EA201270149A1 - Ингибиторы bace - Google Patents
Ингибиторы baceInfo
- Publication number
- EA201270149A1 EA201270149A1 EA201270149A EA201270149A EA201270149A1 EA 201270149 A1 EA201270149 A1 EA 201270149A1 EA 201270149 A EA201270149 A EA 201270149A EA 201270149 A EA201270149 A EA 201270149A EA 201270149 A1 EA201270149 A1 EA 201270149A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- bace inhibitors
- methods
- inhibitors
- bace
- intermediates
- Prior art date
Links
- 102100021257 Beta-secretase 1 Human genes 0.000 title abstract 2
- 101000894895 Homo sapiens Beta-secretase 1 Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
- C07D279/08—1,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Abstract
Согласно настоящему изобретению предложены ингибиторы ВАСЕ формулы Iспособы их применения, промежуточные продукты и способы их получения.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22424109P | 2009-07-09 | 2009-07-09 | |
PCT/US2010/041034 WO2011005738A1 (en) | 2009-07-09 | 2010-07-06 | Bace inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201270149A1 true EA201270149A1 (ru) | 2012-06-29 |
EA019892B1 EA019892B1 (ru) | 2014-07-30 |
Family
ID=42985394
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201270149A EA019892B1 (ru) | 2009-07-09 | 2010-07-06 | Ингибиторы bace |
Country Status (26)
Country | Link |
---|---|
US (2) | US8278441B2 (ru) |
EP (1) | EP2451793B1 (ru) |
JP (1) | JP5666578B2 (ru) |
KR (1) | KR101362557B1 (ru) |
CN (1) | CN102471296B (ru) |
AR (1) | AR077277A1 (ru) |
AU (1) | AU2010270691B8 (ru) |
BR (1) | BR112012000525A2 (ru) |
CA (1) | CA2764429C (ru) |
CL (1) | CL2012000033A1 (ru) |
CO (1) | CO6480979A2 (ru) |
CR (1) | CR20120011A (ru) |
DO (1) | DOP2012000004A (ru) |
EA (1) | EA019892B1 (ru) |
EC (1) | ECSP12011581A (ru) |
HN (1) | HN2012000012A (ru) |
IL (1) | IL216742A0 (ru) |
MA (1) | MA33492B1 (ru) |
MX (1) | MX2012000510A (ru) |
NZ (1) | NZ596579A (ru) |
PE (1) | PE20120632A1 (ru) |
SG (1) | SG177594A1 (ru) |
TN (1) | TN2011000673A1 (ru) |
TW (1) | TWI405765B (ru) |
WO (1) | WO2011005738A1 (ru) |
ZA (1) | ZA201109385B (ru) |
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ITTO20070665A1 (it) * | 2007-09-24 | 2009-03-25 | Rottapharm Spa | Derivati amidinici, tioureici e guanidinici di 2-amminobenzotiazoli e amminobenzotiazine, nuovi agenti farmacologici per il trattamento delle patologie neurodegenerative. |
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KR20130018370A (ko) | 2008-06-13 | 2013-02-20 | 시오노기세야쿠 가부시키가이샤 | β 세크레타제 저해 작용을 갖는 황 함유 복소환 유도체 |
EP2332943B1 (en) * | 2008-09-30 | 2015-04-22 | Eisai R&D Management Co., Ltd. | Novel fused aminodihydrothiazine derivative |
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