BR112014004447A2 - bifenilcarboxamidas como inibidores de quinase rock - Google Patents

bifenilcarboxamidas como inibidores de quinase rock

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Publication number
BR112014004447A2
BR112014004447A2 BR112014004447A BR112014004447A BR112014004447A2 BR 112014004447 A2 BR112014004447 A2 BR 112014004447A2 BR 112014004447 A BR112014004447 A BR 112014004447A BR 112014004447 A BR112014004447 A BR 112014004447A BR 112014004447 A2 BR112014004447 A2 BR 112014004447A2
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BR
Brazil
Prior art keywords
inhibitors
diseases
biphenylcarboxamides
rock
kinase inhibitors
Prior art date
Application number
BR112014004447A
Other languages
English (en)
Inventor
Pierre Jean Bourin Arnaud
Leysen Dirk
Alen Jo
Defert Olivier
Boland Sandro
Original Assignee
Amakem Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amakem Nv filed Critical Amakem Nv
Publication of BR112014004447A2 publication Critical patent/BR112014004447A2/pt

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

resumo patente de invenção: "bifenilcarboxamidas como inibidores de quinase rock". a presente invenção refere-se a novos inibidores de quinase, mais especificamente inibidores de rock, composições, particularmente farmacêuticas, compreendendo tais inibidores e aos usos de tais inibidores para o tratamento e profilaxia de doenças. em particular, a presente invenção se refere a novos inibidores de rock, composições, particularmente farmacêuticas, compreendendo tais inibidores e ao uso de tais inibidores para o tratamento e profilaxia de doenças. além disso, a invenção se refere a métodos de tratamento e ao uso dos ditos compostos na fabricação de um medicamento para a aplicação a um determinado número de indicações terapêuticas, incluindo disfunção sexual, doenças inflamatórias, doenças oftálmicas, doenças gastrintestinais e doenças respiratórias. 20604384v1
BR112014004447A 2011-08-31 2012-08-31 bifenilcarboxamidas como inibidores de quinase rock BR112014004447A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11179491 2011-08-31
PCT/EP2012/067018 WO2013030367A1 (en) 2011-08-31 2012-08-31 Biphenylcarboxamides as rock kinase inhibitors

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BR112014004447A2 true BR112014004447A2 (pt) 2017-03-21

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BR112014004435A BR112014004435A2 (pt) 2011-08-31 2012-08-31 inibidores de quinase rock
BR112014004545A BR112014004545A2 (pt) 2011-08-31 2012-08-31 inibidores leves de rock
BR112014004447A BR112014004447A2 (pt) 2011-08-31 2012-08-31 bifenilcarboxamidas como inibidores de quinase rock

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BR112014004545A BR112014004545A2 (pt) 2011-08-31 2012-08-31 inibidores leves de rock

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US (3) US9079858B2 (pt)
EP (3) EP2751079A1 (pt)
JP (3) JP2014525425A (pt)
KR (2) KR20140079386A (pt)
CN (3) CN103874682A (pt)
AU (3) AU2012300834A1 (pt)
BR (3) BR112014004435A2 (pt)
CA (3) CA2846752A1 (pt)
EA (3) EA201490516A1 (pt)
ES (1) ES2560830T3 (pt)
IL (2) IL231123A0 (pt)
MX (3) MX2014002393A (pt)
PT (1) PT2751080E (pt)
SG (2) SG11201400058PA (pt)
WO (3) WO2013030365A1 (pt)
ZA (3) ZA201401416B (pt)

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US10842669B2 (en) * 2008-11-13 2020-11-24 Gholam A. Peyman Ophthalmic drug delivery method
BR112014004435A2 (pt) * 2011-08-31 2017-03-21 Amakem Nv inibidores de quinase rock
HRP20220913T1 (hr) 2012-10-05 2022-10-28 Kadmon Corporation, Llc Inhibitori rho kinaze
SI2951172T1 (sl) 2013-01-29 2017-08-31 Redx Pharma Plc Piridin derivati kot inhibitorji mehkih kamnov
JP5840324B2 (ja) * 2013-04-15 2016-01-06 株式会社レナサイエンス Ｐａｉ−１阻害剤の新規用途
WO2015094912A1 (en) * 2013-12-17 2015-06-25 Eli Lilly And Company Dimethylbenzoic acid compounds
US20210292766A1 (en) 2018-08-29 2021-09-23 University Of Massachusetts Inhibition of Protein Kinases to Treat Friedreich Ataxia
CN118434843A (zh) 2021-11-11 2024-08-02 学校法人同志社 角膜内皮细胞的冷冻保存制剂及其制造方法

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