GB201111427D0 - Novel bisindolylmaleimides, pan-pkc inhibitors - Google Patents

Novel bisindolylmaleimides, pan-pkc inhibitors

Info

Publication number
GB201111427D0
GB201111427D0 GB201111427A GB201111427A GB201111427D0 GB 201111427 D0 GB201111427 D0 GB 201111427D0 GB 201111427 A GB201111427 A GB 201111427A GB 201111427 A GB201111427 A GB 201111427A GB 201111427 D0 GB201111427 D0 GB 201111427D0
Authority
GB
United Kingdom
Prior art keywords
inhibitors
bisindolylmaleimides
pan
novel
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GB201111427A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amakem NV
Original Assignee
Amakem NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amakem NV filed Critical Amakem NV
Priority to GB201111427A priority Critical patent/GB201111427D0/en
Publication of GB201111427D0 publication Critical patent/GB201111427D0/en
Priority to PCT/EP2012/062951 priority patent/WO2013004709A1/en
Ceased legal-status Critical Current

Links

Abstract

The present invention relates to new kinase inhibitors, more specifically soft PKC inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new soft PKC inhibitors compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including autoimmune and inflammatory diseases.
GB201111427A 2011-07-05 2011-07-05 Novel bisindolylmaleimides, pan-pkc inhibitors Ceased GB201111427D0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB201111427A GB201111427D0 (en) 2011-07-05 2011-07-05 Novel bisindolylmaleimides, pan-pkc inhibitors
PCT/EP2012/062951 WO2013004709A1 (en) 2011-07-05 2012-07-04 Indolylmaleimides as soft pan-pkc inhibitors

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB201111427A GB201111427D0 (en) 2011-07-05 2011-07-05 Novel bisindolylmaleimides, pan-pkc inhibitors

Publications (1)

Publication Number Publication Date
GB201111427D0 true GB201111427D0 (en) 2011-08-17

Family

ID=44512094

Family Applications (1)

Application Number Title Priority Date Filing Date
GB201111427A Ceased GB201111427D0 (en) 2011-07-05 2011-07-05 Novel bisindolylmaleimides, pan-pkc inhibitors

Country Status (2)

Country Link
GB (1) GB201111427D0 (en)
WO (1) WO2013004709A1 (en)

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL89167A (en) * 1988-02-10 1994-02-27 Hoffmann La Roche Substituted pyrroles, their manufacture and pharmaceutical compositions containing them
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
PE91698A1 (en) * 1996-07-29 1998-12-24 Hoffmann La Roche SUBSTITUTED PYRROLES
PE91598A1 (en) * 1996-07-29 1998-12-24 Hoffmann La Roche SUBSTITUTED PYRROLES
GB9828640D0 (en) * 1998-12-23 1999-02-17 Smithkline Beecham Plc Novel method and compounds
WO2001044247A2 (en) * 1999-12-16 2001-06-21 Eli Lilly And Company Agents and methods for the treatment of proliferative diseases
SG159378A1 (en) * 2000-11-07 2010-03-30 Novartis Ag Indolylmaleimide derivatives as protein kinase c inhibitors
EP1645286A1 (en) * 2003-04-18 2006-04-12 Kyowa Hakko Kogyo Co., Ltd. Drug for nerve regeneration
BRPI0613064A2 (en) * 2005-07-11 2010-12-21 Novartis Ag indolylmaleimide derivatives as protein kinase inhibitors
ES2410955T3 (en) * 2006-12-19 2013-07-04 Novartis Ag Indolylmaleimide derivatives as kinase inhibitors
EP2125683B1 (en) * 2006-12-19 2013-10-23 The Board of Trustees of the University of Illinois 3-benzofuranyl-4-indolyl-maleimides as potent gsk-3 inhibitors for neurodegenerative disorders

Also Published As

Publication number Publication date
WO2013004709A1 (en) 2013-01-10

Similar Documents

Publication Publication Date Title
MX2013011908A (en) Compositions and therapeutic uses of ikk-related kinase epsilon and tankbinding kinase 1 inhibitors.
GB201118656D0 (en) New compounds
JO3366B1 (en) Pyrazolyl Quinoxaline Kinase Inhibitors
PH12015500587A1 (en) Combination of regorafenib and acetylsalicylic acid for treating cancer
IN2012DN02805A (en)
AU2012214029A8 (en) Rorgammat inhibitors
NZ720478A (en) Autotaxin inhibitor compounds
MX349004B (en) New compounds.
TN2014000175A1 (en) Novel purine derivatives and their use in the treatment of disease
TN2012000534A1 (en) Pyrazole compounds as sigma receptor inhibitors
MX2013008192A (en) Bace-2 inhibitors for the treatment of metabolic disorders.
WO2011107608A8 (en) Heterocyclic amides as rock inhibitors
MY181602A (en) Isochromene derivatives as phosphoinositide 3-kinases inhibitors
PH12014501967A1 (en) Benzodioxanes in combination with other actives for inhibiting leukotriene production
MX342924B (en) Novel disubstituted 3,4-diamino-3-cyclobutene-1,2-dione compounds for use in the treatment of chemokine-mediated diseases.
MX2014002393A (en) Novel soft rock inhibitors.
IN2015DN02912A (en)
EA032271B9 (en) Compounds, pharmaceutical composition and methods for use in treating inflammatory diseases
MX2015008187A (en) Deuterated alk inhibitors.
EA201370230A1 (en) NEW ROCK INHIBITORS
MX2015003535A (en) Dihydropyrrolidino-pyrimidines as kinase inhibitors.
MX2015008912A (en) Pyrazolyl-based carboxamides ii as crac channel inhibitors.
UA111520C2 (en) [1,2,4]triazolopyridine compounds and used thereof as phosphodiesterase inhibitors
IN2014DN03010A (en)
MX362485B (en) Novel rock inhibitors.

Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)