WO2008113970A3 - Peptides - Google Patents
Peptides Download PDFInfo
- Publication number
- WO2008113970A3 WO2008113970A3 PCT/GB2008/000732 GB2008000732W WO2008113970A3 WO 2008113970 A3 WO2008113970 A3 WO 2008113970A3 GB 2008000732 W GB2008000732 W GB 2008000732W WO 2008113970 A3 WO2008113970 A3 WO 2008113970A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- peptides
- epitope
- seq
- peptide
- variant
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4715—Pregnancy proteins, e.g. placenta proteins, alpha-feto-protein, pregnancy specific beta glycoprotein
Abstract
The present invention relates to peptides comprising a fragment of the human alpha- fetoprotein molecule of SEQ ID NO: 1, wherein said peptides comprise: (a) amino acids 46-55 of SEQ ID NO: 1; (b) a variant of (a) in which one, two or three amino acids are deleted; or (c) a variant of (a) comprising one, two, three or four amino acid substitutions from the sequence of (a); wherein said peptide is capable of activating T cells that produce TGF-β and/or GM-CSF, and wherein said peptide does not comprise a B cell epitope, a CTL epitope or a ThI epitope.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0705115.4 | 2007-03-16 | ||
GB0705115A GB0705115D0 (en) | 2007-03-16 | 2007-03-16 | Peptides |
GB0705251A GB0705251D0 (en) | 2007-03-19 | 2007-03-19 | Peptides |
GB0705251.7 | 2007-03-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008113970A2 WO2008113970A2 (en) | 2008-09-25 |
WO2008113970A3 true WO2008113970A3 (en) | 2008-12-24 |
Family
ID=39637614
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2008/000732 WO2008113970A2 (en) | 2007-03-16 | 2008-03-05 | Peptides |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008113970A2 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109475628A (en) | 2016-05-18 | 2019-03-15 | 库尔生物制药有限公司 | T cell modulability multimeric polypeptide and its application method |
MX2019007611A (en) | 2016-12-22 | 2020-07-29 | Cue Biopharma Inc | T-cell modulatory multimeric polypeptides and methods of use thereof. |
US11851471B2 (en) | 2017-01-09 | 2023-12-26 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
SG11201908391XA (en) | 2017-03-15 | 2019-10-30 | Cue Biopharma Inc | Methods for modulating an immune response |
WO2019139896A1 (en) | 2018-01-09 | 2019-07-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
TW202039541A (en) * | 2018-12-19 | 2020-11-01 | 美商庫爾生物製藥有限公司 | Multimeric t-cell modulatory polypeptides and methods of use thereof |
TW202208395A (en) | 2020-05-12 | 2022-03-01 | 美商信號生物製藥公司 | Multimeric t-cell modulatory polypeptides and methods of use thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996022787A1 (en) * | 1995-01-24 | 1996-08-01 | Murgita Robert A | Recombinant human alpha-fetoprotein and uses thereof |
WO2001058922A2 (en) * | 2000-02-10 | 2001-08-16 | The Regents Of The University Of California | Method and compositions for treating hepatocellular cancer |
-
2008
- 2008-03-05 WO PCT/GB2008/000732 patent/WO2008113970A2/en active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996022787A1 (en) * | 1995-01-24 | 1996-08-01 | Murgita Robert A | Recombinant human alpha-fetoprotein and uses thereof |
WO2001058922A2 (en) * | 2000-02-10 | 2001-08-16 | The Regents Of The University Of California | Method and compositions for treating hepatocellular cancer |
Non-Patent Citations (4)
Title |
---|
ALISA AKEEL ET AL: "Analysis of CD4+ T-Cell responses to a novel alpha-fetoprotein-derived epitope in hepatocellular carcinoma patients", CLINICAL CANCER RESEARCH, THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, vol. 11, no. 18, 15 September 2005 (2005-09-15), pages 6686 - 6694, XP002476998, ISSN: 1078-0432 * |
ALISA AKEEL ET AL: "Human CD4(+) T cells recognize an epitope within alpha-fetoprotein sequence and develop into TGF-beta-producing CD4(+) T cells.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 APR 2008, vol. 180, no. 7, 1 April 2008 (2008-04-01), pages 5109 - 5117, XP002491840, ISSN: 0022-1767 * |
AYARU LAKSHMANA ET AL: "Unmasking of alpha-fetoprotein-specific CD4(+) T cell responses in hepatocellular carcinoma patients undergoing embolization", JOURNAL OF IMMUNOLOGY, THE WILLIAMS AND WILKINS CO. BALTIMORE, vol. 178, no. 3, 1 February 2007 (2007-02-01), pages 1914 - 1922, XP002476999, ISSN: 0022-1767 * |
LIU YANG ET AL: "Hierarchy of alpha fetoprotein (AFP)-specific T cell responses in subjects with AFP-positive hepatocellular cancer.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 JUL 2006, vol. 177, no. 1, 1 July 2006 (2006-07-01), pages 712 - 721, XP002491839, ISSN: 0022-1767 * |
Also Published As
Publication number | Publication date |
---|---|
WO2008113970A2 (en) | 2008-09-25 |
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