ATE234298T1 - Zyklische etherverbindungen als natriumkanal- modulatoren - Google Patents
Zyklische etherverbindungen als natriumkanal- modulatorenInfo
- Publication number
- ATE234298T1 ATE234298T1 AT97937828T AT97937828T ATE234298T1 AT E234298 T1 ATE234298 T1 AT E234298T1 AT 97937828 T AT97937828 T AT 97937828T AT 97937828 T AT97937828 T AT 97937828T AT E234298 T1 ATE234298 T1 AT E234298T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- sodium channel
- lower alkyl
- cyclic ether
- ether compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Optical Modulation, Optical Deflection, Nonlinear Optics, Optical Demodulation, Optical Logic Elements (AREA)
- Transmitters (AREA)
- Liquid Crystal Substances (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP22884596 | 1996-08-29 | ||
JP8649697 | 1997-04-04 | ||
PCT/JP1997/003007 WO1998008842A1 (en) | 1996-08-29 | 1997-08-28 | Cyclic ether compounds as sodium channel modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE234298T1 true ATE234298T1 (de) | 2003-03-15 |
Family
ID=26427602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97937828T ATE234298T1 (de) | 1996-08-29 | 1997-08-28 | Zyklische etherverbindungen als natriumkanal- modulatoren |
Country Status (10)
Country | Link |
---|---|
US (1) | US6172085B1 (de) |
EP (1) | EP0923575B1 (de) |
CN (1) | CN1076022C (de) |
AT (1) | ATE234298T1 (de) |
AU (1) | AU4031697A (de) |
CA (1) | CA2264231A1 (de) |
DE (1) | DE69719766T2 (de) |
HU (1) | HUP9903557A2 (de) |
NO (1) | NO990583D0 (de) |
WO (1) | WO1998008842A1 (de) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE261435T1 (de) | 1998-12-04 | 2004-03-15 | Takeda Chemical Industries Ltd | Benzofuranderivate, verfahren zu ihrer herstellung und deren verwendungen |
WO2000061188A1 (en) | 1999-04-09 | 2000-10-19 | Euro-Celtique S.A. | Sodium channel blocker compositions and the use thereof |
JP2003530432A (ja) * | 2000-04-12 | 2003-10-14 | ミナーヴァ・バイオテクノロジーズ・コーポレーション | 神経変性疾患の治療 |
US6825201B2 (en) * | 2001-04-25 | 2004-11-30 | Bristol-Myers Squibb Company | Indole, azaindole and related heterocyclic amidopiperazine derivatives |
AU2002333374B2 (en) | 2001-09-03 | 2007-03-22 | Newron Pharmaceuticals S.P.A. | Pharmaceutical composition comprising gabapentin or an analogue thereof and an (alpha)- aminoamide and its analgesic use |
ES2338539T3 (es) | 2001-11-01 | 2010-05-10 | Icagen, Inc. | Pirazolamidas para uso en el tratamiento del dolor. |
DK1458386T3 (da) * | 2001-12-27 | 2007-08-13 | Ortho Mcneil Pharm Inc | Aroylpyrrolheteroaryl- og methanolforbindelser til behandling af en lidelse i centralnervesystemet |
US20030236277A1 (en) | 2002-02-14 | 2003-12-25 | Kadow John F. | Indole, azaindole and related heterocyclic pyrrolidine derivatives |
CA2474751A1 (en) | 2002-02-25 | 2003-09-04 | Vanderbilt University | Expression system for human brain-specific voltage-gated sodium channel, type 1 |
US7037913B2 (en) | 2002-05-01 | 2006-05-02 | Bristol-Myers Squibb Company | Bicyclo 4.4.0 antiviral derivatives |
SI1637527T1 (sl) * | 2003-06-26 | 2013-07-31 | Takeda Pharmaceutical Company Limited | Modulator kanabinoidnega receptorja |
JPWO2006022311A1 (ja) * | 2004-08-27 | 2008-05-08 | 武田薬品工業株式会社 | アゾ化合物とその製造方法 |
US20060100432A1 (en) * | 2004-11-09 | 2006-05-11 | Matiskella John D | Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
US20060100209A1 (en) * | 2004-11-09 | 2006-05-11 | Chong-Hui Gu | Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
DE102004061593A1 (de) * | 2004-12-21 | 2006-06-22 | Abbott Gmbh & Co. Kg | Substituierte N-heterocyclische Verbindungen und ihre therapeutische Verwendung |
US7598380B2 (en) * | 2005-08-03 | 2009-10-06 | Bristol-Myers Squibb Company | Method of preparation of azaindole derivatives |
EP1922068A4 (de) | 2005-08-16 | 2010-08-11 | Icagen Inc | Inhibitoren von spannungsgesteuerten natriumkanälen |
EP1945029A4 (de) | 2005-11-02 | 2011-02-02 | Icagen Inc | Ionenkanalinhibitoren |
US7851476B2 (en) * | 2005-12-14 | 2010-12-14 | Bristol-Myers Squibb Company | Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine |
US7807671B2 (en) * | 2006-04-25 | 2010-10-05 | Bristol-Myers Squibb Company | Diketo-piperazine and piperidine derivatives as antiviral agents |
CL2008000835A1 (es) * | 2007-03-23 | 2008-10-03 | Icagen Inc Pfizer Ltd | Compuestos derivados de sulfonamidas, inhibidores de los canales de calcio; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del dolor, sindrome de intestino irritable, enfermedad de crohn, taquiarritm |
WO2009012242A2 (en) | 2007-07-13 | 2009-01-22 | Icagen, Inc. | Sodium channel inhibitors |
CN103554002B (zh) * | 2013-10-08 | 2016-04-27 | 常州大学 | 1-苯基吲哚及其制备方法 |
EP3233077A4 (de) | 2014-12-19 | 2018-08-08 | The Broad Institute Inc. | Dopamin-d2-rezeptor-liganden |
US10752588B2 (en) * | 2014-12-19 | 2020-08-25 | The Broad Institute, Inc. | Dopamine D2 receptor ligands |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE68675B1 (en) * | 1990-11-01 | 1996-07-10 | Takeda Chemical Industries Ltd | Aminocoumaran derivatives their production and use |
JP3198395B2 (ja) * | 1992-05-28 | 2001-08-13 | 武田薬品工業株式会社 | アミノクマラン誘導体 |
TW334433B (en) | 1992-12-09 | 1998-06-21 | Takeda Pharm Industry Co Ltd | Crystalline salt of (S)-(+)-5-amino-2,4,6,7-tetramethyl-2-(4-phenylpiperidinomethyl)-2,3-dihydrobenzo(b)furan dihydrochloride their production and use |
-
1997
- 1997-08-28 CN CN97195849A patent/CN1076022C/zh not_active Expired - Fee Related
- 1997-08-28 WO PCT/JP1997/003007 patent/WO1998008842A1/en not_active Application Discontinuation
- 1997-08-28 AU AU40316/97A patent/AU4031697A/en not_active Abandoned
- 1997-08-28 US US09/242,067 patent/US6172085B1/en not_active Expired - Fee Related
- 1997-08-28 DE DE69719766T patent/DE69719766T2/de not_active Expired - Lifetime
- 1997-08-28 AT AT97937828T patent/ATE234298T1/de not_active IP Right Cessation
- 1997-08-28 HU HU9903557A patent/HUP9903557A2/hu unknown
- 1997-08-28 EP EP97937828A patent/EP0923575B1/de not_active Expired - Lifetime
- 1997-08-28 CA CA002264231A patent/CA2264231A1/en not_active Abandoned
-
1999
- 1999-02-08 NO NO990583A patent/NO990583D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO990583L (no) | 1999-02-08 |
CN1076022C (zh) | 2001-12-12 |
AU4031697A (en) | 1998-03-19 |
EP0923575A1 (de) | 1999-06-23 |
NO990583D0 (no) | 1999-02-08 |
US6172085B1 (en) | 2001-01-09 |
EP0923575B1 (de) | 2003-03-12 |
DE69719766D1 (de) | 2003-04-17 |
WO1998008842A1 (en) | 1998-03-05 |
CN1223652A (zh) | 1999-07-21 |
DE69719766T2 (de) | 2004-01-15 |
HUP9903557A2 (en) | 2002-08-28 |
CA2264231A1 (en) | 1998-03-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |