NO990583L - Cykliske eterforbindelser som natriumkanalmodulatorer - Google Patents

Cykliske eterforbindelser som natriumkanalmodulatorer

Info

Publication number
NO990583L
NO990583L NO990583A NO990583A NO990583L NO 990583 L NO990583 L NO 990583L NO 990583 A NO990583 A NO 990583A NO 990583 A NO990583 A NO 990583A NO 990583 L NO990583 L NO 990583L
Authority
NO
Norway
Prior art keywords
substituted
sodium channel
lower alkyl
cyclic ether
ether compounds
Prior art date
Application number
NO990583A
Other languages
English (en)
Other versions
NO990583D0 (no
Inventor
Shigenori Ohkawa
Tadatoshi Hashimoto
Kohji Fukatsu
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of NO990583D0 publication Critical patent/NO990583D0/no
Publication of NO990583L publication Critical patent/NO990583L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transmitters (AREA)
  • Optical Modulation, Optical Deflection, Nonlinear Optics, Optical Demodulation, Optical Logic Elements (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Liquid Crystal Substances (AREA)

Abstract

Forbindelse av formelen: (CH2)m-N A Y-Za-Zb-Ar hvor R1 og R2 begge betyr hydrogen; lavere alkyl som kan være substituert eller asyl; R3, R4, og R5 hver betyr lavere alkyl som kan være substituert eller lavere alkoksy som kan være substituert eller R4 og R5 sammen betyr en 5- eller 6-leddet karbosyklisk gruppe; R6 betyr lavere alkyl; Ar betyr en aromatisk gruppe som kan være substituert; ring A betyr en 5- til 8-leddet heterosyklisk ring som inneholder nitrogen som kan være substituert; X betyr lavere alkylen som kan være substituert; Y betyr karbon eller nitrogen; Za betyr CH2, COCH2, OCH2, SCH2, NHCH2, etc.; Zb etyr en binding eller en toverdig alifatisk hydrokarbongruppe som kan være substituert og kan inneholde O, N eller S; og m betyr et helt tall fra l til 3, eller et salt derav som er anvendbar i et farmasøytisk preparat for å modulere natriumkanalen.
NO990583A 1996-08-29 1999-02-08 Cykliske eterforbindelser som natriumkanalmodulatorer NO990583L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP22884596 1996-08-29
JP8649697 1997-04-04
PCT/JP1997/003007 WO1998008842A1 (en) 1996-08-29 1997-08-28 Cyclic ether compounds as sodium channel modulators

Publications (2)

Publication Number Publication Date
NO990583D0 NO990583D0 (no) 1999-02-08
NO990583L true NO990583L (no) 1999-02-08

Family

ID=26427602

Family Applications (1)

Application Number Title Priority Date Filing Date
NO990583A NO990583L (no) 1996-08-29 1999-02-08 Cykliske eterforbindelser som natriumkanalmodulatorer

Country Status (10)

Country Link
US (1) US6172085B1 (no)
EP (1) EP0923575B1 (no)
CN (1) CN1076022C (no)
AT (1) ATE234298T1 (no)
AU (1) AU4031697A (no)
CA (1) CA2264231A1 (no)
DE (1) DE69719766T2 (no)
HU (1) HUP9903557A2 (no)
NO (1) NO990583L (no)
WO (1) WO1998008842A1 (no)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2352786C (en) 1998-12-04 2009-02-03 Takeda Chemical Industries, Ltd. Benzofuran derivatives, process for the preparation of the same and uses thereof
EP1169060B1 (en) 1999-04-09 2005-08-31 Euro-Celtique S.A. Sodium channel blocker compositions and the use thereof
US20030060487A1 (en) * 2000-04-12 2003-03-27 Bamdad R. Shoshana Treatment of neurodegenerative disease
US6825201B2 (en) * 2001-04-25 2004-11-30 Bristol-Myers Squibb Company Indole, azaindole and related heterocyclic amidopiperazine derivatives
PT1423168E (pt) 2001-09-03 2006-05-31 Newron Pharm Spa Composicao farmaceutica que compreende gabapentina ou um seu analogo e uma x-aminoamida e a sua utilizacao como analgesico
ES2338539T3 (es) 2001-11-01 2010-05-10 Icagen, Inc. Pirazolamidas para uso en el tratamiento del dolor.
DE60219687T2 (de) * 2001-12-27 2007-12-27 Ortho-Mcneil Pharmaceutical, Inc. Aroylpyrrolheteroeryl und methanole zur behandlung von störungen des zentralnervensystems
US20030236277A1 (en) * 2002-02-14 2003-12-25 Kadow John F. Indole, azaindole and related heterocyclic pyrrolidine derivatives
WO2003072751A2 (en) 2002-02-25 2003-09-04 Vanderbilt University Expression system for human brain-specific voltage-gated sodium channel, type 1
US7037913B2 (en) 2002-05-01 2006-05-02 Bristol-Myers Squibb Company Bicyclo 4.4.0 antiviral derivatives
WO2005000829A1 (ja) * 2003-06-26 2005-01-06 Takeda Pharmaceutical Company Limited カンナビノイド受容体調節剤
US7521545B2 (en) * 2004-08-27 2009-04-21 Takeda Pharmaceutical Company Limited Azo compounds and process for production thereof
US20060100432A1 (en) * 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US20060100209A1 (en) * 2004-11-09 2006-05-11 Chong-Hui Gu Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
DE102004061593A1 (de) 2004-12-21 2006-06-22 Abbott Gmbh & Co. Kg Substituierte N-heterocyclische Verbindungen und ihre therapeutische Verwendung
US7598380B2 (en) * 2005-08-03 2009-10-06 Bristol-Myers Squibb Company Method of preparation of azaindole derivatives
EP1922068A4 (en) 2005-08-16 2010-08-11 Icagen Inc INHIBITORS OF VOLTAGE-CONTROLLED SODIUM CHANNELS
US7705158B2 (en) 2005-11-02 2010-04-27 Icagen, Inc. Inhibitors of ion channels
US7851476B2 (en) * 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
DE602008000809D1 (de) 2007-03-23 2010-04-29 Icagen Inc Ionenkanal-Hemmer
JP5460589B2 (ja) 2007-07-13 2014-04-02 アイカジェン， インコーポレイテッド ナトリウムチャネル阻害物質
CN103554002B (zh) * 2013-10-08 2016-04-27 常州大学 1-苯基吲哚及其制备方法
EP3233799B1 (en) 2014-12-19 2021-05-19 The Broad Institute, Inc. Dopamine d2 receptor ligands
EP3233077A4 (en) 2014-12-19 2018-08-08 The Broad Institute Inc. Dopamine d2 receptor ligands

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE68675B1 (en) * 1990-11-01 1996-07-10 Takeda Chemical Industries Ltd Aminocoumaran derivatives their production and use
JP3198395B2 (ja) * 1992-05-28 2001-08-13 武田薬品工業株式会社 アミノクマラン誘導体
TW334433B (en) 1992-12-09 1998-06-21 Takeda Pharm Industry Co Ltd Crystalline salt of (S)-(+)-5-amino-2,4,6,7-tetramethyl-2-(4-phenylpiperidinomethyl)-2,3-dihydrobenzo(b)furan dihydrochloride their production and use

Also Published As

Publication number Publication date
DE69719766T2 (de) 2004-01-15
WO1998008842A1 (en) 1998-03-05
CN1076022C (zh) 2001-12-12
AU4031697A (en) 1998-03-19
HUP9903557A2 (en) 2002-08-28
EP0923575B1 (en) 2003-03-12
NO990583D0 (no) 1999-02-08
DE69719766D1 (de) 2003-04-17
ATE234298T1 (de) 2003-03-15
CA2264231A1 (en) 1998-03-05
CN1223652A (zh) 1999-07-21
US6172085B1 (en) 2001-01-09
EP0923575A1 (en) 1999-06-23

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