CL2008003095A1 - Procedeimiento de preparacion de dihidrotienopirimidas; uno de los compuestos intermediarios considerados; y el procedimiento de preparacion de dicho compuesto intermediario. - Google Patents

Procedeimiento de preparacion de dihidrotienopirimidas; uno de los compuestos intermediarios considerados; y el procedimiento de preparacion de dicho compuesto intermediario.

Info

Publication number
CL2008003095A1
CL2008003095A1 CL2008003095A CL2008003095A CL2008003095A1 CL 2008003095 A1 CL2008003095 A1 CL 2008003095A1 CL 2008003095 A CL2008003095 A CL 2008003095A CL 2008003095 A CL2008003095 A CL 2008003095A CL 2008003095 A1 CL2008003095 A1 CL 2008003095A1
Authority
CL
Chile
Prior art keywords
preparation
dihydrothienopyrimides
procedure
compounds considered
intermediate compound
Prior art date
Application number
CL2008003095A
Other languages
English (en)
Inventor
Rogelio Frutos
Dhileepkumar Krishnamurthy
Jason Mulder
Sonia Rodriguez
Chris Hugh Senanayake
Thomas G Tampone
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40158557&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2008003095(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CL2008003095A1 publication Critical patent/CL2008003095A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Método para preparar compuestos derivados de dihidrotienopirimidina y los intermediarios utilizados en el proceso.
CL2008003095A 2007-10-18 2008-10-17 Procedeimiento de preparacion de dihidrotienopirimidas; uno de los compuestos intermediarios considerados; y el procedimiento de preparacion de dicho compuesto intermediario. CL2008003095A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US98110507P 2007-10-18 2007-10-18

Publications (1)

Publication Number Publication Date
CL2008003095A1 true CL2008003095A1 (es) 2010-01-22

Family

ID=40158557

Family Applications (2)

Application Number Title Priority Date Filing Date
CL2008003095A CL2008003095A1 (es) 2007-10-18 2008-10-17 Procedeimiento de preparacion de dihidrotienopirimidas; uno de los compuestos intermediarios considerados; y el procedimiento de preparacion de dicho compuesto intermediario.
CL2012000560A CL2012000560A1 (es) 2007-10-18 2012-03-01 Procedimiento de preparacion del compuesto intermediario acido 3-oxo-tetrahidrotiofeno-2-carboxilico, utiles en la preparacion de dihidrotienopirimidinas (divisional de la solicitud 3095-08).

Family Applications After (1)

Application Number Title Priority Date Filing Date
CL2012000560A CL2012000560A1 (es) 2007-10-18 2012-03-01 Procedimiento de preparacion del compuesto intermediario acido 3-oxo-tetrahidrotiofeno-2-carboxilico, utiles en la preparacion de dihidrotienopirimidinas (divisional de la solicitud 3095-08).

Country Status (20)

