UY32077A - Inhibidores de quinasa tipo polo - Google Patents

Inhibidores de quinasa tipo polo

Info

Publication number
UY32077A
UY32077A UY0001032077A UY32077A UY32077A UY 32077 A UY32077 A UY 32077A UY 0001032077 A UY0001032077 A UY 0001032077A UY 32077 A UY32077 A UY 32077A UY 32077 A UY32077 A UY 32077A
Authority
UY
Uruguay
Prior art keywords
polo type
inhibitors
compounds
quinase
quinase inhibitors
Prior art date
Application number
UY0001032077A
Other languages
English (en)
Inventor
Sheldon X Cao
Ichikawa Takashi
Andre A Kiryanov
Mcbride Christopher
Srinivasa Reddy Natala
Stephe W Kaldor
Jeffrey A Stafford
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of UY32077A publication Critical patent/UY32077A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

La presente invención provee inhibidores de PLK de la fórmula en donde las variables son como se definen en la presente. También se proveen composiciones farmacéuticas, kits y artículos de manufactura que comprenden tales compuestos; métodos e intermediarios para preparar los compuestos; y métodos de uso de los compuestos.
UY0001032077A 2008-08-28 2009-08-27 Inhibidores de quinasa tipo polo UY32077A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9270408P 2008-08-28 2008-08-28
US17137109P 2009-04-21 2009-04-21

Publications (1)

Publication Number Publication Date
UY32077A true UY32077A (es) 2010-03-26

Family

ID=41512328

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001032077A UY32077A (es) 2008-08-28 2009-08-27 Inhibidores de quinasa tipo polo

Country Status (5)

Country Link
US (1) US20100075973A1 (es)
AR (1) AR073142A1 (es)
TW (1) TW201021800A (es)
UY (1) UY32077A (es)
WO (1) WO2010025073A1 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012048129A2 (en) 2010-10-08 2012-04-12 Elan Pharmaceuticals, Inc. Inhibitors of polo-like kinase
US8546566B2 (en) * 2010-10-12 2013-10-01 Boehringer Ingelheim International Gmbh Process for manufacturing dihydropteridinones and intermediates thereof
WO2014209978A1 (en) * 2013-06-24 2014-12-31 Merck Patent Gmbh Imidazole compounds as modulators of fshr and uses thereof
US9566280B2 (en) 2014-01-28 2017-02-14 Massachusetts Institute Of Technology Combination therapies and methods of use thereof for treating cancer
US9840503B2 (en) 2015-05-11 2017-12-12 Incyte Corporation Heterocyclic compounds and uses thereof
WO2017027717A1 (en) 2015-08-12 2017-02-16 Incyte Corporation Bicyclic fused pyrimidine compounds as tam inhibitors
WO2017035366A1 (en) 2015-08-26 2017-03-02 Incyte Corporation Pyrrolopyrimidine derivatives as tam inhibitors
EP4321513A2 (en) 2016-03-28 2024-02-14 Incyte Corporation Pyrrolotriazine compounds as tam inhibitors
SI3687996T1 (sl) 2017-09-27 2022-04-29 Incyte Corporation Soli pirolotriazinskih derivatov, ki so uporabne kot zaviralci TAM
EP3813800A1 (en) 2018-06-29 2021-05-05 Incyte Corporation Formulations of an axl/mer inhibitor
CN111018857B (zh) * 2018-10-09 2023-06-02 嘉兴优博生物技术有限公司 靶向蛋白酶降解平台(ted)
CN111217815B (zh) * 2018-11-27 2021-06-18 沈阳药科大学 含有喋啶酮骨架的化合物及其制备方法和应用
CN114269727A (zh) * 2019-08-16 2022-04-01 西克拉塞尔有限公司 制备嘧啶并二氮杂环庚三烯衍生物的方法
US20230263783A1 (en) 2022-02-18 2023-08-24 Massachusetts Institute Of Technology Cancer treatment by combined inhibition of polo-like kinase and microtubule polymerization

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6235740B1 (en) * 1997-08-25 2001-05-22 Bristol-Myers Squibb Co. Imidazoquinoxaline protein tyrosine kinase inhibitors
US6635626B1 (en) * 1997-08-25 2003-10-21 Bristol-Myers Squibb Co. Imidazoquinoxaline protein tyrosine kinase inhibitors
DE69940808D1 (de) * 1998-03-04 2009-06-10 Bristol Myers Squibb Co Heterocyclen substituierte imidazopyrazine als protein- tyrosin-kinase-inhibitoren
US6861422B2 (en) * 2003-02-26 2005-03-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions
MXPA05009068A (es) * 2003-02-26 2005-10-19 Boehringer Ingelheim Pharma Dihidro-pteridinonas, metodo para la produccion y uso del mismo en la forma de farmacos.
US20060074088A1 (en) * 2004-08-14 2006-04-06 Boehringer Ingelheim International Gmbh Dihydropteridinones for the treatment of cancer diseases
EP1784406A1 (de) * 2004-08-27 2007-05-16 Boehringer Ingelheim International GmbH Dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel
ES2359467T3 (es) * 2006-12-14 2011-05-23 Vertex Pharmceuticals Incorporated Compuestos útiles como inhibidores de proteína quinasas.

Also Published As

Publication number Publication date
WO2010025073A1 (en) 2010-03-04
US20100075973A1 (en) 2010-03-25
AR073142A1 (es) 2010-10-13
TW201021800A (en) 2010-06-16

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20181114