BR112016026552A8 - derivados de carboxamida, seus usos, composição farmacêutica, e combinação - Google Patents

derivados de carboxamida, seus usos, composição farmacêutica, e combinação

Info

Publication number
BR112016026552A8
BR112016026552A8 BR112016026552A BR112016026552A BR112016026552A8 BR 112016026552 A8 BR112016026552 A8 BR 112016026552A8 BR 112016026552 A BR112016026552 A BR 112016026552A BR 112016026552 A BR112016026552 A BR 112016026552A BR 112016026552 A8 BR112016026552 A8 BR 112016026552A8
Authority
BR
Brazil
Prior art keywords
combination
pharmaceutical composition
carboxamide derivatives
present
compounds
Prior art date
Application number
BR112016026552A
Other languages
English (en)
Other versions
BR112016026552B1 (pt
BR112016026552A2 (pt
Inventor
Anne-Marie D'souza
Mahbub Ahmed
Robert Alexander Pulz
Lisa Ann Rooney
Nichola Smith
Thomas Josef Troxler
Kamlesh Jagdis Bala
Andrew Brearley
James Dale
David Porter
David Andrew Sandham
Duncan Shaw
Jessica Louise Taylor
Roger John Taylor
Joe Wrigglesworth
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50735903&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112016026552(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR112016026552A2 publication Critical patent/BR112016026552A2/pt
Publication of BR112016026552A8 publication Critical patent/BR112016026552A8/pt
Publication of BR112016026552B1 publication Critical patent/BR112016026552B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

derivados de carboxamida, seus usos, composição farmacêutica, e combinação. a presente invenção forneceu um composto de fórmula (i) ou um sal farmaceuticamente aceitável do mesmo; (i) um método para a fabricação dos compostos da invenção, e seus usos terapêuticos. a presente invenção proporciona ainda uma combinação de agentes farmacologicamente ativos e uma composição farmacêutica.
BR112016026552-1A 2014-05-14 2015-05-14 Derivados de carboxamida, seus usos, composição farmacêutica, e combinação BR112016026552B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14168303 2014-05-14
EP14168303.7 2014-05-14
PCT/US2015/030817 WO2015175796A1 (en) 2014-05-14 2015-05-14 Carboxamide derivatives

Publications (3)

Publication Number Publication Date
BR112016026552A2 BR112016026552A2 (pt) 2017-08-15
BR112016026552A8 true BR112016026552A8 (pt) 2021-07-06
BR112016026552B1 BR112016026552B1 (pt) 2023-02-14

Family

ID=50735903

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016026552-1A BR112016026552B1 (pt) 2014-05-14 2015-05-14 Derivados de carboxamida, seus usos, composição farmacêutica, e combinação

Country Status (38)

Country Link
US (6) US9403810B2 (pt)
EP (1) EP3143018B1 (pt)
JP (1) JP6523338B2 (pt)
KR (2) KR20230074827A (pt)
CN (1) CN106661012B (pt)
AP (1) AP2016009550A0 (pt)
AR (1) AR100440A1 (pt)
AU (1) AU2015259083B2 (pt)
BR (1) BR112016026552B1 (pt)
CA (1) CA2948543C (pt)
CL (1) CL2016002839A1 (pt)
CR (1) CR20160527A (pt)
CU (1) CU24434B1 (pt)
CY (1) CY1124251T1 (pt)
DK (1) DK3143018T3 (pt)
EA (1) EA030938B1 (pt)
ES (1) ES2874882T3 (pt)
HR (1) HRP20210783T1 (pt)
HU (1) HUE054590T2 (pt)
IL (1) IL248785B (pt)
JO (1) JO3610B1 (pt)
LT (1) LT3143018T (pt)
MA (1) MA39983B1 (pt)
MX (1) MX2016014939A (pt)
MY (1) MY186598A (pt)
PE (1) PE20171443A1 (pt)
PH (1) PH12016502246A1 (pt)
PL (1) PL3143018T3 (pt)
PT (1) PT3143018T (pt)
RS (1) RS61874B1 (pt)
SG (1) SG11201609217UA (pt)
SI (1) SI3143018T1 (pt)
SV (1) SV2016005313A (pt)
TN (1) TN2016000489A1 (pt)
TW (2) TW201946921A (pt)
UY (1) UY36124A (pt)
WO (1) WO2015175796A1 (pt)
ZA (1) ZA201607658B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201623288A (zh) 2014-05-14 2016-07-01 諾華公司 甲醯胺衍生物
US9403810B2 (en) 2014-05-14 2016-08-02 Novartis Ag Carboxamide derivatives
KR20200083528A (ko) * 2017-11-01 2020-07-08 브리스톨-마이어스 스큅 컴퍼니 파르네소이드 x 수용체 조정제로서의 스피로시클릭 화합물
CN108689976B (zh) * 2018-07-23 2021-12-28 陕西师范大学 5-磺基水杨酸协同二氯二茂钛催化合成4-碘代四氢吡喃衍生物的方法
MX2023002850A (es) 2020-09-10 2023-07-07 Precirix N V Fragmento de anticuerpo contra proteina activadora de fibroblastos (fap).
WO2023203135A1 (en) 2022-04-22 2023-10-26 Precirix N.V. Improved radiolabelled antibody
WO2023213801A1 (en) 2022-05-02 2023-11-09 Precirix N.V. Pre-targeting

