DE3479726D1 - Benzopyran derivatives. - Google Patents

Benzopyran derivatives.

Info

Publication number
DE3479726D1
DE3479726D1 DE8484104524T DE3479726T DE3479726D1 DE 3479726 D1 DE3479726 D1 DE 3479726D1 DE 8484104524 T DE8484104524 T DE 8484104524T DE 3479726 T DE3479726 T DE 3479726T DE 3479726 D1 DE3479726 D1 DE 3479726D1
Authority
DE
Germany
Prior art keywords
benzopyran derivatives
benzopyran
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484104524T
Other languages
English (en)
Inventor
John Morris Evans
Frederick Cassidy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838313687A external-priority patent/GB8313687D0/en
Priority claimed from GB838334418A external-priority patent/GB8334418D0/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Application granted granted Critical
Publication of DE3479726D1 publication Critical patent/DE3479726D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)
DE8484104524T 1983-05-18 1984-04-21 Benzopyran derivatives. Expired DE3479726D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB838313687A GB8313687D0 (en) 1983-05-18 1983-05-18 Active compounds
GB838334418A GB8334418D0 (en) 1983-12-23 1983-12-23 Active compounds

Publications (1)

Publication Number Publication Date
DE3479726D1 true DE3479726D1 (de) 1989-10-19

Family

ID=26286157

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8484104524T Expired DE3479726D1 (de) 1983-05-18 1984-04-21 Benzopyran derivatives.

Country Status (10)

Country Link
US (1) US4571406A (de)
EP (1) EP0126311B1 (de)
JP (1) JPH0631211B2 (de)
AU (1) AU569513B2 (de)
CA (1) CA1236458A (de)
DE (1) DE3479726D1 (de)
ES (1) ES8601180A1 (de)
GR (1) GR79976B (de)
IE (1) IE57982B1 (de)
NZ (1) NZ208169A (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0126367B1 (de) * 1983-05-18 1994-10-12 Beecham Group Plc Chroman- und Chromenderivate
EP0139992B1 (de) * 1983-09-01 1988-12-28 Beecham Group Plc Chromanol-Derivate
EP0138134B1 (de) * 1983-10-13 1989-04-19 Beecham Group Plc Chroman-Derivate
GB8419515D0 (en) * 1984-07-31 1984-09-05 Beecham Group Plc Treatment
GB8419516D0 (en) * 1984-07-31 1984-09-05 Beecham Group Plc Treatment
GB8513369D0 (en) * 1985-05-28 1985-07-03 Beecham Group Plc Treatment
DE3682331D1 (de) 1985-06-08 1991-12-12 Beecham Group Plc Pyrano(3,2-c)pyridinderivate, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
GB8521857D0 (en) * 1985-09-03 1985-10-09 Beecham Group Plc Active compounds
GB8610911D0 (en) * 1986-05-03 1986-06-11 Beecham Group Plc Active compounds
PT84806B (pt) * 1986-05-03 1989-12-29 Beecham Group Plc Processo para a preparacao de benzopiranos
CA1308108C (en) * 1987-10-27 1992-09-29 Dominick A. Quagliato Antihypertensive benzopyran derivatives
IL88035A0 (en) * 1987-10-27 1989-06-30 American Home Prod Benzopyran derivatives,their preparation and pharmaceutical compositions containing them
GB8800199D0 (en) * 1988-01-06 1988-02-10 Beecham Group Plc Pharmaceutical preparation
US5021432A (en) * 1988-04-26 1991-06-04 Yoshitomi Pharmaceutical Industries, Ltd. Benzopyran compound and its pharmaceutical use
US4988723A (en) * 1988-06-02 1991-01-29 Fujisawa Pharmaceutical Co., Ltd. Benzopyran derivatives and their use as anti-hypertensives
US4992435A (en) * 1988-09-23 1991-02-12 Ortho Pharmaceutical Corporation Substituted thienopyrans as antihypertensive agents
NZ230711A (en) * 1988-09-23 1990-10-26 Ortho Pharma Corp Substituted thienopyrans as antihypertensive agents
US5298512A (en) * 1989-04-07 1994-03-29 Pfizer Inc. Substituted chromans and their use in the treatment of asthma, arthritis and related diseases
ES2030627A6 (es) * 1990-11-28 1992-11-01 Uriach & Cia Sa J Procedimiento para la obtencion de compuestos benzopiranicos.
GB9112721D0 (en) * 1991-06-13 1991-07-31 Smithkline Beecham Plc Novel treatment
US5624954A (en) * 1991-06-13 1997-04-29 Smithkline Beecham P.L.C. Benzo- and pyridopyran derivatives having anxiolytic and anti-convulsant activity
US5453421A (en) * 1992-09-11 1995-09-26 E. R. Squibb & Sons, Inc. Aryl and heterocyclic substituted propenamide derivatives
GR1002276B (el) * 1992-10-08 1996-05-02 Smithkline Beecham P.L.C. Παραγωγα βενζοπυρανιου τα οποια κεκτηνται δραση κνς.
SK281507B6 (sk) * 1992-11-30 2001-04-09 Smithkline Beecham Plc Použitie benzopyránových analógov, benzopyránové analógy, spôsob ich prípravy a farmaceutický prostriedok s ich obsahom
AP360A (en) * 1992-12-04 1994-09-07 Smithkline Beecham Plc Benzo-and pyridopyran derivatives having anxiolytic and anticonvulsant activity.
NZ258610A (en) * 1992-12-11 1997-05-26 Smithkline Beecham Plc Various 4-acylamino-2h-benzo[b]pyran-3-ol derivatives;use in preparation of medicaments
NZ258611A (en) * 1992-12-11 1997-07-27 Smithkline Beecham Plc 4-benzoyl(or heteroarylcarbonyl)amino-3,4-dihydro- 3-hydroxy-2h-benzo[b]pyran derivatives;benzopyrano[4,3-d]oxazole intermediates
US20010021780A1 (en) * 1992-12-11 2001-09-13 Smithkline Beecham P.L.C. Pharmaceutical composition containing bicyclic type compounds
US5837702A (en) * 1993-10-07 1998-11-17 Bristol-Myers Squibb Co. 4-arylamino-benzopyran and related compounds
DE69524871T2 (de) * 1994-06-10 2002-08-22 Smithkline Beecham Plc Benzopyrans und deren verwendung als therapeutische mittel
DE69518322T2 (de) * 1994-06-10 2001-02-15 Smithkline Beecham Plc C-4 amid substituierte verbindungen und deren verwendung als therapeutische mittel
GB9411635D0 (en) 1994-06-10 1994-08-03 Smithkline Beecham Plc Novel treatment
US5574049A (en) * 1994-07-22 1996-11-12 Sandoz Ltd. 2,2-dialkyl- and 2,2-dialkyl-3,4-dihydro-3-hydroxy-2H-1-benzopyrans
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
US7576094B2 (en) * 2004-12-13 2009-08-18 Eli Lilly And Company Spiro derivatives as lipoxygenase inhibitors
US20110016548A1 (en) * 2009-07-16 2011-01-20 University Of Southern California Control of endogenous dnmt1 gene expression by exogenous binary regulatory systems
US20140011773A1 (en) 2012-07-03 2014-01-09 Proximagen Limited Pro-drug Compounds
GB201304814D0 (en) * 2013-03-15 2013-05-01 Proximagen Ltd Pro-drug compounds
CN110183460A (zh) * 2019-04-30 2019-08-30 四川轻化工大学 绵萆薢菲类化合物及应用和提取方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1495526A (en) * 1974-05-31 1977-12-21 Beecham Group Ltd Chroman derivatives
GB1509853A (en) * 1976-01-27 1978-05-04 Beecham Group Ltd 4-amino-3-hydroxy-6-nitrobenzo-pyrans
DE3064286D1 (en) * 1979-09-28 1983-08-25 Beecham Group Plc Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them
EP0028449B1 (de) * 1979-09-28 1983-07-20 Beecham Group Plc Chromanol-Derivate, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzung
EP0046652B1 (de) * 1980-08-21 1985-05-22 Beecham Group Plc Chromanol-Derivate, ihre Herstellung und diese enthaltende Arzneimittel
DE3274350D1 (en) * 1981-09-25 1987-01-08 Beecham Group Plc Pharmaceutically active benzopyran compounds
DE3368057D1 (en) * 1982-05-21 1987-01-15 Beecham Group Plc Pharmaceutically active aminobenzopyrans
EP0126367B1 (de) * 1983-05-18 1994-10-12 Beecham Group Plc Chroman- und Chromenderivate

Also Published As

Publication number Publication date
IE841229L (en) 1984-11-18
IE57982B1 (en) 1993-06-02
AU2808184A (en) 1984-11-22
JPH0631211B2 (ja) 1994-04-27
ES532582A0 (es) 1985-10-16
EP0126311B1 (de) 1989-09-13
EP0126311A3 (en) 1987-05-27
GR79976B (de) 1984-10-31
EP0126311A2 (de) 1984-11-28
JPS59219278A (ja) 1984-12-10
US4571406A (en) 1986-02-18
CA1236458A (en) 1988-05-10
AU569513B2 (en) 1988-02-04
NZ208169A (en) 1987-08-31
ES8601180A1 (es) 1985-10-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition