MX2009012719A - Tiazoles y pirazoles utiles como inhibidores de cinasa. - Google Patents

Tiazoles y pirazoles utiles como inhibidores de cinasa.

Info

Publication number
MX2009012719A
MX2009012719A MX2009012719A MX2009012719A MX2009012719A MX 2009012719 A MX2009012719 A MX 2009012719A MX 2009012719 A MX2009012719 A MX 2009012719A MX 2009012719 A MX2009012719 A MX 2009012719A MX 2009012719 A MX2009012719 A MX 2009012719A
Authority
MX
Mexico
Prior art keywords
thiazoles
kinase inhibitors
compounds
pyrazoles useful
useful
Prior art date
Application number
MX2009012719A
Other languages
English (en)
Inventor
Michael Mortimore
Julian Golec
John Studley
Christopher Davis
Daniel Robinson
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MX2009012719A publication Critical patent/MX2009012719A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a compuestos útiles como inhibidores de proteína cinasa Aurora. La invención también proporciona composiciones farmacéuticamente aceptables que comprenden aquellos compuestos y métodos para usar los compuestos y composiciones en el tratamiento de varias enfermedades, condiciones, y trastornos. La invención también proporciona procesos para la preparación de compuestos de la invención.
MX2009012719A 2007-05-24 2008-05-02 Tiazoles y pirazoles utiles como inhibidores de cinasa. MX2009012719A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93987607P 2007-05-24 2007-05-24
PCT/US2008/062331 WO2008147626A2 (en) 2007-05-24 2008-05-02 Thiazoles and pyrazoles useful as kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2009012719A true MX2009012719A (es) 2010-02-04

Family

ID=39926662

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009012719A MX2009012719A (es) 2007-05-24 2008-05-02 Tiazoles y pirazoles utiles como inhibidores de cinasa.

Country Status (8)

Country Link
US (1) US20110060013A1 (es)
EP (1) EP2164842A2 (es)
JP (2) JP2010528021A (es)
CN (1) CN101687852A (es)
AU (1) AU2008257044A1 (es)
CA (1) CA2687966A1 (es)
MX (1) MX2009012719A (es)
WO (1) WO2008147626A2 (es)

Families Citing this family (24)

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DE60120193T2 (de) 2000-09-15 2007-03-29 Vertex Pharmaceuticals Inc., Cambridge Pyrazolverbindungen als protein-kinasehemmer
WO2004072029A2 (en) 2003-02-06 2004-08-26 Vertex Pharmaceuticals Incorporated Pyrazolopyridazines useful as inhibitors of protein kinases
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JP2010509231A (ja) 2006-11-02 2010-03-25 バーテックス ファーマシューティカルズ インコーポレイテッド プロテインキナーゼの阻害剤として有用なアミノピリジンおよびアミノピリミジン
AU2007333650A1 (en) 2006-12-19 2008-06-26 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as inhibitors of protein kinases
ES2435997T3 (es) 2007-03-09 2013-12-26 Vertex Pharmaceuticals, Inc. Aminopirimidinas útiles como inhibidores de las proteínas cinasas
EP2137183B1 (en) 2007-03-09 2011-09-28 Vertex Pharmaceuticals Incorporated Aminopyrimidines useful as inhibitors of protein kinases
AU2008226461A1 (en) 2007-03-09 2008-09-18 Vertex Pharmaceuticals Incorporated Aminopyridines useful as inhibitors of protein kinases
JP2010523700A (ja) 2007-04-13 2010-07-15 バーテックス ファーマシューティカルズ インコーポレイテッド キナーゼインヒビターとして有用なアミノピリミジン
CA2685876A1 (en) 2007-05-02 2008-11-13 Vertex Pharmaceuticals Incorporated Thiazoles and pyrazoles useful as kinase inhibitors
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US8815877B2 (en) 2011-12-22 2014-08-26 Genentech, Inc. Serine/threonine kinase inhibitors
HUE054031T2 (hu) 2012-04-24 2021-08-30 Vertex Pharma DNS-PK inhibitorok
HUE041544T2 (hu) 2013-03-12 2019-05-28 Vertex Pharma DNS-PK inhibitorok
SI3057953T1 (sl) 2013-10-17 2018-12-31 Vertex Pharmaceuticals Incorporated Ko-kristali(s)-n-metil-8-(1-((2'-metil-(4,5'-bipimiridin)-6-il)amino) propan-2-il)kinolin-4-karboksamida in njegovi devterirani derivati kot inhibitorji dna-pk
EP3302465A1 (en) 2015-06-05 2018-04-11 Vertex Pharmaceuticals Incorporated Triazoles for the treatment of demyelinating diseases
US11214565B2 (en) 2015-11-20 2022-01-04 Denali Therapeutics Inc. Compound, compositions, and methods
US11028080B2 (en) 2016-03-11 2021-06-08 Denali Therapeutics Inc. Substituted pyrimidines as LRKK2 inhibitors
UA126231C2 (uk) 2016-06-16 2022-09-07 Деналі Терапьютікс Інк. Піримідин-2-іламіно-1н-піразоли як інгібітори lrrk2 для застосування при лікуванні нейродегенеративних захворювань
CA3038657A1 (en) 2016-09-27 2018-04-05 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of dna-damaging agents and dna-pk inhibitors

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Also Published As

Publication number Publication date
US20110060013A1 (en) 2011-03-10
JP2010528021A (ja) 2010-08-19
JP2014141529A (ja) 2014-08-07
CN101687852A (zh) 2010-03-31
AU2008257044A1 (en) 2008-12-04
WO2008147626A2 (en) 2008-12-04
EP2164842A2 (en) 2010-03-24
CA2687966A1 (en) 2008-12-04
WO2008147626A3 (en) 2009-03-19

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Legal Events

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FA Abandonment or withdrawal