MX342177B - Inhibidores de cinasa 2 de repeticion rica en leucina (lrrk2) macrociclica. - Google Patents

Inhibidores de cinasa 2 de repeticion rica en leucina (lrrk2) macrociclica.

Info

Publication number
MX342177B
MX342177B MX2014003557A MX2014003557A MX342177B MX 342177 B MX342177 B MX 342177B MX 2014003557 A MX2014003557 A MX 2014003557A MX 2014003557 A MX2014003557 A MX 2014003557A MX 342177 B MX342177 B MX 342177B
Authority
MX
Mexico
Prior art keywords
kinase inhibitors
compounds
disease
lrrk2 kinase
lrrk2
Prior art date
Application number
MX2014003557A
Other languages
English (en)
Other versions
MX2014003557A (es
Inventor
Hoflack Jan
Blom Petra
Original Assignee
Ipsen Pharma Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ipsen Pharma Sas filed Critical Ipsen Pharma Sas
Publication of MX2014003557A publication Critical patent/MX2014003557A/es
Publication of MX342177B publication Critical patent/MX342177B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/504—Pyridazines; Hydrogenated pyridazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D515/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D515/18—Bridged systems

Abstract

La presente invención se refiere a nuevos compuestos macrocíclicos y composiciones que contienen tales compuestos que actúan como inhibidores de cinasa, en particular como inhibidores de LRRK2 (Cinasa 2 de Repetición Rica en Leucina). Sin embargo, la presente invención proporciona procesos para la preparación de los compuestos descritos, así como también métodos para usarlos, por ejemplo como un medicamento o agente de diagnóstico, en particular para el tratamiento y/o diagnóstico de enfermedades caracterizadas por actividad de cinasa LRRK2 tales como trastornos neurológicos que incluyen enfermedad de Parkinson y enfermedad de Alzheimer.
MX2014003557A 2011-09-30 2012-09-28 Inhibidores de cinasa 2 de repeticion rica en leucina (lrrk2) macrociclica. MX342177B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP2011067086 2011-09-30
PCT/IB2012/002318 WO2013046029A1 (en) 2011-09-30 2012-09-28 Macrocyclic lrrk2 kinase inhibitors

Publications (2)

Publication Number Publication Date
MX2014003557A MX2014003557A (es) 2014-11-26
MX342177B true MX342177B (es) 2016-09-20

Family

ID=47326223

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014003557A MX342177B (es) 2011-09-30 2012-09-28 Inhibidores de cinasa 2 de repeticion rica en leucina (lrrk2) macrociclica.

Country Status (18)

Country Link
US (2) US9096609B2 (es)
EP (1) EP2760453B1 (es)
JP (1) JP6082397B2 (es)
KR (1) KR20140095477A (es)
CN (1) CN104023728B (es)
AU (1) AU2012314035B2 (es)
BR (1) BR112014007654A8 (es)
CA (1) CA2850350A1 (es)
DK (1) DK2760453T3 (es)
ES (1) ES2583477T3 (es)
HK (1) HK1199838A1 (es)
HU (1) HUE029728T2 (es)
MX (1) MX342177B (es)
PL (1) PL2760453T3 (es)
PT (1) PT2760453T (es)
RU (1) RU2622104C2 (es)
UA (1) UA113186C2 (es)
WO (1) WO2013046029A1 (es)

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EP3166637B1 (en) 2014-07-10 2020-01-29 The J. David Gladstone Institutes Compositions and methods for treating dengue virus infection
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WO2018155947A1 (ko) * 2017-02-24 2018-08-30 재단법인 대구경북첨단의료산업진흥재단 혈액 뇌관문을 통과할 수 있는 화합물을 유효성분으로 함유하는 뇌암의 예방 또는 치료용 약학적 조성물
CN110891954A (zh) * 2017-07-14 2020-03-17 葛兰素史密斯克莱知识产权发展有限公司 富含亮氨酸的重复激酶2的抑制剂
CN110627812B (zh) 2018-06-25 2022-10-11 北京诺诚健华医药科技有限公司 作为trk抑制剂的杂环化合物
EP3870579A4 (en) 2018-10-22 2022-10-19 Alumis Inc. TYK2 INHIBITORS AND THEIR USES
CN115996932A (zh) * 2020-05-06 2023-04-21 法国施维雅药厂 新的大环lrrk2激酶抑制剂
EP4308570A1 (en) * 2021-03-18 2024-01-24 Les Laboratoires Servier Macrocyclic lrrk2 kinase inhibitors
WO2023076404A1 (en) 2021-10-27 2023-05-04 Aria Pharmaceuticals, Inc. Methods for treating systemic lupus erythematosus
TW202330549A (zh) * 2021-10-27 2023-08-01 丹麥商Ｈ 朗德貝克公司 Lrrk2抑制劑
WO2023222005A1 (zh) * 2022-05-18 2023-11-23 上海翊石医药科技有限公司 一种芳杂环类化合物及其中间体、药物组合物和用途
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Also Published As

Publication number Publication date
HUE029728T2 (en) 2017-03-28
PT2760453T (pt) 2016-08-02
RU2014117515A (ru) 2015-11-10
US9096609B2 (en) 2015-08-04
PL2760453T3 (pl) 2016-11-30
CA2850350A1 (en) 2013-04-04
EP2760453A1 (en) 2014-08-06
DK2760453T3 (en) 2016-08-15
BR112014007654A2 (pt) 2018-04-17
AU2012314035B2 (en) 2016-12-15
BR112014007654A8 (pt) 2018-06-12
AU2012314035A1 (en) 2014-05-15
CN104023728B (zh) 2016-11-02
US20150290198A1 (en) 2015-10-15
JP2014528405A (ja) 2014-10-27
JP6082397B2 (ja) 2017-02-15
CN104023728A (zh) 2014-09-03
EP2760453B1 (en) 2016-05-25
US9370520B2 (en) 2016-06-21
KR20140095477A (ko) 2014-08-01
MX2014003557A (es) 2014-11-26
UA113186C2 (xx) 2016-12-26
WO2013046029A1 (en) 2013-04-04
ES2583477T3 (es) 2016-09-21
RU2622104C2 (ru) 2017-06-13
HK1199838A1 (en) 2015-07-24
US20140206683A1 (en) 2014-07-24

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