DE69719766T2 - Zyklische etherverbindungen als natriumkanal-modulatoren - Google Patents
Zyklische etherverbindungen als natriumkanal-modulatoren Download PDFInfo
- Publication number
- DE69719766T2 DE69719766T2 DE69719766T DE69719766T DE69719766T2 DE 69719766 T2 DE69719766 T2 DE 69719766T2 DE 69719766 T DE69719766 T DE 69719766T DE 69719766 T DE69719766 T DE 69719766T DE 69719766 T2 DE69719766 T2 DE 69719766T2
- Authority
- DE
- Germany
- Prior art keywords
- substituted
- sodium channel
- lower alkyl
- cyclic ether
- channel modulators
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP22884596 | 1996-08-29 | ||
JP8649697 | 1997-04-04 | ||
PCT/JP1997/003007 WO1998008842A1 (en) | 1996-08-29 | 1997-08-28 | Cyclic ether compounds as sodium channel modulators |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69719766D1 DE69719766D1 (de) | 2003-04-17 |
DE69719766T2 true DE69719766T2 (de) | 2004-01-15 |
Family
ID=26427602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69719766T Expired - Lifetime DE69719766T2 (de) | 1996-08-29 | 1997-08-28 | Zyklische etherverbindungen als natriumkanal-modulatoren |
Country Status (10)
Country | Link |
---|---|
US (1) | US6172085B1 (de) |
EP (1) | EP0923575B1 (de) |
CN (1) | CN1076022C (de) |
AT (1) | ATE234298T1 (de) |
AU (1) | AU4031697A (de) |
CA (1) | CA2264231A1 (de) |
DE (1) | DE69719766T2 (de) |
HU (1) | HUP9903557A2 (de) |
NO (1) | NO990583D0 (de) |
WO (1) | WO1998008842A1 (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69915508T2 (de) | 1998-12-04 | 2005-01-27 | Takeda Chemical Industries, Ltd. | Benzofuranderivate, verfahren zu ihrer herstellung und deren verwendungen |
EP1169060B1 (de) | 1999-04-09 | 2005-08-31 | Euro-Celtique S.A. | Natrium kanalblocker zusammensetzungen und deren verwendung |
CA2404858A1 (en) * | 2000-04-12 | 2001-10-25 | Minerva Biotechnologies Corporation | Treatment of neurodegenerative disease |
US6825201B2 (en) * | 2001-04-25 | 2004-11-30 | Bristol-Myers Squibb Company | Indole, azaindole and related heterocyclic amidopiperazine derivatives |
WO2003020273A2 (en) | 2001-09-03 | 2003-03-13 | Newron Pharmaceuticals Spa | Pharmaceutical composition comprising gabapentin or an analogue thereof and an $g(a)-aminoamide and its analgesic use |
ES2338539T3 (es) | 2001-11-01 | 2010-05-10 | Icagen, Inc. | Pirazolamidas para uso en el tratamiento del dolor. |
DE60219687T2 (de) * | 2001-12-27 | 2007-12-27 | Ortho-Mcneil Pharmaceutical, Inc. | Aroylpyrrolheteroeryl und methanole zur behandlung von störungen des zentralnervensystems |
US20030236277A1 (en) | 2002-02-14 | 2003-12-25 | Kadow John F. | Indole, azaindole and related heterocyclic pyrrolidine derivatives |
AU2003219933A1 (en) | 2002-02-25 | 2003-09-09 | Vanderbilt University | Expression system for human brain-specific voltage-gated sodium channel, type 1 |
US7037913B2 (en) | 2002-05-01 | 2006-05-02 | Bristol-Myers Squibb Company | Bicyclo 4.4.0 antiviral derivatives |
ES2420932T3 (es) * | 2003-06-26 | 2013-08-27 | Takeda Pharmaceutical Company Limited | Modulador del receptor de cannabinoides |
KR20070046136A (ko) * | 2004-08-27 | 2007-05-02 | 다케다 야쿠힌 고교 가부시키가이샤 | 아조 화합물과 그 제조 방법 |
