WO2012173521A3 - Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе - Google Patents

Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе Download PDF

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Publication number
WO2012173521A3
WO2012173521A3 PCT/RU2012/000423 RU2012000423W WO2012173521A3 WO 2012173521 A3 WO2012173521 A3 WO 2012173521A3 RU 2012000423 W RU2012000423 W RU 2012000423W WO 2012173521 A3 WO2012173521 A3 WO 2012173521A3
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WO
WIPO (PCT)
Prior art keywords
protein kinase
kinase inhibitors
variants
pharmaceutical composition
composition based
Prior art date
Application number
PCT/RU2012/000423
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English (en)
French (fr)
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WO2012173521A2 (ru
Inventor
Гермес Григорьевич ЧИПОВ
Илья Юрьевич ТИТОВ
Original Assignee
Общество С Ограниченной Ответственностью "Фьюжн Фарма"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to RS20160956A priority Critical patent/RS55380B1/sr
Application filed by Общество С Ограниченной Ответственностью "Фьюжн Фарма" filed Critical Общество С Ограниченной Ответственностью "Фьюжн Фарма"
Priority to LTEP12801171.5T priority patent/LT2743266T/lt
Priority to UAA201404861A priority patent/UA115228C2/ru
Priority to IN635MUN2014 priority patent/IN2014MN00635A/en
Priority to EP12801171.5A priority patent/EP2743266B8/en
Priority to EA201491356A priority patent/EA026704B1/ru
Priority to AU2012269818A priority patent/AU2012269818B2/en
Priority to ES12801171.5T priority patent/ES2602797T3/es
Priority to SI201230763A priority patent/SI2743266T1/en
Priority to CA2850137A priority patent/CA2850137C/en
Priority to DK12801171.5T priority patent/DK2743266T3/en
Publication of WO2012173521A2 publication Critical patent/WO2012173521A2/ru
Publication of WO2012173521A3 publication Critical patent/WO2012173521A3/ru
Priority to US14/242,241 priority patent/US9522910B2/en
Priority to IL232357A priority patent/IL232357A/en
Priority to HK14109243.0A priority patent/HK1195771A1/zh
Priority to HRP20161478TT priority patent/HRP20161478T1/hr
Priority to CY20161101178T priority patent/CY1118513T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Данное изобретение касается терапии онкологических, хронических воспалительных и прочих заболеваний с помощью новых семейств химических соединений, обладающих повышенной эффективностью в ингибировании Аb1- киназ ы и ее мутантных форм, а также других терапевтически значимых киназ. Описаны ингибиторы протеинкиназ, представляющие собой соединения с общей формулой (I), а также соединения общей формулы (II). их таутомеры, индивидуальный изомер или смесь изомеров, их фармацевтически приемлемая соль, сольват или гидрат.
PCT/RU2012/000423 2011-06-16 2012-05-29 Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе WO2012173521A2 (ru)

Priority Applications (16)

Application Number Priority Date Filing Date Title
ES12801171.5T ES2602797T3 (es) 2011-06-16 2012-05-29 Inhibidores de las proteínas cinasas (variantes), su utilización en el tratamiento de enfermedades oncológicas y composición farmacéutica obtenida a partir de los mismos
AU2012269818A AU2012269818B2 (en) 2011-06-16 2012-05-29 Protein kinase inhibitors (variants), use thereof in treating oncological diseases and a pharmaceutical composition based thereon
LTEP12801171.5T LT2743266T (lt) 2011-06-16 2012-05-29 Proteinkinazės slopikliai (variantai), jų panaudojimas onkologinių ligų gydymui ir farmacinė kompozicija jų pagrindu
UAA201404861A UA115228C2 (ru) 2011-06-16 2012-05-29 Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе
IN635MUN2014 IN2014MN00635A (ru) 2011-06-16 2012-05-29
EP12801171.5A EP2743266B8 (en) 2011-06-16 2012-05-29 Protein kinase inhibitors (variants), use thereof in treating oncological diseases and a pharmaceutical composition based thereon
EA201491356A EA026704B1 (ru) 2011-06-16 2012-05-29 Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе
RS20160956A RS55380B1 (sr) 2011-06-16 2012-05-29 Inhibitori proteinske kinaze (varijante), njihova upotreba u tretmanu onkoloških bolesti i njihova farmaceutska kompozicija
DK12801171.5T DK2743266T3 (en) 2011-06-16 2012-05-29 Protein kinase inhibitors (VERSIONS), USE THEREOF FOR TREATMENT OF oncological diseases AND PHARMACEUTICAL COMPOSITION BASED THEN
CA2850137A CA2850137C (en) 2011-06-16 2012-05-29 Protein kinase inhibitors (variants), use thereof in treating oncological diseases and a pharmaceutical composition based thereon
SI201230763A SI2743266T1 (en) 2011-06-16 2012-05-29 Protein kinase inhibitors (variants), their use in the treatment of oncological diseases and the pharmaceutical composition on their basis
US14/242,241 US9522910B2 (en) 2011-06-16 2014-04-01 Protein kinase inhibitors (variants), use thereof in treating oncological diseases and a pharmaceutical composition based thereon
IL232357A IL232357A (en) 2011-06-16 2014-04-29 Keynes-driven proteins (variations), their use in treating cancerous diseases and pharmaceuticals containing them
HK14109243.0A HK1195771A1 (zh) 2011-06-16 2014-09-12 蛋白質激酶抑制劑 變體 ，其在治療腫瘤學疾病中的用途以及基於此的藥物組合物
HRP20161478TT HRP20161478T1 (hr) 2011-06-16 2016-11-08 Inhibitori protein kinaze (varijante), njihova upotreba za liječenje neuroloških bolesti, kao i farmaceutski pripravak koji se na njima temelji
CY20161101178T CY1118513T1 (el) 2011-06-16 2016-11-16 Αναστολεις πρωτεϊνικης κινασης (παραλλαγες), χρηση αυτων στη θεραπεια ογκολογικων νοσων και μια φαρμακευτικη συνθεση βασισμενη σε αυτους

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2011124304 2011-06-16
RU2011124304/04A RU2477723C2 (ru) 2011-06-16 2011-06-16 Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US14/242,241 Continuation US9522910B2 (en) 2011-06-16 2014-04-01 Protein kinase inhibitors (variants), use thereof in treating oncological diseases and a pharmaceutical composition based thereon

Publications (2)

Publication Number Publication Date
WO2012173521A2 WO2012173521A2 (ru) 2012-12-20
WO2012173521A3 true WO2012173521A3 (ru) 2013-03-28

Family

ID=47357651

Family Applications (1)

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PCT/RU2012/000423 WO2012173521A2 (ru) 2011-06-16 2012-05-29 Ингибиторы протеинкиназ (варианты), их применение для лечения онкологических заболеваний и фармацевтическая композиция на их основе

Country Status (22)

Country Link
US (1) US9522910B2 (ru)
EP (1) EP2743266B8 (ru)
AU (1) AU2012269818B2 (ru)
CA (1) CA2850137C (ru)
CY (1) CY1118513T1 (ru)
DK (1) DK2743266T3 (ru)
EA (1) EA026704B1 (ru)
ES (1) ES2602797T3 (ru)
HK (1) HK1195771A1 (ru)
HR (1) HRP20161478T1 (ru)
HU (1) HUE031837T2 (ru)
IL (1) IL232357A (ru)
IN (1) IN2014MN00635A (ru)
LT (1) LT2743266T (ru)
PL (1) PL2743266T3 (ru)
PT (1) PT2743266T (ru)
RS (1) RS55380B1 (ru)
RU (1) RU2477723C2 (ru)
SI (1) SI2743266T1 (ru)
SM (1) SMT201600398B (ru)
UA (1) UA115228C2 (ru)
WO (1) WO2012173521A2 (ru)

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Also Published As

Publication number Publication date
EA026704B1 (ru) 2017-05-31
CA2850137A1 (en) 2012-12-20
CY1118513T1 (el) 2017-07-12
US9522910B2 (en) 2016-12-20
UA115228C2 (ru) 2017-10-10
IL232357A0 (en) 2014-07-01
RS55380B1 (sr) 2017-03-31
ES2602797T3 (es) 2017-02-22
EP2743266A4 (en) 2015-03-11
EA201491356A1 (ru) 2015-01-30
AU2012269818B2 (en) 2016-05-19
RU2477723C2 (ru) 2013-03-20
SMT201600398B (it) 2017-01-10
SI2743266T1 (en) 2017-02-28
EP2743266B1 (en) 2016-08-17
PL2743266T3 (pl) 2017-02-28
HRP20161478T1 (hr) 2016-12-16
DK2743266T3 (en) 2016-12-05
IN2014MN00635A (ru) 2015-07-03
WO2012173521A2 (ru) 2012-12-20
HUE031837T2 (en) 2017-08-28
PT2743266T (pt) 2016-10-14
AU2012269818A1 (en) 2014-06-26
US20140213592A1 (en) 2014-07-31
RU2011124304A (ru) 2012-12-27
IL232357A (en) 2017-05-29
EP2743266A2 (en) 2014-06-18
EP2743266B8 (en) 2016-09-28
LT2743266T (lt) 2016-12-12
HK1195771A1 (zh) 2014-11-21
CA2850137C (en) 2016-10-25

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