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2655009A1 (de) * 1976-12-04 1978-06-15 Hoechst Ag Isoxazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
JP2003502064A (ja) * 1999-06-11 2003-01-21 ザ リサーチ ファウンデーション オブ ステイト ユニバーシティー オブ ニューヨーク ＢＭＰおよびＴＧＦβシグナル伝達経路のアンタゴニスト
US7354722B1 (en) 1999-06-11 2008-04-08 Signal Pharmaceuticals Modulators of Smurf and BMP/TGFβ signaling pathways
EP1631260A2 (en) 2003-02-28 2006-03-08 Transform Pharmaceuticals, Inc. Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen
GB0312368D0 (en) 2003-05-30 2003-07-02 Univ Aston Novel ureido- and amido-pyrazolone derivatives
WO2005030128A2 (en) 2003-09-23 2005-04-07 Merck & Co., Inc. Pyrazole modulators of metabotropic glutamate receptors
US7291743B2 (en) 2005-03-29 2007-11-06 Geneblue Corporation Isoxazole derivatives and methods of treating nitric oxide mediated diseases
WO2008121861A2 (en) 2007-03-28 2008-10-09 Xenon Pharmaceuticals Inc. Pyrazole and pyrrole compounds useful in treating iron disorders
US20090069288A1 (en) 2007-07-16 2009-03-12 Breinlinger Eric C Novel therapeutic compounds
ATE524450T1 (de) 2007-08-02 2011-09-15 Organon Nv 5-phenyl-isoxazol-3-carboxamid-derivate als trpv1-modulatoren
PL2190825T3 (pl) 2007-08-22 2014-09-30 Novartis Ag Związki 5-(4-(chlorowcoalkoksy)-fenylo)-pirymidyno-2-aminowe i kompozycje jako inhibitory kinazy
AU2008345225A1 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
WO2011151361A1 (en) 2010-06-03 2011-12-08 Glaxo Group Limited Novel compounds
ES2541531T3 (es) 2011-02-18 2015-07-21 Actelion Pharmaceuticals Ltd. Nuevos derivados de pirazol e imidazol útiles como antagonistas de orexina
US9403810B2 (en) 2014-05-14 2016-08-02 Novartis Ag Carboxamide derivatives
US20170088546A1 (en) * 2014-05-14 2017-03-30 Novartis Ag Carboxamide inhibitors
TW201623288A (zh) * 2014-05-14 2016-07-01 諾華公司 甲醯胺衍生物
MX2016014878A (es) 2014-05-14 2017-03-08 Pfizer Pirazolopiridinas y pirazolopirimidinas.

Also Published As

Publication number Publication date
KR20170003666A (ko) 2017-01-09
JP6523338B2 (ja) 2019-05-29
CU20160166A7 (es) 2017-03-03
PL3143018T3 (pl) 2021-08-30
CN106661012B (zh) 2019-12-20
WO2015175796A1 (en) 2015-11-19
EP3143018B1 (en) 2021-03-10
US20170014388A1 (en) 2017-01-19
US20190381011A1 (en) 2019-12-19
AP2016009550A0 (en) 2016-11-30
CN106661012A (zh) 2017-05-10
BR112016026552B1 (pt) 2023-02-14
LT3143018T (lt) 2021-06-10
CA2948543C (en) 2022-08-16
TN2016000489A1 (en) 2018-04-04
PT3143018T (pt) 2021-06-01
DK3143018T3 (da) 2021-05-31
US20230301970A1 (en) 2023-09-28
CY1124251T1 (el) 2022-07-22
BR112016026552A2 (pt) 2017-08-15
AU2015259083A1 (en) 2016-11-24
EA201692300A1 (ru) 2017-04-28
TW201623296A (zh) 2016-07-01
UY36124A (es) 2016-01-08
NZ725918A (en) 2023-09-29
US10195181B2 (en) 2019-02-05
ES2874882T3 (es) 2021-11-05
HRP20210783T1 (hr) 2021-06-25
PH12016502246B1 (en) 2017-01-09
MA39983A (fr) 2017-03-22
SV2016005313A (es) 2018-06-12
SI3143018T1 (sl) 2021-08-31
PH12016502246A1 (en) 2017-01-09
AR100440A1 (es) 2016-10-05
CR20160527A (es) 2017-04-28
RS61874B1 (sr) 2021-06-30
US9403810B2 (en) 2016-08-02
CL2016002839A1 (es) 2017-01-27
IL248785B (en) 2020-04-30
MY186598A (en) 2021-07-29
TW201946921A (zh) 2019-12-16
AU2015259083B2 (en) 2017-09-14
JP2017515853A (ja) 2017-06-15
US11672782B2 (en) 2023-06-13
SG11201609217UA (en) 2016-12-29
CA2948543A1 (en) 2015-11-19
TWI714528B (zh) 2021-01-01
US20210052554A1 (en) 2021-02-25
PE20171443A1 (es) 2017-09-29
ZA201607658B (en) 2017-09-27
IL248785A0 (en) 2017-01-31
MX2016014939A (es) 2017-02-28
US20200268718A1 (en) 2020-08-27
EA030938B1 (ru) 2018-10-31
JO3610B1 (ar) 2020-08-27
HUE054590T2 (hu) 2021-09-28
KR20230074827A (ko) 2023-05-31
MA39983B1 (fr) 2021-05-31
KR102534033B1 (ko) 2023-05-19
US20150329529A1 (en) 2015-11-19
EP3143018A1 (en) 2017-03-22
CU24434B1 (es) 2019-09-04

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