ES8601180A1 - Un procedimiento para la preparacion de nuevos cromanos y cromenos. - Google Patents

Un procedimiento para la preparacion de nuevos cromanos y cromenos.

Info

Publication number
ES8601180A1
ES8601180A1 ES532582A ES532582A ES8601180A1 ES 8601180 A1 ES8601180 A1 ES 8601180A1 ES 532582 A ES532582 A ES 532582A ES 532582 A ES532582 A ES 532582A ES 8601180 A1 ES8601180 A1 ES 8601180A1
Authority
ES
Spain
Prior art keywords
alkyl
hydrogen
cyano
nitro
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES532582A
Other languages
English (en)
Other versions
ES532582A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838313687A external-priority patent/GB8313687D0/en
Priority claimed from GB838334418A external-priority patent/GB8334418D0/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES532582A0 publication Critical patent/ES532582A0/es
Publication of ES8601180A1 publication Critical patent/ES8601180A1/es
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE CROMANOS Y CROMENOS DE FORMULA GENERAL (I) EN LA QUE R1 YR2 SE CARACTERIZAN PORQUE SI UNO DE ELLOS ES HIDROGENO EL OTRO SE SELECCIONA ENTRE ALQUIL (C1-6) CARBONILO ALCOXI (C1-6) CARBONILO NITRO CLORO CIANO O AMINOSULFINILO; R3 Y R4 SE CXARACTERIZAN PORQUE SI UNO DE ELLOS ES HIDROGENO O ALQUILO EL OTRO ES ALQUILO; R5 ES HIDROGENO HIDROXI O ACILOXI; R6 ES HIDROGENO; R7 ES ARILO O HETEROARILO; R8 ES HIDROGENO O ALQUILO; Y X ES OXIGENO O AZUFRE Y SUS SALES O SOLVATOS FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN ACILAR UN COMPUESTO DE FORMULA GENERAL (II) CON UN AGENTE ACILANTE DE FORMULA GENERAL (III). DE APLICACION EN EL TRATAMIENTO O PROFILAXIS DE MAMIFEROS ESPECIALMENTE MAMIFEROS CON HIPERTENSION.
ES532582A 1983-05-18 1984-05-17 Un procedimiento para la preparacion de nuevos cromanos y cromenos. Expired ES8601180A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB838313687A GB8313687D0 (en) 1983-05-18 1983-05-18 Active compounds
GB838334418A GB8334418D0 (en) 1983-12-23 1983-12-23 Active compounds

Publications (2)

Publication Number Publication Date
ES532582A0 ES532582A0 (es) 1985-10-16
ES8601180A1 true ES8601180A1 (es) 1985-10-16

Family

ID=26286157

Family Applications (1)

Application Number Title Priority Date Filing Date
ES532582A Expired ES8601180A1 (es) 1983-05-18 1984-05-17 Un procedimiento para la preparacion de nuevos cromanos y cromenos.

Country Status (10)

Country Link
US (1) US4571406A (es)
EP (1) EP0126311B1 (es)
JP (1) JPH0631211B2 (es)
AU (1) AU569513B2 (es)
CA (1) CA1236458A (es)
DE (1) DE3479726D1 (es)
ES (1) ES8601180A1 (es)
GR (1) GR79976B (es)
IE (1) IE57982B1 (es)
NZ (1) NZ208169A (es)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0126367B1 (en) * 1983-05-18 1994-10-12 Beecham Group Plc Chroman and chromene derivatives
DE3475786D1 (de) * 1983-09-01 1989-02-02 Beecham Group Plc Chromanol derivatives
EP0138134B1 (en) * 1983-10-13 1989-04-19 Beecham Group Plc Chroman derivatives
GB8419516D0 (en) * 1984-07-31 1984-09-05 Beecham Group Plc Treatment
GB8419515D0 (en) * 1984-07-31 1984-09-05 Beecham Group Plc Treatment
GB8513369D0 (en) * 1985-05-28 1985-07-03 Beecham Group Plc Treatment
DE3682331D1 (de) 1985-06-08 1991-12-12 Beecham Group Plc Pyrano(3,2-c)pyridinderivate, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
GB8521857D0 (en) * 1985-09-03 1985-10-09 Beecham Group Plc Active compounds
PT84806B (pt) * 1986-05-03 1989-12-29 Beecham Group Plc Processo para a preparacao de benzopiranos
GB8610911D0 (en) * 1986-05-03 1986-06-11 Beecham Group Plc Active compounds
CA1308108C (en) * 1987-10-27 1992-09-29 Dominick A. Quagliato Antihypertensive benzopyran derivatives
IL88035A0 (en) * 1987-10-27 1989-06-30 American Home Prod Benzopyran derivatives,their preparation and pharmaceutical compositions containing them
GB8800199D0 (en) * 1988-01-06 1988-02-10 Beecham Group Plc Pharmaceutical preparation
US5021432A (en) * 1988-04-26 1991-06-04 Yoshitomi Pharmaceutical Industries, Ltd. Benzopyran compound and its pharmaceutical use
US4988723A (en) * 1988-06-02 1991-01-29 Fujisawa Pharmaceutical Co., Ltd. Benzopyran derivatives and their use as anti-hypertensives
NZ230711A (en) * 1988-09-23 1990-10-26 Ortho Pharma Corp Substituted thienopyrans as antihypertensive agents
US4992435A (en) * 1988-09-23 1991-02-12 Ortho Pharmaceutical Corporation Substituted thienopyrans as antihypertensive agents
WO1990012010A1 (en) * 1989-04-07 1990-10-18 Pfizer Inc. Substituted chromans in the treatment of asthma, arthritis and related diseases
ES2030627A6 (es) * 1990-11-28 1992-11-01 Uriach & Cia Sa J Procedimiento para la obtencion de compuestos benzopiranicos.
US5624954A (en) * 1991-06-13 1997-04-29 Smithkline Beecham P.L.C. Benzo- and pyridopyran derivatives having anxiolytic and anti-convulsant activity
GB9112721D0 (en) * 1991-06-13 1991-07-31 Smithkline Beecham Plc Novel treatment
US5453421A (en) * 1992-09-11 1995-09-26 E. R. Squibb & Sons, Inc. Aryl and heterocyclic substituted propenamide derivatives
GR1002276B (el) * 1992-10-08 1996-05-02 Smithkline Beecham P.L.C. Παραγωγα βενζοπυρανιου τα οποια κεκτηνται δραση κνς.
CZ282172B6 (cs) * 1992-11-30 1997-05-14 Smithkline Beecham Plc Benzpyranové analogy pro léčení úzkosti, mánie, deprese nebo symptomů po přerušení podávání drog nebo léčiv, způsob přípravy těchto sloučenin, jejich použití a farmaceutický prostředek obsahující tyto sloučeniny
AP360A (en) * 1992-12-04 1994-09-07 Smithkline Beecham Plc Benzo-and pyridopyran derivatives having anxiolytic and anticonvulsant activity.
SG49907A1 (en) * 1992-12-11 1998-06-15 Smithkline Beecham Corp Pharmaceutical composition containing bicyclic type compounds
JPH08505132A (ja) * 1992-12-11 1996-06-04 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 医薬活性を有する二環式化合物
US20010021780A1 (en) * 1992-12-11 2001-09-13 Smithkline Beecham P.L.C. Pharmaceutical composition containing bicyclic type compounds
US5837702A (en) * 1993-10-07 1998-11-17 Bristol-Myers Squibb Co. 4-arylamino-benzopyran and related compounds
CZ286081B6 (cs) * 1994-06-10 2000-01-12 Smithkline Beecham P. L. C. Benzopyrany a jejich použití jako terapeutických činidel
GB9411635D0 (en) * 1994-06-10 1994-08-03 Smithkline Beecham Plc Novel treatment
DE69518322T2 (de) * 1994-06-10 2001-02-15 Smithkline Beecham P.L.C., Brentford C-4 amid substituierte verbindungen und deren verwendung als therapeutische mittel
US5574049A (en) * 1994-07-22 1996-11-12 Sandoz Ltd. 2,2-dialkyl- and 2,2-dialkyl-3,4-dihydro-3-hydroxy-2H-1-benzopyrans
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
MX2007007103A (es) * 2004-12-13 2008-03-10 Lilly Co Eli Derivados espiro como inhibidores de lipoxigenasa.
US20110016548A1 (en) * 2009-07-16 2011-01-20 University Of Southern California Control of endogenous dnmt1 gene expression by exogenous binary regulatory systems
US9499510B2 (en) 2012-07-03 2016-11-22 Proximagen Limited Pro-drug compounds
GB201304814D0 (en) * 2013-03-15 2013-05-01 Proximagen Ltd Pro-drug compounds
CN110183460A (zh) * 2019-04-30 2019-08-30 四川轻化工大学 绵萆薢菲类化合物及应用和提取方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1495526A (en) * 1974-05-31 1977-12-21 Beecham Group Ltd Chroman derivatives
GB1509853A (en) * 1976-01-27 1978-05-04 Beecham Group Ltd 4-amino-3-hydroxy-6-nitrobenzo-pyrans
EP0028064B1 (en) * 1979-09-28 1983-07-20 Beecham Group Plc Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them
DE3064285D1 (en) * 1979-09-28 1983-08-25 Beecham Group Plc Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them
DE3170604D1 (en) * 1980-08-21 1985-06-27 Beecham Group Plc Chromanol derivatives, their production and pharmaceutical compositions containing them
EP0076075B1 (en) * 1981-09-25 1986-11-20 Beecham Group Plc Pharmaceutically active benzopyran compounds
DE3368057D1 (en) * 1982-05-21 1987-01-15 Beecham Group Plc Pharmaceutically active aminobenzopyrans
EP0126367B1 (en) * 1983-05-18 1994-10-12 Beecham Group Plc Chroman and chromene derivatives

Also Published As

Publication number Publication date
GR79976B (es) 1984-10-31
DE3479726D1 (de) 1989-10-19
ES532582A0 (es) 1985-10-16
CA1236458A (en) 1988-05-10
AU569513B2 (en) 1988-02-04
NZ208169A (en) 1987-08-31
IE841229L (en) 1984-11-18
JPS59219278A (ja) 1984-12-10
EP0126311A3 (en) 1987-05-27
EP0126311B1 (en) 1989-09-13
JPH0631211B2 (ja) 1994-04-27
AU2808184A (en) 1984-11-22
EP0126311A2 (en) 1984-11-28
IE57982B1 (en) 1993-06-02
US4571406A (en) 1986-02-18

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