MX2014002394A - Inhibidores de rock suaves, novedosos. - Google Patents

Inhibidores de rock suaves, novedosos.

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Publication number
MX2014002394A
MX2014002394A MX2014002394A MX2014002394A MX2014002394A MX 2014002394 A MX2014002394 A MX 2014002394A MX 2014002394 A MX2014002394 A MX 2014002394A MX 2014002394 A MX2014002394 A MX 2014002394A MX 2014002394 A MX2014002394 A MX 2014002394A
Authority
MX
Mexico
Prior art keywords
inhibitors
treatment
relates
kinase inhibitors
diseases
Prior art date
Application number
MX2014002394A
Other languages
English (en)
Inventor
Dirk Leysen
Olivier Defert
Sandro Boland
Jo Alen
Arnaud Pierre Jean Bourin
Original Assignee
Amakem Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amakem Nv filed Critical Amakem Nv
Publication of MX2014002394A publication Critical patent/MX2014002394A/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Cardiology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a nuevos inhibidores de quinasa; más específicamente, inhibidores de ROCK; a composiciones, en particular composiciones farmacéuticas, que comprenden esos inhibidores, y a los usos de esos inhibidores en el tratamiento y la profilaxis de enfermedades. En particular, la presente invención se refiere a nuevos inhibidores de ROCK, a composiciones, en particular composiciones farmacéuticas, que comprenden esos inhibidores, y a los usos de esos inhibidores en el tratamiento y la profilaxis de enfermedades. Además, la invención se refiere a métodos de tratamiento y uso de dichos compuestos en la fabricación de un medicamento para la aplicación a numerosas indicaciones terapéuticas, incluyendo: disfunción sexual, enfermedades inflamatorias, enfermedades oftálmicas, enfermedades gastrointestinales y enfermedades respiratorias.
MX2014002394A 2011-08-31 2012-08-31 Inhibidores de rock suaves, novedosos. MX2014002394A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11179491 2011-08-31
PCT/EP2012/067018 WO2013030367A1 (en) 2011-08-31 2012-08-31 Biphenylcarboxamides as rock kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2014002394A true MX2014002394A (es) 2014-06-05

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MX2014002393A MX2014002393A (es) 2011-08-31 2012-08-31 Inhibidores de rock suaves, novedosos.
MX2014002395A MX2014002395A (es) 2011-08-31 2012-08-31 Inhibidores de rock suaves, novedosos.
MX2014002394A MX2014002394A (es) 2011-08-31 2012-08-31 Inhibidores de rock suaves, novedosos.

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MX2014002393A MX2014002393A (es) 2011-08-31 2012-08-31 Inhibidores de rock suaves, novedosos.
MX2014002395A MX2014002395A (es) 2011-08-31 2012-08-31 Inhibidores de rock suaves, novedosos.

Country Status (16)

Country Link
US (3) US9079858B2 (es)
EP (3) EP2751079A1 (es)
JP (3) JP2014525425A (es)
KR (2) KR20140079386A (es)
CN (3) CN103874682A (es)
AU (3) AU2012300834A1 (es)
BR (3) BR112014004435A2 (es)
CA (3) CA2846752A1 (es)
EA (3) EA201490516A1 (es)
ES (1) ES2560830T3 (es)
IL (2) IL231123A0 (es)
MX (3) MX2014002393A (es)
PT (1) PT2751080E (es)
SG (2) SG11201400058PA (es)
WO (3) WO2013030365A1 (es)
ZA (3) ZA201401416B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10842669B2 (en) * 2008-11-13 2020-11-24 Gholam A. Peyman Ophthalmic drug delivery method
BR112014004435A2 (pt) * 2011-08-31 2017-03-21 Amakem Nv inibidores de quinase rock
HRP20220913T1 (hr) 2012-10-05 2022-10-28 Kadmon Corporation, Llc Inhibitori rho kinaze
SI2951172T1 (sl) 2013-01-29 2017-08-31 Redx Pharma Plc Piridin derivati kot inhibitorji mehkih kamnov
JP5840324B2 (ja) * 2013-04-15 2016-01-06 株式会社レナサイエンス Ｐａｉ−１阻害剤の新規用途
WO2015094912A1 (en) * 2013-12-17 2015-06-25 Eli Lilly And Company Dimethylbenzoic acid compounds
US20210292766A1 (en) 2018-08-29 2021-09-23 University Of Massachusetts Inhibition of Protein Kinases to Treat Friedreich Ataxia
CN118434843A (zh) 2021-11-11 2024-08-02 学校法人同志社 角膜内皮细胞的冷冻保存制剂及其制造方法

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005723A1 (en) 1988-11-24 1990-05-31 Yoshitomi Pharmaceutical Industries, Ltd. Trans-4-amino(alkyl)-1-pyridylcarbamoyl-cyclohexane compounds and their medicinal use
IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
IL111080A (en) 1993-10-01 1999-08-17 Astra Ab Method for treating a finely divided powder medicament
US6043358A (en) 1995-11-01 2000-03-28 Merck & Co., Inc. Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
GB0124928D0 (en) * 2001-10-17 2001-12-05 Glaxo Group Ltd Chemical compounds
US7405295B2 (en) * 2003-06-04 2008-07-29 Cgi Pharmaceuticals, Inc. Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
US7683097B2 (en) * 2004-05-27 2010-03-23 Propharmacon Inc. Topoisomerase inhibitors
CN101248046A (zh) * 2005-07-11 2008-08-20 德福根有限公司 作为激酶抑制剂的酰胺衍生物
JP2009505948A (ja) 2005-07-11 2009-02-12 デブジェン エヌブイ キナーゼ阻害剤としてのアミド誘導体
JP2009500437A (ja) * 2005-07-11 2009-01-08 デブジェン エヌブイ キナーゼ阻害剤としてのアミド誘導体
US20070042321A1 (en) * 2005-08-22 2007-02-22 Florman Michael J Grinder guard
RS51470B (en) * 2005-09-16 2011-04-30 Arrow Therapeutics Limited BIPHENYL DERIVATIVES AND THEIR USE FOR THE TREATMENT OF HEPATITIS C
WO2007042321A2 (en) * 2005-10-13 2007-04-19 Devgen N.V. Kinase inhibitors
EP2202229B1 (en) * 2007-08-17 2012-03-14 Eisai R&D Management Co., Ltd. Novel preparation for external use
GB201018996D0 (en) * 2010-11-10 2010-12-22 Amakem Nv Novel ROCK inhibitors
NZ602191A (en) 2010-03-02 2014-07-25 Amakem Nv Heterocyclic amides as rock inhibitors
US8921383B2 (en) * 2011-03-28 2014-12-30 Hoffmann-La Roche Inc. Thiazolopyrimidine compounds
GB201114854D0 (en) * 2011-08-29 2011-10-12 Amakem Nv Novel rock inhibitors
BR112014004435A2 (pt) 2011-08-31 2017-03-21 Amakem Nv inibidores de quinase rock
JP2014526484A (ja) * 2011-09-13 2014-10-06 ノバルティス アーゲー Ｓ１ｐ受容体修飾物質を含む組み合わせ

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