UY32863A - COMPUESTOS DE HEXAHIDROOXAZINOPTERINA PARA USO COMO INHIBIDORES DE mTOR - Google Patents

COMPUESTOS DE HEXAHIDROOXAZINOPTERINA PARA USO COMO INHIBIDORES DE mTOR

Info

Publication number
UY32863A
UY32863A UY0001032863A UY32863A UY32863A UY 32863 A UY32863 A UY 32863A UY 0001032863 A UY0001032863 A UY 0001032863A UY 32863 A UY32863 A UY 32863A UY 32863 A UY32863 A UY 32863A
Authority
UY
Uruguay
Prior art keywords
compounds
mtor inhibitors
hexahydrooxazinopterine
methods
kits
Prior art date
Application number
UY0001032863A
Other languages
English (en)
Inventor
Dong Qing
Jin Bohan
Scorah Nicholas
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of UY32863A publication Critical patent/UY32863A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención provee inhibidores de mTOR de la fórmula en donde las variables son como se definen en la presente.También se proveen composiciones farmacéuticas, kits y artículos manufacturados que comprenden tales compuestos; métodos de preparación de los compuestos y sus intermediarios; y métodos de uso de los compuestos.
UY0001032863A 2009-08-28 2010-08-27 COMPUESTOS DE HEXAHIDROOXAZINOPTERINA PARA USO COMO INHIBIDORES DE mTOR UY32863A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23806409P 2009-08-28 2009-08-28
US31360810P 2010-03-12 2010-03-12

Publications (1)

Publication Number Publication Date
UY32863A true UY32863A (es) 2011-03-31

Family

ID=42768136

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001032863A UY32863A (es) 2009-08-28 2010-08-27 COMPUESTOS DE HEXAHIDROOXAZINOPTERINA PARA USO COMO INHIBIDORES DE mTOR

Country Status (13)

Country Link
US (2) US8163755B2 (es)
EP (1) EP2470546B1 (es)
JP (1) JP2013503183A (es)
AR (1) AR077974A1 (es)
DK (1) DK2470546T3 (es)
ES (1) ES2432315T3 (es)
HR (1) HRP20130951T1 (es)
PL (1) PL2470546T3 (es)
PT (1) PT2470546E (es)
SI (1) SI2470546T1 (es)
TW (1) TW201119656A (es)
UY (1) UY32863A (es)
WO (1) WO2011025889A1 (es)

