EA200001084A1 - Новые производные аналогов камптотецина, способ их получения и содержащие их фармацевтические композиции - Google Patents

Новые производные аналогов камптотецина, способ их получения и содержащие их фармацевтические композиции

Info

Publication number
EA200001084A1
EA200001084A1 EA200001084A EA200001084A EA200001084A1 EA 200001084 A1 EA200001084 A1 EA 200001084A1 EA 200001084 A EA200001084 A EA 200001084A EA 200001084 A EA200001084 A EA 200001084A EA 200001084 A1 EA200001084 A1 EA 200001084A1
Authority
EA
Eurasian Patent Office
Prior art keywords
analogues
group
camptotecine
new
production
Prior art date
Application number
EA200001084A
Other languages
English (en)
Other versions
EA003206B1 (ru
Inventor
Жильбер Лявьей
Патрик Отефей
Алан Пьер
Ганем Атасси
Джон Хикмен
Бернар Симетьер
Original Assignee
Адир Э Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Адир Э Компани filed Critical Адир Э Компани
Publication of EA200001084A1 publication Critical patent/EA200001084A1/ru
Publication of EA003206B1 publication Critical patent/EA003206B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Соединение формулы (I)где n представляет 0, 1 или 2, R, R, R, Rи Rвыбраны из водорода, галогена, алкила, алкенила, алкинила, пергалогеналкила, циклоалкила, циклоалкилалкила, гидроксигруппы, гидрокси, алкокси, алкоксиалкила, алкоксикарбонила, ацилокси, карбокси, нитро, циано, аминокарбонила (необязательно замещенного) и групп (CH)-NRRи -O-C(O)-N-RR, где p, Rи R- такие, как определенные в описании, или две смежные группы R, R, Rи Rвместе образуют группу -O-(CH)-O, где t представляет целое число от 1 до 3, R, R, Rи Rпредставляют атом водорода, гидроксигруппу, алкоксигруппу или группу O-(CO)-X или O-(CO)-NXW такую, как определенная в описании, R, R, Rи Rпредставляют атом водорода, алкил, алкенил или алкинил или, взятые попарно, вместе образуют связь или оксирановую группу или две группы вместе образуют оксогруппу.
EA200001084A 1999-11-18 2000-11-17 Новые производные аналогов камптотецина, способ их получения и содержащие их фармацевтические композиции EA003206B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9914499A FR2801309B1 (fr) 1999-11-18 1999-11-18 Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
EA200001084A1 true EA200001084A1 (ru) 2001-06-25
EA003206B1 EA003206B1 (ru) 2003-02-27

Family

ID=9552253

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200001084A EA003206B1 (ru) 1999-11-18 2000-11-17 Новые производные аналогов камптотецина, способ их получения и содержащие их фармацевтические композиции

Country Status (23)

Country Link
US (1) US6509345B2 (ru)
EP (1) EP1101765B1 (ru)
JP (1) JP3545332B2 (ru)
KR (1) KR100460785B1 (ru)
CN (2) CN1304395C (ru)
AT (1) ATE222253T1 (ru)
AU (1) AU772609B2 (ru)
BR (1) BR0005486A (ru)
CA (1) CA2325776C (ru)
DE (1) DE60000328T2 (ru)
DK (1) DK1101765T3 (ru)
EA (1) EA003206B1 (ru)
ES (1) ES2180501T3 (ru)
FR (1) FR2801309B1 (ru)
HK (2) HK1036803A1 (ru)
HU (1) HUP0004573A3 (ru)
MX (1) MXPA00011238A (ru)
NO (1) NO318464B1 (ru)
NZ (1) NZ508248A (ru)
PL (1) PL202231B1 (ru)
PT (1) PT1101765E (ru)
SI (1) SI1101765T1 (ru)
ZA (1) ZA200006730B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE316971T1 (de) 2001-10-05 2006-02-15 Hoffmann La Roche Polycyclische verbindungen mit antitumor-wirkung
US7071204B2 (en) * 2003-06-30 2006-07-04 Research Triangle Institute Camptothecin analogs having an E-ring ketone
FR2889528B1 (fr) * 2005-08-05 2007-09-07 Servier Lab Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2889527A1 (fr) * 2005-08-05 2007-02-09 Servier Lab Nouveaux composes analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2892417B1 (fr) * 2005-10-24 2010-10-22 Servier Lab Nouveaux composes aminoesterifies a cycle e hydrocarbone a sept chainons analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2892418B1 (fr) * 2005-10-24 2010-10-22 Servier Lab Nouveaux composes aminoesterifies a cycle e hydrocarbone a six chainons analogues de la camptothecine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP1998809B1 (en) 2006-03-30 2014-06-25 Drais Pharmaceuticals, Inc. Camptothecin-cell penetrating peptide conjugates and pharmaceutical compositions containing the same
CN103288842B (zh) * 2012-02-24 2016-01-13 中国人民解放军第二军医大学 氟取代e环喜树碱类似物及其作为药物的用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5829793B2 (ja) * 1975-02-07 1983-06-24 日本ケミフア （株） ７−アルコキシカルボニル−８−メチルインドリジノ〔１，２−ｂ〕キノリン−９（１１Ｈ）−オンの製法
JPS58435B2 (ja) * 1975-12-23 1983-01-06 カメタニ テツジ ルテカルピンノセイホウ
GB8513460D0 (en) * 1985-05-29 1985-07-03 Glaxo Group Ltd Chemical compounds
US4939255A (en) * 1987-06-24 1990-07-03 Daiichi Pharmaceutical Co., Ltd. Hexa-cyclic camptothecin derivatives
US5004758A (en) * 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
CA2102123A1 (en) * 1991-07-22 1993-01-23 Edwin M. Marker, Jr. Reagent handling system for automated clinical analyzer apparatus
US5391745A (en) * 1992-07-23 1995-02-21 Sloan-Kettering Institute For Cancer Research Methods of preparation of camptothecin analogs
DK0835258T3 (da) * 1995-06-21 2003-02-03 Sod Conseils Rech Applic Hidtil ukendte camptothecin-analoger, fremgangsmåder til fremstilling heraf, anvendelse heraf som lægemidler og farmaceutiske præparater indeholdende disse
UA57757C2 (ru) * 1996-12-20 2003-07-15 Сос'Єте Де Консей Де Решерш Е Даплікасьон С'Єнтіфік (С.К.Р.А.С.) Формы пролекарств и новые аналоги камптотецина, их применение в качестве лекарств
DE19815812A1 (de) * 1998-04-08 1999-10-14 Bayer Ag Modifizierte Cytostatika
US6043367A (en) * 1998-09-30 2000-03-28 Roffler; Steve Proactive antitumor compounds

Also Published As

Publication number Publication date
ATE222253T1 (de) 2002-08-15
CA2325776A1 (fr) 2001-05-18
JP2001151776A (ja) 2001-06-05
AU7168300A (en) 2001-05-24
JP3545332B2 (ja) 2004-07-21
HK1071892A1 (en) 2005-08-05
ES2180501T3 (es) 2003-02-16
DE60000328D1 (de) 2002-09-19
HUP0004573A2 (hu) 2001-09-28
PL343949A1 (en) 2001-05-21
PL202231B1 (pl) 2009-06-30
SI1101765T1 (en) 2002-12-31
AU772609B2 (en) 2004-05-06
PT1101765E (pt) 2002-11-29
EP1101765B1 (fr) 2002-08-14
US20020077325A1 (en) 2002-06-20
NZ508248A (en) 2001-08-31
EP1101765A3 (fr) 2001-10-04
FR2801309A1 (fr) 2001-05-25
HU0004573D0 (ru) 2001-02-28
NO20005807L (no) 2001-05-21
CN1301701A (zh) 2001-07-04
EP1101765A2 (fr) 2001-05-23
DE60000328T2 (de) 2003-04-17
CN1158282C (zh) 2004-07-21
HUP0004573A3 (en) 2002-06-28
CA2325776C (fr) 2007-02-20
CN1304395C (zh) 2007-03-14
ZA200006730B (en) 2001-05-31
KR20010051779A (ko) 2001-06-25
HK1036803A1 (en) 2002-01-18
EA003206B1 (ru) 2003-02-27
CN1552712A (zh) 2004-12-08
MXPA00011238A (es) 2002-05-23
FR2801309B1 (fr) 2002-01-04
NO318464B1 (no) 2005-03-21
US6509345B2 (en) 2003-01-21
DK1101765T3 (da) 2002-12-16
BR0005486A (pt) 2001-08-07
KR100460785B1 (ko) 2004-12-09
NO20005807D0 (no) 2000-11-17

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU