PL2470546T3 - Związki heksahydrooksazynopterydynowe do zastosowania jako inhibitory MTOR - Google Patents
Związki heksahydrooksazynopterydynowe do zastosowania jako inhibitory MTORInfo
- Publication number
- PL2470546T3 PL2470546T3 PL10749736T PL10749736T PL2470546T3 PL 2470546 T3 PL2470546 T3 PL 2470546T3 PL 10749736 T PL10749736 T PL 10749736T PL 10749736 T PL10749736 T PL 10749736T PL 2470546 T3 PL2470546 T3 PL 2470546T3
- Authority
- PL
- Poland
- Prior art keywords
- hexahydrooxazinopteridine
- compounds
- mtor inhibitors
- mtor
- inhibitors
- Prior art date
Links
- QCXCHXZKOUVUJT-UHFFFAOYSA-N 3,4,4a,5,5a,8-hexahydro-1H-oxazino[3,4-g]pteridine Chemical class N1OCCC2C1=NC1=CN=CNC1N2 QCXCHXZKOUVUJT-UHFFFAOYSA-N 0.000 title 1
- 229940124302 mTOR inhibitor Drugs 0.000 title 1
- 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23806409P | 2009-08-28 | 2009-08-28 | |
| US31360810P | 2010-03-12 | 2010-03-12 | |
| PCT/US2010/046839 WO2011025889A1 (en) | 2009-08-28 | 2010-08-26 | HEXAHYDROOXAZINOPTERINE COMPOUNDS FOR USE AS mTOR INHIBITORS |
| EP10749736.4A EP2470546B1 (en) | 2009-08-28 | 2010-08-26 | Hexahydrooxazinopteridine compounds for use as mtor inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2470546T3 true PL2470546T3 (pl) | 2013-12-31 |
Family
ID=42768136
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL10749736T PL2470546T3 (pl) | 2009-08-28 | 2010-08-26 | Związki heksahydrooksazynopterydynowe do zastosowania jako inhibitory MTOR |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8163755B2 (pl) |
| EP (1) | EP2470546B1 (pl) |
| JP (1) | JP2013503183A (pl) |
| AR (1) | AR077974A1 (pl) |
| DK (1) | DK2470546T3 (pl) |
| ES (1) | ES2432315T3 (pl) |
| HR (1) | HRP20130951T1 (pl) |
| PL (1) | PL2470546T3 (pl) |
| PT (1) | PT2470546E (pl) |
| SI (1) | SI2470546T1 (pl) |
| TW (1) | TW201119656A (pl) |
| UY (1) | UY32863A (pl) |
| WO (1) | WO2011025889A1 (pl) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA021595B1 (ru) | 2009-06-29 | 2015-07-30 | Инсайт Корпорейшн | Пиримидиноны в качестве ингибиторов pi3k |
| WO2011075643A1 (en) | 2009-12-18 | 2011-06-23 | Incyte Corporation | Substituted heteroaryl fused derivatives as pi3k inhibitors |
| MX2012007273A (es) | 2009-12-23 | 2012-12-17 | Elan Pharm Inc | Pteridinonas como inhibidores de la quinasa tipo polo. |
| AR081823A1 (es) | 2010-04-14 | 2012-10-24 | Incyte Corp | DERIVADOS FUSIONADOS COMO INHIBIDORES DE PI3Kd |
| WO2011163195A1 (en) | 2010-06-21 | 2011-12-29 | Incyte Corporation | Fused pyrrole derivatives as pi3k inhibitors |
| TW201249844A (en) | 2010-12-20 | 2012-12-16 | Incyte Corp | N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors |
| SG192193A1 (en) | 2011-01-31 | 2013-09-30 | Novartis Ag | Novel heterocyclic derivatives |
| CA2828483A1 (en) | 2011-02-23 | 2012-11-01 | Intellikine, Llc | Combination of kinase inhibitors and uses thereof |
| WO2012148548A1 (en) * | 2011-02-25 | 2012-11-01 | Takeda Pharmaceutical Company Limited | N-substituted oxazinopteridines and oxazinopteridinones |
| WO2012125629A1 (en) | 2011-03-14 | 2012-09-20 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors |
| US9126948B2 (en) | 2011-03-25 | 2015-09-08 | Incyte Holdings Corporation | Pyrimidine-4,6-diamine derivatives as PI3K inhibitors |
| TWI543980B (zh) | 2011-09-02 | 2016-08-01 | 英塞特控股公司 | 作為ｐｉ３ｋ抑制劑之雜環基胺 |
| AP2014007601A0 (en) | 2011-10-28 | 2014-04-30 | Novartis Ag | Novel purine derivatives and their use in the treatment of disease |
| AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
| SG10201610869TA (en) | 2012-06-26 | 2017-02-27 | Del Mar Pharmaceuticals | Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalacti |
| AU2013311705A1 (en) | 2012-09-10 | 2015-02-05 | F. Hoffmann-La Roche Ag | 6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of Hepatitis B virus infection |
| TWI736135B (zh) | 2013-03-01 | 2021-08-11 | 美商英塞特控股公司 | 吡唑并嘧啶衍生物治療PI3Kδ相關病症之用途 |
| US9724354B2 (en) | 2013-03-22 | 2017-08-08 | Millennium Pharmaceuticals, Inc. | Combination of catalytic mTORC1/2 inhibitors and selective inhibitors of Aurora A kinase |
