ATE234298T1 - Zyklische etherverbindungen als natriumkanal- modulatoren - Google Patents

Zyklische etherverbindungen als natriumkanal- modulatoren

Info

Publication number
ATE234298T1
ATE234298T1 AT97937828T AT97937828T ATE234298T1 AT E234298 T1 ATE234298 T1 AT E234298T1 AT 97937828 T AT97937828 T AT 97937828T AT 97937828 T AT97937828 T AT 97937828T AT E234298 T1 ATE234298 T1 AT E234298T1
Authority
AT
Austria
Prior art keywords
substituted
sodium channel
lower alkyl
cyclic ether
ether compounds
Prior art date
Application number
AT97937828T
Other languages
English (en)
Inventor
Shigenori Ohkawa
Tadatoshi Hashimoto
Kohji Fukatsu
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ATE234298T1 publication Critical patent/ATE234298T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Optical Modulation, Optical Deflection, Nonlinear Optics, Optical Demodulation, Optical Logic Elements (AREA)
  • Transmitters (AREA)
  • Liquid Crystal Substances (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT97937828T 1996-08-29 1997-08-28 Zyklische etherverbindungen als natriumkanal- modulatoren ATE234298T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP22884596 1996-08-29
JP8649697 1997-04-04
PCT/JP1997/003007 WO1998008842A1 (en) 1996-08-29 1997-08-28 Cyclic ether compounds as sodium channel modulators

Publications (1)

Publication Number Publication Date
ATE234298T1 true ATE234298T1 (de) 2003-03-15

Family

ID=26427602

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97937828T ATE234298T1 (de) 1996-08-29 1997-08-28 Zyklische etherverbindungen als natriumkanal- modulatoren

Country Status (10)

Country Link
US (1) US6172085B1 (de)
EP (1) EP0923575B1 (de)
CN (1) CN1076022C (de)
AT (1) ATE234298T1 (de)
AU (1) AU4031697A (de)
CA (1) CA2264231A1 (de)
DE (1) DE69719766T2 (de)
HU (1) HUP9903557A2 (de)
NO (1) NO990583D0 (de)
WO (1) WO1998008842A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE261435T1 (de) 1998-12-04 2004-03-15 Takeda Chemical Industries Ltd Benzofuranderivate, verfahren zu ihrer herstellung und deren verwendungen
WO2000061188A1 (en) 1999-04-09 2000-10-19 Euro-Celtique S.A. Sodium channel blocker compositions and the use thereof
JP2003530432A (ja) * 2000-04-12 2003-10-14 ミナーヴァ・バイオテクノロジーズ・コーポレーション 神経変性疾患の治療
US6825201B2 (en) * 2001-04-25 2004-11-30 Bristol-Myers Squibb Company Indole, azaindole and related heterocyclic amidopiperazine derivatives
AU2002333374B2 (en) 2001-09-03 2007-03-22 Newron Pharmaceuticals S.P.A. Pharmaceutical composition comprising gabapentin or an analogue thereof and an (alpha)- aminoamide and its analgesic use
ES2338539T3 (es) 2001-11-01 2010-05-10 Icagen, Inc. Pirazolamidas para uso en el tratamiento del dolor.
DK1458386T3 (da) * 2001-12-27 2007-08-13 Ortho Mcneil Pharm Inc Aroylpyrrolheteroaryl- og methanolforbindelser til behandling af en lidelse i centralnervesystemet
US20030236277A1 (en) 2002-02-14 2003-12-25 Kadow John F. Indole, azaindole and related heterocyclic pyrrolidine derivatives
CA2474751A1 (en) 2002-02-25 2003-09-04 Vanderbilt University Expression system for human brain-specific voltage-gated sodium channel, type 1
US7037913B2 (en) 2002-05-01 2006-05-02 Bristol-Myers Squibb Company Bicyclo 4.4.0 antiviral derivatives
SI1637527T1 (sl) * 2003-06-26 2013-07-31 Takeda Pharmaceutical Company Limited Modulator kanabinoidnega receptorja
JPWO2006022311A1 (ja) * 2004-08-27 2008-05-08 武田薬品工業株式会社 アゾ化合物とその製造方法
US20060100432A1 (en) * 2004-11-09 2006-05-11 Matiskella John D Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
US20060100209A1 (en) * 2004-11-09 2006-05-11 Chong-Hui Gu Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
DE102004061593A1 (de) * 2004-12-21 2006-06-22 Abbott Gmbh & Co. Kg Substituierte N-heterocyclische Verbindungen und ihre therapeutische Verwendung
US7598380B2 (en) * 2005-08-03 2009-10-06 Bristol-Myers Squibb Company Method of preparation of azaindole derivatives
EP1922068A4 (de) 2005-08-16 2010-08-11 Icagen Inc Inhibitoren von spannungsgesteuerten natriumkanälen
EP1945029A4 (de) 2005-11-02 2011-02-02 Icagen Inc Ionenkanalinhibitoren
US7851476B2 (en) * 2005-12-14 2010-12-14 Bristol-Myers Squibb Company Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine
US7807671B2 (en) * 2006-04-25 2010-10-05 Bristol-Myers Squibb Company Diketo-piperazine and piperidine derivatives as antiviral agents
CL2008000835A1 (es) * 2007-03-23 2008-10-03 Icagen Inc Pfizer Ltd Compuestos derivados de sulfonamidas, inhibidores de los canales de calcio; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del dolor, sindrome de intestino irritable, enfermedad de crohn, taquiarritm
WO2009012242A2 (en) 2007-07-13 2009-01-22 Icagen, Inc. Sodium channel inhibitors
CN103554002B (zh) * 2013-10-08 2016-04-27 常州大学 1-苯基吲哚及其制备方法
EP3233077A4 (de) 2014-12-19 2018-08-08 The Broad Institute Inc. Dopamin-d2-rezeptor-liganden
US10752588B2 (en) * 2014-12-19 2020-08-25 The Broad Institute, Inc. Dopamine D2 receptor ligands

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE68675B1 (en) * 1990-11-01 1996-07-10 Takeda Chemical Industries Ltd Aminocoumaran derivatives their production and use
JP3198395B2 (ja) * 1992-05-28 2001-08-13 武田薬品工業株式会社 アミノクマラン誘導体
TW334433B (en) 1992-12-09 1998-06-21 Takeda Pharm Industry Co Ltd Crystalline salt of (S)-(+)-5-amino-2,4,6,7-tetramethyl-2-(4-phenylpiperidinomethyl)-2,3-dihydrobenzo(b)furan dihydrochloride their production and use

Also Published As

Publication number Publication date
NO990583L (no) 1999-02-08
CN1076022C (zh) 2001-12-12
AU4031697A (en) 1998-03-19
EP0923575A1 (de) 1999-06-23
NO990583D0 (no) 1999-02-08
US6172085B1 (en) 2001-01-09
EP0923575B1 (de) 2003-03-12
DE69719766D1 (de) 2003-04-17
WO1998008842A1 (en) 1998-03-05
CN1223652A (zh) 1999-07-21
DE69719766T2 (de) 2004-01-15
HUP9903557A2 (en) 2002-08-28
CA2264231A1 (en) 1998-03-05

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