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ME01838B (me) 2009-06-29 2014-12-20 Lncyte Holdings Corp Pirimidinoni kao inhibitori pi3k
US8759359B2 (en) 2009-12-18 2014-06-24 Incyte Corporation Substituted heteroaryl fused derivatives as PI3K inhibitors
US8541418B2 (en) * 2009-12-23 2013-09-24 Elan Pharmaceutical, Inc. Inhibitors of polo-like kinase
EP2558463A1 (en) 2010-04-14 2013-02-20 Incyte Corporation Fused derivatives as i3 inhibitors
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
EP2655374B1 (en) 2010-12-20 2019-10-23 Incyte Holdings Corporation N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors
UY33883A (es) 2011-01-31 2012-08-31 Novartis Ag Novedosos derivados heterocíclicos
WO2012148540A1 (en) 2011-02-23 2012-11-01 Intellikine, Llc Combination of kanase inhibitors and uses threof
EP2678342B1 (en) * 2011-02-25 2015-01-07 Takeda Pharmaceutical Company Limited N-substituted oxazinopteridines and oxazinopteridinones
US9108984B2 (en) 2011-03-14 2015-08-18 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
WO2012135009A1 (en) 2011-03-25 2012-10-04 Incyte Corporation Pyrimidine-4,6-diamine derivatives as pi3k inhibitors
KR102371532B1 (ko) 2011-09-02 2022-03-07 인사이트 홀딩스 코포레이션 Ｐｉ３ｋ 억제제로서 헤테로시클릴아민
WO2013061305A1 (en) 2011-10-28 2013-05-02 Novartis Ag Novel purine derivatives and their use in the treatment of disease
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
EP2872161B1 (en) 2012-06-26 2020-12-16 Del Mar Pharmaceuticals Dianhydrogalactitol for use in treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations
SG11201500377UA (en) 2012-09-10 2015-02-27 Hoffmann La Roche 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
TWI657090B (zh) 2013-03-01 2019-04-21 英塞特控股公司 吡唑并嘧啶衍生物治療PI3Kδ 相關病症之用途
EP2976086B1 (en) 2013-03-22 2020-10-14 Millennium Pharmaceuticals, Inc. Combination of catalytic mtorc 1/2 inhibitors and selective inhibitors of aurora a kinase
US11491154B2 (en) 2013-04-08 2022-11-08 Dennis M. Brown Therapeutic benefit of suboptimally administered chemical compounds
KR20160099081A (ko) 2013-07-26 2016-08-19 업데이트 파마 인코포레이트 비산트렌의 치료 효과 개선용 조합 방법
JP6276852B2 (ja) * 2013-10-15 2018-02-07 ジン，ボハン 新規化合物、使用およびそれらの調製のための方法
CA3158254C (en) 2014-04-08 2024-05-21 Incyte Corporation Treatment of b-cell malignancies by a combination jak and pi3k inhibitors
US10077277B2 (en) 2014-06-11 2018-09-18 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
NZ734993A (en) 2015-02-27 2024-03-22 Incyte Holdings Corp Salts of pi3k inhibitor and processes for their preparation
US9988401B2 (en) 2015-05-11 2018-06-05 Incyte Corporation Crystalline forms of a PI3K inhibitor
US9732097B2 (en) 2015-05-11 2017-08-15 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
WO2016183062A1 (en) 2015-05-11 2016-11-17 Incyte Corporation Salts of (s)-7-(1-(9h-purin-6-ylamino)ethyl)-6-(3-fluorophenyl)-3-methyl-5h-thiazolo[3,2-a]pyrimidin-5-one
KR102017676B1 (ko) * 2018-03-09 2019-09-03 연세대학교 원주산학협력단 익상편 예방 및 치료용 조성물
WO2020076728A1 (en) 2018-10-08 2020-04-16 Takeda Pharmaceutical Company Limited SUBSTITUTED OXAZINOPTERIDINONES AS INHIBITORS OF mTOR

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003213266A1 (en) 2002-03-06 2003-09-22 Smithkline Beecham Corporation Condensed heterocyclic compounds as calcitonin agonists
GB0415364D0 (en) 2004-07-09 2004-08-11 Astrazeneca Ab Pyrimidine derivatives
US8911498B2 (en) 2005-02-10 2014-12-16 DePuy Synthes Products, LLC Intervertebral prosthetic disc
WO2006086464A2 (en) 2005-02-10 2006-08-17 Bristol-Myers Squibb Company Dihydroquinazolinones as 5ht modulators
EP2057129A1 (en) 2006-08-24 2009-05-13 AstraZeneca AB Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders
JP5824213B2 (ja) 2007-10-05 2015-11-25 センワ バイオサイエンシズ インコーポレイテッド キノロン類似体およびそれに関連する方法
WO2009070524A1 (en) * 2007-11-27 2009-06-04 Wyeth Pyrrolo[3,2-d]pyrimidine compounds and their use as pi3 kinase and mtor kinase inhibitors
BR112013008526A2 (pt) * 2010-10-08 2016-07-12 Elan Pharm Inc inibidores de quinase do tipo polo

Also Published As

Publication number Publication date
PT2470546E (pt) 2013-10-14
US8163755B2 (en) 2012-04-24
ES2432315T3 (es) 2013-12-02
TW201119656A (en) 2011-06-16
DK2470546T3 (da) 2013-10-14
WO2011025889A1 (en) 2011-03-03
PL2470546T3 (pl) 2013-12-31
EP2470546A1 (en) 2012-07-04
AR077974A1 (es) 2011-10-05
HRP20130951T1 (hr) 2013-11-22
US20110053921A1 (en) 2011-03-03
EP2470546B1 (en) 2013-07-24
US20120178924A1 (en) 2012-07-12
JP2013503183A (ja) 2013-01-31
SI2470546T1 (sl) 2013-12-31
US8268819B2 (en) 2012-09-18

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20190214