| KR20160061911A (ko) | 2013-04-08 | 2016-06-01 | 데니스 엠. 브라운 | 최적하 투여된 화학 화합물의 치료 효과 |
| WO2015013581A1 (en) | 2013-07-26 | 2015-01-29 | Update Pharma Inc. | Combinatorial methods to improve the therapeutic benefit of bisantrene |
| EP3057972A4 (en) * | 2013-10-15 | 2017-03-22 | V Jin | Novel compositions, uses and methods for their preparation |
| HUE051625T2 (hu) | 2014-04-08 | 2021-03-29 | Incyte Corp | B-sejtes rosszindulatú daganatok kezelése JAK és PI3K inhibitorok kombinációjával |
| WO2015191677A1 (en) | 2014-06-11 | 2015-12-17 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors |
| MA55193B1 (fr) | 2015-02-27 | 2022-10-31 | Incyte Holdings Corp | Procédés de préparation d'un inhibiteur de pi3k |
| US9732097B2 (en) | 2015-05-11 | 2017-08-15 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
| US9988401B2 (en) | 2015-05-11 | 2018-06-05 | Incyte Corporation | Crystalline forms of a PI3K inhibitor |
| WO2016183062A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Salts of (s)-7-(1-(9h-purin-6-ylamino)ethyl)-6-(3-fluorophenyl)-3-methyl-5h-thiazolo[3,2-a]pyrimidin-5-one |
| KR102017676B1 (ko) * | 2018-03-09 | 2019-09-03 | 연세대학교 원주산학협력단 | 익상편 예방 및 치료용 조성물 |
| EP3801533B1 (en) | 2018-06-01 | 2026-03-04 | Incyte Corporation | Dosing regimen for the treatment of pi3k related disorders |
| WO2020076728A1 (en) * | 2018-10-08 | 2020-04-16 | Takeda Pharmaceutical Company Limited | SUBSTITUTED OXAZINOPTERIDINONES AS INHIBITORS OF mTOR |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7189851B2 (en) | 2002-03-06 | 2007-03-13 | Smithkline Beecham Corporation | Condensed heterocyclic compounds as calcitonin agonists |
| GB0415364D0 (en) | 2004-07-09 | 2004-08-11 | Astrazeneca Ab | Pyrimidine derivatives |
| ES2319461T3 (es) | 2005-02-10 | 2009-05-07 | Bristol-Myers Squibb Company | Dihidroquinazolinonas como moduladores de 5ht. |
| US8911498B2 (en) | 2005-02-10 | 2014-12-16 | DePuy Synthes Products, LLC | Intervertebral prosthetic disc |
| JP2010501537A (ja) | 2006-08-24 | 2010-01-21 | アストラゼネカ アクチボラグ | 増殖性障害の治療に有用なモルホリノピリミジン誘導体 |
| BRPI0817806A2 (pt) | 2007-10-05 | 2014-10-07 | Cylene Pharmaceuticals Inc | Análogos de quinolona e métodos relacionados a estes |
| WO2009070524A1 (en) * | 2007-11-27 | 2009-06-04 | Wyeth | Pyrrolo[3,2-d]pyrimidine compounds and their use as pi3 kinase and mtor kinase inhibitors |
| AU2011311960A1 (en) * | 2010-10-08 | 2014-04-10 | Elan Pharmaceuticals, Inc. | Inhibitors of polo-like kinase |
-
2010
- 2010-08-26 PL PL10749736T patent/PL2470546T3/pl unknown
- 2010-08-26 HR HRP20130951AT patent/HRP20130951T1/hr unknown
- 2010-08-26 EP EP10749736.4A patent/EP2470546B1/en not_active Not-in-force
- 2010-08-26 JP JP2012526992A patent/JP2013503183A/ja not_active Ceased
- 2010-08-26 ES ES10749736T patent/ES2432315T3/es active Active
- 2010-08-26 SI SI201030392T patent/SI2470546T1/sl unknown
- 2010-08-26 AR ARP100103122A patent/AR077974A1/es unknown
- 2010-08-26 PT PT107497364T patent/PT2470546E/pt unknown
- 2010-08-26 DK DK10749736.4T patent/DK2470546T3/da active
- 2010-08-26 WO PCT/US2010/046839 patent/WO2011025889A1/en not_active Ceased
- 2010-08-26 US US12/869,452 patent/US8163755B2/en active Active
- 2010-08-27 TW TW099128976A patent/TW201119656A/zh unknown
- 2010-08-27 UY UY0001032863A patent/UY32863A/es not_active Application Discontinuation
-
2012
- 2012-03-26 US US13/429,865 patent/US8268819B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| HRP20130951T1 (hr) | 2013-11-22 |
| SI2470546T1 (sl) | 2013-12-31 |
| ES2432315T3 (es) | 2013-12-02 |
| EP2470546B1 (en) | 2013-07-24 |
| US8163755B2 (en) | 2012-04-24 |
| US8268819B2 (en) | 2012-09-18 |
| DK2470546T3 (da) | 2013-10-14 |
| US20120178924A1 (en) | 2012-07-12 |
| JP2013503183A (ja) | 2013-01-31 |
| WO2011025889A1 (en) | 2011-03-03 |
| PT2470546E (pt) | 2013-10-14 |
| US20110053921A1 (en) | 2011-03-03 |
| UY32863A (es) | 2011-03-31 |
| TW201119656A (en) | 2011-06-16 |
| EP2470546A1 (en) | 2012-07-04 |
| AR077974A1 (es) | 2011-10-05 |
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