EA200200665A1 - Новые соединения бензолсульфонамида, способ их получения и фармацевтические композиции, их содержащие - Google Patents

Новые соединения бензолсульфонамида, способ их получения и фармацевтические композиции, их содержащие

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Publication number
EA200200665A1
EA200200665A1 EA200200665A EA200200665A EA200200665A1 EA 200200665 A1 EA200200665 A1 EA 200200665A1 EA 200200665 A EA200200665 A EA 200200665A EA 200200665 A EA200200665 A EA 200200665A EA 200200665 A1 EA200200665 A1 EA 200200665A1
Authority
EA
Eurasian Patent Office
Prior art keywords
group
benzolsulfonamide
receiving
pharmaceutical compositions
compositions containing
Prior art date
Application number
EA200200665A
Other languages
English (en)
Other versions
EA005403B1 (ru
Inventor
Жильбер Лавиелль
Бернар Симитьер
Тони Вербёрен
Серж Симоне
Кристин Вессетт-Курше
Original Assignee
Ле Лаборатуар Сервье
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ле Лаборатуар Сервье filed Critical Ле Лаборатуар Сервье
Publication of EA200200665A1 publication Critical patent/EA200200665A1/ru
Publication of EA005403B1 publication Critical patent/EA005403B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

Соединение формулы (I)в которой Rпредставляет собой гидрокси, алкокси, арилокси или арилалкилоксигруппу,А представляет собой группу СН атом азота, в в этом случае Rимеет значение, указанное в описании, или R-A совместно представляют собой атом кислорода или группув которой Rи Rимеют значения, указанные в описании,Rпредставляет собой атом водорода или алкильную группу,Rи R, которые могут быть одинаковыми или различными, каждый представляет собой атом водорода, атом галогена, алкильную группу, алкоксигруппу, гидроксигруппу или тригалоалкильную группу,n представляет собой целое число от 2 до 6 включительно,m и р представляют собой целые числа от 0 до 6 включительно.Лекарственные препараты.
EA200200665A 2001-07-13 2002-07-12 Соединения бензолсульфонамида, способ их получения и фармацевтические композиции их содержащие EA005403B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0109338A FR2827287B1 (fr) 2001-07-13 2001-07-13 Nouveaux derives de benzene sulfonamide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
EA200200665A1 true EA200200665A1 (ru) 2003-02-27
EA005403B1 EA005403B1 (ru) 2005-02-24

Family

ID=8865461

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200665A EA005403B1 (ru) 2001-07-13 2002-07-12 Соединения бензолсульфонамида, способ их получения и фармацевтические композиции их содержащие

Country Status (18)

Country Link
US (1) US6589956B2 (ru)
EP (1) EP1275644A1 (ru)
JP (1) JP4138382B2 (ru)
KR (1) KR100498864B1 (ru)
CN (1) CN1168715C (ru)
AR (1) AR036340A1 (ru)
AU (1) AU2002300093B2 (ru)
BR (1) BR0202674A (ru)
CA (1) CA2394037C (ru)
EA (1) EA005403B1 (ru)
FR (1) FR2827287B1 (ru)
HK (1) HK1050681A1 (ru)
HU (1) HUP0202286A2 (ru)
MX (1) MXPA02006852A (ru)
NO (1) NO323868B1 (ru)
NZ (1) NZ520140A (ru)
PL (1) PL354948A1 (ru)
ZA (1) ZA200205598B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4324221B2 (ja) * 2005-08-26 2009-09-02 株式会社医薬分子設計研究所 Ｐｐａｒアゴニスト活性を有する誘導体
US10093640B2 (en) 2012-09-21 2018-10-09 Vanderbilt University Substituted benzofuran, benzothiophene and indole MCL-1 inhibitors
WO2015031608A1 (en) 2013-08-28 2015-03-05 Vanderbilt University Substituted indole mcl-1 inhibitors
AU2015235944B2 (en) 2014-03-27 2020-06-25 Vanderbilt University Substituted indole Mcl-1 inhibitors
US9949965B2 (en) 2014-10-17 2018-04-24 Vanderbilt University Tricyclic indole Mcl-1 inhibitors and uses thereof
WO2017152076A1 (en) 2016-03-04 2017-09-08 Vanderbilt University Substituted indole mcl-1 inhibitors
EP4082616A4 (en) * 2019-12-24 2024-01-03 Sumitomo Pharma Co., Ltd. AMIDE DERIVATIVE OF ALIPHATIC ACID

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3468882A (en) * 1966-10-07 1969-09-23 Sterling Drug Inc Phenylhydrazone derivatives as intermediates for preparing indoles
GB8419575D0 (en) * 1984-08-01 1984-09-05 Glaxo Group Ltd Chemical compounds
KR940007458B1 (ko) * 1991-11-21 1994-08-18 주식회사 금성사 박막 트랜지스터 제조 방법
TW219358B (ru) * 1991-12-20 1994-01-21 Hokuriku Pharmaceutical
WO1994014769A1 (en) * 1992-12-21 1994-07-07 Taisho Pharmaceutical Co., Ltd. N-substituted indole derivative
GB9317764D0 (en) * 1993-08-26 1993-10-13 Pfizer Ltd Therapeutic compound
FR2712591B1 (fr) * 1993-11-19 1996-02-09 Pf Medicament Nouvelles arylpipérazines dérivées d'indole, leur préparation et leur utilisation thérapeutique.
AU714054B2 (en) * 1995-01-06 1999-12-16 Toray Industries, Inc. Benzene-fused heterocyclic derivatives and use of the same
US5998415A (en) * 1995-11-02 1999-12-07 Merck Sharp & Dohme Ltd. Bicyclic heteroaryl-alkylene-(homo)piperazinones and thione analogues thereof, their preparation, and their use of as selective agonists of 5-HT1 -like receptors
GB9523243D0 (en) * 1995-11-14 1996-01-17 Merck Sharp & Dohme Therapeutic agents
GB9523250D0 (en) * 1995-11-14 1996-01-17 Merck Sharp & Dohme Therapeutic agents

Also Published As

Publication number Publication date
US20030109533A1 (en) 2003-06-12
NZ520140A (en) 2003-09-26
MXPA02006852A (es) 2005-07-25
HK1050681A1 (en) 2003-07-04
EP1275644A1 (fr) 2003-01-15
EA005403B1 (ru) 2005-02-24
JP4138382B2 (ja) 2008-08-27
AU2002300093B2 (en) 2007-07-12
NO20023389L (no) 2003-01-14
ZA200205598B (en) 2003-03-27
JP2003064055A (ja) 2003-03-05
CN1397550A (zh) 2003-02-19
AR036340A1 (es) 2004-09-01
NO323868B1 (no) 2007-07-16
CN1168715C (zh) 2004-09-29
FR2827287A1 (fr) 2003-01-17
HUP0202286A2 (hu) 2003-08-28
HU0202286D0 (ru) 2002-09-28
NO20023389D0 (no) 2002-07-12
PL354948A1 (en) 2003-01-27
CA2394037C (fr) 2008-04-29
KR100498864B1 (ko) 2005-07-04
KR20030007173A (ko) 2003-01-23
US6589956B2 (en) 2003-07-08
BR0202674A (pt) 2003-05-06
CA2394037A1 (fr) 2003-01-13
FR2827287B1 (fr) 2003-10-31

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU