ATE380173T1 - Verfahren zur herstellung von (2s,3r,4s)-4- hydroxyisoleucin und analoga - Google Patents

Verfahren zur herstellung von (2s,3r,4s)-4- hydroxyisoleucin und analoga

Info

Publication number
ATE380173T1
ATE380173T1 AT01919554T AT01919554T ATE380173T1 AT E380173 T1 ATE380173 T1 AT E380173T1 AT 01919554 T AT01919554 T AT 01919554T AT 01919554 T AT01919554 T AT 01919554T AT E380173 T1 ATE380173 T1 AT E380173T1
Authority
AT
Austria
Prior art keywords
group
hydroxyisoleucine
analogs
producing
formula
Prior art date
Application number
AT01919554T
Other languages
English (en)
Inventor
Jamal Ouazzani
Pierre Potier
Nobumichi Sasaki
Wang Zhu
Original Assignee
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient filed Critical Centre Nat Rech Scient
Application granted granted Critical
Publication of ATE380173T1 publication Critical patent/ATE380173T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/24—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton
    • C07C255/26—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the same saturated acyclic carbon skeleton containing cyano groups, amino groups and singly-bound oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/02—Sulfinic acids; Derivatives thereof
    • C07C313/06—Sulfinamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
AT01919554T 2000-03-27 2001-03-23 Verfahren zur herstellung von (2s,3r,4s)-4- hydroxyisoleucin und analoga ATE380173T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0003859A FR2806726B1 (fr) 2000-03-27 2000-03-27 Procede de preparation de la (2s,3r,4s)-4-hydroxyisoleucine et de ses analogues

Publications (1)

Publication Number Publication Date
ATE380173T1 true ATE380173T1 (de) 2007-12-15

Family

ID=8848534

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01919554T ATE380173T1 (de) 2000-03-27 2001-03-23 Verfahren zur herstellung von (2s,3r,4s)-4- hydroxyisoleucin und analoga

Country Status (8)

Country Link
US (2) US20030219880A1 (de)
EP (1) EP1268397B1 (de)
AT (1) ATE380173T1 (de)
AU (1) AU4663301A (de)
CA (1) CA2404621C (de)
DE (1) DE60131733T2 (de)
FR (1) FR2806726B1 (de)
WO (1) WO2001072688A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6903136B2 (en) * 2002-04-22 2005-06-07 Experimental And Applied Sciences, Inc. Food supplements containing 4-hydroxyisoleucine and creatine
FR2854629B1 (fr) 2003-05-07 2005-06-17 Centre Nat Rech Scient Procede de synthese de la 4-hydroxyisoleucine et de ses derives
EP1657236A1 (de) * 2004-11-10 2006-05-17 Centre National De La Recherche Scientifique (Cnrs) Verfahren zur Herstellung von Diastereoisomeren von 4-Hydroxyisoleucin
CN101193852A (zh) * 2005-02-18 2008-06-04 因诺迪亚有限公司 4-羟基异亮氨酸类似物及其用途
WO2006131836A2 (en) * 2005-03-22 2006-12-14 Innodia Inc. Compounds and compositions for use in the prevention and treatment of obesity and related syndromes
WO2007107008A1 (en) * 2006-03-22 2007-09-27 Innodia Inc. Compounds and compositions for use in the prevention and treatment of disorders of fat metabolism and obesity
WO2012162507A1 (en) 2011-05-24 2012-11-29 Apicore, Llc Process for preparing saxagliptin and its novel intermediates useful in the synthesis thereof
CN104152505B (zh) * 2014-08-08 2016-11-23 江南大学 一种利用重组菌株转化制备4-羟基-l-异亮氨酸的方法
CN105566136A (zh) * 2016-01-19 2016-05-11 天津科技大学 一种从发酵液中分离提取4-羟基异亮氨酸的方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2745718B1 (fr) * 1996-03-08 1998-05-07 Gestion Jouvenet Soc Civ De Composition antidiabetique a base de 4-hydroxyisoleucine

Also Published As

Publication number Publication date
FR2806726B1 (fr) 2003-01-03
WO2001072688A3 (fr) 2002-04-11
AU4663301A (en) 2001-10-08
CA2404621A1 (fr) 2001-10-04
DE60131733T2 (de) 2008-10-30
DE60131733D1 (de) 2008-01-17
WO2001072688A2 (fr) 2001-10-04
US20030219880A1 (en) 2003-11-27
EP1268397A2 (de) 2003-01-02
US20050079587A1 (en) 2005-04-14
CA2404621C (fr) 2012-11-20
FR2806726A1 (fr) 2001-09-28
EP1268397B1 (de) 2007-12-05
US7432087B2 (en) 2008-10-07

Similar Documents

Publication Publication Date Title
IS6257A (is) Frumuviðloðunartálmar
DE59108707D1 (de) Verfahren zur Herstellung von Oxetanonen
ATE132145T1 (de) Verfahren zur herstellung von bacchatin iii und von desacetyl-10-bacchatin iii derivate
ATE410412T1 (de) Oxopyrrolidin verbindungen, verfahren zur herstellung dieser verbindungen und deren verwendung zur herstellung von levetiracetam und analogen
ATE380173T1 (de) Verfahren zur herstellung von (2s,3r,4s)-4- hydroxyisoleucin und analoga
DE60309251D1 (de) Verfahren zur Herstellung von Donepezil
DE59509910D1 (de) Verfahren zur Herstellung von Alkylhydrogenchlorsilanen
ATE197150T1 (de) Verfahren zur herstellung von dihydroxypyrimidin- derivaten
DE50107981D1 (de) Verfahren zur reinigung von abgasströmen
DE50309260D1 (de) Verfahren zur herstellung von bicalutamid
EA200200807A1 (ru) Аминокислотные соединения и их применение в качестве ингибиторов nep, ace и ece
DE60222244D1 (de) Verfahren zur herstellung von zwischenverbindungen in der herstellung von discodermolid und discodermolid-analoga
DE60001807D1 (de) VERFAHREN ZU HERSTELLUNG VON o-FLUORIERTEN TETRAHYDROTHIOPYRAN CARBAMATEN
DE60107292D1 (de) Verfahren zur herstellung von (+)-trans-4-p-fluorophenyl-3-hydroxymethyl-1-methylpiperidin
DE60003169D1 (de) Verfahren zur herstellung von [s-(r*,s*)]-g(b)-[[1-[1-oxo-3-(4-piperidinyl)propyl]-3-piperidinyl]carbonyl] amino]-3-pyridinpropansäurederivate
ATE496038T1 (de) Verfahren zur herstellung von quetiapin
EA200200665A1 (ru) Новые соединения бензолсульфонамида, способ их получения и фармацевтические композиции, их содержащие
DE60133395D1 (de) Verfahren zur herstellung von alpha'-chlorketonen
NO984206L (no) Fremgangsmaate for fremstilling av N-beskyttende D-prolinderivater
DE60308204D1 (de) Verfahren zur herstellung von aminopyrrolidinderivaten
ATE237583T1 (de) Verfahren zur herstellung von depsipeptiden und zwischenprodukten davon
DE60306361D1 (de) Verfahren zur herstellung von benazeprilhydrochloride
AT387214B (de) Verfahren zur herstellung neuer n-substituierter, estergruppen enthaltender acrylamide
ATE473208T1 (de) Isodipeptid als syntheseeinheit zur herstellung von peptiden
DE50114223D1 (de) Verfahren zur herstellung von 1-substituierten 5-chlor-4methylpyrazolen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties