ES8601180A1 - Un procedimiento para la preparacion de nuevos cromanos y cromenos. - Google Patents
Un procedimiento para la preparacion de nuevos cromanos y cromenos.Info
- Publication number
- ES8601180A1 ES8601180A1 ES532582A ES532582A ES8601180A1 ES 8601180 A1 ES8601180 A1 ES 8601180A1 ES 532582 A ES532582 A ES 532582A ES 532582 A ES532582 A ES 532582A ES 8601180 A1 ES8601180 A1 ES 8601180A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- hydrogen
- cyano
- nitro
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE CROMANOS Y CROMENOS DE FORMULA GENERAL (I) EN LA QUE R1 YR2 SE CARACTERIZAN PORQUE SI UNO DE ELLOS ES HIDROGENO EL OTRO SE SELECCIONA ENTRE ALQUIL (C1-6) CARBONILO ALCOXI (C1-6) CARBONILO NITRO CLORO CIANO O AMINOSULFINILO; R3 Y R4 SE CXARACTERIZAN PORQUE SI UNO DE ELLOS ES HIDROGENO O ALQUILO EL OTRO ES ALQUILO; R5 ES HIDROGENO HIDROXI O ACILOXI; R6 ES HIDROGENO; R7 ES ARILO O HETEROARILO; R8 ES HIDROGENO O ALQUILO; Y X ES OXIGENO O AZUFRE Y SUS SALES O SOLVATOS FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN ACILAR UN COMPUESTO DE FORMULA GENERAL (II) CON UN AGENTE ACILANTE DE FORMULA GENERAL (III). DE APLICACION EN EL TRATAMIENTO O PROFILAXIS DE MAMIFEROS ESPECIALMENTE MAMIFEROS CON HIPERTENSION.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB838313687A GB8313687D0 (en) | 1983-05-18 | 1983-05-18 | Active compounds |
GB838334418A GB8334418D0 (en) | 1983-12-23 | 1983-12-23 | Active compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
ES532582A0 ES532582A0 (es) | 1985-10-16 |
ES8601180A1 true ES8601180A1 (es) | 1985-10-16 |
Family
ID=26286157
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES532582A Expired ES8601180A1 (es) | 1983-05-18 | 1984-05-17 | Un procedimiento para la preparacion de nuevos cromanos y cromenos. |
Country Status (10)
Country | Link |
---|---|
US (1) | US4571406A (es) |
EP (1) | EP0126311B1 (es) |
JP (1) | JPH0631211B2 (es) |
AU (1) | AU569513B2 (es) |
CA (1) | CA1236458A (es) |
DE (1) | DE3479726D1 (es) |
ES (1) | ES8601180A1 (es) |
GR (1) | GR79976B (es) |
IE (1) | IE57982B1 (es) |
NZ (1) | NZ208169A (es) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0126367B1 (en) * | 1983-05-18 | 1994-10-12 | Beecham Group Plc | Chroman and chromene derivatives |
DE3475786D1 (de) * | 1983-09-01 | 1989-02-02 | Beecham Group Plc | Chromanol derivatives |
EP0138134B1 (en) * | 1983-10-13 | 1989-04-19 | Beecham Group Plc | Chroman derivatives |
GB8419516D0 (en) * | 1984-07-31 | 1984-09-05 | Beecham Group Plc | Treatment |
GB8419515D0 (en) * | 1984-07-31 | 1984-09-05 | Beecham Group Plc | Treatment |
GB8513369D0 (en) * | 1985-05-28 | 1985-07-03 | Beecham Group Plc | Treatment |
DE3682331D1 (de) | 1985-06-08 | 1991-12-12 | Beecham Group Plc | Pyrano(3,2-c)pyridinderivate, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen. |
GB8521857D0 (en) * | 1985-09-03 | 1985-10-09 | Beecham Group Plc | Active compounds |
PT84806B (pt) * | 1986-05-03 | 1989-12-29 | Beecham Group Plc | Processo para a preparacao de benzopiranos |
GB8610911D0 (en) * | 1986-05-03 | 1986-06-11 | Beecham Group Plc | Active compounds |
CA1308108C (en) * | 1987-10-27 | 1992-09-29 | Dominick A. Quagliato | Antihypertensive benzopyran derivatives |
IL88035A0 (en) * | 1987-10-27 | 1989-06-30 | American Home Prod | Benzopyran derivatives,their preparation and pharmaceutical compositions containing them |
GB8800199D0 (en) * | 1988-01-06 | 1988-02-10 | Beecham Group Plc | Pharmaceutical preparation |
US5021432A (en) * | 1988-04-26 | 1991-06-04 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzopyran compound and its pharmaceutical use |
US4988723A (en) * | 1988-06-02 | 1991-01-29 | Fujisawa Pharmaceutical Co., Ltd. | Benzopyran derivatives and their use as anti-hypertensives |
NZ230711A (en) * | 1988-09-23 | 1990-10-26 | Ortho Pharma Corp | Substituted thienopyrans as antihypertensive agents |
US4992435A (en) * | 1988-09-23 | 1991-02-12 | Ortho Pharmaceutical Corporation | Substituted thienopyrans as antihypertensive agents |
WO1990012010A1 (en) * | 1989-04-07 | 1990-10-18 | Pfizer Inc. | Substituted chromans in the treatment of asthma, arthritis and related diseases |
ES2030627A6 (es) * | 1990-11-28 | 1992-11-01 | Uriach & Cia Sa J | Procedimiento para la obtencion de compuestos benzopiranicos. |
US5624954A (en) * | 1991-06-13 | 1997-04-29 | Smithkline Beecham P.L.C. | Benzo- and pyridopyran derivatives having anxiolytic and anti-convulsant activity |
GB9112721D0 (en) * | 1991-06-13 | 1991-07-31 | Smithkline Beecham Plc | Novel treatment |
US5453421A (en) * | 1992-09-11 | 1995-09-26 | E. R. Squibb & Sons, Inc. | Aryl and heterocyclic substituted propenamide derivatives |
GR1002276B (el) * | 1992-10-08 | 1996-05-02 | Smithkline Beecham P.L.C. | Παραγωγα βενζοπυρανιου τα οποια κεκτηνται δραση κνς. |
CZ282172B6 (cs) * | 1992-11-30 | 1997-05-14 | Smithkline Beecham Plc | Benzpyranové analogy pro léčení úzkosti, mánie, deprese nebo symptomů po přerušení podávání drog nebo léčiv, způsob přípravy těchto sloučenin, jejich použití a farmaceutický prostředek obsahující tyto sloučeniny |
AP360A (en) * | 1992-12-04 | 1994-09-07 | Smithkline Beecham Plc | Benzo-and pyridopyran derivatives having anxiolytic and anticonvulsant activity. |
SG49907A1 (en) * | 1992-12-11 | 1998-06-15 | Smithkline Beecham Corp | Pharmaceutical composition containing bicyclic type compounds |
JPH08505132A (ja) * | 1992-12-11 | 1996-06-04 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 医薬活性を有する二環式化合物 |
US20010021780A1 (en) * | 1992-12-11 | 2001-09-13 | Smithkline Beecham P.L.C. | Pharmaceutical composition containing bicyclic type compounds |
US5837702A (en) * | 1993-10-07 | 1998-11-17 | Bristol-Myers Squibb Co. | 4-arylamino-benzopyran and related compounds |
CZ286081B6 (cs) * | 1994-06-10 | 2000-01-12 | Smithkline Beecham P. L. C. | Benzopyrany a jejich použití jako terapeutických činidel |
GB9411635D0 (en) * | 1994-06-10 | 1994-08-03 | Smithkline Beecham Plc | Novel treatment |
DE69518322T2 (de) * | 1994-06-10 | 2001-02-15 | Smithkline Beecham P.L.C., Brentford | C-4 amid substituierte verbindungen und deren verwendung als therapeutische mittel |
US5574049A (en) * | 1994-07-22 | 1996-11-12 | Sandoz Ltd. | 2,2-dialkyl- and 2,2-dialkyl-3,4-dihydro-3-hydroxy-2H-1-benzopyrans |
US5612370A (en) * | 1995-06-07 | 1997-03-18 | Bristol-Myers Squibb Company | Phenylglycine and phenylalaninen amido benzopyran derivatives |
US5612323A (en) * | 1995-06-07 | 1997-03-18 | Bristol-Myers Squibb Company | Phosphinic ester substituted benzopyran derivatives |
US5629429A (en) * | 1995-06-07 | 1997-05-13 | Bristol-Myers Squibb Company | Process for preparing 4-arylamino-benzopyran and related compounds |
US5869478A (en) * | 1995-06-07 | 1999-02-09 | Bristol-Myers Squibb Company | Sulfonamido substituted benzopyran derivatives |
MX2007007103A (es) * | 2004-12-13 | 2008-03-10 | Lilly Co Eli | Derivados espiro como inhibidores de lipoxigenasa. |
US20110016548A1 (en) * | 2009-07-16 | 2011-01-20 | University Of Southern California | Control of endogenous dnmt1 gene expression by exogenous binary regulatory systems |
US9499510B2 (en) | 2012-07-03 | 2016-11-22 | Proximagen Limited | Pro-drug compounds |
GB201304814D0 (en) * | 2013-03-15 | 2013-05-01 | Proximagen Ltd | Pro-drug compounds |
CN110183460A (zh) * | 2019-04-30 | 2019-08-30 | 四川轻化工大学 | 绵萆薢菲类化合物及应用和提取方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1495526A (en) * | 1974-05-31 | 1977-12-21 | Beecham Group Ltd | Chroman derivatives |
GB1509853A (en) * | 1976-01-27 | 1978-05-04 | Beecham Group Ltd | 4-amino-3-hydroxy-6-nitrobenzo-pyrans |
EP0028064B1 (en) * | 1979-09-28 | 1983-07-20 | Beecham Group Plc | Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them |
DE3064285D1 (en) * | 1979-09-28 | 1983-08-25 | Beecham Group Plc | Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them |
DE3170604D1 (en) * | 1980-08-21 | 1985-06-27 | Beecham Group Plc | Chromanol derivatives, their production and pharmaceutical compositions containing them |
EP0076075B1 (en) * | 1981-09-25 | 1986-11-20 | Beecham Group Plc | Pharmaceutically active benzopyran compounds |
DE3368057D1 (en) * | 1982-05-21 | 1987-01-15 | Beecham Group Plc | Pharmaceutically active aminobenzopyrans |
EP0126367B1 (en) * | 1983-05-18 | 1994-10-12 | Beecham Group Plc | Chroman and chromene derivatives |
-
1984
- 1984-04-21 DE DE8484104524T patent/DE3479726D1/de not_active Expired
- 1984-04-21 EP EP84104524A patent/EP0126311B1/en not_active Expired
- 1984-05-16 US US06/610,623 patent/US4571406A/en not_active Expired - Lifetime
- 1984-05-16 AU AU28081/84A patent/AU569513B2/en not_active Expired
- 1984-05-16 NZ NZ208169A patent/NZ208169A/en unknown
- 1984-05-16 CA CA000454467A patent/CA1236458A/en not_active Expired
- 1984-05-17 GR GR74749A patent/GR79976B/el unknown
- 1984-05-17 IE IE1229/84A patent/IE57982B1/en not_active IP Right Cessation
- 1984-05-17 ES ES532582A patent/ES8601180A1/es not_active Expired
- 1984-05-18 JP JP59098929A patent/JPH0631211B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
GR79976B (es) | 1984-10-31 |
DE3479726D1 (de) | 1989-10-19 |
ES532582A0 (es) | 1985-10-16 |
CA1236458A (en) | 1988-05-10 |
AU569513B2 (en) | 1988-02-04 |
NZ208169A (en) | 1987-08-31 |
IE841229L (en) | 1984-11-18 |
JPS59219278A (ja) | 1984-12-10 |
EP0126311A3 (en) | 1987-05-27 |
EP0126311B1 (en) | 1989-09-13 |
JPH0631211B2 (ja) | 1994-04-27 |
AU2808184A (en) | 1984-11-22 |
EP0126311A2 (en) | 1984-11-28 |
IE57982B1 (en) | 1993-06-02 |
US4571406A (en) | 1986-02-18 |
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