US20110313131A1 (en) | 2010-06-21 | 2011-12-22 | Christelle Carl | Reversed phase hplc purification of a glp-1 analogue |
| US20120157382A1 (en) | 2010-12-21 | 2012-06-21 | Siegfried Krimmer | Pharmaceutical glp-1 compositions having an improved release profile |
| EP3412680B1 (en) | 2011-04-05 | 2020-11-04 | Curara AB | Novel peptides that bind to types of mhc class ii and their use in diagnosis and treatment |
| EP2729157B1 (en) | 2011-07-06 | 2019-01-16 | The General Hospital Corporation | A pentapeptide derived from the c-terminus of glucagon-like peptide 1 (glp-1) for use in treatment |
| CN104936610A (zh) | 2012-11-13 | 2015-09-23 | 益普生制药股份有限公司 | Glp-1类似物的纯化方法 |
| WO2014077801A1 (en) | 2012-11-13 | 2014-05-22 | Ipsen Pharma S.A.S. | Purification process for preparing highly pure taspoglutide |
| EP2948468A1 (en) | 2013-01-28 | 2015-12-02 | Solae, LLC | Novel polypeptides having satiety hormone releasing activity |
| ES2624961T3 (es) | 2013-03-21 | 2017-07-18 | Sanofi-Aventis Deutschland Gmbh | Síntesis de productos de péptido que contienen imida cíclica |
| US10087221B2 (en) | 2013-03-21 | 2018-10-02 | Sanofi-Aventis Deutschland Gmbh | Synthesis of hydantoin containing peptide products |
| GR20140100479A (el) * | 2014-09-23 | 2016-05-05 | Novetide, Ltd., | Συνθεση λιραγλουτιδης |
| EP3692056A1 (en) * | 2017-10-04 | 2020-08-12 | Chemical & Biopharmaceutical Laboratories of Patras S.A. | A process for preparing a glucagon-like peptide |
| KR20200001546A (ko) * | 2018-06-27 | 2020-01-06 | 주식회사 시선바이오머티리얼스 | Pna 올리고머의 제조방법 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2324348C (en) * | 1998-03-23 | 2006-03-14 | Trimeris, Inc. | Methods and compositions for peptide synthesis |
| CZ295890B6 (cs) * | 1998-12-07 | 2005-11-16 | Societe De Conseils De Recherches Et D'application | Analogy GLP-1, mající kyselinu aminoizomáselnou pozici 8 a D-arginin na pozici 36, jejich použití a farmaceutické prostředky je obsahující |
| US6469136B1 (en) * | 1999-07-07 | 2002-10-22 | Trimeris, Inc. | Methods and composition for peptide synthesis |
| CN1918177A (zh) * | 2003-12-18 | 2007-02-21 | 诺和诺德公司 | 新型glp－1化合物 |
| WO2005066207A1 (en) * | 2004-01-08 | 2005-07-21 | Theratechnologies Inc. | Glucagon-like peptide-1 analogs with long duration of action |
| MX2007007917A (es) * | 2004-12-30 | 2007-08-14 | Hoffmann La Roche | Sintesis del peptido t-20 utilizando fragmentos peptidicos intermediarios. |
| CA2593866C (en) * | 2004-12-30 | 2013-08-06 | F. Hoffmann-La Roche Ag | Synthesis of peptide t-1249 using peptide intermediate fragments |
| KR20070111463A (ko) * | 2004-12-30 | 2007-11-21 | 에프. 호프만-라 로슈 아게 | 펩타이드 중간체 단편 ⅲ을 사용하는 합성 방법 |
| EP1891106A2 (en) * | 2005-05-05 | 2008-02-27 | Cadila Healthcare Ltd. | Novel compounds as glp-i agonists |
| KR101297942B1 (ko) * | 2006-02-08 | 2013-08-19 | 론자 아게 | 글루카곤형 펩티드의 합성 |
| PT2035451E (pt) * | 2006-06-23 | 2010-06-09 | Hoffmann La Roche | Síntese de péptidos insulinotrópicos |
| EP2205624B1 (en) * | 2007-10-27 | 2016-09-07 | Corden Pharma Colorado, Inc. | Insulinotropic peptide synthesis using solid and solution phase combination techniques |
-
2008
- 2008-12-02 EP EP08860359A patent/EP2222695A2/en not_active Withdrawn
- 2008-12-02 RU RU2010128247/10A patent/RU2010128247A/ru not_active Application Discontinuation
- 2008-12-02 MX MX2010006044A patent/MX2010006044A/es active IP Right Grant
- 2008-12-02 AU AU2008334783A patent/AU2008334783A1/en not_active Abandoned
- 2008-12-02 KR KR1020107015264A patent/KR20100102652A/ko active IP Right Grant
- 2008-12-02 WO PCT/EP2008/066585 patent/WO2009074483A2/en active Application Filing
- 2008-12-02 CN CN2008801198008A patent/CN101903400B/zh not_active Expired - Fee Related
- 2008-12-02 JP JP2010537379A patent/JP2011506376A/ja active Pending
- 2008-12-02 CA CA2707132A patent/CA2707132A1/en not_active Abandoned
- 2008-12-02 BR BRPI0820765-8A patent/BRPI0820765A2/pt not_active IP Right Cessation
- 2008-12-08 TW TW097147695A patent/TWI374890B/zh not_active IP Right Cessation
- 2008-12-09 AR ARP080105329A patent/AR069608A1/es not_active Application Discontinuation
- 2008-12-09 PE PE2008002033A patent/PE20091214A1/es not_active Application Discontinuation
- 2008-12-10 CL CL2008003660A patent/CL2008003660A1/es unknown
- 2008-12-11 US US12/316,309 patent/US8227571B2/en not_active Expired - Fee Related
-
2010
- 2010-05-24 IL IL205932A patent/IL205932A0/en unknown
- 2010-05-28 ZA ZA2010/03849A patent/ZA201003849B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20090292108A1 (en) | 2009-11-26 |
| CN101903400B (zh) | 2013-12-18 |
| ZA201003849B (en) | 2011-04-28 |
| AU2008334783A1 (en) | 2009-06-18 |
| JP2011506376A (ja) | 2011-03-03 |
| WO2009074483A2 (en) | 2009-06-18 |
| EP2222695A2 (en) | 2010-09-01 |
| BRPI0820765A2 (pt) | 2015-06-16 |
| CN101903400A (zh) | 2010-12-01 |
| US8227571B2 (en) | 2012-07-24 |
| WO2009074483A3 (en) | 2010-05-14 |
| IL205932A0 (en) | 2010-11-30 |
| MX2010006044A (es) | 2010-06-23 |
| TWI374890B (en) | 2012-10-21 |
| KR20100102652A (ko) | 2010-09-24 |
| PE20091214A1 (es) | 2009-08-14 |
| CA2707132A1 (en) | 2009-06-18 |
| RU2010128247A (ru) | 2012-01-20 |
| CL2008003660A1 (es) | 2010-01-04 |
| TW200927756A (en) | 2009-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |