EA201490515A1 - Новые ингибиторы rock-киназ - Google Patents

Новые ингибиторы rock-киназ

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Publication number
EA201490515A1
EA201490515A1 EA201490515A EA201490515A EA201490515A1 EA 201490515 A1 EA201490515 A1 EA 201490515A1 EA 201490515 A EA201490515 A EA 201490515A EA 201490515 A EA201490515 A EA 201490515A EA 201490515 A1 EA201490515 A1 EA 201490515A1
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EA
Eurasian Patent Office
Prior art keywords
inhibitors
diseases
rock
treatment
kinaz
Prior art date
Application number
EA201490515A
Other languages
English (en)
Inventor
Йо Ален
Сандро Боланд
Арно Пьер Жан Бурен
Оливье Дефер
Дирк Лейзен
Original Assignee
Амакем Нв
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Амакем Нв filed Critical Амакем Нв
Publication of EA201490515A1 publication Critical patent/EA201490515A1/ru

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    • C07—ORGANIC CHEMISTRY
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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Abstract

Настоящее изобретение относится к новым ингибиторам киназ, а именно к ингибиторам ROCK, к композициям, в частности фармацевтическим препаратам, содержащим такие ингибиторы, и к применениям таких ингибиторов в лечении и профилактике заболеваний. В частности, настоящее изобретение относится к новым ингибиторам ROCK, к композициям, в частности фармацевтическим препаратам, содержащим такие ингибиторы, и к применениям таких ингибиторов в лечении и профилактике заболеваний. Помимо этого, настоящее изобретение относится к способам лечения и к применению указанных соединений в производстве лекарственного препарата для применения при ряде терапевтических показаний, включая сексуальную дисфункцию, воспалительные заболевания, глазные заболевания и респираторные заболевания.
EA201490515A 2011-08-31 2012-08-31 Новые ингибиторы rock-киназ EA201490515A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11179491 2011-08-31
PCT/EP2012/067016 WO2013030365A1 (en) 2011-08-31 2012-08-31 Novel rock kinase inhibitors

Publications (1)

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EA201490515A1 true EA201490515A1 (ru) 2014-08-29

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Application Number Title Priority Date Filing Date
EA201490495A EA024232B1 (ru) 2011-08-31 2012-08-31 Новые легкоразрушающиеся ингибиторы rock
EA201490515A EA201490515A1 (ru) 2011-08-31 2012-08-31 Новые ингибиторы rock-киназ
EA201490516A EA201490516A1 (ru) 2011-08-31 2012-08-31 Бифенилкарбоксиамиды в качестве ингибиторов rock-киназ

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EA201490495A EA024232B1 (ru) 2011-08-31 2012-08-31 Новые легкоразрушающиеся ингибиторы rock

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EA201490516A EA201490516A1 (ru) 2011-08-31 2012-08-31 Бифенилкарбоксиамиды в качестве ингибиторов rock-киназ

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US (3) US9174939B2 (ru)
EP (3) EP2751079A1 (ru)
JP (3) JP2014525425A (ru)
KR (2) KR20140072879A (ru)
CN (3) CN103874684A (ru)
AU (3) AU2012300832A1 (ru)
BR (3) BR112014004435A2 (ru)
CA (3) CA2846695A1 (ru)
EA (3) EA024232B1 (ru)
ES (1) ES2560830T3 (ru)
IL (2) IL231123A0 (ru)
MX (3) MX2014002395A (ru)
PT (1) PT2751080E (ru)
SG (2) SG11201400117QA (ru)
WO (3) WO2013030365A1 (ru)
ZA (3) ZA201401417B (ru)

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US10842669B2 (en) * 2008-11-13 2020-11-24 Gholam A. Peyman Ophthalmic drug delivery method
WO2013030365A1 (en) * 2011-08-31 2013-03-07 Amakem Nv Novel rock kinase inhibitors
PT2903618T (pt) 2012-10-05 2022-08-19 Kadmon Corp Llc Inibidores de rho cinase
EP2951172B8 (en) * 2013-01-29 2017-08-02 Redx Pharma Plc Pyridine derivatives as soft rock inhibitors
US10092537B2 (en) 2013-04-15 2018-10-09 Renascience Co., Ltd. Use for PAI-1 inhibitor
ES2727329T3 (es) * 2013-12-17 2019-10-15 Lilly Co Eli Compuestos de ácido dimetilbenzoico
WO2020047229A1 (en) 2018-08-29 2020-03-05 University Of Massachusetts Inhibition of protein kinases to treat friedreich ataxia
AU2022385051A1 (en) 2021-11-11 2024-06-20 Actualeyes Inc. Cryopreservation preparation for corneal endothelial cells and method for producing said cryopreservation preparation

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