IN2012DN03846A - - Google Patents

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Publication number
IN2012DN03846A
IN2012DN03846A IN3846DEN2012A IN2012DN03846A IN 2012DN03846 A IN2012DN03846 A IN 2012DN03846A IN 3846DEN2012 A IN3846DEN2012 A IN 3846DEN2012A IN 2012DN03846 A IN2012DN03846 A IN 2012DN03846A
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India
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compounds
formula
syndromes
disorders
compositions
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Inventor
J Coats Steven
Bian Haiyan
Cai Chaozhong
L Decorte Bart
Liu Li
J Macielag Mark
L Dax Scott
M Pitis Philip
J Connolly Peter
He Wei
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Janssen Pharmaceutica Nv
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Publication of IN2012DN03846A publication Critical patent/IN2012DN03846A/en

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    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07C211/50Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring having at least two amino groups bound to the carbon skeleton with at least two amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
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    • C07D207/08Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • C07D453/02Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
IN3846DEN2012 2009-10-30 2010-10-28 IN2012DN03846A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25641209P 2009-10-30 2009-10-30
PCT/US2010/054497 WO2011053706A1 (en) 2009-10-30 2010-10-28 4-substituted-2-phenoxy-phenylamine delta opioid receptor modulators

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IN2012DN03846A true IN2012DN03846A (es) 2015-08-28

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US (1) US8846655B2 (es)
EP (1) EP2493852B1 (es)
JP (1) JP5781527B2 (es)
CN (1) CN102741226B (es)
AU (1) AU2010313402B2 (es)
BR (1) BR112012011443A2 (es)
CA (1) CA2779108C (es)
IN (1) IN2012DN03846A (es)
RU (1) RU2553453C2 (es)
WO (1) WO2011053706A1 (es)

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CN102686569B (zh) * 2009-10-30 2014-11-26 詹森药业有限公司 用作阿片类受体调节剂的苯氧基取代嘧啶
WO2011053696A1 (en) * 2009-10-30 2011-05-05 Janssen Pharmaceutica Nv Pyrazines as delta opioid receptor modulators
EP2968359B1 (en) 2013-03-12 2021-01-20 Celltaxis, LLC Methods of inhibiting leukotriene a4 hydrolase
EP2968264A4 (en) * 2013-03-14 2016-11-02 Celtaxsys Inc INHIBITORS OF LEUCOTRIENE A4 HYDROLASE
EP2970309A4 (en) 2013-03-14 2016-11-09 Celtaxsys Inc INHIBITORS OF LEUCOTRIENE A4 HYDROLASE
CN103788019B (zh) * 2014-01-22 2015-10-07 苏州明锐医药科技有限公司 沃替西汀的制备方法
CA2986083A1 (en) * 2015-06-11 2016-12-15 Basilea Pharmaceutica International AG Efflux-pump inhibitors and therapeutic uses thereof
AU2019278935A1 (en) 2018-05-31 2020-12-10 Celltaxis, Llc Method of reducing pulmonary exacerbations in respiratory disease patients

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT86407B (pt) * 1986-12-31 1990-11-20 Fujisawa Pharmaceutical Co Processo para a preparacao de novos derivados de alcano-sulfonanilida, e de composicoes farmaceuticas compreendendo os mesmos
JP4302207B2 (ja) * 1997-08-04 2009-07-22 大正製薬株式会社 アリールオキシアニリン誘導体
DK1049676T3 (da) * 1997-12-24 2006-01-16 Ortho Mcneil Pharm Inc 4-[Aryl(piperidin-4-yl)]aminobenzamider, som binder til delta-opioidreceptoren
UA81749C2 (uk) * 2001-10-04 2008-02-11 Х. Луннбек А/С Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну
CN101115751A (zh) * 2004-12-22 2008-01-30 詹森药业有限公司 三环δ-阿片样物质调节剂
CN101128460A (zh) * 2005-01-06 2008-02-20 詹森药业有限公司 三环的δ-阿片样物质调节剂
WO2008032156A1 (en) * 2006-09-08 2008-03-20 Pfizer Products Inc. Diaryl ether derivatives and uses thereof

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CA2779108C (en) 2018-01-02
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