Country Link
US (1) US8653282B2 (es)
EP (1) EP2205608B1 (es)
JP (1) JP5538231B2 (es)
KR (1) KR20100095528A (es)
CN (2) CN101903394B (es)
AR (1) AR069077A1 (es)
AU (1) AU2008312624B2 (es)
BR (1) BRPI0818671A2 (es)
CA (1) CA2702500A1 (es)
CL (2) CL2008003095A1 (es)
DK (1) DK2205608T3 (es)
ES (1) ES2424445T3 (es)
IL (1) IL204854A0 (es)
MX (1) MX2010003826A (es)
NZ (2) NZ592534A (es)
PL (1) PL2205608T3 (es)
RU (1) RU2528340C2 (es)
TW (1) TW200918541A (es)
WO (1) WO2009052138A1 (es)
ZA (1) ZA201002425B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1847543A1 (de) 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
PL2114873T3 (pl) 2006-12-26 2013-08-30 Lantheus Medical Imaging Inc N-[3-Bromo-4-(3-[18F]fluoropropoksy)-benzylo]-guanidyna do obrazowania unerwienia serca
CA2705414C (en) * 2007-10-19 2016-05-24 Boehringer Ingelheim International Gmbh Substituted piperidino-dihydrothienopyrimidines
NZ585348A (en) 2007-10-19 2012-02-24 Boehringer Ingelheim Int Heterocycle-substituted piperazino-dihydrothienopyrimidines
CA2702518A1 (en) 2007-10-19 2009-04-23 Boehringer Ingelheim International Gmbh New piperazino-dihydrothienopyrimidine derivatives
US9802954B2 (en) 2011-08-24 2017-10-31 Boehringer Ingelheim International Gmbh Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma
US20130059866A1 (en) 2011-08-24 2013-03-07 Boehringer Ingelheim International Gmbh Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
US9840517B2 (en) 2013-09-18 2017-12-12 Beijing Hanmi Pharmaceutical Co., Ltd. Compound inhibiting activities of BTK and/or JAK3 kinases
WO2024032673A1 (zh) * 2022-08-09 2024-02-15 西藏海思科制药有限公司 Pde4b抑制剂及其用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1470336A1 (de) * 1962-07-04 1969-03-20 Thomae Gmbh Dr K Neue Dihydrothieno-[3,4-d]-pyrimidine und Verfahren zu ihrer Herstellung
DE2700215A1 (de) * 1977-01-05 1978-07-13 Basf Ag Thiophenverbindungen und verfahren zur herstellung von thiophenverbindungen
CH632755A5 (de) 1976-04-10 1982-10-29 Basf Ag Verfahren zur herstellung von thiophenverbindungen.
US4974609A (en) * 1986-08-18 1990-12-04 Philip Morris Incorporated Tobacco flavorants
JP3398152B2 (ja) 1993-10-12 2003-04-21 ブリストル‐マイヤーズ・スクイブ・ファーマ・カンパニー １ｎ−アルキル−ｎ−アリールピリミジンアミンおよびその誘導体
DE19540737A1 (de) 1995-11-02 1997-05-07 Bayer Ag Substituierte Sulfonylamino(thio)carbonylverbindungen
CZ20001709A3 (cs) * 1997-11-11 2001-12-12 Pfizer Products Inc. Deriváty thienopyrimidu a thienopyridinu, farmaceutické kompozice a způsoby léčení na jejich bázi
TW564247B (en) * 1999-04-08 2003-12-01 Akzo Nobel Nv Bicyclic heteraromatic compound
EP1847543A1 (de) 2006-04-19 2007-10-24 Boehringer Ingelheim Pharma GmbH & Co. KG Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
EP1874781B9 (de) 2006-04-19 2010-09-08 Boehringer Ingelheim International GmbH Dihydrothienopyrimidine zur behandlung von entzündlichen erkrankungen
WO2009042138A1 (en) 2007-09-25 2009-04-02 Actimis Pharmaceuticals, Inc. Alkylthio pyrimidines as crth2 antagonists
NZ585348A (en) * 2007-10-19 2012-02-24 Boehringer Ingelheim Int Heterocycle-substituted piperazino-dihydrothienopyrimidines
CA2705414C (en) 2007-10-19 2016-05-24 Boehringer Ingelheim International Gmbh Substituted piperidino-dihydrothienopyrimidines

Also Published As

Publication number Publication date
CA2702500A1 (en) 2009-04-23
MX2010003826A (es) 2010-04-21
CN101903394A (zh) 2010-12-01
PL2205608T3 (pl) 2013-09-30
TW200918541A (en) 2009-05-01
RU2010119647A (ru) 2011-11-27
EP2205608B1 (en) 2013-05-08
NZ584962A (en) 2011-07-29
ZA201002425B (en) 2011-02-23
CN103497201A (zh) 2014-01-08
AU2008312624B2 (en) 2014-07-10
DK2205608T3 (da) 2013-07-01
JP2011500701A (ja) 2011-01-06
AR069077A1 (es) 2009-12-30
KR20100095528A (ko) 2010-08-31
JP5538231B2 (ja) 2014-07-02
WO2009052138A1 (en) 2009-04-23
BRPI0818671A2 (pt) 2015-09-15
EP2205608A1 (en) 2010-07-14
WO2009052138A8 (en) 2012-11-15
CN101903394B (zh) 2013-12-25
CL2012000560A1 (es) 2012-09-14
US8653282B2 (en) 2014-02-18
US20100222585A1 (en) 2010-09-02
NZ592534A (en) 2013-03-28
IL204854A0 (en) 2010-11-30
AU2008312624A1 (en) 2009-04-23
RU2528340C2 (ru) 2014-09-10
ES2424445T3 (es) 2013-10-02

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