BR0005486A - Compostos análogos de camptotecina, processo para a sua preparação e composições farmacêuticas contendo os mesmos - Google Patents

Compostos análogos de camptotecina, processo para a sua preparação e composições farmacêuticas contendo os mesmos

Info

Publication number
BR0005486A
BR0005486A BR0005486-0A BR0005486A BR0005486A BR 0005486 A BR0005486 A BR 0005486A BR 0005486 A BR0005486 A BR 0005486A BR 0005486 A BR0005486 A BR 0005486A
Authority
BR
Brazil
Prior art keywords
group
sym
preparation
pharmaceutical compositions
compositions containing
Prior art date
Application number
BR0005486-0A
Other languages
English (en)
Inventor
Gilbert Lavielle
Patrick Hautefaye
Alain Pierre
Ghanem Atassi
John Hickman
Bernard Cimetiere
Original Assignee
Adir
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adir filed Critical Adir
Publication of BR0005486A publication Critical patent/BR0005486A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Patente de Invenção: <B>"COMPOSTOS ANáLOGOS DE CAMPTOTECINA, PROCESSO PARA A SUA PREPARAçãO E COMPOSIçõES FARMACêUTICAS CONTENDO OS MESMOS"<D>. Composto da fórmula (I): onde <sym> n é 0, 1 ou 2, <sym> R~ 1~, R~ 2~, R~ 3~, R~ 4~ e R~ 5~ são selecionados hidrogênio, halogênio, alquila, alquenila, alquinila, peraloalquila, cicloalquila, cicloalquilalquila, hidróxi, hidroxialquila, alcóxi, alcoxialquila, alcoxicarbonila, acilóxi, carbóxi, nitro, ciano, aminocarbonila (opcionalmente substituído) e os grupos (CH~ 2~)p-NR~ a~R~ b~ e -O-C(O)-N-R~ a~R~ b~, com p, R~ a~ e R~ b~ sendo conforme definido no relatório, ou dois grupos adjacentes R~ 2~, R~ 3~, R~ 4~ R~ 5~ e formam juntos um grupo -O-(CH~ 2~)~ t~-O, t sendo um número inteiro de 1 a 3, <sym> R~ 60~, R~ 70n~, R~ 80~ e R~ 90~ representam um átomo de hidrogênio, um grupo hidróxi, um grupo alcóxi ou um grupo O-(CO)-X ou O-(CO)-NXW conforme definido no relatório, <sym> R~ 61~, R~ 71n~, R~ 81~ e R~ 91~ representam um átomo de hidrogênio, alquila, alquenila ou alquinila, ou tomado em pares juntos formam um grupo oxo.
BR0005486-0A 1999-11-18 2000-11-21 Compostos análogos de camptotecina, processo para a sua preparação e composições farmacêuticas contendo os mesmos BR0005486A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9914499A FR2801309B1 (fr) 1999-11-18 1999-11-18 Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
BR0005486A true BR0005486A (pt) 2001-08-07

Family

ID=9552253

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0005486-0A BR0005486A (pt) 1999-11-18 2000-11-21 Compostos análogos de camptotecina, processo para a sua preparação e composições farmacêuticas contendo os mesmos

Country Status (23)

Country Link
US (1) US6509345B2 (pt)
EP (1) EP1101765B1 (pt)
JP (1) JP3545332B2 (pt)
KR (1) KR100460785B1 (pt)
CN (2) CN1304395C (pt)
AT (1) ATE222253T1 (pt)
AU (1) AU772609B2 (pt)
BR (1) BR0005486A (pt)
CA (1) CA2325776C (pt)
DE (1) DE60000328T2 (pt)
DK (1) DK1101765T3 (pt)
EA (1) EA003206B1 (pt)
ES (1) ES2180501T3 (pt)
FR (1) FR2801309B1 (pt)
HK (2) HK1036803A1 (pt)
HU (1) HUP0004573A3 (pt)
MX (1) MXPA00011238A (pt)
NO (1) NO318464B1 (pt)
NZ (1) NZ508248A (pt)
PL (1) PL202231B1 (pt)
PT (1) PT1101765E (pt)
SI (1) SI1101765T1 (pt)
ZA (1) ZA200006730B (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1284781C (zh) * 2001-10-05 2006-11-15 霍夫曼-拉罗奇有限公司 具有抗肿瘤活性的多环化合物
US7071204B2 (en) * 2003-06-30 2006-07-04 Research Triangle Institute Camptothecin analogs having an E-ring ketone
FR2889528B1 (fr) * 2005-08-05 2007-09-07 Servier Lab Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2889527A1 (fr) * 2005-08-05 2007-02-09 Servier Lab Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2892418B1 (fr) * 2005-10-24 2010-10-22 Servier Lab Nouveaux composes aminoesterifies a cycle e hydrocarbone a six chainons analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2892417B1 (fr) * 2005-10-24 2010-10-22 Servier Lab Nouveaux composes aminoesterifies a cycle e hydrocarbone a sept chainons analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA2658015A1 (en) 2006-03-30 2007-10-11 Diatos S.A. Camptothecin-peptide conjugates and pharmaceutical compositions containing the same
CN103288842B (zh) * 2012-02-24 2016-01-13 中国人民解放军第二军医大学 氟取代e环喜树碱类似物及其作为药物的用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5829793B2 (ja) * 1975-02-07 1983-06-24 日本ケミフア （株） ７−アルコキシカルボニル−８−メチルインドリジノ〔１，２−ｂ〕キノリン−９（１１Ｈ）−オンの製法
JPS58435B2 (ja) * 1975-12-23 1983-01-06 カメタニ テツジ ルテカルピンノセイホウ
GB8513460D0 (en) * 1985-05-29 1985-07-03 Glaxo Group Ltd Chemical compounds
US4939255A (en) * 1987-06-24 1990-07-03 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic camptothecin derivatives
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH06509175A (ja) * 1991-07-22 1994-10-13 アボツト・ラボラトリーズ 医療用自動分析装置用試薬処理システム
US5391745A (en) * 1992-07-23 1995-02-21 Sloan-Kettering Institute For Cancer Research Methods of preparation of camptothecin analogs
JP3576171B2 (ja) * 1995-06-21 2004-10-13 ソシエテ・ド・コンセイユ・ド・ルシエルシエ・エ・ダアツプリカーション・シヤンテイフイツク・（エス．セー．エール．アー．エス） カンプトテシンの新規な同族体、その製造方法、その医薬としての用途及びこれを含有する医薬組成物
UA57757C2 (uk) * 1996-12-20 2003-07-15 Сос'Єте Де Консей Де Решерш Е Даплікасьон С'Єнтіфік (С.К.Р.А.С.) Аналоги камптотецину, спосіб їх отримання (варіанти) і фармацевтична композиція
DE19815812A1 (de) * 1998-04-08 1999-10-14 Bayer Ag Modifizierte Cytostatika
US6043367A (en) * 1998-09-30 2000-03-28 Roffler; Steve Proactive antitumor compounds

Also Published As

Publication number Publication date
HK1036803A1 (en) 2002-01-18
EA003206B1 (ru) 2003-02-27
DK1101765T3 (da) 2002-12-16
AU7168300A (en) 2001-05-24
CA2325776A1 (fr) 2001-05-18
NO318464B1 (no) 2005-03-21
HU0004573D0 (pt) 2001-02-28
HUP0004573A2 (hu) 2001-09-28
CA2325776C (fr) 2007-02-20
MXPA00011238A (es) 2002-05-23
JP3545332B2 (ja) 2004-07-21
AU772609B2 (en) 2004-05-06
SI1101765T1 (en) 2002-12-31
DE60000328D1 (de) 2002-09-19
HK1071892A1 (en) 2005-08-05
EP1101765A3 (fr) 2001-10-04
PT1101765E (pt) 2002-11-29
PL343949A1 (en) 2001-05-21
ES2180501T3 (es) 2003-02-16
EP1101765A2 (fr) 2001-05-23
ATE222253T1 (de) 2002-08-15
US6509345B2 (en) 2003-01-21
EA200001084A1 (ru) 2001-06-25
CN1301701A (zh) 2001-07-04
FR2801309B1 (fr) 2002-01-04
FR2801309A1 (fr) 2001-05-25
NO20005807L (no) 2001-05-21
KR20010051779A (ko) 2001-06-25
JP2001151776A (ja) 2001-06-05
US20020077325A1 (en) 2002-06-20
EP1101765B1 (fr) 2002-08-14
CN1304395C (zh) 2007-03-14
HUP0004573A3 (en) 2002-06-28
KR100460785B1 (ko) 2004-12-09
NO20005807D0 (no) 2000-11-17
ZA200006730B (en) 2001-05-31
NZ508248A (en) 2001-08-31
CN1552712A (zh) 2004-12-08
DE60000328T2 (de) 2003-04-17
CN1158282C (zh) 2004-07-21
PL202231B1 (pl) 2009-06-30

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Free format text: LES LABORATOIRES SERVIER (FR)

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]

Free format text: DE ACORDO COM O ART. 34 "II" DA LPI ( LEI 9279, DE 14/05/96), O EXAME FICA SUSPENSO PARA QUE O REQUERENTE APRESENTE DOCUMENTOS NECESSARIOS A REGULARIZACAO DO PROCESSO E EXAME DO PEDIDO.

B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11N Dismissal: publication cancelled [chapter 11.14 patent gazette]

Free format text: REFERENTE A RPI NO 2083 DE 07/12/2010.

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2412 DE 28-03-2017 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.