US20060100209A1 (en) * | 2004-11-09 | 2006-05-11 | Chong-Hui Gu | Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
US20060100432A1 (en) * | 2004-11-09 | 2006-05-11 | Matiskella John D | Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
DE102004061593A1 (de) | 2004-12-21 | 2006-06-22 | Abbott Gmbh & Co. Kg | Substituierte N-heterocyclische Verbindungen und ihre therapeutische Verwendung |
US7598380B2 (en) * | 2005-08-03 | 2009-10-06 | Bristol-Myers Squibb Company | Method of preparation of azaindole derivatives |
EP1922068A4 (de) | 2005-08-16 | 2010-08-11 | Icagen Inc | Inhibitoren von spannungsgesteuerten natriumkanälen |
US7705158B2 (en) | 2005-11-02 | 2010-04-27 | Icagen, Inc. | Inhibitors of ion channels |
US7851476B2 (en) * | 2005-12-14 | 2010-12-14 | Bristol-Myers Squibb Company | Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine |
US7807671B2 (en) | 2006-04-25 | 2010-10-05 | Bristol-Myers Squibb Company | Diketo-piperazine and piperidine derivatives as antiviral agents |
JP5361857B2 (ja) * | 2007-03-23 | 2013-12-04 | ファイザー・リミテッド | イオンチャネルの阻害剤 |
EP2173743A2 (de) * | 2007-07-13 | 2010-04-14 | Icagen, Inc. | Natriumkanalinhibitoren |
CN103554002B (zh) * | 2013-10-08 | 2016-04-27 | 常州大学 | 1-苯基吲哚及其制备方法 |
US10752588B2 (en) * | 2014-12-19 | 2020-08-25 | The Broad Institute, Inc. | Dopamine D2 receptor ligands |
WO2016100940A1 (en) | 2014-12-19 | 2016-06-23 | The Broad Institute, Inc. | Dopamine d2 receptor ligands |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE68675B1 (en) * | 1990-11-01 | 1996-07-10 | Takeda Chemical Industries Ltd | Aminocoumaran derivatives their production and use |
JP3198395B2 (ja) * | 1992-05-28 | 2001-08-13 | 武田薬品工業株式会社 | アミノクマラン誘導体 |
TW334433B (en) | 1992-12-09 | 1998-06-21 | Takeda Pharm Industry Co Ltd | Crystalline salt of (S)-(+)-5-amino-2,4,6,7-tetramethyl-2-(4-phenylpiperidinomethyl)-2,3-dihydrobenzo(b)furan dihydrochloride their production and use |
-
1997
- 1997-08-28 DE DE69719766T patent/DE69719766T2/de not_active Expired - Lifetime
- 1997-08-28 HU HU9903557A patent/HUP9903557A2/hu unknown
- 1997-08-28 AT AT97937828T patent/ATE234298T1/de not_active IP Right Cessation
- 1997-08-28 EP EP97937828A patent/EP0923575B1/de not_active Expired - Lifetime
- 1997-08-28 AU AU40316/97A patent/AU4031697A/en not_active Abandoned
- 1997-08-28 CN CN97195849A patent/CN1076022C/zh not_active Expired - Fee Related
- 1997-08-28 US US09/242,067 patent/US6172085B1/en not_active Expired - Fee Related
- 1997-08-28 CA CA002264231A patent/CA2264231A1/en not_active Abandoned
- 1997-08-28 WO PCT/JP1997/003007 patent/WO1998008842A1/en not_active Application Discontinuation
-
1999
- 1999-02-08 NO NO990583A patent/NO990583D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO990583L (no) | 1999-02-08 |
DE69719766D1 (de) | 2003-04-17 |
US6172085B1 (en) | 2001-01-09 |
AU4031697A (en) | 1998-03-19 |
EP0923575B1 (de) | 2003-03-12 |
CN1223652A (zh) | 1999-07-21 |
ATE234298T1 (de) | 2003-03-15 |
CN1076022C (zh) | 2001-12-12 |
EP0923575A1 (de) | 1999-06-23 |
HUP9903557A2 (en) | 2002-08-28 |
NO990583D0 (no) | 1999-02-08 |
CA2264231A1 (en) | 1998-03-05 |
WO1998008842A1 (en) | 1998-03-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: TAKEDA PHARMACEUTICAL CO. LTD., OSAKA, JP |